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Volumn 110, Issue 2, 2008, Pages 93-100

Stearoyl-CoA desaturase: A novel control point of lipid metabolism and insulin sensitivity

Author keywords

Insulin signaling; Lipids; Metabolism

Indexed keywords

MUS;

EID: 42949155123     PISSN: 14387697     EISSN: 14389312     Source Type: Journal    
DOI: 10.1002/ejlt.200700249     Document Type: Review
Times cited : (22)

References (62)
  • 1
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • L. H. Storlien, A. B. Jenkins, D. J. Chisholm, W. S. Pascoe, S. Khouri, E. W. Kraegen: Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes. 1991, 40, 280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 2
    • 0027938409 scopus 로고
    • Dietary fats, membrane phospholipids and obesity
    • D. A. Pan, A. J. Hulbert, L. H. Storlein: Dietary fats, membrane phospholipids and obesity. J Nutr. 1994, 124, 1555-1565.
    • (1994) J Nutr , vol.124 , pp. 1555-1565
    • Pan, D.A.1    Hulbert, A.J.2    Storlein, L.H.3
  • 3
    • 0029809472 scopus 로고    scopus 로고
    • Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids
    • B. H. Jones, M. A. Maher, W. J. Banz, M. B. Zemel, J. Whelan, P. J. Smith, N. Moustaid: Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids. Am J Physiol. 1996, 271, E44-E49.
    • (1996) Am J Physiol , vol.271
    • Jones, B.H.1    Maher, M.A.2    Banz, W.J.3    Zemel, M.B.4    Whelan, J.5    Smith, P.J.6    Moustaid, N.7
  • 4
    • 0033857245 scopus 로고    scopus 로고
    • Abnormalities of erythrocyte membrane fluidity, lipid composition, and lipid peroxidation in systemic sclerosis: Evidence of free radical-mediated injury
    • R. Solans, C. Motta, R. Sola, A. E. La Ville, J. Lima, P. Simeon, N. Montella, L. Armadans-Gil, V. Fonollosa, M. Vilardell: Abnormalities of erythrocyte membrane fluidity, lipid composition, and lipid peroxidation in systemic sclerosis: Evidence of free radical-mediated injury. Arthritis Rheum. 2000, 43, 894-900.
    • (2000) Arthritis Rheum , vol.43 , pp. 894-900
    • Solans, R.1    Motta, C.2    Sola, R.3    La Ville, A.E.4    Lima, J.5    Simeon, P.6    Montella, N.7    Armadans-Gil, L.8    Fonollosa, V.9    Vilardell, M.10
  • 5
    • 0035965565 scopus 로고    scopus 로고
    • Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia
    • G. Agatha, R. Hafer, F. Zintl: Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. Cancer Lett. 2001, 173, 139-144.
    • (2001) Cancer Lett , vol.173 , pp. 139-144
    • Agatha, G.1    Hafer, R.2    Zintl, F.3
  • 7
    • 1542404084 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in body weight regulation
    • A. Dobrzyn, J. M. Ntambi: The role of stearoyl-CoA desaturase in body weight regulation. Trends Cardiovasc Med. 2004, 14, 77-81.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 77-81
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 8
    • 20444484914 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in the control of metabolism
    • A. Dobrzyn, J. M. Ntambi: The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins Leukot Essent Fatty Acids. 2005, 73, 35-41.
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.73 , pp. 35-41
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 9
    • 0141813781 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    • S. M. Rahman, A. Dobrzyn, P. Dobrzyn, S. H. Lee, M. Miyazaki, J. M. Ntambi: Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci USA. 2003, 100, 11110-11115.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11110-11115
    • Rahman, S.M.1    Dobrzyn, A.2    Dobrzyn, P.3    Lee, S.H.4    Miyazaki, M.5    Ntambi, J.M.6
  • 10
    • 33845263672 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase: A new therapeutic target of liver steatosis
    • P. Dobrzyn, A. Dobrzyn: Stearoyl-CoA desaturase: A new therapeutic target of liver steatosis. Drug Dev Res. 2006, 67, 643-650.
