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Volumn 3, Issue 4, 2008, Pages 391-401

A structural biology view of target drugability

Author keywords

Drugability prediction; Structural biology; Structural target assessment

Indexed keywords

AMINOPYRIDINE DERIVATIVE; ANGIOPOIETIN RECEPTOR; ASPARAGINE; BLOOD CLOTTING FACTOR 10A; CYCLIN DEPENDENT KINASE 2; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GLUTAMINE; HORMONE RECEPTOR; ION CHANNEL; PHOSPHATASE; PROLINE; PROTEIN MDM2; PROTEINASE; RAF PROTEIN; SORAFENIB; SULFATE;

EID: 42949151886     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.3.4.391     Document Type: Review
Times cited : (48)

References (67)
  • 1
    • 14044266006 scopus 로고    scopus 로고
    • Failure rates in drug discovery and development: Will we ever get any better?
    • Bains W. Failure rates in drug discovery and development: will we ever get any better? Drug Discov World 2004:9-18
    • (2004) Drug Discov World , pp. 9-18
    • Bains, W.1
  • 2
    • 0032942042 scopus 로고    scopus 로고
    • Research & development. Basic science and pharmaceutical innovation
    • Drews J. Research & development. Basic science and pharmaceutical innovation. Nat Biotechnol 1999;17(5):406
    • (1999) Nat Biotechnol , vol.17 , Issue.5 , pp. 406
    • Drews, J.1
  • 4
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming P, Sinning C, Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 2006;5(10):821-34
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.10 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 5
    • 33644876210 scopus 로고    scopus 로고
    • Wishart DS, Knox C, Guo AC, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res 2006;34(Database issue):D668-72
    • Wishart DS, Knox C, Guo AC, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res 2006;34(Database issue):D668-72
  • 6
    • 33646754515 scopus 로고    scopus 로고
    • Therapeutic targets: Progress of their exploration and investigation of their characteristics
    • Zheng CJ, Han LY, Yap CW, et al. Therapeutic targets: progress of their exploration and investigation of their characteristics. Pharmacol Rev 2006;58(2):259-79
    • (2006) Pharmacol Rev , vol.58 , Issue.2 , pp. 259-279
    • Zheng, C.J.1    Han, L.Y.2    Yap, C.W.3
  • 8
    • 0036084258 scopus 로고    scopus 로고
    • Chen X, Ji ZL, Chen YZ. TTD: Therapeutic Target Database. Nucleic Acids Res 2002;30(1):412-5
    • Chen X, Ji ZL, Chen YZ. TTD: Therapeutic Target Database. Nucleic Acids Res 2002;30(1):412-5
  • 10
    • 29144531173 scopus 로고    scopus 로고
    • The druggable genome: An update
    • Russ AP, Lampel S. The druggable genome: an update. Drug Discov Today 2005;10(23-24):1607-10
    • (2005) Drug Discov Today , vol.10 , Issue.23-24 , pp. 1607-1610
    • Russ, A.P.1    Lampel, S.2
  • 12
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 2000;44(1):235-49
    • (2000) J Pharmacol Toxicol Methods , vol.44 , Issue.1 , pp. 235-249
    • Lipinski, C.A.1
  • 13
    • 33947600314 scopus 로고    scopus 로고
    • Support vector machines approach for predicting druggable proteins: Recent progress in its exploration and investigation of its usefulness
    • Han LY, Zheng CJ, Xie B, et al. Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness. Drug Discov Today 2007;12(7-8):304-13
    • (2007) Drug Discov Today , vol.12 , Issue.7-8 , pp. 304-313
    • Han, L.Y.1    Zheng, C.J.2    Xie, B.3
  • 16
    • 33646532662 scopus 로고    scopus 로고
    • Progress and problems in the exploration of therapeutic targets
    • Zheng C, Han L, Yap CW, et al. Progress and problems in the exploration of therapeutic targets. Drug Discov Today 2006;11(9-10):412-20
    • (2006) Drug Discov Today , vol.11 , Issue.9-10 , pp. 412-420
    • Zheng, C.1    Han, L.2    Yap, C.W.3
  • 17
    • 3342967725 scopus 로고    scopus 로고
    • The chemical hunt for the identification of drugable targets
    • Meisner NC, Hintersteiner M, Uhl V, et al. The chemical hunt for the identification of drugable targets. Curr Opin Chem Biol 2004;8(4):424-31
    • (2004) Curr Opin Chem Biol , vol.8 , Issue.4 , pp. 424-431
