AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 5 46-5, 2002, Pages

  Olsen, Grith S ^a   Hansen, Bo F ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

5 aminoimidazole 4 carboxamide 1 D ribonucleoside; Glycogen synthesis; Insulin sensitivity; Palmitate

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE PHOSPHATE; ADENYLATE KINASE; FATTY ACID; GLUCOSE 6 PHOSPHATE; PALMITIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; GLUCOSE TRANSPORT; GLYCOGEN ANALYSIS; GLYCOGEN SYNTHESIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0036838494     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00118.2002     Document Type: Article

References (33)

1. Armstrong RB and Phelps RO. Muscle fiber type composition of the rat hindlimb. Am J Anat 171: 259-272, 1984.
2. Bergeron R, Previs SF, Cline GW, Perret P, Russell RR, Young LH, and Shulman GI. Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes 50: 1076-1082, 2001.
3. Bergeron R, Russell RR, Young LH, Ren JM, Marcucci M, Lee A, and Shulman GI. Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am J Physiol Endocrinol Metab 276: E938-E944, 1999.
4. Boden G, Chen X, Ruiz J, White JV, and Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93: 2438-2446, 1994.
5. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, and Smith C. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88: 960-966, 1991.
6. Bonen A, Clark MG, and Henriksen EJ. Experimental approaches in muscle metabolism: hindlimb perfusion and isolated muscle incubations. Am J Physiol Endocrinol Metab 266: E1-E16, 1994.
7. Chalkley SM, Hettiarachchi M, Chisholm DJ, and Kraegen EW. Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat. Metabolism 47: 1121-1126, 1998.
8. Cheung PCF, Salt IP, Davies SP, Hardie DG, and Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 346: 659-669, 2000.
9. Cortez MY, Torgan CE, Brozinick JT, and Ivy JL. Insulin resistance of obese Zucker rats exercise trained at two different intensities. Am J Physiol Endocrinol Metab 261: E613-E619, 1991.
10. DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, and Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76: 149-155, 1985.
11. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, and Shulman GI. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103: 253-259, 1999.
12. Eriksson JG. Exercise and the treatment of type 2 diabetes mellitus. An update. Sports Med 27: 381-391, 1999.
13. Fiedler M, Zierath JR, Selen G, Wallberg-Henriksson H, Liang Y, and Sakariassen KS. 5-Aminoimidazole-4-carboxyamide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKA(y)-CETP mice. Diabetologia 44: 2180-2186, 2001.
14. Fisher JS, Gao JP, Han DH, Holloszy JO, and Nolte LA. Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab 282: E18-E23, 2002.
15. Fujii N, Hayashi T, Hirshman MF, Smith JT, Habinowski SA, Kaijser L, Mu J, Ljungqvist O, Birnbaum MJ, Witters LA, Thorell A, and Goodyear LJ. Exercise induces isoform-specific increase in 5′ AMP-activated protein kinase activity in human skeletal muscle. Biochem Biophys Res Commun 273: 1150-1155, 2000.
16. Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, and Goodyear LJ. Metabolic stress and altered glucose transport: Activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49: 527-531, 2000.
17. Hayashi T, Hirshman MF, Kurth EJ, Winder WW, and Goodyear LJ. Evidence for 5′AMP-activated protein-kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47: 1369-1373, 1998.
18. Kawanaka K, Han DH, Gao JP, Nolte LA, and Holloszy JO. Development of glucose-induced insulin resistance in muscle requires protein synthesis. J Biol Chem 276: 20101-20107, 2001.
19. Kelley DE, Mokan M, Simoneau JA, and Mandarino LJ. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92: 91-98, 1993.
20. Kim JB, Shulman GI, and Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and PKC/ but not on glycogen synthase kinase-3. J Biol Chem. In press.
21. Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, and Winder WW. 5′-AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48: 1667-1671, 1999.
22. Lowry OH and Passonneau JV. A Flexible System of Enzymatic Analysis. London: Academic, 1972, p. 1-291.
23. McGarry J. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18, 2002.
24. Merrill GF, Kurth EJ, Hardie DG, and Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol Endocrinol Metab 273: E1107-E1112, 1997.
25. Sugden C, Crawford RM, Halford NG, and Hardie DG. Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′-AMP. Plant J 19: 433-439, 1999.
26. Thomas JA, Schlender KK, and Larner J. A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem 25: 486-499, 1968.
27. Thompson A, Lim-Fraser MYC, Kraegen EW, and Cooney GJ. Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro, Am J Physiol Endocrinol Metab 279: E577-E584, 2000.
28. Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, and Ruderman NB. Contraction-induced changes in acetyl-CoA carboxylase and 5′-AMP-activated kinase in skeletal-muscle. J Biol Chem 272: 13255-13261, 1997.
29. Winder WW and Hardie DG. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol Endocrinol Metab 270: E299-E304, 1996.
30. Winder WW and Hardie DG. AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes. Am J Physiol Endocrinol Metab 277: E1-E10, 1999.
31. Wojtaszewski JFP, Nielsen P, Hansen BF, Richter EA, and Kiens B. Isoform-specific and exercise intensity-dependent activation of 5′-AMP-activated protein kinase in human skeletal muscle. J Physiol (Lond) 528: 221-226, 2000.
32. Wojtaszewski JFP, Nielsen JN, and Richter EA. Exercise effects on muscle insulin signaling and action: Effect of acute exercise on insulin signaling and action in humans. J Appl Physiol 93: 384-392, 2002.
33. Zhou GC, Myers R, Li Y, Chen YL, Shen XL, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, and Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174, 2001.