Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1α interactions

Oncogene

Volumn 25, Issue 3, 2006, Pages 370-377

  Knauth, K ^a   Bex, C ^a   Jemth, P ^b,c   Buchberger, A ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

HIF 1 ; RCC; VHL

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MUTANT PROTEIN; UBIQUITIN PROTEIN LIGASE; VON HIPPEL LINDAU PROTEIN;

ARTICLE; BINDING AFFINITY; CANCER RISK; CHEMICAL ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; IN VITRO STUDY; KIDNEY CARCINOMA; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEFECT; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TEMPERATURE; THERMOSTABILITY; VON HIPPEL LINDAU DISEASE;

AMINO ACID SEQUENCE; CARCINOMA, RENAL CELL; HIPPEL-LINDAU DISEASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOPRECIPITATION; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; RISK FACTORS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 30944451969     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209062     Document Type: Article

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