-
2
-
-
0032905924
-
c-Myc target genes involved in cell growth, apoptosis, and metabolism
-
Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999;19:1-11.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1-11
-
-
Dang, C.V.1
-
3
-
-
23144464363
-
Transcriptional regulation and transformation by Myc proteins
-
Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 2005;6:635-45.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 635-645
-
-
Adhikary, S.1
Eilers, M.2
-
5
-
-
33646843753
-
Activation by c-Myc of transcription by RNA polymerases I, II and III
-
Gomez-Roman N, Felton-Edkins ZA, Kenneth NS, et al. Activation by c-Myc of transcription by RNA polymerases I, II and III. Biochem Soc Symp 2006;73:141-54.
-
(2006)
Biochem Soc Symp
, vol.73
, pp. 141-154
-
-
Gomez-Roman, N.1
Felton-Edkins, Z.A.2
Kenneth, N.S.3
-
6
-
-
33745558509
-
Myc influences global chromatin structure
-
Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Myc influences global chromatin structure. EMBO J 2006;25:2723-34.
-
(2006)
EMBO J
, vol.25
, pp. 2723-2734
-
-
Knoepfler, P.S.1
Zhang, X.Y.2
Cheng, P.F.3
Gafken, P.R.4
McMahon, S.B.5
Eisenman, R.N.6
-
7
-
-
0037663490
-
Werner syndrome protein limits MYC-induced cellular senescence
-
Grandori C, Wu KJ, Fernandez P, et al. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 2003;17:1569-74.
-
(2003)
Genes Dev
, vol.17
, pp. 1569-1574
-
-
Grandori, C.1
Wu, K.J.2
Fernandez, P.3
-
8
-
-
0033521960
-
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation
-
Greenberg RA, O'Hagan RC, Deng H, et al. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 1999;18:1219-26.
-
(1999)
Oncogene
, vol.18
, pp. 1219-1226
-
-
Greenberg, R.A.1
O'Hagan, R.C.2
Deng, H.3
-
9
-
-
0042169025
-
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
-
Horikawa I, Barrett JC. Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis 2003;24:1167-76.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1167-1176
-
-
Horikawa, I.1
Barrett, J.C.2
-
10
-
-
2642610318
-
Myc activates telomerase
-
Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Myc activates telomerase. Genes Dev 1998;12:1769-74.
-
(1998)
Genes Dev
, vol.12
, pp. 1769-1774
-
-
Wang, J.1
Xie, L.Y.2
Allan, S.3
Beach, D.4
Hannon, G.J.5
-
11
-
-
0032911694
-
Direct activation of TERT transcription by c-MYC
-
Wu KJ, Grandori C, Amacker M, et al. Direct activation of TERT transcription by c-MYC. Nat Genet 1999;21:220-4.
-
(1999)
Nat Genet
, vol.21
, pp. 220-224
-
-
Wu, K.J.1
Grandori, C.2
Amacker, M.3
-
12
-
-
0020520516
-
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
-
Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983;304:596-602.
-
(1983)
Nature
, vol.304
, pp. 596-602
-
-
Land, H.1
Parada, L.F.2
Weinberg, R.A.3
-
13
-
-
0032145569
-
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
-
Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998;12:2424-33.
-
(1998)
Genes Dev
, vol.12
, pp. 2424-2433
-
-
Zindy, F.1
Eischen, C.M.2
Randle, D.H.3
-
15
-
-
22144489899
-
INK4a/ARF: A multifunctional tumor suppressor locus
-
Sharpless NE. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res 2005;576:22-38.
-
(2005)
Mutat Res
, vol.576
, pp. 22-38
-
-
Sharpless, N.E.1
-
16
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo T, Zindy F, Roussel MF, et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 1997;91:649-59.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
-
17
-
-
0032169516
-
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
-
Stott FJ, Bates S, James MC, et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998;17:5001-14.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
-
18
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-34.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
19
-
-
0032549704
-
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
-
Pomerantz J, Schreiber-Agus N, Liegeois NJ, et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998;92:713-23.
-
(1998)
Cell
, vol.92
, pp. 713-723
-
-
Pomerantz, J.1
Schreiber-Agus, N.2
Liegeois, N.J.3
-
20
-
-
0035487104
-
The INK4a/ARF network in tumour suppression
-
Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2001;2:731-7.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 731-737
-
-
Sherr, C.J.1
-
21
-
-
0026066232
-
Characteristics of an infinite life span diploid human fibroblast cell strain and a near-diploid strain arising from a clone of cells expressing a transfected v-myc oncogene
-
Morgan TL, Yang DJ, Fry DG, et al. Characteristics of an infinite life span diploid human fibroblast cell strain and a near-diploid strain arising from a clone of cells expressing a transfected v-myc oncogene. Exp Cell Res 1991;197:125-36.
