Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum

Neurobiology of Disease

Volumn 8, Issue 1, 2001, Pages 114-126

  Kim, G W ^a   Chan, P H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROPROPIONIC ACID; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; TOXIN; URIDINE TRIPHOSPHATE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CORPUS STRIATUM; CYTOTOXICITY; GEL ELECTROPHORESIS; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035116104     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0327     Document Type: Article

References (43)

1. Glial cell line-derived neurotrophic factor attenuates the locomotor hypofunction and striatonigral neurochemical deficits induced by chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid
2. Aging, energy, and oxidative stress in neurodegenerative diseases
3. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
4. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
5. Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
6. Age dependence of striatal neuronal death caused by mitochondrial dysfunction
7. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
8. Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid
9. Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
10. Glutamate neurotoxicity and diseases of the nervous system
11. DNA damage and repair in central nervous system injury. National Institute of Neurological Disorders and Stroke workshop summary
12. Age-related changes in Cu,Zn superoxide dismutase. Se-dependent and -independent glutathione peroxidase and catalase activities in specific areas of rat brain
13. Inactivation of succinate dehydrogenase by 3-nitropropionate
14. Oxidative stress, glutamate, and neurodegenerative disorders
15. Preparation and assay of superoxide dismutases
16. Excitotoxins, aging, and environmental neurotoxins: Implications for understanding human neurodegenerative diseases
17. APE/Ref-1 responses to oxidative stress in aged rats
18. Establishment of a cell-free system of neuronal apoptosis: Comparison of premitochondrial, mitochondrial, and postmitochondrial phases
19. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
20. Copper-zinc superoxide dismutase prevents the early decrease of apurinic/pyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
21. 2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid
22. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
23. Response of postmitotic neurons to x-irradiation: Implications for the role of DNA damage in neuronal apoptosis
24. Correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-nitropropionic acid toxicity in rats
25. Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: A type of hypoxic (energy deficient) brain damage
26. Selective inhibition of the tricarboxylic acid cycle of GABAergic neurons with 3-nitropropionic acid in vivo
27. Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain
28. Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid
29. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase
30. The proto-oncogene Bcl-2 and its role in regulating apoptosis
31. Differential expression of two glial glutamate transporters in the rat brain: Quantitative and immunocytochemical observations
32. 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin
33. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease
34. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
35. Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders
36. Excitatory amino acid neurotoxicity and neurodegenerative disease
37. Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat
38. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
39. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
40. Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid
41. Age changes of mitochondria of rat kidney
42. The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition
43. Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade