NeuroAIDS: Characteristics and diagnosis of the neurological complications of AIDS

Molecular Diagnosis and Therapy

Volumn 12, Issue 1, 2008, Pages 25-43

  Minagar, Alireza ^a   Commins, Deborah ^b,c   Alexander, J Steven ^d   Hoque, Romy ^a   Chiappelli, Francesco ^e   Singer, Elyse J ^c,f   Nikbin, Behrooz ^g   Shapshak, Paul ^h  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c National Neurological AIDS Bank   (United States)

^d LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^e UCLA SCHOOL OF DENTISTRY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^h UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Acquired immunodeficiency syndrome; Biomarkers; CNS infections; Cognitive function; Dementia; Diagnostics

Indexed keywords

ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER; VIRUS PROTEIN; ZALCITABINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BLOOD BRAIN BARRIER; BRAIN CELL; CELL PROLIFERATION; CEREBROSPINAL FLUID; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; DEMENTIA; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MASS SPECTROMETRY; MENTAL FUNCTION; MONOCYTE; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 39549083229     PISSN: 11771062     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03256266     Document Type: Review

References (239)

1. Navia BA, Jordan BD, Price RW. The AIDS dementia complex: I. Clinical features. Ann Neurol 1986; 19: 517-24
2. Hinkin CH, Hardy DJ, Mason KI, et al. Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse. AIDS 2004; 18 (1 Suppl.): 19S-25S
3. Ellis RJ, Deutsch R, Heaton RK, et al. Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group. Arch Neurol 1997; 54: 416-24
4. Sacktor N. The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J Neurovirol 2002; 8 (2 Suppl.): 115S-21S
5. Tozzi V, Balestra P, Bellagamba R, et al. Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment: prevalence and risk factors. J Acquir Immune Defic Syndr 2007; 45: 174-82
6. Nath A, Sacktor N. Influence of highly active antiretroviral therapy on persistence of HIV in the central nervous system. Curr Opin Neurol 2006; 19: 358-61
7. McGee B, Smith N, Aweeka F. HIV pharmacology: barriers to the eradication of HIV from the CNS. HIV Clin Trials 2006; 7: 142-53
8. Lambotte O, Deiva K, Tardieu M. HIV-1 persistence, viral reservoir, and the central nervous system in the HAART era. Brain Pathol 2003; 13: 95-103
9. Price R, Sidtis J. Early HIV infection and the AIDS dementia complex. Neurology 1990; 40: 323-6
10. Tambussi G, Gori A, Capiluppi B, et al. Neurological symptoms during primary human immunodeficiency virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid. Clin Infect Dis 2000; 30: 962-5
11. Chang L, Lee PL, Yiannoutsos CT, et al. HIV MRS Consortium. A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age. Neuroimage 2004; 23: 1336-47
12. Dore GJ, Correll PK, Li Y, et al. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 1999; 13: 1249-53
13. Marshall DW, Brey RL, Cahill WT, et al. Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection. Arch Neurol 1988; 45: 954-8
14. Valcour V, Shikuma C, Shiramizu B, et al. Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort. Neurology 2004; 63: 822-7
15. King JE, Eugenin EA, Buckner CM, et al. HIV tat and neurotoxicity. Microbes Infect 2006; 8: 1347-57
16. Singer EJ, Syndulko K, Fahy-Chandon B, et al. Intrathecal IgG synthesis and albumin leakage are increased in subjects with HIV-1 neurologic disease. J Acquir Immune Defic Syndr 1994; 7: 265-71
17. Singer EJ, Syndulko K, Fahy-Chandon BN, et al. Cerebrospinal fluid p24 antigen levels and intrathecal immunoglobulin G synthesis are associated with cognitive disease severity in HIV-1. AIDS 1994, 204
18. Resnick L, Berger JR, Shapshak P, et al. Early penetration of the blood-brain-barrier by HIV. Neurology 1988; 38:: 9-14
19. Tourtellotte WW, Singer E, Syndulko K, et al. Intra-blood-brain-barrier IgG synthesis in HIV. In: Palfreyman MG, McCann PP, Lovenberg W, et al., editors. Enzymes as targets for drug design. San Diego (CA): Academic Press, 1990: 211-7
20. Böttiger D, Keys B, Putkonen P, et al. Simian immunodeficiency virus (SIVsm) isolation from blood and brain of experimentally infected macaques. Aids, 1991; 5 (4): 445-9
21. Smith MO, Heyes MP, Lackner AA. Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus. Lab Invest 1995; 72: 547-58
22. Denning DW. The neurological features of acute HIV infection. Biomed Pharmacother 1988; 42: 11-4
23. Jones Jr HR, Ho DD, Forqacs P, et al. Acute fulminating fatal leukoencephalopathy as the only manifestation of human immunodeficiency virus infection. Ann Neurol 1988; 23: 519-22
24. Price RW, Brew BJ. The AIDS dementia complex. J Infect Dis 1988; 158 (5): 1079-83
25. Ellen SR, Judd FK, Mijch AM, et al. Secondary mania in patients with HIV infection. Aust N Z J Psychiatry 1999; 33: 353-60