    • (2006) Drug Dev Res , vol.67 , pp. 643-650
    • Dobrzyn, P.1    Dobrzyn, A.2
  • 12
    • 4544231849 scopus 로고    scopus 로고
    • Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha
    • M. Miyazaki, A. Dobrzyn, H. Sampath, S. H. Lee, W. C. Man, K. Chu, J. M. Peters, F. J. Gonzalez, J. M Ntambi: Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J Biol Chem. 2004, 279, 35017-35024.
    • (2004) J Biol Chem , vol.279 , pp. 35017-35024
    • Miyazaki, M.1    Dobrzyn, A.2    Sampath, H.3    Lee, S.H.4    Man, W.C.5    Chu, K.6    Peters, J.M.7    Gonzalez, F.J.8    Ntambi, J.M.9
  • 13
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • J. D. McGarry: Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 2002, 51, 7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 14
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • G. F. Lewis, A. Carpentier, K. Adeli, A. Giacca: Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev. 2002, 23, 201-229.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 15
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • R. H. Unger: Lipotoxic diseases. Annu Rev Med. 2002, 53, 319-336.
    • (2002) Annu Rev Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 16
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • G. I. Shulman: Cellular mechanisms of insulin resistance. J Clin Invest. 2000, 106, 171-176.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 17
    • 0345276007 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturases and role in metabolism
    • J. M. Ntambi, M. Miyazaki: Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res. 2004, 43, 91-104.
    • (2004) Prog Lipid Res , vol.43 , pp. 91-104
    • Ntambi, J.M.1    Miyazaki, M.2
  • 20
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • M. Miyazaki, Y. C. Kim, M. P. Gray-Keller, A. D. Attie, J. M. Ntambi: The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem. 2000, 275, 30132-30138.
    • (2000) J Biol Chem , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 21
    • 19744379323 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    • A. Dobrzyn, P. Dobrzyn, M. Miyazaki, H. Sampath, K. Chu, J. M. Ntambi: Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J Biol Chem. 2005, 280, 23356-23362.
    • (2005) J Biol Chem , vol.280 , pp. 23356-23362
    • Dobrzyn, A.1    Dobrzyn, P.2    Miyazaki, M.3    Sampath, H.4    Chu, K.5    Ntambi, J.M.6
  • 22
    • 33748655454 scopus 로고    scopus 로고
    • Stearoylcoenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    • K. Chu, M. Miyazaki, W. C. Man, J. M. Ntambi: Stearoylcoenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol. 2006, 26, 6786-6798.
    • (2006) Mol Cell Biol , vol.26 , pp. 6786-6798
    • Chu, K.1    Miyazaki, M.2    Man, W.C.3    Ntambi, J.M.4
  • 24
    • 2942588527 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    • M. Miyazaki, A. Dobrzyn, W. C. Man, K. Chu, H. Sampath, H. J. Kim, J. M. Ntambi: Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J Biol Chem. 2004, 279, 25164-25171.
    • (2004) J Biol Chem , vol.279 , pp. 25164-25171
    • Miyazaki, M.1    Dobrzyn, A.2    Man, W.C.3    Chu, K.4    Sampath, H.5    Kim, H.J.6    Ntambi, J.M.7
  • 26
    • 33747034520 scopus 로고    scopus 로고
    • Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    • S. B. Biddinger, M. Miyazaki, J. Boucher, J. M. Ntambi, C. R. Kahn: Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes. 2006, 55, 2032-2041.
    • (2006) Diabetes , vol.55 , pp. 2032-2041
    • Biddinger, S.B.1    Miyazaki, M.2    Boucher, J.3    Ntambi, J.M.4    Kahn, C.R.5
  • 27
    • 0026561011 scopus 로고
    • Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes
    • H. K. Stals, G. P. Mannaerts, P. E. Declercq: Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes. Biochem J. 1992, 283, 719-725.
