Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell line

Neuroendocrinology

Volumn 87, Issue 3, 2008, Pages 168-181

  Grozinsky Glasberg, Simona ^a,b   Franchi, Giulia ^a,c   Teng, Mabel ^a   Leontiou, Chrysanthia A ^a   Ribeiro De Oliveira Jr , Antônio ^a,e   Dalino, Paolo ^a,d   Salahuddin, Nabila ^a   Korbonits, Márta ^a   Grossman, Ashley B ^a,f  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b RABIN MEDICAL CENTER   (Israel)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^f ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Akt mTOR p70S6 kinase pathway; Neuro endocrine tumours; Octreotide; RAD001; Somatostatin analogs

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OCTREOTIDE; PROTEIN KINASE B; PROTEIN P70; PROTEIN P70S6K; S6 KINASE; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG BINDING SITE; DRUG CROSS REACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; INHIBITION KINETICS; INSULINOMA; NEUROENDOCRINE TUMOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; TREATMENT OUTCOME; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; NEUROENDOCRINE TUMORS; OCTREOTIDE; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; TUMOR CELLS, CULTURED;

EID: 42449118823     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111501     Document Type: Article

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