26. Scharko AM, Baker EH, Kothari P, et al. Case study: delirium in an adolescent girl with human immunodeficiency virus-associated dementia. J Am Acad Child Adolesc Psychiatry 2006 Jan; 45 (1): 104-8
27. Report of a Working Group of the American Academy of Neurology AIDS Task Force. Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection. Neurology 1991; 41: 778-85
28. Antinori A, Arendt G, Becker JT, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007; 69: 1789-99
29. Cherner M, Cysique L, Heaton RK, et al. Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disorders. J Neurovirol 2007; 13: 23-8
30. Sweeney JA, Brew BJ, Keilp JG, et al. Pursuit eye movement dysfunction in HIV-1 seropositive individuals. J Psychiatry Neurosci 1991; 16: 247-52
31. The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders. Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. Neurology 1996; 47: 1247-53
32. Cardoso F. HIV-related movement disorders: epidemiology, pathogenesis and management. CNS Drugs 2002; 16: 663-8
33. Power C, Selnes OA, Grim JA, et al. HIV Dementia Scale: a rapid screening test. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 8 (3): 273-8
34. van Harten B, Courant MN, Scheltens P, et al. Validation of the HIV dementia scale in an elderly cohort of patients with subcortical cognitive impairment caused by subcortical ischaemic vascular disease or a normal pressure hydrocephalus. Dement Geriatr Cogn Disord 2004; 18: 109-14
35. Richardson MA, Morgan EE, Vielhauer MJ, et al. Utility of the HIV dementia scale in assessing risk for significant HIV-related cognitive-motor deficits in a high-risk urban adult sample. AIDS Care 2005; 17: 1013-21
36. Robertson KR, Parsons TD, Sidtis JJ, et al. Timed gait test: normative data for the assessment of the AIDS dementia complex. J Clin Exp Neuropsychol 2006; 28: 1053-64
37. Marder K, Liu X, Stern Y, et al. Neurologic signs and symptoms in a cohort of homosexual men followed for 4.5 years. Neurology 1995; 45: 261-7
38. Dallasta LM, Pisarov LA, Esplen JE, et al. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol 1999; 155: 1915-27
39. Tremont-Lukats IW, Serbanescu R, Teixeira GM, et al. Multivariate analysis of primitive reflexes in patients with human immunodeficiency virus type-1 infection and neurocognitive dysfunction. Ital J Neurol Sci 1999; 20: 17-22
40. Marder K, Liu X, Stern Y, et al. Risk of human immunodeficiency virus type 1-related neurologic disease in a cohort of intravenous drug users. Arch Neurol 1995; 52: 1174-82
41. Marcario JK, Raymond LA, McKiernan BJ, et al. Motor skill impairment in SIV-infected rhesus macaques with rapidly and slowly progressing disease. J Med Primatol 1999; 28: 105-17
42. Cloak CC, Chang L, Ernst T. Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV. J Neuroimmunol 2004; 157: 147-52
43. Maruff P, Currie J, Malone V, et al. Neuropsychological characterization of the AIDS dementia complex and rationalization of a test battery. Arch Neurol 1994; 51: 689-95
44. Amador F, Mayor-Rios J, del Castillo-Martin N. Cognitive slowing in asymptomatic individuals who are seropositive for human immunodeficiency virus type 1. Rev Neurol 2006; 42: 132-6
45. Shiramizu B, Paul R, Williams A, et al. HIV proviral DNA associated with decreased neuropsychological function. J Neuropsychiatry Clin Neurosci 2007; 19: 157-63
46. Tucker KA, Robertson KR, Lin W, et al. Neuroimaging in human immunodeficiency virus infection. J Neuroimmunol 2004; 157: 153-62
47. Aylward EH, Henderer JD, McArthur JC, et al. Reduced basal ganglia volume in HIV-1-associated dementia: results from quantitative neuroimaging. Neurology 1993; 43: 2099-104
48. Suwanwelaa N, Phanuphak P, Phanthumchinda K, et al. Magnetic resonance spectroscopy of the brain in neurologically asymptomatic HIV-infected patients. Magn Reson Imaging 2000; 18: 859-65
49. Filippi CG, Ulug AM, Ryan E, et al. Diffusion tensor imaging of patients with HIV and normal-appearing white matter on MR images of the brain. Am J Neuroradiol 2001; 22: 277-83
50. Ances BM, Roc AC, Wang J, et al. Caudate blood flow and volume are reduced in HIV+ neurocognitively impaired patients. Neurology 2006; 66: 862-6
51. Rottenberg DA, Sidtis JJ, Strother SC, et al. Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 1996; 37: 1133-41
52. Brunetti A, Berg G, Di Chiro G, et al. Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3′-azido-2′,3′-dideoxythymidine (AZT, zidovudine): a PET-FDG study. J Nucl Med 1989; 30: 581-90
53. Krebs FC, Ross H, McAllister J, et al. HIV-1-associated central nervous system dysfunction. Adv Pharmacol 2000; 49: 315-85
54. Marshall DW. HIV penetration of the BBB. Neurology 1988; 38: 1000-1
55. Kim WK, Corey S, Alvarez X, et al. Monocyte/macrophage traffic in HIV and SIV encephalitis. J Leukoc Biol 2003; 74: 650-6
56. Stevceva L, Yoon V, Anastasiades D, et al. Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res 2007; 5: 47-54