    • (1992) Biochem J , vol.283 , pp. 719-725
    • Stals, H.K.1    Mannaerts, G.P.2    Declercq, P.E.3
  • 28
    • 0034958783 scopus 로고    scopus 로고
    • A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    • M. Miyazaki, Y. C. Kim, J. M. Ntambi: A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res. 2001, 42, 1018-1024.
    • (2001) J Lipid Res , vol.42 , pp. 1018-1024
    • Miyazaki, M.1    Kim, Y.C.2    Ntambi, J.M.3
  • 31
    • 13844250258 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    • A. Dobrzyn, P. Dobrzyn, S. H. Lee, M. Miyazaki, P. Cohen, E. Asilmaz, D. G. Hardie, J. M. Friedman, J. M. Ntambi: Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab. 2005, 288, E599-E607.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Dobrzyn, A.1    Dobrzyn, P.2    Lee, S.H.3    Miyazaki, M.4    Cohen, P.5    Asilmaz, E.6    Hardie, D.G.7    Friedman, J.M.8    Ntambi, J.M.9
  • 32
    • 4644340815 scopus 로고    scopus 로고
    • Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    • S. H. Lee, A. Dobrzyn, P. Dobrzyn, S. M. Rahman, M. Miyazaki, J. M. Ntambi: Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res. 2004, 45, 1674-1682.
    • (2004) J Lipid Res , vol.45 , pp. 1674-1682
    • Lee, S.H.1    Dobrzyn, A.2    Dobrzyn, P.3    Rahman, S.M.4    Miyazaki, M.5    Ntambi, J.M.6
  • 33
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway - new players upstream and downstream
    • D. G. Hardie: The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Sci. 2004, 117, 5479-5487.
    • (2004) J Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 34
    • 19744379230 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues
    • A. Dobrzyn, P. Dobrzyn, M. Miyazaki, J. M. Ntambi: Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues. Biochem Biophys Res Commun. 2005, 332, 892-896.
    • (2005) Biochem Biophys Res Commun , vol.332 , pp. 892-896
    • Dobrzyn, A.1    Dobrzyn, P.2    Miyazaki, M.3    Ntambi, J.M.4
  • 35
    • 34047269605 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
    • H. Sampath, M. Miyazaki, A. Dobrzyn, J. M. Ntambi: Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem. 2007, 282, 2483-2493.
    • (2007) J Biol Chem , vol.282 , pp. 2483-2493
    • Sampath, H.1    Miyazaki, M.2    Dobrzyn, A.3    Ntambi, J.M.4
  • 36
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • S. Kersten, J. Seydoux, J. M. Peters, F. J. Gonzalez, B. Desvergne, W. Wahli: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999, 103, 1489-1498.
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 37
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • P. Angulo: Nonalcoholic fatty liver disease. N Engl J Med. 2002, 346, 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 41
    • 0842269198 scopus 로고    scopus 로고
    • Hepatic steatosis in obese patients: Clinical aspects and prognostic significance
    • D. Festi, A. Colecchia, T. Sacco, M. Bondi, E. Roda, G. Marchesini: Hepatic steatosis in obese patients: Clinical aspects and prognostic significance. Obes Rev. 2004, 5, 27-42.
    • (2004) Obes Rev , vol.5 , pp. 27-42
    • Festi, D.1    Colecchia, A.2    Sacco, T.3    Bondi, M.4    Roda, E.5    Marchesini, G.6
  • 42
    • 36448991861 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    • M. Miyazaki, M. T. Flowers, H. Sampath, K. Chu, C. Otzelberger, X. Liu, J. M. Ntambi: Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007, 6, 484-496.
    • (2007) Cell Metab , vol.6 , pp. 484-496
    • Miyazaki, M.1    Flowers, M.T.2    Sampath, H.3    Chu, K.4    Otzelberger, C.5    Liu, X.6    Ntambi, J.M.7
  • 43
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • J. Araya, R. Rodrigo, L. A. Videla, L. Thielemann, M. Orellana, P. Pettinelli, J. Poniachik: Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci. 2004, 106, 635-643.
