Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line

EMBO Journal

Volumn 21, Issue 18, 2002, Pages 4809-4819

  Cao, Youjia ^a   Janssen, Erin M ^a   Duncan, Andrew W ^a   Altman, Amnon ^a   Billadeau, Daniel D ^a   Abraham, Robert T ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Protein kinase C ; Signal transduction; T cell antigenreceptor; Vav

Indexed keywords

CD28 ANTIGEN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; VAV PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; ENZYME ACTIVITY; GENE LOCUS; GENE TARGETING; GENETIC COMPLEMENTATION; LEUKEMIA CELL LINE; NONHUMAN; NULL CELL; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FAMILY; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CALCIUM; CALCIUM SIGNALING; CELL CYCLE PROTEINS; CELL FRACTIONATION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE TARGETING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTERLEUKIN-2; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MEMBRANE MICRODOMAINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; RECEPTORS, ANTIGEN, T-CELL; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037119994     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf499     Document Type: Article

References (41)

1. Abraham, R.T. (2000) Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways. Immunol. Res., 22, 95-117.
2. Anborgh, P.H., Qian, X., Papageorge, A.G., Vass, W.C., DeClue, J.E. and Lowy, D.R. (1999) Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol. Cell. Biol., 19, 4611-4622.
3. Astoul, E., Edmunds, C., Cantrell, D.A. and Ward, S.G. (2001) PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models. Trends Immunol., 22, 490-496.
4. Bi, K., Tanaka, Y., Coudronniere, N., Sugie, K., Hong, S.J., van Stipdonk, M.J.B. and Altman, A. (2001) Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation. Nat. Immunol., 2, 556-563.
5. Billadeau, D.D., Mackie, S.M., Schoon, R.A. and Leibson, P.J. (2000) The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity. J. Exp. Med., 192, 381-392.
6. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J.P., Sedivy, J.M., Kinzler, K.W. and Vogelstein, B. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science, 282, 1497-1501.
7. Bustelo, X.R. (2000) Regulatory and signaling properties of the Vav family. Mol. Cell. Biol., 20, 1461-1477.
8. Bustelo, X.R. (2001) Vav proteins, adaptors and cell signaling. Oncogene, 20, 6372-6381.
9. Costello, P.S., Walters, A.E., Mee, P.J., Turner, M., Reynolds, L.F., Prisco, A., Sarner, N., Zamoyska, R. and Tybulewicz, V.L. (1999) The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κ1B pathways. Proc. Natl Acad. Sci. USA, 96, 3035-3040.
10. Crabtree, G.R. and Clipstone, N.A. (1994) Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem., 63, 1045-1083.
11. Crespo, P., Bustelo, X.R., Aaronson, D.S., Coso, O.A., Lopez- Barahona, M., Barbacid, M. and Gutkind, J.S. (1996) Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene, 13, 455-460.
12. ras activation in T cell CD69 expression. Eur. J. Immunol., 24, 616-620.
13. Denkinger, D.J., Borges, C.R., Butler, C.L., Cushman, A.M. and Kawahara, R.S. (2000) Genomic organization and regulation of the vav proto-oncogene. Biochim. Biophys. Acta, 1491, 253-262.
14. Dienz, O., Hehner, S.P., Droge, W. and Schmitz, M.L. (2000) Synergistic activation of NF-κB by functional cooperation between vav and PKCθ in T lymphocytes. J. Biol. Chem., 275, 24547-24551.
15. Doody, G.M., Billadeau, D.D., Clayton, E., Hutchings, A., Berland, R., McAdam, S., Leibson, P.J. and Turner, M. (2000) Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J., 19, 6173-6184.
16. Fischer, K.D., Zmuldzinas, A., Gardner, S., Barbacid, M., Bernstein, A. and Guidos, C. (1995) Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature, 374, 474-477.
17. Fischer, K.D. et al. (1998) Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol., 8, 554-562.
