Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production

NeuroToxicology

Volumn 29, Issue 2, 2008, Pages 244-258

  Villarán, Ruth F ^a   Tomas Camardiel M ^a   de Pablos, Rocío M ^a   Santiago, Marti ^a   Herrera, Antonio J ^a   Navarro, Ana ^b   Machado, Alberto ^a   Cano, Josefina ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF CÁDIZ   (Spain)

Author keywords

3 Nitropropionic acid; Deprenyl; Endogenous dopamine; Neurodegeneration; Nomifensine; The striatum

Indexed keywords

3 NITROPROPIONIC ACID; DOPAMINE; FREE RADICAL; METIROSINE; NOMIFENSINE; RESERPINE; SELEGILINE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BREATHING RATE; CATABOLISM; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC ACTIVITY; MACROGLIA; MALE; MICROGLIA; MITOCHONDRION; NERVE INJURY; NEUROTOXICITY; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

ALPHA-METHYLTYROSINE; ANIMALS; APOPTOSIS; ASTROCYTES; CELL RESPIRATION; CORPUS STRIATUM; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; MALE; MICROGLIA; MITOCHONDRIA; MONOAMINE OXIDASE INHIBITORS; NERVE DEGENERATION; NEURONS; NITRO COMPOUNDS; NOMIFENSINE; OXYGEN CONSUMPTION; PROPIONIC ACIDS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RESERPINE; SELEGILINE; SUCCINATE DEHYDROGENASE; SUPEROXIDES; SYNAPTOSOMES; TYROSINE 3-MONOOXYGENASE; UP-REGULATION;

EID: 39749150607     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.11.001     Document Type: Article

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