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Volumn 65, Issue 10, 2005, Pages 4117-4125

BRCA2 regulates homologous recombination in response to DNA damage: Implications for genome stability and carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; ESTROGEN; RAD51 PROTEIN;

EID: 20144367619     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3071     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 0142178215 scopus 로고    scopus 로고
    • Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    • King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003;302:643-6.
    • (2003) Science , vol.302 , pp. 643-646
    • King, M.C.1    Marks, J.H.2    Mandell, J.B.3
  • 2
    • 0037268338 scopus 로고    scopus 로고
    • The Fanconi anaemia/BRCA pathway
    • D'Andrea AD, Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 2003;3:23-34.
    • (2003) Nat Rev Cancer , vol.3 , pp. 23-34
    • D'Andrea, A.D.1    Grompe, M.2
  • 3
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully R, Livingston DM. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 2000;408:429-32.
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.M.2
  • 4
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002;108:171-82.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 5
    • 0037115914 scopus 로고    scopus 로고
    • Homologous repair of DNA damage and tumorigenesis: The BRCA connection
    • Jasin M. Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 2002;21:8981-93.
    • (2002) Oncogene , vol.21 , pp. 8981-8993
    • Jasin, M.1
  • 6
    • 0031060263 scopus 로고    scopus 로고
    • Chromosome instability syndromes: Lessons for carcinogenesis
    • Meyn MS. Chromosome instability syndromes: lessons for carcinogenesis. Curr Top Microbiol Immunol 1997;221:71-148.
    • (1997) Curr Top Microbiol Immunol , vol.221 , pp. 71-148
    • Meyn, M.S.1
  • 7
    • 0032574750 scopus 로고    scopus 로고
    • Homology-directed repair is a major double-strand break repair pathway in mammalian cells
    • Liang F, Han M, Romanienko PJ, Jasin M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc Natl Acad Sci U S A 1998;95:5172-7.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5172-5177
    • Liang, F.1    Han, M.2    Romanienko, P.J.3    Jasin, M.4
  • 8
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001;27:247-54.
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 9
    • 0034600975 scopus 로고    scopus 로고
    • Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
    • Johnson RD, Jasin M. Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. Embo J 2000;19:3398-407.
    • (2000) Embo J , vol.19 , pp. 3398-3407
    • Johnson, R.D.1    Jasin, M.2
  • 10
    • 0038700698 scopus 로고    scopus 로고
    • Molecular views of recombination proteins and their control
    • West SC. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 2003;4:435-45.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 435-445
    • West, S.C.1
  • 11
    • 0028286906 scopus 로고
    • One-sided invasion events in homologous recombination at double-strand breaks
    • Belmaaza A, Chartrand P. One-sided invasion events in homologous recombination at double-strand breaks. Mutat Res 1994;314:199-208.
    • (1994) Mutat Res , vol.314 , pp. 199-208
    • Belmaaza, A.1    Chartrand, P.2
  • 12
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques F, Haber JE. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 1999;63:349-404.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 13
    • 2442477786 scopus 로고    scopus 로고
    • p53's double life: Transactivation-independent repression of homologous recombination
    • Bertrand P, Saintigny Y, Lopez BS. p53's double life: transactivation-independent repression of homologous recombination. Trends Genet 2004;20:235-43.
    • (2004) Trends Genet , vol.20 , pp. 235-243
    • Bertrand, P.1    Saintigny, Y.2    Lopez, B.S.3
  • 14
    • 0036778597 scopus 로고    scopus 로고
    • The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors
    • Kolomietz E, Meyn MS, Pandita A, Squire JA. The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors. Genes Chromosomes Cancer 2002;35:97-112.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 97-112
    • Kolomietz, E.1    Meyn, M.S.2    Pandita, A.3    Squire, J.A.4
  • 15
    • 1942502234 scopus 로고    scopus 로고
    • Tracing the network connecting brca and fanconi anaemia proteins
    • Venkitaraman AR. Tracing the network connecting brca and fanconi anaemia proteins. Nat Rev Cancer 2004;4:266-76.
    • (2004) Nat Rev Cancer , vol.4 , pp. 266-276
    • Venkitaraman, A.R.1
  • 16
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan ME, Pierce AJ, Jasin M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 2001;7:263-72.