-
(1991)
Exp Cell Res
, vol.197
, pp. 125-136
-
-
Morgan, T.L.1
Yang, D.J.2
Fry, D.G.3
-
22
-
-
0025066416
-
Introduction of the activated N-ras oncogene into human fibroblasts by retroviral vector induces morphological transformation and tumorigenicity
-
Kinsella AR, Fiszer-Maliszewska L, Mitchell EL, Guo YP, Fox M, Scott D. Introduction of the activated N-ras oncogene into human fibroblasts by retroviral vector induces morphological transformation and tumorigenicity. Carcinogenesis 1990;11:1803-9.
-
(1990)
Carcinogenesis
, vol.11
, pp. 1803-1809
-
-
Kinsella, A.R.1
Fiszer-Maliszewska, L.2
Mitchell, E.L.3
Guo, Y.P.4
Fox, M.5
Scott, D.6
-
23
-
-
0019973132
-
Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens
-
Newbold RF, Overell RW, Connell JR. Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens. Nature 1982;299:633-5.
-
(1982)
Nature
, vol.299
, pp. 633-635
-
-
Newbold, R.F.1
Overell, R.W.2
Connell, J.R.3
-
24
-
-
16844371813
-
Immortalization of primary human prostate epithelial cells by c-Myc
-
Gil J, Kerai P, Lleonart M, et al. Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res 2005;65:2179-85.
-
(2005)
Cancer Res
, vol.65
, pp. 2179-2185
-
-
Gil, J.1
Kerai, P.2
Lleonart, M.3
-
25
-
-
0034641720
-
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
-
Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci U S A 2000;97:10544-8.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10544-10548
-
-
Felsher, D.W.1
Zetterberg, A.2
Zhu, J.3
Tlsty, T.4
Bishop, J.M.5
-
26
-
-
0142258072
-
Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes
-
Drayton S, Rowe J, Jones R, et al. Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes. Cancer Cell 2003;4:301-10.
-
(2003)
Cancer Cell
, vol.4
, pp. 301-310
-
-
Drayton, S.1
Rowe, J.2
Jones, R.3
-
27
-
-
11244357067
-
The normal response to RAS: Senescence or transformation?
-
Benanti JA, Galloway DA. The normal response to RAS: senescence or transformation? Cell Cycle 2004;3:715-7.
-
(2004)
Cell Cycle
, vol.3
, pp. 715-717
-
-
Benanti, J.A.1
Galloway, D.A.2
-
28
-
-
1642355129
-
Normal human fibroblasts are resistant to RAS-induced senescence
-
Benanti JA, Galloway DA. Normal human fibroblasts are resistant to RAS-induced senescence. Mol Cell Biol 2004;24:2842-52.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2842-2852
-
-
Benanti, J.A.1
Galloway, D.A.2
-
29
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-52.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
30
-
-
0034744957
-
Repression of p15INK4b expression by Myc through association with Miz-1
-
Staller P, Peukert K, Kiermaier A, et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 2001;3:392-9.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 392-399
-
-
Staller, P.1
Peukert, K.2
Kiermaier, A.3
-
31
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995;83:993-1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
32
-
-
0033616602
-
Transient excess of MYC activity can elicit genomic instability and tumorigenesis
-
Felsher DW, Bishop JM. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A 1999;96:3940-4.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3940-3944
-
-
Felsher, D.W.1
Bishop, J.M.2
-
33
-
-
0036285034
-
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
-
Vafa O, Wade M, Kern S, et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 2002;9:1031-44.
-
(2002)
Mol Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
Wade, M.2
Kern, S.3
-
34
-
-
0033842950
-
Genetic and epigenetic changes in human epithelial cells immortalized by telomerase
-
Farwell DG, Shera KA, Koop JI, et al. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol 2000;156:1537-47.
-
(2000)
Am J Pathol
, vol.156
, pp. 1537-1547
-
-
Farwell, D.G.1
Shera, K.A.2
Koop, J.I.3
-
35
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998;396:84- 8.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
36
-
-
0033979731
-
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
-
Dickson MA, Hahn WC, Ino Y, et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000;20:1436-47.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1436-1447
-
-
Dickson, M.A.1
Hahn, W.C.2
Ino, Y.3
-
37
-
-
0030822196
-
Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
-
Alevizopoulos K, Vlach J, Hennecke S, Amati B. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J 1997;16:5322-33.
