Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation

Journal of Neurochemistry

Volumn 79, Issue 1, 2001, Pages 63-70

  Xia, Xu Gang ^a   Schmidt, Nicole ^b   Teismann, Peter ^b   Ferger, Boris ^b   Schulz, Jörg B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Dopamine agonists; Dopamine transporter; Excitotoxicity; Microdialysis; Oxidative stress; Striatum

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; EXCITOTOXIN; HYDROXYL RADICAL; LEVODOPA; MALONIC ACID; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; VANOXERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; HUNTINGTON CHOREA; HYPOXIA; MICRODIALYSIS; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; 3,4-DIHYDROXYPHENYLACETIC ACID; ALPHA-METHYLTYROSINE; ANIMALS; BRAIN DISEASES; CARBIDOPA; CARRIER PROTEINS; CORPUS STRIATUM; DIZOCILPINE MALEATE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ENZYME INHIBITORS; HOMOVANILLIC ACID; LEVODOPA; MALE; MALONATES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; OXIDOPAMINE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, N-METHYL-D-ASPARTATE; RESERPINE; SUCCINATE DEHYDROGENASE; SULPIRIDE; VESICULAR BIOGENIC AMINE TRANSPORT PROTEINS; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 0034790565     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00525.x     Document Type: Article

References (43)

1. α-methyl-p-tyrosine pretreatment partially prevents methamphetamine-induced endogenous neurotoxin formation
2. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
3. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
4. Oxidative stress in Huntington's disease
5. L-DOPA does not enhance hydroxyl radical formation in the nigrostriatal dopamine system of rats with a unilateral 6-hydroxydopamine lesion
6. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues
7. Pergolide potentiates L-DOPA-induced dopamine release in rat striatum after lesioning with 6-hydroxydopamine
8. A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release
9. Effects of α-phenyl-tert-butylnitrone and selegiline on hydroxyl free radicals in rat striatum produced by local application of glutamate
10. Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation
11. Comparative effects of D1 an D2 dopamine agonists on somatostatin and neuropeptide Y release in cultured striatal neurons
12. Dopamine-glutamate interactions in the striatum: Behaviourally relevant modification of excitotoxicity by dopamine receptor-mediated mechanisms
13. Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate
14. Inhibition of succinate dehydrogenase by malonic acid produces an 'excitotoxic' lesion in rat striatum
15. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections
16. The site of dopamine formation in rat striatum after L-DOPA administration
17. Malonate produces striatal lesions by indirect NMDA receptor activation
18. Comparison of the acute actions of amine-depleting drugs and dopamine receptor antagonists on dopamine function in the brain in rats
19. Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain
20. Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist
21. Repeated administration of high dose levodopa enhances hydroxyl radical production in the rat striatum denervated with 6-hydroxydopamine
22. Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity
23. Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells
24. Parkinson's disease: Activity of L-DOPA decarboxylase in discrete brain regions
25. Differential interaction of competitive NMDA and AMPA antagonists with selective dopamine D1 and D2 agonists in a rat model of Parkinson's disease
26. Cytochrome P-450 metabolism of arachidonic acid
27. Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor
28. Suppression of L-DOPA-induced circling in rats with nigral lesions by blockade of central DOPA-decarboxylase: Implications for mechanism of action of L-DOPA in parkinsonism
29. Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures
30. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
31. Methamphetamine-induced dopamine overflow and injury to striatal dopamine terminals: Attenuation by dopamine D1 or D2 antagonists
32. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism
33. Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease
34. Involvement of free radicals in excitotoxicity in vivo
35. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap
36. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice
37. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia
38. L-Dopa increases nigral production of hydroxyl radicals in vivo: Potential L-DOPA toxicity?
39. Roles of D1 and D2 dopamine receptor subtypes in mediating the methamphetamine-induced changes in monoamine systems
40. Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats
41. Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine
42. α-methyltyrosine attenuates and reserpine increases methamphetamine-induced neuronal changes