Molecular mechanism investigation of phenobarbital-induced serum cholesterol elevation in rat livers by microarray analysis

Archives of Toxicology

Volumn 78, Issue 8, 2004, Pages 435-442

  Kiyosawa, Naoki ^a   Tanaka, Kohji ^a   Hirao, Jun ^a   Ito, Kazumi ^a   Niino, Noriyo ^a   Sakuma, Kyoko ^a   Kanbori, Miyuki ^a   Yamoto, Takashi ^a   Manabe, Sunao ^a   Matsunuma, Naochika ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Cholesterol; Ketone body; Metabolism; Microarray; Phenobarbital

Indexed keywords

ACETYL COENZYME A; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; KETONE BODY; LIPOPROTEIN LIPASE; MESSENGER RNA; PHENOBARBITAL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DNA MICROARRAY; GENETIC TRANSCRIPTION; GLYCOLYSIS; HYPOTHESIS; KETOGENESIS; LIVER; MALE; MODEL; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ANIMALS; CHOLESTEROL; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; HYPNOTICS AND SEDATIVES; KETONE BODIES; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOBARBITAL; PHENOTYPE; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIGLYCERIDES;

RODENTIA;

EID: 4544225667     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0565-0     Document Type: Article

References (41)

1. Andersson M, Ericsson J, Appelkvist EL, Schedin S, Chojnacki T, Dallner G (1994) Modulations in hepatic branch-point enzymes involved in isoprenoid biosynthesis upon dietary and drug treatments of rats. Biochim Biophys Acta 1214:79-87
2. Aynaci FM, Orhan F, Orem A, Yildirmis S, Gedik Y (2001) Effect of antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood. J Child Neurol 16:367-369
3. Ayte J, Gil-Gomez G, Haro D, Marrero PF, Hegardt FG (1990) Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes. Proc Natl Acad Sci USA 87:3874-3878
4. Brault D, Noe L, Etienne J, Hamelin J, Raisonnier A, Souli A, Chuat JC, Dugail I, Quignard-Boulange A, Lavau M, Galibert F (1992) Sequence of rat lipoprotein lipase-encoding cDNA. Gene 121:237-246
5. Cullingford TE, Clark JB, Phillips IR (1994) The pyruvate dehydrogenase complex: cloning of the rat somatic E1α subunit and its coordinate expression with the mRNAs for the E1β, E2, and E3 catalytic subunits in developing rat brain. J Neurochem 62:1682-1690
6. Emmerling M, Dauner M, Ponti A, Fiaux J, Hochuli M, Szyperski T, Wuthrich K, Bailey JE, Sauer U (2002) Metabolic flux responses to pyruvate kinase knockout in Escherichia coli. J Bacteriol 184:152-164
7. Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C (2001) An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25:386-401
8. Goldberg IJ (1996) Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 37:693-707
9. Goldman MJ, Back DW, Goodridge AG (1985) Nutritional regulation of the synthesis and degradation of malic enzyme messenger RNA in duck liver. J Biol Chem 260:4404-4408
10. Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425-430
11. Hegardt FG (1999) Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem J 338:569-582
12. Hettema EH, Tabak HF (2000) Transport of fatty acids and metabolites across the peroxisomal membrane. Biochim Biophys Acta 1486:18-27
13. Hijikata M, Ishii N, Kagamiyama H, Osumi T, Hashimoto T (1987) Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. J Biol Chem 262:8151-8158
14. Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131
15. Jirtle RL, Meyer SA, Brockenbrough JS (1991) Liver tumor promoter phenobarbital: a biphasic modulator of hepatocyte proliferation. Prog Clin Biol Res 369:209-216
16. Kanai K, Watanabe J, Fujimoto S, Kanamura S (1993) Quantitative analysis of smooth endoplasmic reticulum proliferation in periportal, midzonal and perivenular hepatocytes of mice after administration of phenobarbital. Exp Toxicol Pathol 45:199-203
17. Karvonen I, Huupponen R, Niemela KM, Sotaniemi E (1989) Effects of phenobarbital on hepatic glucose metabolism and NADPH production in Zucker rats. Arch Int Pharmacodyn Ther 302:40-48
