4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: Enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1511-1517

  Hashimoto, Hiromasa ^a   Imamura, Katsuaki ^a   Haruta, Jun Ichi ^a   Wakitani, Korekiyo ^a  

^a JT Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLUORINE; INDOMETACIN; PHENYL GROUP; ROFECOXIB; SULFONAMIDE; TILMACOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL TRIAL; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; OSTEOARTHRITIS; PAIN; PHASE 2 CLINICAL TRIAL; RAT; RHEUMATOID ARTHRITIS; STEREOCHEMISTRY;

ANTI-INFLAMMATORY AGENTS; ARTHRITIS, RHEUMATOID; BENZENESULFONATES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FLUORINE; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MEMBRANE PROTEINS; MODELS, CHEMICAL; OXAZOLES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SULFONAMIDES; TEMPERATURE;

EID: 0037187427     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010484p     Document Type: Article

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