Pathological heterogeneity of idiopathic central nervous system inflammatory demyelinating disorders

Current Topics in Microbiology and Immunology

Volumn 318, Issue , 2008, Pages 19-43

  Lucchinetti, C ^a  

^a Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; AUTOANTIBODY; CORTICOSTEROID; CYTOKINE; GLUTAMIC ACID; IMMUNOGLOBULIN G ANTIBODY; MYELIN BASIC PROTEIN; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

B LYMPHOCYTE; BALO CONCENTRIC SCLEROSIS; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID; CLINICAL FEATURE; CYTOKINE PRODUCTION; DEMYELINATING DISEASE; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DRUG MEGADOSE; EXCITOTOXICITY; HUMAN; HYPOXIA; IDIOPATHIC DISEASE; IMMUNOPATHOGENESIS; MACROPHAGE; MICROGLIA; MULTIPLE SCLEROSIS; MULTIPLE SCLEROSIS MARBURG VARIANT; MULTIPLE SCLEROSIS PLAQUE; MYELOOPTIC NEUROPATHY; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; PLASMAPHERESIS; POSTVACCINAL ENCEPHALITIS; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; T LYMPHOCYTE; TUMEFACTIVE MULTIPLE SCLEROSIS; WHITE MATTER; ANIMAL; CLASSIFICATION; IMMUNOLOGY; INFLAMMATION; MOUSE; PATHOLOGY;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; DEMYELINATING DISEASES; HUMANS; INFLAMMATION; MICE; MULTIPLE SCLEROSIS;

EID: 39549105607     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-73677-6_2     Document Type: Review

References (109)

1. Aboul-Enein F, Lassmann H (2005) Mitochondrial damage and histiotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease. Acta Neuropathol 109:49-55
2. Aboul-Enein F, Rauschka H, Kornek B, Stadelmann C, Stefferl A, Bruck W, Lucchinetti C, Schmidbauer M, Jellinger K et al (2003) Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Exp Neurol 62:25-33
3. Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A (2003) An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci U St A 100:2106-2111
4. Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schroder R, Deckert M, Schmidt S, Ravid R, Rajewsky K (2000) Clonal expansion of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 192:393-404
5. Baig S, Olsson O, Olsson T, Love A, Jeansson S, Link H (1989) Cells producing antibody to measles and herpes simplex virus in cerebrospinal fluid and blood of patients with multiple sclerosis and controls. Clin Exp Immunol 78:390-395
6. Baker AB (1968) Problems in the classification of multiple sclerosis. In: Alter M, Kurtzke JF (eds) The epidemiology of multiple sclerosis. Charles C. Thomas, Springfield, IL, pp 14-25.
7. Baranzini SE, Jeong MC, Butunoi C et al (1999) B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 163:5133-5144
8. Barkhof F, Bruck W, De Groot C, Bergers E, Hulshof S, Geurts J, Polman CH, van der Valk P (2003) Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch. Neurol. 60:1073-1081
9. Barnett MH, Prineas JW (2004) Pathological heterogeneity in multiple sclerosis: a reflection of lesion stage? Ann Neurol 56:309
10. Barnett MH, Prineas JW (2004) Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Annals of Neurology 55:458-468
11. Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M (2003) Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med 349:139-145
12. Bieber AJ, Ure DR, Rodriguez M (2005) Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis. J Neuropathol Exp Neurol 64:46-57
13. Bitsch A, Bruhn H, Vougioukas V, Stringaris A, Lassmann H, Frahm J, Bruck W (1999) Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 20:1619-1627