57. Moore JP, Kitchen SG, Pugach P, et al. The CCR5 and CXCR4 coreceptors: central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 2004; 20: 111-26
58. Cardozo T, Kimura T, Philpott S, et al. Structural basis for coreceptor selectivity by the HIV type 1 V3 loop. AIDS Res Hum Retroviruses 2007; 23: 415-26
59. Bomsel M. Trans-cytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier. Nat Med 1997; 3: 42-7
60. Banks WA, Freed EO, Wolf KM, et al. Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis. J Virol 2001; 75: 4681-91
61. Liu NQ, Lossinsky AS, Popik W, et al. Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol 2002; 76: 6689-700
62. Toborek M, Lee YW, Flora G, et al. A mechanisms of the blood-brain barrier disruption in HIV-1 infection. Cell Mol Neurobiol 2005 Feb; 25 (1): 181-99
63. Avison MJ, Nath A, Greene-Avison R, et al. Neuroimaging correlates of HIV-associated BBB compromise. J Neuroimmunol 2004; 157: 140-6
64. Ricardo-Dukelow M, Kadiu I, Rozek W, et al. HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia. J Neuroimmunol 2007; 185: 37-46
65. Kramer-Hammerle S, Rothenaigner I, Wolff H, et al. Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus. Virus Res 2005; 111: 194-213
66. Gendelman HE, Lipton SA, Tardieu M, et al. The neuropathogenesis of HIV-1 infection. J Leukoc Biol 1994; 56: 389-98
67. Wiley CA, Schrier RD, Nelson JA, et al. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A 1986; 83: 7089-93
68. Pumarola-Sune T, Navia BA, Cordon-Cardo C, et al. HIV antigen in the brains of patients with the AIDS dementia complex. Ann Neurol 1987; 21: 490-6
69. Bissel SJ, Wang G, Trichel AM, et al. Longitudinal analysis of activation markers on monocyte subsets during the development of simian immunodeficiency virus encephalitis. J Neuroimmunol 2006; 177 (1-2): 85-98
70. Lawrence DM, Durham LC, Schwartz L, et al. Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J Virol 2004 Jul; 78 (14): 7319-28
71. Churchill MJ, Gorry PR, Cowley D, et al. Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues. J Neurovirol 2006 Apr; 12 (2): 146-52
72. Tozzi V, Balestra P, Galgani S, et al. Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years. J Acquir Immune Defic Syndr 2001; 28: 19-27
73. Mandraju RK, Kondapi AK. Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways. Arch Biochem Biophys 2007 May 1; 461 (1): 40-9
74. Kaul M, Lipton SA. Mechanisms of neuronal injury and death in HIV associated dementia. Curr HIV Res 2006; 4: 307-18
75. Fischer-Smith T, Rappaport J. Evolving paradigms in the pathogenesis of HIV-1-associated dementia. Expert Rev Mol Med 2005; 7: 1-26
76. Gorry PR, Ong C, Thorpe J, et al. Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. Curr HIV Res 2003; 1: 463-73
77. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 1999; 13: 1-22
78. Carroll-Anzinger D, Al-Harthi L. Gamma interferon primes productive human immunodeficiency virus infection in astrocytes. J Virol 2006; 80: 541-4
79. Jacotot E, Ravagnan L, Loeffler M, et al. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med 2000; 191: 33-46
80. Valle LD, Croul S, Morgello S, et al. Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with progressive multifocal leukoencephalopathy. J Neurovirol 2000; 6: 221-8
81. Bagasra O, Lavi E, Bobroski L, et al. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 1996; 10: 573-85
82. Nath A. Pathobiology of human immunodeficiency virus dementia. Semin Neurol 1999; 19: 113-27
83. Nath A, Conant K, Chen P, et al. Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: a hit and run phenomenon. J Biol Chem 1999; 274: 17098-102
84. Fine SM, Angel RA, Perry SW, et al. Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes: implications for pathogenesis of HIV-1 dementia. J Biol Chem 1996; 271: 15303-6
85. Bhakar AL, Tannis LL, Zeindler C, et al. Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci 2002; 22: 8466-75
86. Sanchez AC, Davis RL, Syapin PJ. Identification of cis-regulatory regions necessary for robust Nos2 promoter activity in glial cells: indirect role for NF-kappaB. J Neurochem 2003; 86: 1379-90
87. Sui Z, Sniderhan LF, Fan S, et al. Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons. Eur J Neurosci 2006; 23: 2623-34
88. Meucci O, Fatatis A, Simen AA, et al. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival [published erratum appears in Proc Natl Acad Sci U S A 2001 Dec 18; 98 (26): 15393]. Proc Natl Acad Sci U S A 2000 Jul 5; 97 (14): 8075-80
89. Ramirez SH, Sanchez JF, Dimitri CA, et al. Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. J Neurochem 2001; 78: 874-89
90. Mattson MP, Haughey NJ, Nath A. Cell death in HIV dementia. Cell Death Differ 2005; 12 (1 Suppl.): 893S-904S
91. Haughey NJ, Mattson MP. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr 2002; 31 (2 Suppl.): 55S-61S
