Extracellular HIV-1 Nef increases migration of monocytes

Experimental Cell Research

Volumn 312, Issue 18, 2006, Pages 3659-3668

  Lehmann, Michael H ^a,b   Walter, Stefan ^b   Ylisastigui, Loyda ^c   Striebel, Frank ^b   Ovod, Vladimir ^d   Geyer, Matthias ^e   Claude Gluckman, Jean ^c   Erfle, Volker ^a,b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c CNRS   (France)

^d FIT Biotech Oyj Plc   (Finland)

^e MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

AIDS immunopathogenesis; Calcein; Chemotaxis; Human immunodeficiency virus; Monocytes; Nef; THP 1 cells

Indexed keywords

CHEMOKINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MACROPHAGE INHIBITORY PROTEIN 1ALPHA; MACROPHAGE INHIBITORY PROTEIN 1BETA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; NEF PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; HEATING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33749133413     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.08.008     Document Type: Article

References (47)

1. Frankel A.D., and Young J.A. HIV-1: fifteen proteins and an RNA. Annu. Rev. Biochem. 67 (1998) 1-25
2. Dyer W.B., Geczy A.F., Kent S.J., McIntyre L.B., Blasdall S.A., Learmont J.C., and Sullivan J.S. Lymphoproliferative immune function in the Sydney Blood Bank Cohort, infected with natural nef/long terminal repeat mutants, and in other long-term survivors of transfusion-acquired HIV-1 infection. AIDS 11 (1997) 1565-1574
3. Hofmann-Lehmann R., Vlasak J., Williams A.L., Chenine A.L., McClure H.M., Anderson D.C., O'Neil S., and Ruprecht R.M. Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. AIDS 17 (2003) 157-166
4. Kestler III H.W., Ringler D.J., Mori K., Panicali D.L., Sehgal P.K., Daniel M.D., and Desrosiers R.C. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65 (1991) 651-662
5. Simard M.C., Chrobak P., Kay D.G., Hanna Z., Jothy S., and Jolicoeur P. Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease. J. Virol. 76 (2002) 3981-3995
6. Hanna Z., Kay D.G., Rebai N., Guimond A., Jothy S., and Jolicoeur P. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95 (1998) 163-175
7. Williams K.C., and Hickey W.F. Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu. Rev. Neurosci. 25 (2002) 537-562
8. Weeks B.S. The role of HIV-1 activated leukocyte adhesion mechanisms and matrix metalloproteinase secretion in AIDS pathogenesis (Review). Int. J. Mol. Med. 1 (1998) 361-366
9. Macreadie I.G., Castelli L.A., Lucantoni A., and Azad A.A. Stress- and sequence-dependent release into the culture medium of HIV-1 Nef produced in Saccharomyces cerevisiae. Gene 162 (1995) 239-243
10. Guy B., Riviere Y., Dott K., Regnault A., and Kieny M.P. Mutational analysis of the HIV nef protein. Virology 176 (1990) 413-425
11. Qiao X., He B., Chiu A., Knowles D.M., Chadburn A., and Cerutti A. Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat. Immunol. 7 (2006) 302-310
12. Fujii Y., Otake K., Tashiro M., and Adachi A. Soluble Nef antigen of HIV-1 is cytotoxic for human CD4+ T cells. FEBS Lett. 393 (1996) 93-96
13. Sabatier J.M., Clerget-Raslain B., Fontan G., Fenouillet E., Rochat H., Granier C., Gluckman J.C., Van Rietschoten J., Montagnier L., and Bahraoui E. Use of synthetic peptides for the detection of antibodies against the nef regulating protein in sera of HIV-infected patients. AIDS 3 (1989) 215-220
14. Koedel U., Kohleisen B., Sporer B., Lahrtz F., Ovod V., Fontana A., Erfle V., and Pfister H.W. HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system. J. Immunol. 163 (1999) 1237-1245
15. James C.O., Huang M.B., Khan M., Garcia-Barrio M., Powell M.D., and Bond V.C. Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors. J. Virol. 78 (2004) 3099-3109
16. Shutt D.C., and Soll D.R. HIV-induced T-cell syncytia release a two component T-helper cell chemoattractant composed of Nef and Tat. J. Cell. Sci. 112 Pt. 22 (1999) 3931-3941
17. Kieny M.P., Lathe R., Riviere Y., Dott K., Schmitt D., Girard M., Montagnier L., and Lecocq J. Improved antigenicity of the HIV env protein by cleavage site removal. Protein Eng. 2 (1988) 219-225
18. Guy B., Kieny M.P., Riviere Y., Le Peuch C., Dott K., Girard M., Montagnier L., and Lecocq J.P. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330 (1987) 266-269
19. Kohleisen B., Gaedigk-Nitschko K., Ohlmann M., Gotz E., Ostolaza H., Goni F.M., and Erfle V. Heparin-binding capacity of the HIV-1 NEF-protein allows one-step purification and biochemical characterization. J. Virol. Methods 60 (1996) 89-101
20. Gill S.C., and von Hippel P.H. Calculation of protein extinction coefficients from amino acid sequence data. Anal. Biochem. 182 (1989) 319-326
