Binding causes the remote [5′-3H]thymidine kinetic isotope effect in human thymidine phosphorylase

Journal of the American Chemical Society

Volumn 126, Issue 22, 2004, Pages 6882-6883

  Birck, Matthew R ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATE; THYMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; TRITIUM;

ARTICLE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME IMMOBILIZATION; GEOMETRY; HYDROLYSIS; KINETIC ISOTOPE EFFECT; KINETICS; ULTRAFILTRATION; X RAY CRYSTALLOGRAPHY;

BINDING, COMPETITIVE; CATALYSIS; HUMANS; ISOTOPES; KINETICS; MOLECULAR STRUCTURE; PROTEIN BINDING; THYMIDINE; THYMIDINE PHOSPHORYLASE; TRITIUM;

EID: 3042734708     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0492642     Document Type: Article

References (25)

1. Northrop, D. B. Annu. Rev. Biochem. 1981, 50, 103-131.
2. Northrop, D. B. Methods Enzymol. 1982, 87, 607-625.
3. Cleland, W. W. Bioorg. Chem. 1987, 15, 283-302.
4. Cleland, W. W. Methods Enzymol. 1982, 87, 625-641.
5. LaRue, R. D.; Wan, W.; Anderson, V. E. Biochemistry 1989, 28, 3619-3624.
6. Lewis, B. E.; Schramm, V. L. J. Am. Chem. Soc. 2003, 125, 4672-4673.
7. Lewis, B. E.; Schramm, V. L. J. Am. Chem. Soc. 2003, 125, 4785-4798.
8. Gawlita, E.; Paneth, P.; Anderson, V. E. Biochemistry 1995, 34, 6050-6058.
9. Birck, M. R.; Schramm, V. J. Am. Chem. Soc. 2004, 126. 2447-2453.
10. Ishikawa, F.; Miyazono, K.; Hellman, U.; Drexler, H.; Wernstedt, C.; Usuki, K.; Takaku, F.; Risau, W.; Heldin, C.-H. Nature 1989, 338, 557-562.
11. Furukawa, T.; Yoshimura, A.; Sumizawa, T.; Haraguchi, M.; Akiyama, S.-I.; Fukui, K.; Ishizawa, M.; Yamada, Y. Nature (London) 1992, 356, 668.
12. Haraguchi, M.; Miyadera, K.; Uemura, K.; Sumizawa, T.; Furukawa, T.; Yamada, K.; Akiyama, S.; Yamada, Y. Nature 1994, 368, 198.
13. Matshushita, S.; Nitanda, T.; Furukawa, T.; Sumizawa, T.; Tani, A.; Nishimoto, K.; Akiba, S.; Miyadera, K.; Fukushima, M.; Yamada, Y.; Yoshida, H.; Kanzaki, T.; Akiyama, S. Cancer Res. 1999, 59, 1911-1916.
14. Kitazono, M.; Takebayashi, Y.; Ishitsuka, K.; Takao, S.: Tani, A.; Furukawa, T.; Miyadera, K.; Yamada, Y.; Aikou, T.; Akiyama, S. Biochem. Biophys. Res. Commun. 1998, 253, 797-803.
15. Ikeda, R.; Furukawa, T.; Kitazono, M.; Ishitsuka, K.; Okumura, H.; Tani, A.; Sumizawa, T.; Haraguchi, M.; Komatsu, M.; Uchimiya, H.; Ren, X. Q.; Motoya, T.; Yamada, K.; Akiyama, S. Biochem. Biophys. Res. Commun. 2002, 291, 806-812.
16. Saeki. T.; Tanada, M.; Takashima, S.; Saeki, H.; Takiyama, W.; Nishimoto, N.; Moriwaki, S. Jpn. J. Clin. Oncol. 1997, 27, 227-230.
17. Miyadera, K.; Sumizawa, T.; Haraguchi, M.; Yoshida, H.; Konstanty, W.; Yamada, Y.; Akiyama, S. Cancer Res. 1995, 55, 1687-1690.
18. Kline, P. C.; Schramm, V. L. Biochemistry 1993, 32, 13212-13219.
19. Lewandowicz, A.; Schramm, V. Biochemistry 2004, 43, 1458-1468.
20. Fedorov, A.; Shi, W.; Kicska, G.; Fedorov, E.; Tyler, P. C.; Furneaux, R. H.; Hanson, J. C.; Gainsford, G. J.; Larese, J. Z.; Schramm, V. L.; Almo, S. C. Biochemistry 2001, 40, 853-860.
21. Turowski, M.; Yamakawa, N.; Meller, J. K., K.; Ikegami, T.; Hosoya, K.; Tanaka, N.; Thornton, E. R. J. Am. Chem. Soc. 2003, 125, 13836-13849.
22. Schramm, V. L. J. Biol. Chem. 1976, 251, 3417-3424.
23. Norman, R. A.; Barry, S. T.; Bate, M.; Breed, J.; Colls, J. G.; Ernill, R. J.; Luke, R. W.; Minshull, C. A.; McAlister, M. S.; McCall, E. J.; McMiken, H. H.; Paterson, D. S.; Timms, D.; Tucker, J. A.; Pauptit, R. A. Structure (Cambridge) 2004, 12, 75-84.
24. Mendieta, J.; Martin-Santamaria, S.; Priego, E. M.; Balzarini, J.; Camarasa, M. J.; Perez-Perez, M. J.; Gago, F. Biochemistry 2004, 43, 405-414.
25. Avraham, Y.; Grossowicz, N.; Yashphe, J. Biochim. Biophys. Acta. 1990, 1040, 287-293.