92. Kanmogne GD, Schall K, Leubhart J, et al. HIV-1 gp120 compromises blood-brain barrier integrity and enhance monocyte migration across blood-brain barrier: implication for viral neuropathogenesis. J Cereb Blood Flow Metab 2007; 27: 123-34
93. Takahashi K, Wesselingh SL, Griffin DE, et al. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996; 39: 705-11
94. Stewart SA, Poon B, Jowett JB, et al. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J Virol 1997 Jul; 71 (7): 5579-92
95. Trillo-Pazos G, Diamanturos A, Rislove L, et al. Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain Pathol 2003; 13: 144-54
96. Greene WC, Peterlin BM. Charting HIV's remarkable voyage through the cell: basic science as a passport to future therapy. Nat Med 2002; 8: 673-80
97. Lehmann MH, Walter S, Ylisastigui L, et al. Extracellular HIV-1 Nef increases migration of monocytes. Exp Cell Res 2006; 312: 3659-68
98. Eugenin EA, Osiecki K, Lopez L, et al. CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS. J Neurosci 2006; 26: 1098-106
99. Levy DN, Refaeli Y, Weiner DB. The Vpr regulatory gene of HIV. Curr Top Microbiol Immunol 1995; 193: 209-36
100. Patel CA, Mukhtar M, Pomerantz RJ. Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells. J Virol 2000; 74: 9717-26
101. Stewart SA, Poon B, Song JY, et al. Human immunodeficiency virus type 1 Vpr induces apoptosis through caspase activation. J Virol 2000 Apr; 74 (7): 3105-11
102. Yedavalli VS, Shih HM, Chiang YP, et al. Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1. J Virol 2005; 79: 13735-46
103. Wheeler ED, Achim CL, Ayyavoo V. Immunodetection of human immunodeficiency virus type 1 (HIV-1) Vpr in brain tissue of HIV-1 encephalitic patients. J Neurovirol 2006; 12: 200-10
104. Norman JP, Perry SW, Kasischke KA, et al. HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons. J Immunol 2007; 178: 869-76
105. Anderson E, Zink W, Xiong H, et al. HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes. J Acquir Immune Defic Syndr 2002; 31 Suppl. 2: S43-54
106. Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis ain HIV-associated dementia. Nature 2001; 410: 988-94
107. Sui Z, Sniderhan LF, Schifitto G, et al. Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. J Immunol 2007; 178: 3226-36
108. Zhang K, McQuibban GA, Silva C, et al. HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration. Nat Neurosci 2003; 6: 1064-71
109. Yi Y, Lee C, Liu QH, et al. Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: implications for neuropathogenesis. J Neurovirol 2004; 10 (1 Suppl.): 91S-6S
110. Brabers NA, Nottet HS. Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia. Eur J Clin Invest 2006; 36: 447-58
111. Shapshak P, Duncan R, Minagar A, et al. Elevated expression of IFN-gamma in the HIV-1 infected brain. Front Biosci 2004 May 1; 9: 1073-81
112. Giunta B, Obregon D, Hou H, et al. EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/ STAT1 signaling and implications for HIV-associated dementia. Brain Res 2006; 1123: 216-25
113. Opii WO, Sultana R, Abdul HM, et al. Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI) -2′,3′-dideoxycytidine (ddC): relevance to HIV-dementia. Exp Neurol 2007; 204: 29-38
114. Sevigny JJ, Albert SM, McDermott MP, et al. Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology 2004; 63: 2084-90
115. Demuth M, Czub S, Sauer U, et al. Relationship between viral load in blood, cerebrospinal fluid, brain tissue and isolated microglia with neurological disease in macaques infected with different strains of SIV. J Neurovirol 2000; 6: 187-201
116. An SF, Groves M, Giometto B, et al. Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/in situ hybridisation technique. Acta Neuropathol (Berl) 1999 Nov; 98 (5): 481-7
117. Glass JD, Wesselingh SL, Selnes OA, et al. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 1993; 43: 2230-7
118. Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol 2004; 157: 93-8
119. Fischer-Smith T, Croul S, Sverstiuk AE, et al. CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection. J Neurovirol 2001; 7: 528-41
120. McCrossan M, Marsden M, Carnie FW, et al. An immune control model for viral replication in the CNS during presymptomatic HIV infection. Brain 2006; 129: 503-16
121. Wojna V, Carlson KA, Luo X, et al. Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study. J Neurovirol 2004; 10 (1 Suppl.): 74-81
122. Marshall DW, Brey RL, Butzin CA, et al. CSF changes in a longitudinal study of 124 neurologically normal HIV-1-infected U.S. Air Force personnel. J Acquir Immune Defic Syndr 1991; 4: 777-81
123. Weber T. Cerebrospinal fluid analysis for the diagnosis of human immunodeficiency virus-related neurologic diseases. Semin Neurol 1999; 19: 223-33
124. McArthur JC, McClernon DR, Cronin MF, et al. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol 1997; 42: 689-98
125. Berger JR, Nath A, Greenberg RN, et al. Cerebrovascular changes in the basal ganglia with HIV dementia. Neurology 2000; 54: 921-6