    • Meisner, N.C.1    Hintersteiner, M.2    Uhl, V.3
  • 18
    • 20444484518 scopus 로고    scopus 로고
    • The target discovery process
    • Egner U, Kratzschmar J, Kreft B, et al. The target discovery process. Chembiochem 2005;6(3):468-79
    • (2005) Chembiochem , vol.6 , Issue.3 , pp. 468-479
    • Egner, U.1    Kratzschmar, J.2    Kreft, B.3
  • 19
    • 29144483936 scopus 로고    scopus 로고
    • Predicting protein druggability
    • Hajduk PJ, Huth JR, Tse C. Predicting protein druggability. Drug Discov Today 2005;10(23-24):1675-82
    • (2005) Drug Discov Today , vol.10 , Issue.23-24 , pp. 1675-1682
    • Hajduk, P.J.1    Huth, J.R.2    Tse, C.3
  • 21
    • 32544436259 scopus 로고    scopus 로고
    • NMR fragment screening: Advantages and applications
    • Schade M. NMR fragment screening: advantages and applications. IDrugs 2006;9(2):110-3
    • (2006) IDrugs , vol.9 , Issue.2 , pp. 110-113
    • Schade, M.1
  • 23
    • 17144373303 scopus 로고    scopus 로고
    • Druggability indices for protein targets derived from NMR-based screening data
    • Hajduk PJ, Huth JR, Fesik SW. Druggability indices for protein targets derived from NMR-based screening data. J Med Chem 2005;48(7):2518-25
    • (2005) J Med Chem , vol.48 , Issue.7 , pp. 2518-2525
    • Hajduk, P.J.1    Huth, J.R.2    Fesik, S.W.3
  • 24
    • 0037103004 scopus 로고    scopus 로고
    • Prediction of protein solvent accessibility using support vector machines
    • Yuan Z, Burrage K, Mattick JS. Prediction of protein solvent accessibility using support vector machines. Proteins 2002;48(3):566-70
    • (2002) Proteins , vol.48 , Issue.3 , pp. 566-570
    • Yuan, Z.1    Burrage, K.2    Mattick, J.S.3
  • 25
    • 33745607880 scopus 로고    scopus 로고
    • Prioritizing genomic drug targets in pathogens: Application to Mycobacterium tuberculosis
    • Hasan S, Daugelat S, Rao PS, Schreiber M. Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2006;2(6):e61
    • (2006) PLoS Comput Biol , vol.2 , Issue.6
    • Hasan, S.1    Daugelat, S.2    Rao, P.S.3    Schreiber, M.4
  • 26
    • 33747829590 scopus 로고    scopus 로고
    • Li H, Gao Z, Kang L, et al. TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res 2006;34(Web Server issue):W219-24
    • Li H, Gao Z, Kang L, et al. TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res 2006;34(Web Server issue):W219-24
  • 27
    • 33749618171 scopus 로고    scopus 로고
    • Interrogating the druggable genome with structural informatics
    • Hambly K, Danzer J, Muskal S, Debe DA. Interrogating the druggable genome with structural informatics. Mol Divers 2006;10(3):273-81
    • (2006) Mol Divers , vol.10 , Issue.3 , pp. 273-281
    • Hambly, K.1    Danzer, J.2    Muskal, S.3    Debe, D.A.4
  • 28
    • 33644876020 scopus 로고    scopus 로고
    • Finn RD, Mistry J, Schuster-Bockler B, et al. Pfam: clans, web tools and services. Nucleic Acids Res 2006;34(Database issue):D247-51
    • Finn RD, Mistry J, Schuster-Bockler B, et al. Pfam: clans, web tools and services. Nucleic Acids Res 2006;34(Database issue):D247-51
  • 29
    • 12144249613 scopus 로고    scopus 로고
    • Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening
    • Chuaqui C, Deng Z, Singh J. Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening. J Med Chem 2005;48(1):121-33
    • (2005) J Med Chem , vol.48 , Issue.1 , pp. 121-133
    • Chuaqui, C.1    Deng, Z.2    Singh, J.3
  • 30
    • 0346962971 scopus 로고    scopus 로고
    • Structural interaction fingerprint (SIFt): A novel method for analyzing three-dimensional protein-ligand binding interactions
    • Deng Z, Chuaqui C, Singh J. Structural interaction fingerprint (SIFt): a novel method for analyzing three-dimensional protein-ligand binding interactions. J Med Chem 2004;47(2):337-44
    • (2004) J Med Chem , vol.47 , Issue.2 , pp. 337-344
    • Deng, Z.1    Chuaqui, C.2    Singh, J.3
  • 31
    • 24944552075 scopus 로고    scopus 로고
    • High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding
    • Sheinerman FB, Giraud E, Laoui A. High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding. J Mol Biol 2005;352(5):1134-56