-
(1997)
EMBO J
, vol.16
, pp. 5322-5333
-
-
Alevizopoulos, K.1
Vlach, J.2
Hennecke, S.3
Amati, B.4
-
38
-
-
0031771497
-
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
-
Robertson KD, Jones PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 1998;18:6457-73.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6457-6473
-
-
Robertson, K.D.1
Jones, P.A.2
-
39
-
-
33745714364
-
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer
-
Kim YH, Petko Z, Dzieciatkowski S, et al. CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer 2006;45:781-9.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 781-789
-
-
Kim, Y.H.1
Petko, Z.2
Dzieciatkowski, S.3
-
40
-
-
0033985151
-
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
-
Esteller M, Tortola S, Toyota M, et al. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 2000;60:129-33.
-
(2000)
Cancer Res
, vol.60
, pp. 129-133
-
-
Esteller, M.1
Tortola, S.2
Toyota, M.3
-
41
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006;443:214-7.
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
42
-
-
18644371442
-
Negative regulation of the mammalian UV response by Myc through association with Miz-1
-
Herold S, Wanzel M, Beuger V, et al. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 2002;10:509-21.
-
(2002)
Mol Cell
, vol.10
, pp. 509-521
-
-
Herold, S.1
Wanzel, M.2
Beuger, V.3
-
43
-
-
0037126303
-
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
-
Seoane J, Le HV, Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 2002;419:729-34.
-
(2002)
Nature
, vol.419
, pp. 729-734
-
-
Seoane, J.1
Le, H.V.2
Massague, J.3
-
44
-
-
6044254972
-
p19ARF directly and differentially controls the functions of c-Myc independently of p53
-
Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR. p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature 2004;431:712-7.
-
(2004)
Nature
, vol.431
, pp. 712-717
-
-
Qi, Y.1
Gregory, M.A.2
Li, Z.3
Brousal, J.P.4
West, K.5
Hann, S.R.6
-
45
-
-
4344668161
-
Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc
-
Datta A, Nag A, Pan W, et al. Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. J Biol Chem 2004;279:36698-707.
-
(2004)
J Biol Chem
, vol.279
, pp. 36698-36707
-
-
Datta, A.1
Nag, A.2
Pan, W.3
-
46
-
-
33846214693
-
Regulation of the Arf tumor suppressor in Eμ-Myc transgenic mice: Longitudinal study of Myc-induced lymphomagenesis
-
Bertwistle D, Sherr CJ. Regulation of the Arf tumor suppressor in Eμ-Myc transgenic mice: longitudinal study of Myc-induced lymphomagenesis. Blood 2007;109:792-4.
-
(2007)
Blood
, vol.109
, pp. 792-794
-
-
Bertwistle, D.1
Sherr, C.J.2
-
47
-
-
0033569422
-
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
-
Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999;13:2658-69.
-
(1999)
Genes Dev
, vol.13
, pp. 2658-2669
-
-
Eischen, C.M.1
Weber, J.D.2
Roussel, M.F.3
Sherr, C.J.4
Cleveland, J.L.5
-
48
-
-
13444270415
-
Myc represses transcription through recruitment of DNA methyltransferase corepressor
-
Brenner C, Deplus R, Didelot C, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J 2005;24:336-46.
-
(2005)
EMBO J
, vol.24
, pp. 336-346
-
-
Brenner, C.1
Deplus, R.2
Didelot, C.3
-
49
-
-
0031214241
-
Production of high-titer human immunodeficiency virus type 1 pseudotyped with vesicular stomatitis virus glycoprotein
-
Bartz SR, Vodicka MA. Production of high-titer human immunodeficiency virus type 1 pseudotyped with vesicular stomatitis virus glycoprotein. Methods 1997;12:337-42.
-
(1997)
Methods
, vol.12
, pp. 337-342
-
-
Bartz, S.R.1
Vodicka, M.A.2
-
50
-
-
0036837660
-
Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1
-
Benanti JA, Williams DK, Robinson KL, Ozer HL, Galloway DA. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Mol Cell Biol 2002;22:7385-97.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7385-7397
-
-
Benanti, J.A.1
Williams, D.K.2
Robinson, K.L.3
Ozer, H.L.4
Galloway, D.A.5
-
51
-
-
0033989829
-
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
-
Dimri GP, Itahana K, Acosta M, Campisi J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 2000;20:273-85.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 273-285
-
-
Dimri, G.P.1
Itahana, K.2
Acosta, M.3
Campisi, J.4
-
52
-
-
0029843950
-
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
-
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
|