126. Carlson KA, Limoges J, Pohlman GD, et al. OTK 18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. J Neuroimmunol 2004; 150: 186-98
127. Conrad AJ, Schmid P, Syndulko K, et al. Quantifying HIV-1 RNA using the polymerase chain reaction on cerebrospinal fluid and serum of seropositive individuals with and without neurologic abnormalities. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 10: 425-35
128. Ellis RJ, Moore DJ, Childers ME, et al. Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA. Arch Neurol 2002; 59: 923-8
129. Marcotte TD, Deutsch R, McCutchan JA, et al., San Diego HIV Neurobehavioral Research Center (HNRC) Group. Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion. Arch Neurol 2003; 60: 1406-12
130. McArthur JC, McDermott MP, McClernon D, et al. Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy. Arch Neurol 2004; 61: 1687-96
131. Schmid P, Conrad A, Syndulko K, et al. Quantifying HIV-1 proviral DNA using the polymerase chain reaction on cerebrospinal fluid and blood of seropositive individuals with and without neurologic abnormalities. J Acquir Immune Defic Syndr 1994; 7: 777-88
132. Yilmaz A, Fuchs D, Hagberg L, et al. Cerebrospinal fluid HIV-1 RNA, intrathecal immunoactivation, and drug concentrations after treatment with a combination of saquinavir, nelfinavir, and two nucleoside analogues: the M61022 study. BMC Infect Dis 2006; 6: 63
133. McCoig C, Castrejon MM, Saavedra-Lozano J, et al. Cerebrospinal fluid and plasma concentrations of proinflammatory mediators in human immunodeficiency virus-infected children. Pediatr Infect Dis J 2004; 23: 114-8
134. Sevigny JJ, Albert SM, McDermott MP, et al. Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology 2004; 63: 2084-90
135. Luo X, Carlson KA, Wojna V, et al. Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment. Neurology 2003; 60: 1931-7
136. Buffet R, Agut H, Chieze F, et al. Virological markers in the cerebrospinal fluid from HIV-1-infected individuals. AIDS 1991; 5: 1419-24
137. Spector SA, Hsia K, Pratt D, et al. Virologic markers of human immunodeficiency virus type 1 in cerebrospinal fluid. The HIV Neurobehavioral Research Center Group. J Infect Dis 1993; 168: 68-74
138. Brew BJ, Bhalla RB, Paul M, et al. Cerebrospinal fluid beta 2-microglobulin in patients with AIDS dementia complex: an expanded series including response to zidovudine treatment. AIDS 1992; 6: 461-5
139. Brew BJ, Dunbar N, Pemberton L, et al. Predictive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta 2-microglobulin and neopterin. J Infect Dis 1996; 174: 294-8
140. Erichsen D, Lopez AL, Peng H, et al. Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia. J Neuroimmunol 2003; 138: 144-55
141. Bayer M, Schmitz S, Westermann J, et al. Evaluation of a new enzyme-linked immunosorbent assay for the determination of neopterin. Clin Lab 2005; 51: 495-504
142. Heyes MP, Ellis RJ, Ryan L, et al. Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection. Brain 2001; 124: 1033-42
143. Gonzalez E, Rovin BH, Sen L, et al. HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci U S A 2002; 99: 13795-800
144. Letendre S, Marquie-Beck J, Singh K, et al., The HNRC Group. The monocyte chemotactic protein-1 -2578 G allele is associated with elevated MCP-1 concentrations in cerebrospinal. 11th Conference on Retroviruses and Opportunistic Infections; 2004 Feb 8-11; San Francisco (CA).
145. Meeker RB, Boles JC, Bragg DC, et al. Development of neuronal sensitivity to toxins in cerebrospinal fluid from HIV-type 1-infected individuals. AIDS Res Hum Retroviruses 2004; 20: 1072-86
146. Heyes MP, Brew BJ, Martin A, et al. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 1991; 29: 202-9
147. Valle M, Price RW, Nilsson A, et al. CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modeling of dynamics following antiretroviral therapy. Brain 2004; 127 (Pt 5): 1047-60
148. Liu P, Hudson LC, Tompkins MB, et al. Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intra-cerebroventricular or systemic inoculation. J Neurovirol 2006; 12: 307-21
149. Abdulle S, Mellgren A, Brew BJ, et al. CSF neurofilament protein (NFL): a marker of active HIV-related neurodegeneration. J Neurol 2007; 254 (8): 1026-32
150. Larsson M, Hagberg L, Forsman A, et al. Cerebrospinal fluid catecholamine metabolites in HIV-infected patients. J Neurosci Res 1991; 28: 406-9
151. Conant K, Garzion-Demo A, Nath A, et al. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci U S A 1998; 95: 3117-21
152. Mankowski JL, Queen SE, Clements JE, et al. Cerebrospinal fluid markers that predict SIV CNS disease. J Neuroimmunol 2004; 157: 66-70
153. Gupta SM, Ray K, Bala M. Evaluation of beta2 microglobulin level as a marker to determine HIV/AIDS progression. J Commun Dis 2004; 36: 166-70
154. Abdulle S, Hagberg L, Svennerholm B, et al. Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection. AIDS 2002; 16: 2145-9