    • (2005) J Mol Biol , vol.352 , Issue.5 , pp. 1134-1156
    • Sheinerman, F.B.1    Giraud, E.2    Laoui, A.3
  • 32
    • 33646839120 scopus 로고    scopus 로고
    • Characterization of protein-ligand interaction sites using experimental and computational methods
    • Vajda S, Guarnieri F. Characterization of protein-ligand interaction sites using experimental and computational methods. Curr Opin Drug Discov Devel 2006;9(3):354-62
    • (2006) Curr Opin Drug Discov Devel , vol.9 , Issue.3 , pp. 354-362
    • Vajda, S.1    Guarnieri, F.2
  • 33
    • 0033757806 scopus 로고    scopus 로고
    • The Protein Data Bank and the challenge of structural genomics
    • Berman HM, Bhat TN, Bourne PE, et al. The Protein Data Bank and the challenge of structural genomics. Nat Struct Biol 2000;7(Suppl):957-9
    • (2000) Nat Struct Biol , vol.7 , Issue.SUPPL. , pp. 957-959
    • Berman, H.M.1    Bhat, T.N.2    Bourne, P.E.3
  • 35
    • 29144506872 scopus 로고    scopus 로고
    • Representativity of target families in the Protein Data Bank: Impact for family-directed structure-based drug discovery
    • Mestres J. Representativity of target families in the Protein Data Bank: impact for family-directed structure-based drug discovery. Drug Discov Today 2005;10(23-24):1629-37
    • (2005) Drug Discov Today , vol.10 , Issue.23-24 , pp. 1629-1637
    • Mestres, J.1
  • 36
    • 34548439949 scopus 로고    scopus 로고
    • Structural Biology approaches to antibacterial drug discovery
    • Holler TP, Evdokimov AG, Narasimhan L. Structural Biology approaches to antibacterial drug discovery. Expert Opin Drug Discov 2007;2(8):1085-101
    • (2007) Expert Opin Drug Discov , vol.2 , Issue.8 , pp. 1085-1101
    • Holler, T.P.1    Evdokimov, A.G.2    Narasimhan, L.3
  • 37
    • 33747189732 scopus 로고    scopus 로고
    • Sinnecker S, Neese F. QM/MM calculations with DFT for taking into account protein effects on the EPR and optical spectra of metalloproteins. Plastocyanin as a case study. J Comput Chem 2006;27(12):1463-75
    • Sinnecker S, Neese F. QM/MM calculations with DFT for taking into account protein effects on the EPR and optical spectra of metalloproteins. Plastocyanin as a case study. J Comput Chem 2006;27(12):1463-75
  • 38
    • 24144448070 scopus 로고    scopus 로고
    • Are AM1 ligand-protein binding enthalpies good enough for use in the rational design of new drugs?
    • Villar R, Gil MJ, Garcia JI, Martinez-Merino V. Are AM1 ligand-protein binding enthalpies good enough for use in the rational design of new drugs? J Comput Chem 2005;26(13):1347-58
    • (2005) J Comput Chem , vol.26 , Issue.13 , pp. 1347-1358
    • Villar, R.1    Gil, M.J.2    Garcia, J.I.3    Martinez-Merino, V.4
  • 39
    • 33749506205 scopus 로고    scopus 로고
    • Methods for the prediction of protein-ligand binding sites for structure-based drug design and virtual ligand screening
    • Laurie AT, Jackson RM. Methods for the prediction of protein-ligand binding sites for structure-based drug design and virtual ligand screening. Curr Protein Pept Sci 2006;7(5):395-406
    • (2006) Curr Protein Pept Sci , vol.7 , Issue.5 , pp. 395-406
    • Laurie, A.T.1    Jackson, R.M.2
  • 40
    • 33646757492 scopus 로고    scopus 로고
    • On the nature of cavities on protein surfaces: Application to the identification of drug-binding sites
    • Nayal M, Honig B. On the nature of cavities on protein surfaces: application to the identification of drug-binding sites. Proteins 2006;63(4):892-906
    • (2006) Proteins , vol.63 , Issue.4 , pp. 892-906
    • Nayal, M.1    Honig, B.2
  • 42
    • 21044444449 scopus 로고    scopus 로고
    • Pocketome via comprehensive identification and classification of ligand binding envelopes
    • An J, Totrov M, Abagyan R. Pocketome via comprehensive identification and classification of ligand binding envelopes. Mol Cell Proteomics 2005;4(6):752-61
    • (2005) Mol Cell Proteomics , vol.4 , Issue.6 , pp. 752-761
    • An, J.1    Totrov, M.2    Abagyan, R.3
  • 43
    • 30144442036 scopus 로고    scopus 로고
