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Volumn 788, Issue 1-2, 1998, Pages 215-222

Effects of haloperidol metabolites on neurotransmitter uptake and release: Possible role in neurotoxicity and tardive dyskinesia

Author keywords

Haloperidol pyridinium; Haloperidol tetrahydropyridine; Parkinsonism; Reduced haloperidol pyridinium; Schizophrenia

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; DRUG METABOLITE; HALOPERIDOL; HALOPERIDOL PYRIDINIUM; HALOPERIDOL TETRAHYDROPYRIDINE; NEUROTRANSMITTER; PYRIDINIUM DERIVATIVE; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

EID: 0032579840     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01551-5     Document Type: Article
Times cited : (81)

References (23)
  • 1
    • 0030722966 scopus 로고    scopus 로고
    • Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: Is HPTP an intermediate?
    • Avent K., Riker R., Fraser G., Van der Schyf C., Usuki E., Pond S. Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: is HPTP an intermediate? Life Sci. 61:1997;2383-2390.
    • (1997) Life Sci. , vol.61 , pp. 2383-2390
    • Avent, K.1    Riker, R.2    Fraser, G.3    Van Der Schyf, C.4    Usuki, E.5    Pond, S.6
  • 4
    • 0344696576 scopus 로고
    • In vitro neurotoxicity assessment of oxidative and reductive metabolites of haloperidol
    • Bloomquist J., Wright A., Bempong J. In vitro neurotoxicity assessment of oxidative and reductive metabolites of haloperidol. Fundam. Appl. Toxicol., The Toxicologist. 15:1995;69.
    • (1995) Fundam. Appl. Toxicol., the Toxicologist , vol.15 , pp. 69
    • Bloomquist, J.1    Wright, A.2    Bempong, J.3
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.1
  • 7
    • 0009704759 scopus 로고
    • Site of action of antischizophrenics
    • in: W. Winslow, R. Markstein (Eds.), Manchester Univ. Press, New York
    • A. El-Sobky, Site of action of antischizophrenics, in: W. Winslow, R. Markstein (Eds.), The Neurobiology of Dopamine Systems, Manchester Univ. Press, New York, 1986, pp. 240-251.
    • (1986) The Neurobiology of Dopamine Systems , pp. 240-251
    • El-Sobky, A.1
  • 8
    • 0031575398 scopus 로고    scopus 로고
    • Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem
    • Eyles D., Avent K., Stedman T., Pond S. Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem. Life Sci. 60:1997;529-534.
    • (1997) Life Sci. , vol.60 , pp. 529-534
    • Eyles, D.1    Avent, K.2    Stedman, T.3    Pond, S.4
  • 9
    • 0026066622 scopus 로고
    • Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite
    • Fang J., Gorrod G.W. Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite. Toxicol. Lett. 59:1991;117-123.
    • (1991) Toxicol. Lett. , vol.59 , pp. 117-123
    • Fang, J.1    Gorrod, G.W.2
  • 10
    • 0028850432 scopus 로고
    • Effect of haloperidol and its metabolites on dopamine and noradrenaline uptake in rat brain slices
    • Fang J., Yu P. Effect of haloperidol and its metabolites on dopamine and noradrenaline uptake in rat brain slices. Psychopharmacology. 121:1995;379-384.
    • (1995) Psychopharmacology , vol.121 , pp. 379-384
    • Fang, J.1    Yu, P.2
  • 11
    • 0028805857 scopus 로고
    • +) towards cultured dopaminergic neuroblastoma cells
    • +) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. 121:1995;373-378.
    • (1995) Psychopharmacology , vol.121 , pp. 373-378
    • Fang, J.1    Zuo, D.2    Yu, P.3
  • 12
    • 0029973802 scopus 로고    scopus 로고
    • Neurotoxic effect of 4-(4-chlorophenyl)-1-[4-(4′-fluorophenyl)-4-oxobutyl]-pyridinium (HP+), a major metabolite of haloperidol, in the dopaminergic system in vitro and in vivo
    • Fang J., Zuo D., Yu P. Neurotoxic effect of 4-(4-chlorophenyl)-1-[4-(4′-fluorophenyl)-4-oxobutyl]-pyridinium (HP+), a major metabolite of haloperidol, in the dopaminergic system in vitro and in vivo. Biog. Amines. 12:1996;125-134.