155. Murr C, Widner B, Wirleitner B, et al. Neopterin as a marker for immune system activation. Curr Drug Metab 2002; 3: 175-87
156. Carru C, Zinellu A, Sotgia S, et al. A new HPLC method for serum neopterin measurement and relationships with plasma thiol levels in healthy subjects. Biomed Chromatogr 2004; 18: 360-6
157. Ryan LA, Peng H, Reichsen DA, et al. TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia. J Neuroimmunol 2004; 148: 127-39
158. Gendelman HE, Zheng J, Coulter CL, et al. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. J Infect Dis 1998; 178 (4): 1000-7
159. Laverda AM, Gallo P, De Rossi A, et al. Cerebrospinal fluid analysis in HIV-1-infected children: immunological and virological findings before and after AZT therapy. Acta Paediatr 1994; 83: 1038-42
160. Towfighi A, Skolasky RL, St Hillaire C, et al. CSF soluble Fas correlates with the severity of HIV-associated dementia. Neurology 2004; 62: 654-6
161. De Milito A, Hejdeman B, Albert J, et al. High plasma levels of soluble fas in HIV type 1-infected subjects are not normalized during highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2000; 16: 1379-84
162. Sabri F, De Milito A, Pirskanen R, et al. Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex. J Neuroimmunol 2001; 114: 197-206
163. Bednarska A, Podlasin R, Karczewski G, et al. Utility of multiplex PCR for diagnosis of neurological disorders in HIV-infected patients and patients with AIDS [in Polish]. Przegl Epidemiol 2005; 59: 873-9
164. Harrington PR, Haas DW, Ritola K, et al. Compartmentalized human immunodeficiency virus type 1 present in cerebrospinal fluid is produced by short-lived cells. J Virol 2005; 79: 7959-66
165. Ellis RJ, Gamst AC, Capparelli E, et al. Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources. Neurology 2000; 54: 927-36
166. Neuenburg JK, Sinclair E, Nilsson A, et al. HIV-producing T cells in cerebrospinal fluid. J Acquir Immune Defic Syndr 2004; 37: 1237-44
167. Martin C, Albert J, Hansson P, et al. Cerebrospinal fluid mononuclear cell counts influence CSF HIV-1 RNA levels. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 17: 214-9
168. Wiley CA, Soontornniyomkij V, Radhakrishnan L, et al. Distribution of brain HIV load in AIDS. Brain Pathol 1998; 8: 277-84
169. Abramo F, Abramo F, Bo S, et al. Regional distribution of lesions in the central nervous system of cats infected with feline immunodeficiency virus. AIDS Res Hum Retroviruses 1995; 11: 1247-53
170. Aschner M. Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction - a forum position paper. Neurotoxicology 1998; 19: 7-17
171. Baily GG, Mandal BK. Recurrent transient neurological deficits in advanced HIV infection. AIDS 1995; 9: 709-12
172. Ball JK, Holmes EC, Whitwell H, et al. Genomic variation of human immunodeficiency virus type 1 (HIV-1): molecular analyses of HIV-1 in sequential blood samples and various organs obtained at autopsy. J Gen Virol 1994; 75: 67-79
173. Banks WA, Ibrahimi F, Farr SA, et al. Effects of wheat germ agglutinin and aging on the regional brain uptake of HIV-1GP120. Life Sci 1999; 65: 81-9
174. Barks JD, Liu XH, Sun R, et al. gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats. Neuroscience 1997; 76: 397-409
175. Barks JD, Sun R, Malinak C, et al. gp120, an HIV-1 protein, increases susceptibility to hypoglycemic and ischemic brain injury in perinatal rats. Exp Neurol 1995; 132: 123-33
176. Beldarrain MG, Garcia-Monco JC, Llorens V, et al. Neuropsychological differences but comparable regional cerebral blood changes in asymptomatic HIV-1-positive and -negative drug addicts. Eur Neurol 1994; 34: 193-8
177. Bell JE, Anthony IC, Simmonds P. Impact of HIV on regional and cellular organization of the brain. Curr HIV Res 2006; 4: 249-57
178. Bell JE, Donaldson YK, Lowrie S, et al. Influence of risk group and zidovudine therapy on the development of HIV encephalitis and cognitive impairment in AIDS patients. AIDS 1996; 10: 493-9
179. Buckstein R, Lim W, Franssen E, et al. CNS prophylaxis and treatment in non-Hodgkin's lymphoma: variation practice and lessons from the literature. Leuk Lymphoma 2003; 44: 955-62
180. Burdo TH, Gartner S, Mauger D, et al. Region-specific distribution of human immunodeficiency virus type 1 long terminal repeats containing specific configurations of CCAAT/enhancer-binding protein site II in brains derived from demented and nondemented patients. J Neurovirol 2004; 10 (1 Suppl.): S7-S14
181. Bussiere JL, Hardy LM, Peterson M, et al. Lack of developmental neurotoxicity of MN rgp 120/HIV-1 administered subcutaneously to neonatal rats. Toxicol Sci 1999; 48: 90-9
182. Cardenas VA, Studholme C, Meyerhoff DJ, et al. Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes. Psychiatry Res 2005; 138: 115-30
183. Chang J, Jozwiak R, Wang B, et al. Unique HIV type 1 V3 region sequences derived from six different regions of brain: region-specific evolution within host-determined quasispecies. AIDS Res Hum Retroviruses 1998; 14: 25-30