    • A method for localizing ligand binding pockets in protein structures
    • Glaser F, Morris RJ, Najmanovich RJ, et al. A method for localizing ligand binding pockets in protein structures. Proteins 2006;62(2):479-88
    • (2006) Proteins , vol.62 , Issue.2 , pp. 479-488
    • Glaser, F.1    Morris, R.J.2    Najmanovich, R.J.3
  • 44
    • 33947420470 scopus 로고    scopus 로고
    • New method for fast and accurate binding-site identification and analysis
    • Halgren T. New method for fast and accurate binding-site identification and analysis. Chem Biol Drug Des 2007;69(2):146-8
    • (2007) Chem Biol Drug Des , vol.69 , Issue.2 , pp. 146-148
    • Halgren, T.1
  • 45
    • 33646228824 scopus 로고    scopus 로고
    • Kellenberger E, Muller P, Schalon C, et al. sc-PDB: an annotated database of druggable binding sites from the Protein Data Bank. J Chem Inf Model 2006;46(2):717-27
    • Kellenberger E, Muller P, Schalon C, et al. sc-PDB: an annotated database of druggable binding sites from the Protein Data Bank. J Chem Inf Model 2006;46(2):717-27
  • 46
    • 10844282814 scopus 로고    scopus 로고
    • MSDsite: A database search and retrieval system for the analysis and viewing of bound ligands and active sites
    • Golovin A, Dimitropoulos D, Oldfield T, et al. MSDsite: a database search and retrieval system for the analysis and viewing of bound ligands and active sites. Proteins 2005;58(1):190-9
    • (2005) Proteins , vol.58 , Issue.1 , pp. 190-199
    • Golovin, A.1    Dimitropoulos, D.2    Oldfield, T.3
  • 47
    • 14144254344 scopus 로고    scopus 로고
    • Identification of the ligand binding sites on the molecular surface of proteins
    • Kinoshita K, Nakamura H. Identification of the ligand binding sites on the molecular surface of proteins. Protein Sci 2005;14(3):711-8
    • (2005) Protein Sci , vol.14 , Issue.3 , pp. 711-718
    • Kinoshita, K.1    Nakamura, H.2
  • 48
    • 33746076877 scopus 로고    scopus 로고
    • Effects of conformational dynamics on predicted protein druggability
    • Brown SP, Hajduk PJ. Effects of conformational dynamics on predicted protein druggability. ChemMedChem 2006;1(1):70-2
    • (2006) ChemMedChem , vol.1 , Issue.1 , pp. 70-72
    • Brown, S.P.1    Hajduk, P.J.2
  • 49
    • 34547583152 scopus 로고    scopus 로고
    • Transient pockets on protein surfaces involved in protein-protein interaction
    • Eyrisch S, Helms V. Transient pockets on protein surfaces involved in protein-protein interaction. J Med Chem 2007;50(15):3457-64
    • (2007) J Med Chem , vol.50 , Issue.15 , pp. 3457-3464
    • Eyrisch, S.1    Helms, V.2
  • 50
    • 33846155913 scopus 로고    scopus 로고
    • Structure-based maximal affinity model predicts small-molecule druggability
    • Cheng AC, Coleman RG, Smyth KT, et al. Structure-based maximal affinity model predicts small-molecule druggability. Nat Biotechnol 2007;25(1):71-5
    • (2007) Nat Biotechnol , vol.25 , Issue.1 , pp. 71-75
    • Cheng, A.C.1    Coleman, R.G.2    Smyth, K.T.3
  • 51
    • 33845806987 scopus 로고    scopus 로고
    • Structure-based identification of small molecule binding sites using a free energy model
    • Coleman RG, Salzberg AC, Cheng AC. Structure-based identification of small molecule binding sites using a free energy model. J Chem Inf Model 2006;46(6):2631-7
    • (2006) J Chem Inf Model , vol.46 , Issue.6 , pp. 2631-2637
    • Coleman, R.G.1    Salzberg, A.C.2    Cheng, A.C.3
  • 52
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Del Rev 2001;46(1-3):3-26
    • (2001) Adv Drug Del Rev , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 54
    • 16344389354 scopus 로고    scopus 로고
    • The evolution of synthetic oral drug properties
    • Proudfoot JR. The evolution of synthetic oral drug properties. Bioorg Med Chem Lett 2005;15(4):1087-90
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.4 , pp. 1087-1090
    • Proudfoot, J.R.1
  • 55
    • 18744391429 scopus 로고    scopus 로고
    • The nuclear receptor ligand-binding domain: A family-based structure analysis