    • (2004) Clin Sci , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6    Poniachik, J.7
  • 44
    • 0032567445 scopus 로고    scopus 로고
    • Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
    • I. Shimomura, H. Shimano, B. S. Korn, Y. Bashmakov, J. D. Horton: Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem. 1998, 273, 35299-35306.
    • (1998) J Biol Chem , vol.273 , pp. 35299-35306
    • Shimomura, I.1    Shimano, H.2    Korn, B.S.3    Bashmakov, Y.4    Horton, J.D.5
  • 46
    • 0034770290 scopus 로고    scopus 로고
    • Turning WAT into BAT gets rid of fat
    • H. C. Chen, R. V. Farese: Turning WAT into BAT gets rid of fat. Nat Med. 2001, 7, 1102-1103.
    • (2001) Nat Med , vol.7 , pp. 1102-1103
    • Chen, H.C.1    Farese, R.V.2
  • 47
    • 34248198871 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    • J. B. Flowers, M. E. Rabaglia, K. L. Schueler, M. T. Flowers, H. Lan, M. P. Keller, J. M. Ntambi, A. D. Attie: Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes. 2007, 56, 1228-1239.
    • (2007) Diabetes , vol.56 , pp. 1228-1239
    • Flowers, J.B.1    Rabaglia, M.E.2    Schueler, K.L.3    Flowers, M.T.4    Lan, H.5    Keller, M.P.6    Ntambi, J.M.7    Attie, A.D.8
  • 48
    • 33745212925 scopus 로고    scopus 로고
    • Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    • R. Gutierrez-Juarez, A. Pocai, C. Mulas, H. Ono, S. Bhanot, B. P. Monia, L. Rossetti: Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest. 2006, 116, 1686-1695.
    • (2006) J Clin Invest , vol.116 , pp. 1686-1695
    • Gutierrez-Juarez, R.1    Pocai, A.2    Mulas, C.3    Ono, H.4    Bhanot, S.5    Monia, B.P.6    Rossetti, L.7
  • 49
    • 0036838494 scopus 로고    scopus 로고
    • AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle
    • G. S. Olsen, B. F. Hansen: AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2002, 283, E965-E970.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Olsen, G.S.1    Hansen, B.F.2
  • 50
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    • M. A. Iglesias, J. M. Ye, G. Frangioudakis, A. K. Saha, E. Tomas, N. B. Ruderman, G. J. Cooney, E. W. Kraegen: AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 2002, 51, 2886-2894.
    • (2002) Diabetes , vol.51 , pp. 2886-2894
    • Iglesias, M.A.1    Ye, J.M.2    Frangioudakis, G.3    Saha, A.K.4    Tomas, E.5    Ruderman, N.B.6    Cooney, G.J.7    Kraegen, E.W.8
  • 51
    • 0030784947 scopus 로고    scopus 로고
    • Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
    • N. D. Oakes, K. S. Bell, S. M. Furler, S. Camilleri, A. K. Saha, N. B. Ruderman, D. J. Chisholm, E. W. Kraegen: Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes. 1997, 46, 2022-2028.
    • (1997) Diabetes , vol.46 , pp. 2022-2028
    • Oakes, N.D.1    Bell, K.S.2    Furler, S.M.3    Camilleri, S.4    Saha, A.K.5    Ruderman, N.B.6    Chisholm, D.J.7    Kraegen, E.W.8
  • 52
    • 12144268751 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue
    • S. M. Rahman, A. Dobrzyn, S. H. Lee, P. Dobrzyn, M. Miyazaki, J. M. Ntambi: Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am J Physiol Endocrinol Metab. 2005, 288, E381-E387.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Rahman, S.M.1    Dobrzyn, A.2    Lee, S.H.3    Dobrzyn, P.4    Miyazaki, M.5    Ntambi, J.M.6
  • 54
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids
    • M. Borkman, L. H. Storlien, D. A. Pan, A. B. Jenkins, D. J. Chisholm, L. V. Campbell: The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med. 1993, 328, 238-244.