21. Breuer S., Gerlach H., Kolaric B., Urbanke C., Opitz N., and Geyer M. Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef. Biochemistry 45 (2006) 2339-2349
22. Bohm G., Muhr R., and Jaenicke R. Quantitative analysis of protein far UV circular dichroism spectra by neural networks. Protein Eng. 5 (1992) 191-195
23. Ylisastigui L., Vizzavona J., Drakopoulou E., Paindavoine P., Calvo C.F., Parmentier M., Gluckman J.C., Vita C., and Benjouad A. Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages. AIDS 12 (1998) 977-984
24. Lehmann M.H., Schreiber S., Vogelsang H., and Sigusch H.H. Constitutive expression of MCP-1 and RANTES in the human histiocytic lymphoma cell line U-937. Immunol. Lett. 76 (2001) 111-113
25. Auwerx J. The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia 47 (1991) 22-31
26. Kito K., and Nishida K. Nonrequirement of continuous stimulation with MCP-1 for cell migration and determination of directional migration by initial stimulation with chemokine. Exp. Cell Res. 281 (2002) 157-166
27. Olivetta E., Percario Z., Fiorucci G., Mattia G., Schiavoni I., Dennis C., Jager J., Harris M., Romeo G., Affabris E., and Federico M. HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-kappa B activation. J. Immunol. 170 (2003) 1716-1727
28. Liu Q.N., Reddy S., Sayre J.W., Pop V., Graves M.C., and Fiala M. Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis. AIDS Res. Hum. Retrovir. 17 (2001) 1423-1433
29. Bodi I., Abraham A.A., and Kimmel P.L. Macrophages in human immunodeficiency virus-associated kidney diseases. Am. J. Kidney Dis. 24 (1994) 762-767
30. Seidman R., Peress N.S., and Nuovo G.J. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids in skeletal muscle in patients with myopathy. Mod. Path. 7 (1994) 369-375
31. Evans M.R., and Wansbrough-Jones M.H. Alveolar macrophage activation in HIV infection. J. Infect. 33 (1996) 91-94
32. Gartner S. HIV infection and dementia. Science 287 (2000) 602-604
33. Samaniego F., Markham P.D., Gendelman R., Gallo R.C., and Ensoli B. Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice. J. Immunol. 158 (1997) 1887-1894
34. Chi D., Henry J., Kelley J., Thorpe R., Smith J.K., and Krishnaswamy G. The effects of HIV infection on endothelial function. Endothelium 7 (2000) 223-242
35. Kienzle N., Freund J., Kalbitzer H.R., and Mueller-Lantzsch N. Oligomerization of the Nef protein from human immunodeficiency virus (HIV) type 1. Eur. J. Biochem. 214 (1993) 451-457
36. Dennis C.A., Baron A., Grossmann J.G., Mazaleyrat S., Harris M., and Jaeger J. Co-translational myristoylation alters the quaternary structure of HIV-1 Nef in solution. Proteins 60 (2005) 658-669
37. Morita E., and Sundquist W.I. Retrovirus budding. Annu. Rev. Cell Dev. Biol. 20 (2004) 395-425
38. Swingler S., Mann A., Jacque J., Brichacek B., Sasseville V.G., Williams K., Lackner A.A., Janoff E.N., Wang R., Fisher D., and Stevenson M. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat. Med. 5 (1999) 103-997
39. Alessandrini L., Santarcangelo A.C., Olivetta E., Ferrantelli F., d'Aloja P., Pugliese K., Pelosi E., Chelucci C., Mattia G., Peschle C., Verani P., and Federico M. T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS. J. Gen. Virol. 81 (2000) 2905-2917
40. Quaranta M.G., Mattioli B., Spadaro F., Straface E., Giordani L., Ramoni C., Malorni W., and Viora M. HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells. FASEB J. 17 (2003) 2025-2036
41. Renkema G.H., Manninen A., and Saksela K. Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX. J. Virol. 75 (2001) 2154-2160
42. Wolf D., Witte V., Laffert B., Blume K., Stromer E., Trapp S., d'Aloja P., Schurmann A., and Baur A.S. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat. Med. 7 (2001) 1217-1224
43. Chung C.Y., Funamoto S., and Firtel R.A. Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26 (2001) 557-566
44. Albini A., Ferrini S., Benelli R., Sforzini S., Giunciuglio D., Aluigi M.G., Proudfoot A.E., Alouani S., Wells T.N., Mariani G., Rabin R.L., Farber J.M., and Noonan D.M. HIV-1 Tat protein mimicry of chemokines. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13153-13158
45. Tobiume M., Fujinaga K., Suzuki S., Komoto S., Mukai T., and Ikuta K. Extracellular Nef protein activates signal transduction pathway from Ras to mitogen-activated protein kinase cascades that leads to activation of human immunodeficiency virus from latency. AIDS Res. Hum. Retrovir. 18 (2002) 461-467
46. Konopka K., and Duzgunes N. Expression of CD4 controls the susceptibility of THP-1 cells to infection by R5 and X4 HIV type 1 isolates. AIDS Res. Hum. Retrovir. 18 (2002) 123-131
47. Bleul C.C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., and Springer T.A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382 (1996) 829-833