Constitutive nuclear factor-κB activity is required for central neuron survival

Journal of Neuroscience

Volumn 22, Issue 19, 2002, Pages 8466-8475

  Bhakar, Asha L ^a   Tannis, Laura Lee ^a   Zeindler, Christine ^a   Russo, Maria Pia ^b   Jobin, Christian ^b   Park, David S ^c   MacPherson, Sandra ^a   Barker, Philip A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Adenovirus; Apoptosis; NF B; NIK; RelA; TRAF; Transgenic mouse

Indexed keywords

APOPTOSIS INHIBITOR; I KAPPA B ALPHA; I KAPPA B ALPHA M; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REPRESSOR PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADENOVIRUS; AMYGDALOID NUCLEUS; ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; GENE OVEREXPRESSION; HIPPOCAMPUS; MESENCHYME CELL; MOUSE; NEOCORTEX; NERVE CELL; NEUROPROTECTION; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0036813662     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-19-08466.2002     Document Type: Article

References (60)

1. Bakalkin G, Yakovleva T, Terenius L (1993) NF-kappa B-like factors in the murine brain. Developmentally-regulated and tissue-specific expression. Brain Res Mol Brain Res 20:137-146.
2. Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J, Mattson MP (1995) Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci USA 92:9328-9332.
3. Barkett M, Gilmore TD (1999) Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 18:6910-6924.
4. Beg AA, Baltimore D (1996) An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274:782-784.
5. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167-170.
6. Blondeau N, Widmann C, Lazdunski M, Heurteaux C (2001) Activation of the nuclear factor-kappaB is a key event in brain tolerance. J Neurosci 21:4668-4677.
7. Buzy JM, Lindstrom LM, Zink MC, Clements JE (1995) HIV-1 in the developing CNS: Developmental differences in gene expression. Virology 210:361-371.
8. Carrasco D, Weih F, Bravo R (1994) Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development 120:2991-3004.
9. Corboy JR, Buzy JM, Zink MC, Clements JE (1992) Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 258:1804-1808.
10. Delhase M, Hayakawa M, Chen Y, Karin M (1999) Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284:309-313.
11. Digicaylioglu M, Lipton SA (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412:641-647.
12. Foehr ED, Lin X, O'Mahony A, Geleziunas R, Bradshaw RA, Greene WC (2000) NF-κ B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J Neurosci 20:7556-7563.
13. Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U (1997) Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11:3482-3496.
14. Gilmore TD (1999) The Rel/NF-kappaB signal transduction pathway. Oncogene 18:6842-6844.
15. Goodman Y, Mattson MP (1996) Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity. J Neurochem 66:869-872.
16. Grilli M, Memo M (1999) Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell Death Differ 6:22-27.
17. Grilli M, Pizzi M, Memo M, Spano P (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274:1383-1385.
18. Guerrini L, Blasi F, Denis-Donini S (1995) Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro. Proc Natl Acad Sci USA 92:9077-9081.
19. Guo Q, Robinson N, Mattson MP (1998) Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-I by activation of NF-kappaB and stabilization of calcium homeostasis. J Biol Chem 273:12341-12351.
20. Hamanoue M, Middleton G, Wyatt S, Jaffray E, Hay RT, Davies AM (1999) p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci 14:28-40.
21. Hatada EN, Krappmann D, Scheidereit C (2000) NF-kappaB and the innate immune response. Curr Opin Immunol 12:52-58.
22. He TC, Zhou S, Da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514.
23. Hitt MM, Addison CL, Graham FL (1997) Human adenovirus vectors for gene transfer into mammalian cells. Adv Pharmacol 40:137-206.
24. Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R (1997) Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3:1285-1289.
25. Kaltschmidt B, Baeuerle PA, Kaltschmidt C (1993) Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med 14:171-190.
26. Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C (1999) Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis. Proc Natl Acad Sci USA 96:9409-9414.
27. Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA (1994) Constitutive NF-kappa B activity in neurons. Mol Cell Biol 14:3981-3992.
28. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 18:621-663.
29. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A (1991) Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19:4293.