    • (1993) N Engl J Med , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, L.H.2    Pan, D.A.3    Jenkins, A.B.4    Chisholm, D.J.5    Campbell, L.V.6
  • 55
    • 9344237090 scopus 로고    scopus 로고
    • Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice
    • V. K. Yechoor, M. E. Patti, K. Ueki, P. G. Laustsen, R. Saccone, R. Rauniyar, C. R. Kahn: Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice. Proc Natl Acad Sci USA. 2004, 101, 16525-16530.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16525-16530
    • Yechoor, V.K.1    Patti, M.E.2    Ueki, K.3    Laustsen, P.G.4    Saccone, R.5    Rauniyar, R.6    Kahn, C.R.7
  • 56
    • 28444457749 scopus 로고    scopus 로고
    • Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: Implications for a role of stearoyl-CoA desaturase 1 in insulin resistance
    • M. D. Voss, A. Beha, N. Tennagels, G. Tschank, A. W. Herling, M. Quint, M. Gerl, C. Metz-Weidmann, G. Haun, M. Korn: Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: Implications for a role of stearoyl-CoA desaturase 1 in insulin resistance. Diabetologia. 2005, 48, 2622-2630.
    • (2005) Diabetologia , vol.48 , pp. 2622-2630
    • Voss, M.D.1    Beha, A.2    Tennagels, N.3    Tschank, G.4    Herling, A.W.5    Quint, M.6    Gerl, M.7    Metz-Weidmann, C.8    Haun, G.9    Korn, M.10
  • 57
    • 0033563109 scopus 로고    scopus 로고
    • Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites
    • L. Zhang, L. Ge, S. Parimoo, K. Stenn, S. M. Prouty: Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J. 1999, 340, 255-264.
    • (1999) Biochem J , vol.340 , pp. 255-264
    • Zhang, L.1    Ge, L.2    Parimoo, S.3    Stenn, K.4    Prouty, S.M.5
  • 58
    • 0037464551 scopus 로고    scopus 로고
    • Identification and characterization of a novel gene disrupted by a pericentric inversion inv (4)(p13_1q21.1) in a family with cleft lip
    • S. Beiraghi, M. Zhou, C. B. Talmadge, N. Went-Sumegi, J. R. Davis, D. Huang, H. Saal, T. A. Seemayer, J. Sumegi: Identification and characterization of a novel gene disrupted by a pericentric inversion inv (4)(p13_1q21.1) in a family with cleft lip. Gene. 2003, 309, 11-21.
    • (2003) Gene , vol.309 , pp. 11-21
    • Beiraghi, S.1    Zhou, M.2    Talmadge, C.B.3    Went-Sumegi, N.4    Davis, J.R.5    Huang, D.6    Saal, H.7    Seemayer, T.A.8    Sumegi, J.9
  • 59
    • 19544391176 scopus 로고    scopus 로고
    • Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells
    • S. Zhang, Y. Yang, Y. Shi: Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Biochem J. 2005, 15, 135-142.
    • (2005) Biochem J , vol.15 , pp. 135-142
    • Zhang, S.1    Yang, Y.2    Shi, Y.3
  • 62
    • 0037458568 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure
    • Y. Sun, M. Hao, Y. Luo, C. P. Liang, D. L. Silver, C. Cheng, F. R. Maxfield, A. R. Tall: Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure. J Biol Chem. 2003, 278, 5813-5820.
    • (2003) J Biol Chem , vol.278 , pp. 5813-5820
    • Sun, Y.1    Hao, M.2    Luo, Y.3    Liang, C.P.4    Silver, D.L.5    Cheng, C.6    Maxfield, F.R.7    Tall, A.R.8


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