184. Chang L, Ernst T, Leonido-Yee M, et al. Perfusion MRI detects rCBF abnormalities in early stages of HIV-cognitive motor complex. Neurology 2000; 54: 389-96
185. Chen MF, Westmoreland S, Ryzhova EV, et al. Simian immunodeficiency virus envelope compartmentalizes in brain regions independent of neuropathology. J Neurovirol 2006; 12: 73-89
186. Cheval P, Kinzonzi P, Allaert-Cheval C. Principal clinical manifestations during the course of disease caused by the human immunodeficiency virus (HIV) in Pointe-Noire (Republic of Congo). (307 cases hospitalized during 2 years at the medical service of the Regional Hospital of the Army) [in French]. Med Trop (Mars) 1993; 53: 225-39
187. Christensson B, Ljungberg B, Ryding E, et al. SPECT with 99mTc-HMPAO in subjects with HIV infection: cognitive dysfunction correlates with high uptake. Scand J Infect Dis 1999; 31: 349-54
188. Cole JW, Pinto AN, Hebel JR, et al. Acquired immunodeficiency syndrome and the risk of stroke. Stroke 2004; 35: 51-6
189. Costa DC, Ell PJ, Burns A, et al. CBF tomograms with [99]mTc-HM-PAO in patients with dementia (Alzheimer type and HIV) and Parkinson's disease: initial results. J Cereb Blood Flow Metab 1988; 8: 109S-15S
190. Crespo Valades E, Vera Tome A, Diaz Pinto P, et al. An intracranial mass in a patient with HIV infection [in Spanish]. Rev Clin Esp 2000; 200: 33-4
191. Cunningham AL, Naif H, Saksena N, et al. HIV infection of macrophages and pathogenesis of AIDS dementia complex: interaction of the host cell and viral genotype. J Leukoc Biol 1997; 62: 117-25
192. Egan VG, Chiswick A, Brettle RP, et al. The Edinburgh cohort of HIV-positive drug users: the relationship between auditory P3 latency, cognitive function and self-rated mood. Psychol Med 1993; 23: 613-22
193. Ernst T, Itti E, Itti L, et al. Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: a coregistered (1)H MRS and SPECT study. J Magn Reson Imaging 2000; 12: 859-65
194. Ernst TM, Chang L, Witt MD, et al. Cerebral toxoplasmosis and lymphoma in AIDS: perfusion MR imaging experience in 13 patients. Radiology 1998; 208: 663-9
195. Fujimura RK, Khamis I, Shapshak P, et al. Regional quantitative comparison of multispliced to unspliced ratios of HIV-1 RNA copy number in infected human brain. J NeuroAIDS 2004; 2: 45-60
196. Gelman BB, Guinto Jr FC. Morphometry, histopathology, and tomography of cerebral atrophy in the acquired immunodeficiency syndrome. Ann Neurol 1992; 32: 31-40
197. Ghorpade A, Persidsky Y, Swindells S, et al. Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects. J Neuroimmunol 2005; 163: 145-56
198. Groopman JE. Neoplasms in the acquired immune deficiency syndrome: the multidisciplinary approach to treatment. Semin Oncol 1987; 14 Suppl. 2: 1S-6S
199. Gullotta F, Masini T, Scarlato G, et al. Progressive multifocal leukoencephalopathy and gliomas in a HIV-negative patient. Pathol Res Pract 1992; 188: 964-72
200. Harris GJ, Pearlson GD, McArthur JC, et al. Altered cortical blood flow in HIV-seropositive individuals with and without dementia: a single photon emission computed tomography study. AIDS 1994; 8: 495-9
201. Hellman RS, Tikofsky RS, Van Heertum R, et al. A multi-institutional study of interobserver agreement in the evaluation of dementia with rCBF/SPET technetium-99m exametazime (HMPAO). Eur J Nucl Med 1994; 21: 306-13
202. Hestad K, McArthur JH, Dal Pan GJ, et al. Regional brain atrophy in HIV-1 infection: association with specific neuropsychological test performance. Acta Neurol Scand 1993; 88: 112-8
203. Holman BL, Johnson KA, Gerada B, et al. The scintigraphic appearance of Alzheimer's disease: a prospective study using technetium-99m-HMPAO SPECT. J Nucl Med 1992; 33: 181-5
204. Hughes PJ, McLean KA, Lane RJ. Cranial polyneuropathy and brainstem disorder at the time of seroconversion in HIV infection. Int J STD AIDS 1992; 3: 60-1
205. Jernigan TL, Garnst AC, Archibald SL, et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. Am J Psychiatry 2005; 162: 1461-72
206. Katayama S, Momose T, Sano I, et al. The mechanism of controlling regional cerebral blood flow in patients with localization-related epilepsy [in Japanese]. Seishin Shinkeigaku Zasshi 1996; 98: 89-114
207. Keohane C, Gray F. Central nervous system pathology in children with AIDS: a review. Ir J Med Sci 1991; 160: 277-81
208. Keohane C, Robain O, Ponsot G, et al. Cerebral lymphoma and HIV encephalitis in a case of pediatric AIDS, with pre-existing multicystic encephalomalacia. Ir J Med Sci 1991; 160: 179-82
209. Kieburtz K, Ketonen L, Cox C, et al. Cognitive performance and regional brain volume in human immunodeficiency virus type 1 infection. Arch Neurol 1996; 53: 155-8
210. Kolson DL, Sabnekar P, Baybis M, et al. Gene expression in TUNEL-positive neurons in human immunodeficiency virus-infected brain. J Neurovirol 2004; 10 (1 Suppl.): 102S-7S