14. Bo L, Dawson T, Wesselingh S et al (1994) Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 36:778-786
15. Booss J, Esiri MM, Tourtellotte WW, Mason DY (1983) Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J Neurol Sci 62:219-232
16. Boven LA, Van Meurs M, Van Zwam M, Wierenga-Wolf A, Hintzen RQ, Boot RG et al (2006) Myelin-laden macrophages are anti-inflammatory consistent with foam cells in multiple sclerosis. Brain 129:517-526
17. Brown GC, Borutaite V (2002) Nitric oxide inhibition of mitochondrial respiration and its role in cell death. Free Radic Biol Med 33:1440-1450
18. Bruck W, Porada P, Poser S, Rieckmann P, Hanefeld F, Kretchmar HA, et al (1995) Monocyte-macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 38:788-796
19. Charcot JM (1868) Histologie de la sclérose en plaques. Gaz Hop Civils Militaires 140, 141, 143:554-555, 557-558, 566
20. Chen C, Ro L, Chang C, Ho Y, Lu C (1996) Serial MRI studies in pathologically verified Balo's concentric sclerosis. J Comput Assist Tomogr 20:732-735
21. Christians ES, Yan LJ, Benjamin IJ (202) Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. Crit Care Med 30:S43-S50
22. Corcione A, Aloisi F, Serafini B, Capello E, Mancardi GL, Pistoia V, Uccelli A (2005) B-cell differentiation in the CNS of patients with multiple sclerosis. Autoimmun Rev 4:594-654
23. Corcione A, Casazza S, Ferretti E, Giunti G, Zappia E, Pistorio A, Gambini C, Mancardi GL, Uccelli A, Pistoia V (2004) Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc Natl Acad Sci USA 10:11064-11069
24. Courville C (1970) Concentric sclerosis. In: Bruyn PV (ed) Handbook of Clinical Neurology. Elsevier, Amsterdam, pp 437-451.
25. Cross A, Trotter J, Lyons J (2001) B cells and antibodies in CNS demyelinating disease. J Neuroimmunol 112:1-14
26. De Groot C, Ruuls S, Theeuwes J, Dijkstra C, van der Valk P (1997) Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis lesions. J Neuropathol Exp Neurol 56:10-20
27. Esiri MM (1977) Immunoglobulin-containing cells in multiple sclerosis plaques. Lancet 2:478
28. Forstermann U, Kleinert H (1995) Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn-Schmiedebergs Arch Pharmacol 352:351-364
29. Franklin RJ (2002) Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci 3:705-714
30. Friese M, Fugger L (2005) Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain 128:1747-1763
31. Garbern J, Spence A, Alvord E (1986) Balo's concentric demyelination diagnosed premortem. Neurology 36:1610-1614
32. Garthwaite G, Goodwin DA, Batchelor AM et al (2002) Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve. Neuroscience 109:145-155
33. Genain CP, Cannella B, Hauser SL, Raine CS (1999) Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5:170-175
34. Geurts JJ, Wolswijk G, Bo L, van der Valk P, Polman CH, Troost D, Aronica E (2003) Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. Brain 126:1755-1766
35. Gharagozloo A, Poe L, Collins G (1994) Antemortem diagnosis of Balo concentric sclerosis: correlative MR imaging and pathologic features. Radiology 191:817-819
36. Giovannoni G, Heales S, Land J, Thompson E (1998) The potential role of nitric oxide in multiple sclerosis. Multiple Sclerosis 4:212-216
37. Goes vd A, Boorsma W, Hoekstra K, Montagne L, De Groot CJ, Dijkstra CD (2005) Determination of the sequential degradation of myelin proteins by macropahges. J Neuroimm 161:12-20
38. Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C (2005) Multiple sclerosis. Immunol Rev 204:208-231
39. Hanemann C, Kleinschmidt A, Reifenberger G, Freud H, Seitz R (1993) Balo concentric sclerosis followed by MRI and positron emission tomography. Neuroradiology 35:578-580
40. Hart M, Earle K (1975) Haemorrhagic and perivenous encephalitis: a clinical-pathological review of 38 cases. J Neurol Neurosurg Psychiatry 38:585-591
41. Hendricks JJ, Teunissen CE, de Vries HE, Dijkstra CD (2005) Macrophages and neurodegeneration. Brain Res Reviews 48:185-195
42. Hill KE, Zollinger LV, Watt HE, Carlson NG, Rose JW (2004) Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression, and association with myelin damage. J Neuroimmunol 151:171-179
43. Hoftberger R, Aboul-Enein F, Brueck W, Lucchinetti CF, Rodriguez M, Schmidbauer M, Jellinger K et al (2004) Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions. Brain Pathol 14:43-50
44. Huseby ES, Liggitt D, Brabb T, Schnabel B, Öhlén C, Goverman J (2001) A pathogenic role for myelin-specific CD8+ T cells in a model for multiple sclerosis. J Exp Med 194:669-676
45. Jung J, Bhat R, Preston G, Guggino W, Baraban J, Agre P (1994) Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci USA 91:13052-13056
46. Karaarslan E, Altintas A, Senol U, Yeni N, Dincer A, Bayindir C, KIaraagac N, Siva A (2001) Balo's concentric sclerosis: clinical and radiologic features of five cases. AJNR Am J Neuroradiol 22:1362-1367
47. Keegan M, Konig F, McClelland R, Bruck W, Morales Y, Bitsch A, Panitch H, Lassmann H, Weinshenker B, Rodriguez M, Parisi J, Lucchinetti CF (2005) Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet 366:579-582
48. Kerschensteiner M, Gallmeier E, Behrens L, Klinkert WEF, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R (1999) Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: a neuroprotective role for inflammation? J Exp Med 189:865-870
49. Kerschensteiner M, Stadelmann C, Dechang G, Wekerle H, Hohlfeld R (2003) Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Ann Neurol 53:292-304
50. Korte J, Born E, Vos L, Breuer T, Wondergem J (1994) Balo concentric sclerosis: MR diagnosis. AJNR Am J Neuroradiol 15:1284-1285
51. Kuhle J, Pohl, Mehling M, Edan G, Freedman M, Hartung HP, Polman C, Miller D, Montalban X, Barkhof F, Bauer L, Dahms S, Lindberg R, Kappos L, Sandbrink R (2007) Lack of association between antimyelin antibodies and progression to multiple sclerosis. N Engl J Med 356:371-378
52. Kuroiwa Y (1982) Clinical and epidemiological aspects of multiple sclerosis in Japan. Jpn J Med 21:135-140
53. Lassmann H (1983) Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Springer Schriftenr Neurol 25:1-135
54. Lassmann H, Raine C, Antel J, Prineas J (1998) Immunopathology of multiple sclerosis: Report on an international meeting held at the Institute of Neurology of the University of Vienna. J Neuroimmunol 86:213-217
55. Lassmann H, Wisniewski HM (1979) Chronic relapsing experimental allergic encephalomyelitis: morphological sequence of myelin degradation. Brain Res 169:357-368
56. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005) IgG marker of opticspinal MS binds to the aquaporin-4 water channel. J Exp Med 202:473-477
57. Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG (2004) A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis. Lancet 364:2106-2112
