In the quest for stable rescuing mutants of p53: Computational mutagenesis of flexible loop L1

Biochemistry

Volumn 44, Issue 5, 2005, Pages 1423-1432

  Pan, Yongping ^a   Ma, Buyong ^a   Venkataraghavan, R Babu ^b   Levine, Arnold J ^b   Nussinov, Ruth ^a,c,d  

^a SAIC FREDERICK INC   (United States)

^b INSTITUTE FOR ADVANCED STUDY   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d NCI Frederick Building 469 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRODUCT DESIGN;

DESIGN STABLE FUNCTIONAL; MUTATIONS;

MUTAGENESIS;

MUTANT PROTEIN; MUTANT PROTEIN P53; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING MOTIF; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; STRUCTURE ANALYSIS; THERMOSTABILITY;

AMINO ACID SUBSTITUTION; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CYSTEINE; HUMANS; HYDROGEN BONDING; METHIONINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PROLINE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SERINE; THERMODYNAMICS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 13444267551     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047845y     Document Type: Article

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