A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening

Acta Pharmacologica Sinica

Volumn 24, Issue 6, 2003, Pages 497-504+619

  Xiong, Bin ^a   Gui, Chun Shan ^a   Xu, Xiao Ying ^a   Luo, Cheng ^a   Chen, Jing ^a   Luo, Hai Bin ^a   Chen, Li Li ^a   Li, Guo Wei ^a   Sun, Tao ^a   Yu, Chang Ying ^a   Yue, Li Duo ^a   Duan, Wen Hu ^a   Shen, Jing Kang ^a   Qin, Lei ^b   Shi, Ti Liu ^c   Li, Yi Xue ^b,c   Chen, Kai Xian ^a   Luo, Xiao Min ^a   Shen, Xu ^a   Shen, Jian Hua ^a   Jiang, Hua Liang ^a   more..

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI CENTER FOR BIOINFORMATION TECHNOLOGY   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

3CL proteinase; Bioinformatics; Inhibitors; Molecular modeling; Severe acute respiratory syndrome (SARS); Virtual screening

Indexed keywords

ANTIVIRUS AGENT; PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; BIOINFORMATICS; CORONAVIRUS; CRYSTAL STRUCTURE; DATA BASE; DRUG DESIGN; DRUG SCREENING; ENZYME ACTIVE SITE; GENBANK; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN TARGETING; SARS CORONAVIRUS; STRUCTURE ANALYSIS; TRANSMISSIBLE GASTROENTERITIS VIRUS; X RAY CRYSTALLOGRAPHY;

COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SARS VIRUS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SEVERE ACUTE RESPIRATORY SYNDROME; STRUCTURAL HOMOLOGY, PROTEIN; TRANSMISSIBLE GASTROENTERITIS VIRUS;

EID: 12444278968     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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