Structure-Based Design of an Indolicidin Peptide Analogue with Increased Protease Stability

Biochemistry

Volumn 42, Issue 48, 2003, Pages 14130-14138

  Rozek, Annett ^a,b   Powers, Jon Paul S ^a   Friedrich, Carol L ^a   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Inimex Pharmaceuticals Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; FLUORESCENCE; MEMBRANES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPIDS;

ANTIBACTERIAL ACTIVITY;

BIOCHEMISTRY;

AMPHOPHILE; ANTIMICROBIAL CATIONIC PEPTIDE; CP 11; CYCLO CP 11; CYCLOPEPTIDE; DODECYLPHOSPHORYLCHOLINE; INDOLICIDIN; ISOLEUCYLCYSTEINYLLEUCYLLYSYLLYSYLTRYPTOPHYLPROLYLTRYPTOPHYLTRYPTOPHYLPROLY LTRYPTOPHYLARGINYLARGINYLCYSTEINYLLYSINAMIDE; ISOLEUCYLLEUCYLLYSYLLYSYLTRYPTOPHYLPROLYLTRYPTOPHYLTRYPTOPHYLPROLYLTRYPTOPH YLARGINYLARGINYLLYSINAMIDE; LYSINE; PEPTIDE DERIVATIVE; PROTEINASE; TRYPSIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATTLE; CHEMISTRY; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DISULFIDE BOND; DRUG DESIGN; DRUG EFFECT; DRUG HALF LIFE; DRUG STRUCTURE; ENZYME STABILITY; ERYTHROCYTE; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH, DEVELOPMENT AND AGING; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROLYSIS; METABOLISM; MICELLE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR GENETICS; MOLECULE; NEUTROPHIL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN LIPID INTERACTION; PROTEIN STABILITY; SPECTROFLUOROMETRY; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNTHESIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATTLE; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; SPECTROMETRY, FLUORESCENCE; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRYPSIN;

ANIMALIA; BACTERIA (MICROORGANISMS); BOS TAURUS; BOVINAE; ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 0344198180     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035643g     Document Type: Article

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