    • (2001) Mol Cell , vol.7 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 17
    • 0035801472 scopus 로고    scopus 로고
    • Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
    • Tutt A, Bertwistle D, Valentine J, et al. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. Embo J 2001;20:4704-16.
    • (2001) Embo J , vol.20 , pp. 4704-4716
    • Tutt, A.1    Bertwistle, D.2    Valentine, J.3
  • 18
    • 0034660620 scopus 로고    scopus 로고
    • Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms
    • Lambert S, Lopez BS. Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms. Embo J 2000;19: 3090-9.
    • (2000) Embo J , vol.19 , pp. 3090-3099
    • Lambert, S.1    Lopez, B.S.2
  • 19
    • 0347987856 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase suppresses crossing over during homologous recombination
    • Wu L, Hickson ID. The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 2003;426:870-4.
    • (2003) Nature , vol.426 , pp. 870-874
    • Wu, L.1    Hickson, I.D.2
  • 20
    • 0036671755 scopus 로고    scopus 로고
    • XRCC3 controls the fidelity of homologous recombination: Roles for XRCC3 in late stages of recombination
    • Brenneman MA, Wagener BM, Miller CA, Allen C, Nickoloff JA. XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination. Mol Cell 2002;10:387-95.
    • (2002) Mol Cell , vol.10 , pp. 387-395
    • Brenneman, M.A.1    Wagener, B.M.2    Miller, C.A.3    Allen, C.4    Nickoloff, J.A.5
  • 21
    • 0346340054 scopus 로고    scopus 로고
    • RAD51C is required for Holliday junction processing in mammalian cells
    • Liu Y, Masson JY, Shah R, O'Regan P, West SC. RAD51C is required for Holliday junction processing in mammalian cells. Science 2004;303:243-6.
    • (2004) Science , vol.303 , pp. 243-246
    • Liu, Y.1    Masson, J.Y.2    Shah, R.3    O'Regan, P.4    West, S.C.5
  • 22
    • 0035951405 scopus 로고    scopus 로고
    • A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression
    • Marmorstein LY, Kinev AV, Chan GK, et al. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Cell 2001;104:247-57.
    • (2001) Cell , vol.104 , pp. 247-257
    • Marmorstein, L.Y.1    Kinev, A.V.2    Chan, G.K.3
  • 23
    • 0034638924 scopus 로고    scopus 로고
    • DNA polymerase stalling, sister chromatid recombination and the BRCA genes
    • Scully R, Puget N, Vlasakova K. DNA polymerase stalling, sister chromatid recombination and the BRCA genes. Oncogene 2000;19:6176-83.
    • (2000) Oncogene , vol.19 , pp. 6176-6183
    • Scully, R.1    Puget, N.2    Vlasakova, K.3
  • 24
    • 0032159062 scopus 로고    scopus 로고
    • Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
    • Chen J, Silver DP, Walpita D, et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 1998;2:317-28.
    • (1998) Mol Cell , vol.2 , pp. 317-328
    • Chen, J.1    Silver, D.P.2    Walpita, D.3
  • 25
    • 0037731322 scopus 로고    scopus 로고
    • MSH2-defident human cells exhibit a defect in the accurate termination of homology-directed repair of DNA double-strand breaks
    • Villemure JF, Abaji C, Cousineau I, Belmaaza A. MSH2-defident human cells exhibit a defect in the accurate termination of homology-directed repair of DNA double-strand breaks. Cancer Res 2003;63: 3334-9.
    • (2003) Cancer Res , vol.63 , pp. 3334-3339
    • Villemure, J.F.1    Abaji, C.2    Cousineau, I.3    Belmaaza, A.4
  • 26
    • 0015544411 scopus 로고
    • A table for the estimation of the spontaneous mutation rate of cells in culture
    • Capizzi RL, Jameson JW. A table for the estimation of the spontaneous mutation rate of cells in culture. Mutat Res 1973;17:147-8.
