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0029025244
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45
-
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0029043448
-
Inhibition of human neutrophil elastase. 3. An orally active enol acetate prodrug
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47
-
-
15144350748
-
-
Assigned configurations were based on inhibitory activity
-
Assigned configurations were based on inhibitory activity.
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48
-
-
15144360778
-
-
note
-
m relative to those substrates incorporating alanine. See refs 22b,c.
-
-
-
-
49
-
-
15144345784
-
-
A number of other amide substitutions based on compounds 39 and 51 were tested, however no improvement in inhibitor potency was noted relative to 51
-
A number of other amide substitutions based on compounds 39 and 51 were tested, however no improvement in inhibitor potency was noted relative to 51.
-
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-
50
-
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0027484224
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15144344698
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i value of approximately 40 nM was extrapolated from the Dixon plot
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i value of approximately 40 nM was extrapolated from the Dixon plot.
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54
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15144354008
-
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50 values greater than 250 μM
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50 values greater than 250 μM.
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55
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0026600147
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Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones
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o will be published separately
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o will be published separately.
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