Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 18, 2004, Pages 7106-7111

  Takaishi, Kiyosumi ^a,c   Duplomb, Laurence ^a   Wang, May Yun ^a   Li, Jinping ^a,d   Unger, Roger H ^a,b,e  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^c DAIICHI SANKYO CO   (Japan)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; COMPLEMENTARY DNA; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; EPIDIDYMIS FAT; FATTY LIVER; FOOD INTAKE; GENE; GENETIC TRANSFECTION; HYPERLIPIDEMIA; INSIG 1 GENE; INSIG 2 GENE; INSULIN INDUCED GENE 1; LIPOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; REFEEDING; TRANSGENE;

ADENOVIRIDAE; ANIMALS; CARRIER PROTEINS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; GENETIC VECTORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPIDS; LIVER; MEMBRANE PROTEINS; OBESITY; RATS; RATS, ZUCKER;

ADENOVIRIDAE; ANIMALIA;

EID: 2342557826     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0401715101     Document Type: Article

References (26)

1. Peng, Y., Schwarz, E. J., Lazar, M. A., Genin, A., Spinner, N. B. & Taub, R. (1997) Genomics 43, 278-284.
2. Li, J., Yu, X., Pan, W. & Unger R. H. (2002) Am. J. Physiol. 282, E1334-E1341.
3. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L. & Brown, M. S. (2002) Cell 110, 489-500.
4. Brown, M. S. & Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. USA 96, 11041-11048.
5. Li, J., Takaishi, K., Cook, W., McCorkle, S. K. & Unger, R. H. (2003) Proc. Natl. Acad. Sci. USA 100, 9476-9481.
6. Yabe, D., Brown, M. S. & Goldstein, J. L. (2002) Proc. Natl. Acad. Sci. USA 99, 12753-12758.
7. Kakuma, T., Lee, Y., Higa, M., Wang, Z., Pan, W., Shimomura, I. & Unger, R. H. (2000) Proc. Natl. Acad. Sci. USA 97, 8536-8541.
8. Zhou, Y. T., Shimabukuro, M., Lee, Y., Koyama, K., Higa, M., Ferguson, T. & Unger, R. H. (1998) Diabetes 47, 1904-1908.
9. Koyama, K., Chen, G., Lee, Y. & Unger, R. H. (1997) Am. J. Physiol. 273, 708-713.
10. Zhou, Y. T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L. & Unger, R. H. (2000) Proc. Natl. Acad. Sci. USA. 97, 1784-1789.
11. Lee, Y., Hirose, H., Ohneda, M., Johnson, J. H., McGarry, J. D. & Unger, R. H. (1994) Proc. Natl. Acad. Sci. USA 91, 10878-10882.
12. Gomez-Foix, A. M., Coats, W. S., Baque, S., Alam, T., Gerard, R. D. & Newgard, C. B. (1992) J. Biol. Chem. 267, 25129-25134.
13. McGrory, W. J., Bautista, D. S. & Graham, F. L. (1988) Virology 163, 614-617.
14. Becker, T. C., Noel, R. J., Coats, W. S., Gomez-Foix, A. M., Alam, T., Gerard, R. D. & Newgard, C. B. (1994) Methods Cell Biol. 43, 161-189.
15. Yabe, D., Komuro, R., Liang, G., Goldstein, J. L. & Brown, M. S. (2003) Proc. Natl. Acad. Sci. USA 100, 3155-3160.
16. Herz, J. & Gerard, R. D. (1993) Proc. Natl. Acad. Sci. USA. 90, 2812-2816.
17. Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y. T., O'Doherty, R., Newgard, C. B. & Unger, R. H. (1996) Proc. Natl. Acad. Sci. USA 93, 14795-14799.
18. Sheng, Z., Otani, H., Brown, M. S. & Goldstein, J. L. (1995) Proc. Natl. Acad. Sci. USA 92, 935-938.
19. Folch, J., Lees, M. & Sloane Stanley, G. H. (1957). J. Biol. Chem. 226, 497-509.
20. Applied Biosystems (2001) User Bulletin No. 2 Rev. B (Applied Biosystems, Foster City, CA).
21. Shimomura, I., Shimano, H., Horton, J. D., Goldstein, J. L. & Brown, M. S. (1997) J. Clin. Invest. 99, 838-845.
22. Horton, J. D., Bashmakov, Y., Shimomura, I. & Shimano, H. (1998) Proc. Natl. Acad. Sci. USA 95, 5987-5992.
23. Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L. & Brown, M. S. (2002) J. Biol. Chem. 277, 9520-9528.
24. Matsuda, M., Korn, B. S., Hammer, R. E., Moon, Y. A., Komuro, R., Horton, J. D., Goldstein, J. L., Brown, M. S. & Shimomura, I. (2001) Genes Dev. 15, 1206-1216.
25. Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., et al. (2002)
26. Engelking, L. J., Kuriyama, H., Hammer R. E., Horton, J. D., Brown, M.S., Goldstein, J. L. & Liang, G. (2004) J. Clin. Invest., in press.