    • (1973) Mutat Res , vol.17 , pp. 147-148
    • Capizzi, R.L.1    Jameson, J.W.2
  • 27
    • 0035902551 scopus 로고    scopus 로고
    • Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
    • Xia F, Taghian DG, DeFrank JS, et al. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc Natl Acad Sci U S A 2001;98:8644-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8644-8649
    • Xia, F.1    Taghian, D.G.2    DeFrank, J.S.3
  • 28
    • 0029240276 scopus 로고
    • Genetic control of intrachromosomal recombination
    • Klein HL. Genetic control of intrachromosomal recombination. Bioessays 1995;17:147-59.
    • (1995) Bioessays , vol.17 , pp. 147-159
    • Klein, H.L.1
  • 30
    • 0037468267 scopus 로고    scopus 로고
    • BRCA2-dependent and independent formation of RAD51 nuclear foci
    • Tarsounas M, Davies D, West SC. BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 2003;22:1115-23.
    • (2003) Oncogene , vol.22 , pp. 1115-1123
    • Tarsounas, M.1    Davies, D.2    West, S.C.3
  • 31
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 32
    • 0347991859 scopus 로고    scopus 로고
    • Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
    • Lomonosov M, Anand S, Sangrithi M, Davies R, Venkitaraman AR. Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev 2003;17:3017-22.
    • (2003) Genes Dev , vol.17 , pp. 3017-3022
    • Lomonosov, M.1    Anand, S.2    Sangrithi, M.3    Davies, R.4    Venkitaraman, A.R.5
  • 33
    • 0032512750 scopus 로고    scopus 로고
    • Regulation of RadSl function by C-Abl in response to DNA damage
    • Yuan ZM, Huang Y, Ishiko T, et al. Regulation of RadSl function by C-Abl in response to DNA damage. J Biol Chem 1998;273:3799-802.
    • (1998) J Biol Chem , vol.273 , pp. 3799-3802
    • Yuan, Z.M.1    Huang, Y.2    Ishiko, T.3
  • 34
    • 2542496073 scopus 로고    scopus 로고
    • Location of tyrosine 315, a target for phosphorylation by cAbl tyrosine kinase, at the edge of the subunit-subunit interface of the human Rad51 filament
    • Conilleau S, Takizawa Y, Tachiwana H, Fleury F, Kurumizaka H, Takahashi M. Location of tyrosine 315, a target for phosphorylation by cAbl tyrosine kinase, at the edge of the subunit-subunit interface of the human Rad51 filament. J Mol Biol 2004;339: 797-804.
    • (2004) J Mol Biol , vol.339 , pp. 797-804
    • Conilleau, S.1    Takizawa, Y.2    Tachiwana, H.3    Fleury, F.4    Kurumizaka, H.5    Takahashi, M.6
  • 35
    • 0034760095 scopus 로고    scopus 로고
    • BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
    • Slupianek A, Schmutte C, Tombline G, et al. BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance. Mol Cell 2001;8:795-806.
    • (2001) Mol Cell , vol.8 , pp. 795-806
    • Slupianek, A.1    Schmutte, C.2    Tombline, G.3
  • 36
    • 0036258350 scopus 로고    scopus 로고
    • Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation
    • Foray N, Marot D, Randrianarison V, et al. Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Mol Cell Biol 2002;22:4020-32.
    • (2002) Mol Cell Biol , vol.22 , pp. 4020-4032
    • Foray, N.1    Marot, D.2    Randrianarison, V.3
  • 37
    • 0034638921 scopus 로고    scopus 로고
    • Lessons learned from BRCA1 and BRCA2
    • Zheng L, Li S, Boyer TG, Lee WH. Lessons learned from BRCA1 and BRCA2. Oncogene 2000;19:6159-75.
    • (2000) Oncogene , vol.19 , pp. 6159-6175
    • Zheng, L.1    Li, S.2    Boyer, T.G.3    Lee, W.H.4
  • 38
    • 0037428069 scopus 로고    scopus 로고
    • Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing
    • Adams MD, McVey M, Sekelsky JJ. Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science 2003;299:265-7.
    • (2003) Science , vol.299 , pp. 265-267
    • Adams, M.D.1    McVey, M.2    Sekelsky, J.J.3
  • 39
    • 0028131619 scopus 로고
    • Interference of DNA sequence divergence with precise recombtnational DNA repair in mammalian cells
    • Belmaaza A, Milot E, Villemure JF, Chartrand P. Interference of DNA sequence divergence with precise recombtnational DNA repair in mammalian cells. Embo J 1994;13:5355-60.
