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Owen A, Janneh O, Hartkoorn RC, et al. In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. J Pharmacol Exp Ther 2005; 314:1202-1209. This study shows how novel strategies can be developed to enhance the delivery of antiretroviral compounds to the brain.
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Severe HIV-1 encephalitis and development of cerebral non-Hodgkin lymphoma in a patient with persistent strong HIV-1 replication in the brain despite potent HAART - Case report and review of the literature
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Baeuerle M, Schmitt-Haendle M, Taubald A, et al. Severe HIV-1 encephalitis and development of cerebral non-Hodgkin lymphoma in a patient with persistent strong HIV-1 replication in the brain despite potent HAART - case report and review of the literature. Eur J Med Res 2005; 10:309-316.
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Capparelli EV, Holland D, Okamoto C, et al. Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV. Aids 2005; 19:949-952. This paper provides a rationale for the use of Lopinavir in patients at risk for HIV dementia.
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