30. Lernbecher T, Muller U, Wirth T (1993) Distinct NF-kappa B/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature 365:767-770.
31. Lezoualc'h F, Sagara Y, Holsboer F, Behl C (1998) High constitutive NF-κB activity mediates resistance to oxidative stress in neuronal cells. J Neurosci 18:3224-3232.
32. Z. W.Li Q, Lu Q, Hwang, JY, Buscher D, Lee KF, Izpisua-Belmonte JC, Verma IM (1999) IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 13:1322-1328.
33. Li Q, Estepa G, Memet S, Israel A, Verma IM (2000) Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation. Genes Dev 14:1729-1733.
34. Li ZW, Chu W, Hu Y, Delhase HU, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189:1839-1845.
35. Ling L, Cao Z, Goeddel DV (1998) NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci USA 95:3792-3797.
36. Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS (1998) Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. J Neurosci 18:10356-10365.
37. Malinin NL, Boldin MP, Kovalenko AV, Wallach D (1997) MAP3Krelated kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 385:540-544.
38. Mattson MP, Camandola S (2001) NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107:247-254.
39. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K (1997) Activation of NF-kappaB protects hippocampal neurons against oxidative stressinduced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681-697.
40. Meberg PJ, Kinney WR, Valcourt EG, Routtenberg A (1996) Gene expression of the transcription factor NF-kappa B in hippocampus: Regulation by synaptic activity. Brain Res Mol Brain Res 38:179-190.
41. Mercer EH, Hoyle GW, Kapur RP, Brinster RL, Palmiter RD (1991) The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron 7:703-716.
42. Middleton G, Hamanoue M, Enokido Y, Wyatt S, Pennica D, Jaffray E, Hay RT, Davies AM (2000) Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol 148:325-332.
43. Natoli G, Costanzo A, Moretti F, Fulco M, Balsano C, Levrero M (1997) Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem 272:26079-26082.
44. Perkins ND (2000) The Rel/NF-kappa B family: Friend and foe. Trends Biochem Sci 25:434-440.
45. Post A, Holsboer F, Behl C (1998) Induction of NF-κB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: Suppression of NF-κB and neuroprotection by antioxidants. J Neurosci 18:8236-8246.
46. Rattner A, Korner M, Walker MD, Citri Y (1993) NF-kappa B activates the HIV promoter in neurons. EMBO J 12:4261-4267.
47. Ravati A, Ahlemeyer B, Becker A, Klumpp S, Krieglstein J (2001) Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB. J Neurochem 78:909-919.
48. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (1997) Identification and characterization of an IkappaB kinase. Cell 90:373-383.
49. Russo MP, Bennett BL, Manning AM, Brenner DA, Jobin C (2002) Differential requirement for NF-kB-inducing kinase (NIK) in the induction of NF-kB by IL-1β, TNFa and Fas. Am J Physiol 283:C347-C357.
50. Sarmiere PD, Freeman RS (2001) Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons. Mol Cell Neurosci 18:320-331.
51. Schmidt-Ullrich R, Memet S, Lilienbaum A, Feuillard J, Raphael M, Israel A (1996) NF-kappaB activity in transgenic mice: Developmental regulation and tissue specificity. Development 122:2117-2128.
52. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M (1999) NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 5:554-559.
53. Simpson CS, Morris BJ (1999) Activation of nuclear factor kappaB by nitric oxide in rat striatal neurones: Differential inhibition of the p50 and p65 subunits by dexamethasone. J Neurochem 73:353-361.
54. Van Antwerp DJ, Martin SJ, Verma IM, Green DR (1998) Inhibition of TNF-induced apoptosis by NF-kappa B. Trends Cell Biol 8:107-111.
55. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin Jr AS (1998) NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683.
56. Weih F, Carrasco D, Bravo R (1994) Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen. Oncogene 9:3289-3297.
57. Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck RP, Lira SA, Bravo R (1995) Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 80:331-340.
58. Wellmann H, Kaltschmidt B, Kaltschmidt C (2001) Retrograde transport of transcription factor NF-kappa B in living neurons. J Biol Chem 276:11821-11829.
59. Yin L, Wu L, Wesche H, Arthur CD, White JM, Goeddel DV, Schreiber RD (2001) Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 291:2162-2165.
60. Yu ZD, Bruce-Keller AJ, Kindy MS, Mattson MP (1999) Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury. J Neurosci 19:8856-8865.