211. Kustova Y, Espey MG, Sei Y, et al. Regional decreases [corrected] in AMPA receptor density in mice infected with the LP-BM5 murine leukemia virus. Neuroreport 1997; 8: 1243-7
212. Lackner AA, Dandekar S, Gardner MB. Neurobiology of simian and feline immunodeficiency virus infections. Brain Pathol 1991; 1: 201-12
213. Laing RB, Flegg PJ, Brettle RP, et al. Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients. Int J STD AIDS 1996; 7: 258-64
214. Lane JH, Sasseville VG, Smith MO, et al. Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation. J Neurovirol 1996; 2: 423-32
215. Lane JH, Tarantal AF, Pauley D, et al. Localization of simian immunodeficiency virus nucleic acid and antigen in brains of fetal macaques inoculated in utero. Am J Pathol 1996; 149: 1097-104
216. Antinori A, Perno CF, Giancola ML, et al. Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma. Clin Infect Dis 2005; 41: 1787-93
217. Clements JE, Li M, Gama L. The central nervous system is a viral reservoir in simian immunodeficiency virus-infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy. J Neurovirol 2005; 11: 180-9
218. Spudich S, Lollo N, Liegler T, et al. Treatment benefit on cerebrospinal fluid HIV-1 Levels in the setting of systemic virological suppression and failure. J Infect Dis 2006; 194: 1686-96
219. De Ronchi D, Faranca I, Berardi D, et al. Risk factors for cognitive impairment in HIV-1-infected persons with different risk behaviors. Arch Neurol 2002; 59: 812-8
220. Brew BJ. Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS 2004; 18 (1 Suppl.): 75S-8S
221. Maschke M, Kastrup O, Esser S, et al. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 2000; 69: 376-80
222. Valcour V, Yee P, Williams AE, et al. Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection: the Hawaii Aging with HIV Cohort. J Neurovirol 2006; 12: 387-91
223. Tozzi V, Balestra P, Lorenzini P, et al. Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: results from an urban observational cohort. J Neurovirol 2005; 11: 265-73
224. McArthur JC, Haughey N, Gartner S, et al. Human immunodeficiency virus-associated dementia: an evolving disease. J Neurovirol 2003; 9: 205-21
225. Cysique LA, Brew BJ, Halman M, et al. Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients. J Acquir Immune Defic Syndr 2005; 39: 426-9
226. Anthony IC, Ramage SN, Carnie FW, et al. Influence of HAART on HIV-related CNS disease and neuroinflammation. J Neuropathol Exp Neurol 2005; 64: 529-36
227. Roberts ES, Zandonatti MA, Watry DD, et al. Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol 2003; 162: 2041-57
228. Chiappelli F, Alwan J, Prolo P, et al. Neuro-immunity in stress-related oral ulcerations: a fractal analysis. Frontiers Biosci 2005; 10: 3034-41
229. Chiappelli F. Immunophysiological role and clinical implications of non-immunoglobulin soluble products of immune effector cells. Adv Neuoimmunol 1991; 1: 234-40
230. Heaton RK, Grant I, Butters N, et al. The HNRC 500: neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center. J Int Neuropsychol Soc 1995; 1: 231-51
231. Marcondes MC, Burudi EM, Huitron-Resendiz S, et al. Highly activated CD8(+) T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection. J Immunol 2001; 167: 5429-38
232. Roberts ES, Masliah E, Fox HS. CD163 identifies a unique population of ramified microglia in HIV encephalitis (HIVE). J Neuropathol Exp Neurol 2004; 63: 1255-64
233. Antinori A, Arendt G, Becker JT, et al. Biomarkers of HIV-associated neurocognitive disorders. HIV Infection and the Central Nervous System: Developed and Resource limited Settings; 2005 Jun 11-13; Rome
234. Shapshak P, Duncan R, Turchan J, et al. Bioinformatics models in drug abuse and NeuroAIDS: using and developing databases. Bioinformation 2006; 1 (3): 86-8
235. Shapshak P, Duncan R, Nath A, et al. Gene chromosomal organization and expression in cultured human neurons exposed to cocaine and HIV-1 proteins gp120 and tat: drug abuse and NeuroAIDS. Frontiers Biosci 2006; 11: 1774-93
236. Shapshak, P, Duncan, R, Torres-Munoz JE, et al. Analytic approaches to differential gene expression in AIDS vs. control brains. Frontiers Biosci 2004; 9: 2935-46
237. Shapshak P, Minagar A, Duran EM, et al. Gene expression in HIV associated dementia. In: Minagar A, Alexander JS, editors. Inflammatory disorders of the nervous system: clinical aspects, pathogenesis, and management. Totowa (NJ): Humana Press, 2005: 305-18
238. Minagar A, Shapshak P, Alexander JS. Pathogenesis of HIV associated dementia and multiple sclerosis: role of microglia and astrocytes. In: Aschner M, Costa LG, editors. The role of Glia in neurotoxicity. 2nd ed. Boca Raton (FL): CRC Press, 2005: 263-78
239. Minagar A, Shapshak P. HIV associated dementia: clinical features and pathogenesis. In: Minagar A, Shapshak P, editors. NEURO-AIDS. Hauppauge (NY): Nova Science Publications, 2005