    • (1994) Embo J , vol.13 , pp. 5355-5360
    • Belmaaza, A.1    Milot, E.2    Villemure, J.F.3    Chartrand, P.4
  • 40
    • 0020518746 scopus 로고
    • Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
    • Cavenee WK, Dryja TP, Phillips RA, et al. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 1983;305:779-84.
    • (1983) Nature , vol.305 , pp. 779-784
    • Cavenee, W.K.1    Dryja, T.P.2    Phillips, R.A.3
  • 41
    • 0032534975 scopus 로고    scopus 로고
    • Homologous recombination between p53 and its pseudogene in a radiation-induced mouse tumor
    • Tanooka H, Ootsuyama A, Sasaki H. Homologous recombination between p53 and its pseudogene in a radiation-induced mouse tumor. Cancer Res 1998;58: 5649-51.
    • (1998) Cancer Res , vol.58 , pp. 5649-5651
    • Tanooka, H.1    Ootsuyama, A.2    Sasaki, H.3
  • 42
    • 0032403070 scopus 로고    scopus 로고
    • Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement
    • Slebos RJ, Resnick MA, Taylor JA. Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement. Cancer Res 1998;58:5333-6.
    • (1998) Cancer Res , vol.58 , pp. 5333-5336
    • Slebos, R.J.1    Resnick, M.A.2    Taylor, J.A.3
  • 43
    • 0034706911 scopus 로고    scopus 로고
    • Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells
    • Bogliolo M, Taylor RM, Caldecott BCW, Frosina G. Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells. Oncogene 2000; 19:5781-7.
    • (2000) Oncogene , vol.19 , pp. 5781-5787
    • Bogliolo, M.1    Taylor, R.M.2    Caldecott, B.C.W.3    Frosina, G.4
  • 44
    • 0041378046 scopus 로고    scopus 로고
    • XRCC1 and DNA strand break repair
    • Caldecott KW. XRCC1 and DNA strand break repair. DNA Repair (Amst) 2003;2:955-69.
    • (2003) DNA Repair (Amst) , vol.2 , pp. 955-969
    • Caldecott, K.W.1
  • 45
    • 1942453356 scopus 로고    scopus 로고
    • How homologous recombination is initia ted: Unexpected evidence for single-strand nicks from v(d)j site-specific recombination
    • Smith GR. How homologous recombination is initia ted: unexpected evidence for single-strand nicks from v(d)j site-specific recombination. Cell 2004;117:146-8.
    • (2004) Cell , vol.117 , pp. 146-148
    • Smith, G.R.1
  • 46
    • 18544372595 scopus 로고    scopus 로고
    • BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
    • Yang H, Jeffrey PD, Miller J, et al. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 2002;297:1837-48.
    • (2002) Science , vol.297 , pp. 1837-1848
    • Yang, H.1    Jeffrey, P.D.2    Miller, J.3
  • 48
    • 0034463957 scopus 로고    scopus 로고
    • Is estradiol a genotoxic mutagenic carcinogen?
    • Liehr J. G. Is estradiol a genotoxic mutagenic carcinogen? Endocr Rev 2000;21:40-54.
    • (2000) Endocr Rev , vol.21 , pp. 40-54
    • Liehr, J.G.1
  • 49
    • 0037050741 scopus 로고    scopus 로고
    • Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2
    • Buchholz TA, Wu X, Hussain A, et al. Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. Int J Cancer 2002;97:557-61.
    • (2002) Int J Cancer , vol.97 , pp. 557-561
    • Buchholz, T.A.1    Wu, X.2    Hussain, A.3
  • 50
    • 0034142268 scopus 로고    scopus 로고
    • Insights into the functions of BRCA1 and BRCA2
    • Welcsh PL, Owens KN, King MC. Insights into the functions of BRCA1 and BRCA2. Trends Genet 2000; 16:69-74.
    • (2000) Trends Genet , vol.16 , pp. 69-74
    • Welcsh, P.L.1    Owens, K.N.2    King, M.C.3


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