18. Harder, T. and Simons, K. (1999) Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulatmn accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol., 29, 556-562.
19. Hehner, S.P., Hofmann, T.G., Dienz, O., Droge, W. and Schmitz, M.L. (2000) Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription. J. Biol. Chem., 275, 18160-18171.
20. Holsinger, L.J., Graef, I.A., Swat, W., Chi, T., Bautista, D.M., Davidson, L., Lewis, R.S., Alt, F.W. and Crabtree, G.R. (1998) Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol., 8, 563-572.
21. Kaminuma, O., Deckert, M., Elly, C., Liu, Y.C. and Altman, A. (2001) Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. Mol. Cell. Biol., 21, 3126-3136.
22. Krawczyk, C. et al. (2000) Cb1-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity, 13, 463-473.
23. Kuhne, M.R., Ku, G. and Weiss, A. (2000) A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J. Biol. Chem., 275, 2185-2190.
24. Lewis, R.S. (2001) Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol., 19, 497-521.
25. Lou, Z.K., Billadeau, D.D., Savoy, D.N., Schoon, R.A. and Leibson, P.J. (2001) A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes. J. Immunol., 167, 5749-5757.
26. Mateyak, M.K., Obaya, A.J., Adachi, S. and Sedivy, J.M. (1997) Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ., 8, 1039-1048.
27. Moller, A., Dienz, O., Hehner, S.P., Droge, W. and Schmitz, M.L. (2001) Protein kinase Cθ cooperates with Vavl to induce JNK activity in T-cells. J. Biol. Chem., 276, 20022-20028.
28. ras. J. Exp. Med., 180, 1067-1076.
29. Salojin, K.V., Zhang, J. and Delovitch, T.L. (1999) TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway. J. Immunol., 163, 844-853.
30. Sedivy, J.M. and Dutriaux, A. (1999) Gene targeting and somatic cell genetics-a rebirth or a coming of age? Trends Genet., 15, 88-90.
31. Shan, X., Czar, M.J., Bunnell, S.C., Liu, P., Liu, Y., Schwartzberg, P.L. and Wange, R.L. (2000) Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol. Cell. Biol., 20, 6945-6957.
32. Sweetser, M.T., Hoey, T., Sun, Y.L., Weaver, W.M., Price, G.A. and Wilson, C.B. (1998) The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-γ promoter in T cells. J. Biol. Chem., 273, 34775-34783.
33. Tarakhovsky, A., Turner, M., Schaal, S., Mee, P.J., Duddy, L.P., Rajewsky, K. and Tybulewicz, V.L. (1995) Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature, 374, 467-470.
34. Tedford, K., Nitschke, L., Girkontaite, I., Charlesworth, A., Chan, G., Sakk, V., Barbacid, M. and Fischer, K.D. (2001) Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat. Immunol., 2, 548-555.
35. Turner, M., Mee, P.J., Walters, A.E., Quinn, M.E., Mellor, A.L., Zamoyska, R. and Tybulewicz, V.L. (1997) A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity, 7, 451-460.
36. Villalba, M., Kasibhatla, S., Genestier, L., Mahboubi, A., Green, D.R. and Altman, A. (1999) Protein kinase cθ cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. J. Immunol., 163, 5813-5819.
37. Villalba, M., Coudronniere, N., Deckert, M., Teixeiro, E., Mas, P. and Altman, A. (2000) A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation. Immunity, 12, 151-160.
38. Villalba, M., Bi, K., Rodriguez, F., Tanaka, Y., Schoenberger, S. and Altman, A. (2001) Vav1/Rac1-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J. Cell Biol., 155, 331-338.
39. Williams, B.L., Schreiber, K.L., Zhang, W., Wange, R.L., Samelson, LE, Leibson, P.J. and Abraham, R.T. (1998) Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol. Cell. Biol., 18, 1388-1399.
40. Williams, B.L., Irvin, B.J., Sutor, S.L., Chini, C.C., Yacyshyn, E., Bubeck, W.J., Dalton, M., Chan, A.C. and Abraham, R.T. (1999) Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor- dependent phospholipase C-γ1 and Ras activation. EMBO J., 18, 1832-1844.
41. Zhu, K., Debreceni, B., Bi, F. and Zheng, Y. (2001) Oligomerization of DH domain is essential for Dbl-induced transformation. Mol. Cell. Biol., 21, 425-437.