58. Linington C, Bradl M, Lassmann H, Brunner C, Vass K (1988) Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 130:443-454
59. Liu J, Zhao M, Brosnan C, Lee S (2001) Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol 158:2057-2066
60. Lock C, Hermans G, Pedotti R et al (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8:500-508
61. Lucchinetti CF, Bruck W, Lassmann H (2004) Evidence for pathogenic heterogeneity in multiple sclerosis. Ann Neurol 56:308
62. Lucchinetti CF, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47:707-717
63. Lucchinetti CF, Brueck W, Rodriguez M, Parisi J, Scheithauer B, Lassmann H (1999) A quantitative study on the fate of the oligodendrocyte in multiple sclerosis lesions: a study of 113 cases. Brain 122:2279-2295
64. Lucchinetti CF, Mandler RN, McGavern D, Bruck W, Gleich G, Ransohoff RM, Trebst C, Weinshenker B, Wingerchuk D, Parisi JE, Lassmann H (2002) A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 125:1450-1461
65. Mantovani A, Sica A, Locati M (2005) Macrophage polarization comes of age. Immunity 23:344-346
66. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677-686
67. Marburg O (1906) Die sogenannte "akute Multiple Sklerose". J Psychiatr Neurol 27:211-212
68. Martino G, Olsson T, Fredrikson S, Hojeberg B, Kostulas V, Grimaldi LM, Link H (1991) Cells producing antibodies specific for myelin basic protein region 70-89 are predominant in cerebrospinal fluid from patients with multiple sclerosis. Eur J Immunol 21:2971-2976
69. Matute C, Alberdi E, Domercq M, Perez-Cerda F, Perez-Samartin A, Sanchez-Gomez MV (2001) The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci 24:224-230
70. Mehta PD, Frisch S, Thormar H et al (1981) Bound antibody in multiple sclerosis brains. J Neurol Sci 49:91-98
71. Neumann H, Medana IM, Bauer J, Lassmann H (2002) Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci 25:313-319
72. O'Connor KC B-OA, Hafler DA (2001) The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J Clin Immunol 21:81-92
73. Olsson T, Zhi WW, Hojeberg B, Kostulas V, Jiang YP, Anderson G, Ekre HP, Link H (1990) Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. J Clin Invest 86:981-985
74. Oppenheimer DR (1976) Demyelinating diseases. In: Blackwood W, Corsellis JAN (eds) Greenfield's neuropathology. Edward Arnold, London pp 470-499
75. Owens GP, Kraus H, Burgoon MP et al (1998) Restricted use of VH4 germline segments in an acute multiple sclerosis brain. Ann Neurol 43:236-243
76. Owens GP, Ritchie AM, Burgoon MP et al (2003) Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal flu. J Immunol 171:2725-2733
77. Patrikios P, Stadelmann C, Kutzelnigg A, Rauschka H, Schmidbauer M, Laursen H, Sorensen.P, Brück W, Lucchinetti CF, Lassmann H (2006) Remyelination is extensive in a subset of multiple sclerosis patients. Brain 129:3165-3172
78. Pittock SJ, McClelland RL, Achenbach SJ, Konig F, Bitsch A, Bruck W, Lassmann H, Parisi J, Lucchinetti CF (2005) Clinical course, pathologic correlations and outcome of biopsy proven inflammatory demyelinating disease. J Neurol Neurosurg Psychiatry 767:1693-1697
79. Prineas J (1985) The neuropathology of multiple sclerosis. In: Vinken P, Bruyn G, Klawans H (eds) Handbook of clinical neurology. Elsevier Science, New York pp 213-257
80. Prineas J, McDonald WI, Franklin JM (2002) Demyelinating diseases. In: Graham LP (ed) Greenfield's neuropathology. Edward Arnold, London pp 471-550.
