A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: Implication for a potential anti-inflammatory effect

International Immunopharmacology

Volumn 8, Issue 4, 2008, Pages 548-555

  Choi, Youngju ^a   Moon, Aree ^b   Kim, Young Choong ^a  

^a Seoul National University   (South Korea)

^b Duksung Women's University   (South Korea)

Author keywords

15 Methoxypinusolidic acid; ; Inducible nitric oxide synthase; Lipopolysaccharide;

Indexed keywords

15 METHOXYPINUSOLIDIC ACID; CYCLOOXYGENASE 2; ENZYME INHIBITOR; I KAPPA B ALPHA; I KAPPA B KINASE GAMMA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL NUCLEUS; ENZYME DEGRADATION; MICROGLIA; NONHUMAN; PRIORITY JOURNAL;

EID: 39949085423     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.12.010     Document Type: Article

References (41)

1. J.X. Zhu Y. Wang L.D. Kong C. Yang X. Zhang Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver J Ethnopharmacol 93 2004 133 140
2. K.A. Koo S.H. Kim M.K. Lee Y.C. Kim 15-Methoxypinusolidic acid from Biota orientalis attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells Toxicol In Vitro 20 2006 936 941
3. K.A. Koo M.K. Lee S.H. Kim E.J. Jeong S.Y. Kim T.H. Oh Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells Br J Pharmacol 150 2007 65 71
4. M.A. Cuadros J. Navascués The origin and differentiation of microglial cells during development Prog Neurobiol 56 1998 173 189
5. C. Kaur A.J. Hao C.H. Wu E.A. Ling Origin of microglia Microsc Res Tech 54 2001 2 9
6. Y.S. Kim T.H. Joh Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease Exp Mol Med 38 2006 333 347
7. S.C. Morgan D.L. Taylor J.M. Pocock Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta-Notch signaling cascades J Neurochem 90 2004 89 101
8. A. Nimmerjahn F. Kirchhoff F. Helmchen Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 2005 1314 1318
9. A.Y. Lai K.G. Todd Microglia in cerebral ischemia: molecular actions and interactions Can J Physiol Pharmacol 84 2006 49 59
10. B. Liu J.S. Hong Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention J Pharmacol Exp Ther 304 2003 1 7
11. G. Stoll S. Jander The role of microglia and macrophages in the pathophysiology of the CNS Prog Neurobiol 58 1999 233 247
12. L. Minghetti G. Levi Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide Prog Neurobiol 54 1998 99 125
13. B. Brüne A. von Knethen K.B. Sandau Nitric oxide and its role in apoptosis Eur J Pharmacol 351 1998 261 272
14. F.C. Fang Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity J Clin Invest 99 1997 2818 2825
15. G. Kolios V. Valatas S.G. Ward Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle Immunology 113 2004 427 437
16. V. Mollace C. Muscoli E. Masini S. Cuzzocrea D. Salvemini Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors Pharmacol Rev 57 2005 217 252
17. H. Kleinert A. Pautz K. Linker P.M. Schwarz Regulation of the expression of inducible nitric oxide synthase Eur J Pharmacol 500 2004 255 266
18. C. Nathan Q.W. Xie Regulation of biosynthesis of nitric oxide J Biol Chem 269 1994 13725 13728
19. C. Nathan Inducible nitric oxide synthase: what difference does it make? J Clin Invest 100 1997 2417 2423
20. R.N. Dubois S.B. Abramson L. Crofford R.A. Gupta L.S. Simon L.B. Van De Putte Cyclooxygenase in biology and disease FASEB J 12 1998 1063 1073
21. K.A. Koo S.H. Sung Y.C. Kim A new neuroprotective pinusolide derivative from the leaves of Biota orientalis Chem Pharm Bull 50 2002 834 836
22. E. Blasi R. Barluzzi V. Bocchini R. Mazzolla F. Bistoni Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus J Neuroimmunol 27 1990 229 237
23. 15N]nitrate in biological fluids Anal Biochem 126 1982 131 138
24. H. Kojima K. Sakurai K. Kikuchi S. Kawahara Y. Kirino H. Nagoshi Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore Chem Pharm Bull 46 1998 373 375
25. N. Nakatsubo H. Kojima K. Kikuchi H. Nagoshi Y. Hirata D. Maeda Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins FEBS Lett 427 1998 263 266
26. A.F. Mendes A.P. Carvalho M.M. Caramona M.C. Lopes Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species Mediators Inflamm 10 2001 209 215
27. D.J. Stuehr O.A. Fasehun N.S. Kwon S.S. Gross J.A. Gonzalez R. Levi Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs FASEB J 5 1991 98 103
28. A.S. Baldwin The NF-kappa B and I kappa B proteins: new discoveries and insights Annu Rev Immunol 14 1996 649 683
29. C.J. Lowenstein E.W. Alley P. Raval A.M. Snowman S.H. Snyder S.W. Russell Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide Proc Natl Acad Sci USA 90 1993 9730 9734
30. M. Aga J.J. Watters Z.A. Pfeiffer G.J. Wiepz J.A. Sommer P.J. Bertics Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages Am J Physiol Cell Physiol 286 2004 C923 C930
31. N.R. Bhat P. Zhang J.C. Lee E.L. Hogan Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures J Neurosci 18 1998 1633 1641
32. C.C. Chen J.K. Wang p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages Mol Pharmacol 55 1999 481 488
33. J.J. Watters J.A. Sommer Z.A. Pfeiffer U. Prabhu A.N. Guerra P.J. Bertics A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production J Biol Chem 277 2002 9077 9087
34. G.J. Feng H.S. Goodridge M.M. Harnett X.Q. Wei A.V. Nikolaev A.P. Higson Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase J Immunol 163 1999 6403 6412
35. I.O. Han K.W. Kim J.H. Ryu W.K. Kim p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells Neurosci Lett 325 2002 9 12
36. mapk in a mouse macrophage cell line Am J Physiol Cell Physiol 280 2001 C441 C450
37. T.P. Garrington G.L. Johnson Organization and regulation of mitogen-activated protein kinase signaling pathways Curr Opin Cell Biol 11 1999 211 218
38. M. Koistinaho J. Koistinaho Role of p38 and p44/42 mitogen-activated protein kinases in microglia Glia 40 2002 175 183
39. K. Fukunaga E. Miyamoto Role of MAP kinase in neurons Mol Neurobiol 16 1998 79 95
40. P.H. Sugden A. Clerk Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors Cell Signal 9 1997 337 351
41. S. Yoon R. Seger The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions Growth Factors 24 2006 21 44