    • Folkertsma S, van Noort PI, Brandt RF, et al. The nuclear receptor ligand-binding domain: a family-based structure analysis. Curr Med Chem 2005;12(9):1001-16
    • (2005) Curr Med Chem , vol.12 , Issue.9 , pp. 1001-1016
    • Folkertsma, S.1    van Noort, P.I.2    Brandt, R.F.3
  • 56
    • 39549113183 scopus 로고    scopus 로고
    • Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site
    • Mochalkin I, Lightle S, Narasimhan L, et al. Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site. Protein Sci 2008;17(3):577-82
    • (2008) Protein Sci , vol.17 , Issue.3 , pp. 577-582
    • Mochalkin, I.1    Lightle, S.2    Narasimhan, L.3
  • 58
    • 33847620760 scopus 로고    scopus 로고
    • Structural aspects of drugability and selectivity of protein kinases in inflammation
    • Schäfer M, Egner U. Structural aspects of drugability and selectivity of protein kinases in inflammation. Anti Inflamm Anti Allergy Agents Med Chem 2007;6:5-17
    • (2007) Anti Inflamm Anti Allergy Agents Med Chem , vol.6 , pp. 5-17
    • Schäfer, M.1    Egner, U.2
  • 59
    • 4644259265 scopus 로고    scopus 로고
    • Kinase inhibition with BAY 43-9006 in renal cell carcinoma
    • Ahmad T, Eisen T. Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin Cancer Res 2004;10(18 Pt 2):S6388-92
    • (2004) Clin Cancer Res , vol.10 , Issue.18 PART 2
    • Ahmad, T.1    Eisen, T.2
  • 60
    • 34548146568 scopus 로고    scopus 로고
    • Crystal structure of human estrogen-related receptor {alpha} in complex with a synthetic inverse agonist reveals its novel molecular mechanism
    • Kallen J, Lattmann R, Beerli R, et al. Crystal structure of human estrogen-related receptor {alpha} in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem 2007;282(32):23231-9
    • (2007) J Biol Chem , vol.282 , Issue.32 , pp. 23231-23239
    • Kallen, J.1    Lattmann, R.2    Beerli, R.3
  • 61
    • 34447281530 scopus 로고    scopus 로고
    • Small molecule protein-protein inhibitors for the p53-MDM2 interaction
    • Dudkina AS, Lindsley CW. Small molecule protein-protein inhibitors for the p53-MDM2 interaction. Curr Top Med Chem 2007;7(10):952-60
    • (2007) Curr Top Med Chem , vol.7 , Issue.10 , pp. 952-960
    • Dudkina, A.S.1    Lindsley, C.W.2
  • 62
    • 0037207123 scopus 로고    scopus 로고
    • Crystal structures of two potent nonamidine inhibitors bound to factor Xa
    • Adler M, Kochanny MJ, Ye B, et al. Crystal structures of two potent nonamidine inhibitors bound to factor Xa. Biochemistry 2002;41(52):15514-23
    • (2002) Biochemistry , vol.41 , Issue.52 , pp. 15514-15523
    • Adler, M.1    Kochanny, M.J.2    Ye, B.3
  • 63
    • 42949157650 scopus 로고    scopus 로고
    • Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities
    • Lucking U, Siemeister G, Schafer M, et al. Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities. ChemMedChem 2007;2(1):63-77
    • (2007) ChemMedChem , vol.2 , Issue.1 , pp. 63-77
    • Lucking, U.1    Siemeister, G.2    Schafer, M.3
  • 64
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303(5659):844-8
    • (2004) Science , vol.303 , Issue.5659 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 65
    • 0035265679 scopus 로고    scopus 로고
    • Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2
    • Song H, Hanlon N, Brown NR, et al. Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol Cell 2001;7(3):615-26
    • (2001) Mol Cell , vol.7 , Issue.3 , pp. 615-626
    • Song, H.1    Hanlon, N.2    Brown, N.R.3
  • 66
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PT, Garnett MJ, Roe SM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004;116(6):855-67
    • (2004) Cell , vol.116 , Issue.6 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3
  • 67
    • 0034435424 scopus 로고    scopus 로고
    • Structure of the Tie2 RTK domain: Self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail
    • Shewchuk LM, Hassell AM, Ellis B, et al. Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. Structure 2000;8(11):1105-13
    • (2000) Structure , vol.8 , Issue.11 , pp. 1105-1113
    • Shewchuk, L.M.1    Hassell, A.M.2    Ellis, B.3


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