Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site

Protein Science

Volumn 17, Issue 3, 2008, Pages 577-582

  Mochalkin, Igor ^a,b   Lightle, Sandra ^a   Narasimhan, Lakshmi ^a   Bornemeier, Dirk ^a   Melnick, Michael ^a   Vanderroest, Steven ^a   Mcdowell, Laura ^a  

^a PFIZER INC   (United States)

^b Pfizer Inc ^*  (United States)

Author keywords

Allosteric inhibitors; Mechanism; UDP N acetylglucosamine; Uridyltransferase

Indexed keywords

HEXOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; N ACETYLGLUCOSAMINE 1 PHOSPHATE URIDYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HAEMOPHILUS INFLUENZAE TYPE A; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

ALLOSTERIC SITE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BENZAMIDES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HAEMOPHILUS INFLUENZAE; MODELS, MOLECULAR; NUCLEOTIDYLTRANSFERASES; PIPERIDINES; PROTEIN BINDING;

HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 39549113183     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.073271408     Document Type: Article

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