18. Ketterman AJ, Pond SM, Becker CE (1987) The effects of differential induction of cytochrome P-450, carboxylesterase and glutathione S-transferase activities on malathion toxicity in mice. Toxicol Appl Pharmacol 87:389-392
19. Kiyosawa N, Watanabe T, Sakuma K, Kanbori M, Niino N, Ito K, Yamoto T, Manabe S (2003) Phylogenetic tree facilitates the understanding of gene expression data on drug metabolizing enzymes obtained by microarray analysis. Toxicol Lett 145:281-289
20. Lang C, Berardi S, Schafer M, Serra D, Hegardt FG, Krahenbuhl L, Krahenbuhl S (2002) Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction. J Hepatol 37:564-571
21. Millatt LJ, Bocher V, Fruchart JC, Staels B (2003) Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim Biophys Acta 1631:107-118
22. Minami-Ishii N, Taketani S, Osumi T, Hashimoto T (1989) Molecular cloning and sequence analysis of the cDNA for rat mitochondrial enoyl-CoA hydratase. Structural and evolutionary relationships linked to the bifunctional enzyme of the peroxisomal beta-oxidation system. Eur J Biochem 185:73-78
23. Nadal A, Marrero PF, Haro D (2002) Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1. Biochem J 366:289-297
24. Nousiainen U (1985) Effects of phenobarbital and p,p′-DDT on carboxylesterase activity and hydrolysis of propanidid in rat liver. Gen Pharmacol 16:49-53
25. Oh MK, Rohlin L, Kao KC, Liao JC (2002) Global expression profiling of acetate-grown Escherichia coli. J Biol Chem 277:13175-13183
26. Olivier LM, Kovacs W, Masuda K, Keller GA, Krisans SK (2000) Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. AA-CoA thiolase, HMG-CoA synthase, MPPD, and FPP synthase. J Lipid Res 41:1921-1935
27. Ourlin JC, Handschin C, Kaufmann M, Meyer UA (2002) A link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochem Biophys Res Commun 291:378-384
28. Ramakrishna R, Edwards JS, McCulloch A, Palsson BO (2001) Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. Am J Physiol 280:R695-R704
29. Rushmore TH, Kong AN (2002) Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 3:481-490
30. Sanghani SP, Davis WI, Dumaual NG, Mahrenholz A, Bosron WF (2002) Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Eur J Biochem 269:4387-4398
31. Sudjana-Sugiaman E, Eggertsen G, Bjorkhem I (1994) Stimulation of HMG-CoA reductase as a consequence of phenobarbital-induced primary stimulation of cholesterol 7α-hydroxylase in rat liver. J Lipid Res 35:319-327
32. Tanaka RD, Lee LY, Schafer BL, Kratunis VJ, Mohler WA, Robinson GW, Mosley ST (1990) Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver. Proc Natl Acad Sci U S A 87:2872-2876
33. Tansey TR, Shechter I (2000) Structure and regulation of mammalian squalene synthase. Biochim Biophys Acta 1529:49-62
34. Teusink B, Voshol PJ, Dahlmans VE, Rensen PC, Pijl H, Romijn JA, Havekes LM (2003) Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake. Diabetes 52:614-620
35. Thomas KD (1984) Plasma cholesterol levels in adult male and female rats after chronic treatment with phenobarbitone. Isr J Med Sci 20:240-241
36. Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, Afshari CA, Lehmann JM, Negishi M (2002) Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol 61:1-6
37. Varma A, Palsson BO (1994) Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl Environ Microbiol 60:3724-3731
38. Venkatesan N, Davidson MB, Simsolo RB, Kern PA (1994) Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat. Metabolism 43:348-356
39. Warner A, Privitera M, Bates D (1998) Standards of laboratory practice: antiepileptic drug monitoring. Clin Chem 44:1085-1095
40. Yamamoto Y, Kawamoto T, Negishi M (2003) The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch Biochem Biophys 409:207-211
41. Yang MC, Ruan QG, Yang JJ, Eckenrode S, Wu S, McIndoe RA, She JX (2001) A statistical method for flagging weak spots improves normalization and ratio estimates in microarrays. Physiol Genomics 7:45-53