    • (1996) Biog. Amines , vol.12 , pp. 125-134
    • Fang, J.1    Zuo, D.2    Yu, P.3
  • 13
    • 0027510177 scopus 로고
    • Pre- And postsynaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection
    • Filloux F., Townsend J. Pre- and postsynaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection. Exp. Neurol. 119:1993;79-88.
    • (1993) Exp. Neurol. , vol.119 , pp. 79-88
    • Filloux, F.1    Townsend, J.2
  • 15
    • 0021806805 scopus 로고
    • Dopaminergic neurotoxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats
    • Heikkila R.E., Nicklas W.J., Duvoisin R.C. Dopaminergic neurotoxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats. Neurosci. Lett. 59:1985;135-140.
    • (1985) Neurosci. Lett. , vol.59 , pp. 135-140
    • Heikkila, R.E.1    Nicklas, W.J.2    Duvoisin, R.C.3
  • 16
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite n-methyl-4-phenyl-pyridine by dopamine neurons explains selective toxicity
    • Javitch J., D'Amato R., Strittmatter S., Synder S. Parkinsonism-inducing neurotoxin n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite n-methyl-4-phenyl-pyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. U.S.A. 82:1985;2173-2177.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 2173-2177
    • Javitch, J.1    D'Amato, R.2    Strittmatter, S.3    Synder, S.4
  • 17
    • 0022504553 scopus 로고
    • Effect of MPTP and its pyridinium metabolites on monoamine uptake and on central catecholamine neurons in mice
    • Jonsson G., Nwanae E., Luthman J., Sundstrom E. Effect of MPTP and its pyridinium metabolites on monoamine uptake and on central catecholamine neurons in mice. Acta Physiol. Scand. 128:1986;187-194.
    • (1986) Acta Physiol. Scand. , vol.128 , pp. 187-194
    • Jonsson, G.1    Nwanae, E.2    Luthman, J.3    Sundstrom, E.4
  • 18
    • 0025362328 scopus 로고
    • Kinetics and block of dopamine uptake in synaptosomes from rat caudate nucleus
    • Krueger B.K. Kinetics and block of dopamine uptake in synaptosomes from rat caudate nucleus. J. Neurochem. 5:1990;260-267.
    • (1990) J. Neurochem. , vol.5 , pp. 260-267
    • Krueger, B.K.1
  • 19
    • 0027304231 scopus 로고
    • The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopamine neurons from the substantia nigra
    • Marey-Semper I., Gelman M., Levi-Strauss M. The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopamine neurons from the substantia nigra. Eur. J. Neurosci. 5:1993;1029-1034.
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 1029-1034
    • Marey-Semper, I.1    Gelman, M.2    Levi-Strauss, M.3
  • 21
    • 0023833504 scopus 로고
    • Dopamine-releasing action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) in the neostriatum of the rat as demonstrated in vivo by the push-pull perfusion technique: Dependence on sodium but not calcium ions
    • Sirinathsinghji D., Heavens R., McBride C. Dopamine-releasing action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) in the neostriatum of the rat as demonstrated in vivo by the push-pull perfusion technique: dependence on sodium but not calcium ions. Brain Res. 443:1988;101-116.
    • (1988) Brain Res. , vol.443 , pp. 101-116
    • Sirinathsinghji, D.1    Heavens, R.2    McBride, C.3
  • 22
    • 0028957761 scopus 로고
    • The tyramine-labelled vesicular transporter for dopamine: A putative target of pesticides and neurotoxins
    • Vaccari A., Saba P. The tyramine-labelled vesicular transporter for dopamine: a putative target of pesticides and neurotoxins. Eur. J. Pharmacol. 292:1995;309-314.
    • (1995) Eur. J. Pharmacol. , vol.292 , pp. 309-314
    • Vaccari, A.1    Saba, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.