Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore

European Journal of Medicinal Chemistry

Volumn 40, Issue 10, 2005, Pages 977-990

  Singh, Sunil K ^a   Saibaba, V ^a   Rao, K Srinivasa ^a   Reddy, P Ganapati ^a   Daga, Pankaj R ^a   Rajjak, S Abdul ^a   Misra, Parimal ^a   Rao, Y Koteswar ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

1,5 Diarylpyrazoles; 3D QSAR; COX 2 inhibitors; SAR

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PYRAZOLE DERIVATIVE; SULFONAMIDE; TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; NONHUMAN; PHARMACOPHORE; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444615423     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.03.016     Document Type: Article

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