81. Prineas JW, Barnard RO, Revesz T, Kwon EE, Sharer L, Cho ES (1993) Multiple sclerosis. Pathology of recurrent lesions. Brain 116:681-693
82. Prineas JW, Kwon EE, Cho ES, Sharer LR, Barnett MH, Oleszak EL, Hoffman B, Morgan BP (2001) Immunopathology of secondary-progressive multiple sclerosis. Ann Neurol 50:646-657
83. Prineas JW, Wright RG (1978) Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis. Lab Invest 38:409-421
84. Qin Y, Duquette P, Zhang Y et al (1998) Clonal expansion and somatic hypermutation of V (H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 102:1045-1050
85. Redford EJ, Kapoor R, Smith KJ (1997) Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible. Brain 120:2149-2157
86. Revel M, Valiente E, Gray F, Beges C, Degos J, Brugieres P (1993) Concentric MR patterns in multiple sclerosis. Report of two cases. J Neuroradiol 20:252-257
87. Roemer SF, Parisi JE, Lennon VA, Benarroch EE, Lassmann H, Bruck W, Mandler RN, Weinshenker BG, Pittock SJ, Wingerchuk DM, Lucchinetti CF (2007) Pattern specific loss of aquaporin 4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. Brain 130:1174-1205
88. Schwartz M, Butovsky O, Bruck W et al (2006) Microglial phenotype: is the commitment reversible? Trends Neurosci 29:68-74
89. Serafini B, Rosicarelli B, Magliozzi R et al (2004) Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 14:164-174
90. Sharp FR, Bernaudin M (2004) HIF1 and oxygen sensing in the brain. Nat Rev Neurosci 5:437-448
91. Smith KJ, Kapoor R, Hall SM, Davies M (2001) Electrically active axons degenerate when exposed to nitric oxide. Ann Neurol 49:470-476
92. Smith KJ, Lassmann H (2002) The role of nitric oxide in multiple sclerosis. Lancet Neurol 1:232-241
93. Smith-Jensen T, Burgoon MP, Anthony J et al (2000) Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven response. Neurology 54:1227-1232
94. Spiegel M, Kruger H, Hofmann E, Kappos L (1989) MRI study of Balo's concentric sclerosis before and after immunosuppressant therapy. J Neurol 236:487-488
95. Stadelmann C, Kerschensteiner M, Misgeld T et al (2002) BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune cells and neuronal cells. Brain 125:75-85
96. Stadelmann C, Ludwin SK, Tabira T, Guseo A, Lucchinetti C, Brück W, Lassmann H (2005) Hypoxic preconditioning explains concentric lesions in Balo's type of multiple sclerosis. Brain 128:979-987
97. Storch MK, Piddlesden S, Haltia M, Livanainen M, Morgan P, Lassmann H (1998) Multiple sclerosis: in situ evidence for antibody- and complement-mediated demyelination. Ann Neurol 43:465-471
98. Sun D, Whitaker JN, Huang Z, Liu D, Coleclough C, Wekerle H, Raine CS (2001) Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 166:7579-7587
99. Sun J, Link H, Olsson T et al (1991) T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 146:1490-1495
100. Traugott U (1983) Multiple sclerosis: relevance of class I and class II MHC-expressing cells to lesion development. J Neuroimmunol 16:283-302
101. Turnbull HM, McIntosh J (1926) Encephalomyelitis following vaccination. Br J Exp Pathol 7:181-222
102. Van Bogaert L (1950) Post-infectious encephalomyelitis and multiple sclerosis; the significance of perivenous encephalomyelitis. J Neuropathol Exp Neurol 9:219-249
103. Vass K, Welch WJ, Nowak TS (1988) Localization of 70-kDa stress protein induction in gerbil brain after ischemia. Acta Neuropathol 77:128-135
104. Werner P Pitt D, Raine CS (2001) Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Ann Neurol 50:169-180
105. Williamson RA, Burgoon MP, Owens GP et al (2001) Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis. Proc Natl Acad Sci USA 98:1793-1798
106. Wingerchuk D, Pittock S, Lennon V, Lucchinetti C, Weinshenker B (2005) Neuromyelitis optica diagnostic criteria revisited: validation and incorporation of the NMO-IgG serum autoantibody. Neurology 64:A38
107. Wolswijk G (1998) Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J Neurosci 18:601-609
108. Wood DD, Bilbao JM, O'Connors P, Moscarello MA (1996) Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein. Ann Neurol 40:18-24
109. Youl BD, Kermode AG, Thompson AJ, Revesz T, Scaravilli F, Barnard RO, Kirkham FJ, Kendall BE, Kingsley D, Moseley IF (1991) Destructive lesions in demyelinating disease. J Neurol Neurosurg Psychiatry 54:288-292