메뉴 건너뛰기




Volumn 20, Issue 1, 1999, Pages 77-84

Aberrant methylation of p16(INK4a) and deletion of p15(INK4b) a frequent events in human esophageal cancer in Linxian, China

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; MICROSATELLITE DNA; PROTEIN P15; CARRIER PROTEIN; CDKN2B PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DNA; PROTEIN P16INK4A; TUMOR SUPPRESSOR PROTEIN;

EID: 0032587192     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.1.77     Document Type: Article
Times cited : (89)

References (33)
  • 1
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 2
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan, D.O. (1995) Principles of CDK regulation. Nature, 374, 131-133.
    • (1995) Nature , vol.374 , pp. 131-133
    • Morgan, D.O.1
  • 3
    • 0027301324 scopus 로고
    • Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation
    • Xiong, Y., Zhang, H. and Beach, D. (1993) Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev., 7, 1572-1583.
    • (1993) Genes Dev. , vol.7 , pp. 1572-1583
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 4
    • 0030614715 scopus 로고    scopus 로고
    • The subcellular locations of p15(ink4b) and p27(kip1) coordinate their inhibitory interactions with cdk4 and cdk2
    • Reynisdottir, I. and Massague, J. (1997) The subcellular locations of p15(ink4b) and p27(kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev., 11, 492-503.
    • (1997) Genes Dev. , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 9
    • 0029857939 scopus 로고    scopus 로고
    • Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplaslic progression in Barrett's esophagus
    • Barrett, M.T., Sanchez, C.A., Galipeau, P.C., Neshat, K., Emond, M. and Reid, B.J. (1996) Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplaslic progression in Barrett's esophagus. Oncogene, 13, 1867-1873.
    • (1996) Oncogene , vol.13 , pp. 1867-1873
    • Barrett, M.T.1    Sanchez, C.A.2    Galipeau, P.C.3    Neshat, K.4    Emond, M.5    Reid, B.J.6
  • 10
    • 0028897307 scopus 로고
    • Homozygous deletion of the multiple tumor suppressor gene in the progression of human astrocytomas
    • Walker, D.G., Duan, W., Povovic, E.A., Kaye, A.H., Tomlinson, F.H. and Lavin, M. (1995) Homozygous deletion of the multiple tumor suppressor gene in the progression of human astrocytomas. Cancer Res., 55, 20-23.
    • (1995) Cancer Res. , vol.55 , pp. 20-23
    • Walker, D.G.1    Duan, W.2    Povovic, E.A.3    Kaye, A.H.4    Tomlinson, F.H.5    Lavin, M.6
  • 11
    • 0028987265 scopus 로고
    • Mutations in the p16INK4A/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer
    • Okamoto, A., Hussain, S.P., Hagiwara, K. et al. (1995) Mutations in the p16INK4A/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res., 55, 1448-1451.
    • (1995) Cancer Res. , vol.55 , pp. 1448-1451
    • Okamoto, A.1    Hussain, S.P.2    Hagiwara, K.3
  • 12
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle, D.E., Zindy, F., Ashmun, R.A. and Sherr, C.J. (1995) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell, 83, 993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 13
    • 0029658666 scopus 로고    scopus 로고
    • Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma
    • Flores, J.F., Walker, G.J., Glendening, J.M. et al. (1996) Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. Cancer Res., 56, 5023-5032.
    • (1996) Cancer Res. , vol.56 , pp. 5023-5032
    • Flores, J.F.1    Walker, G.J.2    Glendening, J.M.3
  • 14
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman, J.G., Merlo, A., Mao, L., Lapidus, R.G., Issa, J.P., Davidson, N.E., Sidransky, D. and Baylin, S.B. (1995) Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530.
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 15
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/ CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J.G., Mao, L., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B. and Sidransky, D. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/ CDKN2/MTS1 in human cancers. Nat. Med., 1, 686-692.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 16
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta, M., Bender, C.M., Yang, A.S., Nguyen, T., Beart, R.W., Van Tornout, J.M. and Jones, P.A. (1995) Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55, 4531-4535.
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 17
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
    • Herman, J.G., Jen, J., Merlo, A. and Baylin, S.B. (1996) Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res., 56, 722-727.
    • (1996) Cancer Res. , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3    Baylin, S.B.4
  • 18
    • 0031025368 scopus 로고    scopus 로고
    • Distinct pattern of inactivation of p15INK4B and p16INK4A characterize the major types of hemotological malignancies
    • Herman, J.G., Civin, C.I., Issa, J.J., Collector, M.I., Sharkis, S.J. and Baylin, S.B. (1997) Distinct pattern of inactivation of p15INK4B and p16INK4A characterize the major types of hemotological malignancies. Cancer Res., 57, 837-841.
    • (1997) Cancer Res. , vol.57 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.J.3    Collector, M.I.4    Sharkis, S.J.5    Baylin, S.B.6
  • 19
    • 0030897676 scopus 로고
    • p16 tumor suppressor gene mutations in Chinese esophageal carcinomas in Hong Kong
    • Chan, W.C., Tang, C.M.C., Lau, K.W. and Lung, M.L. (1995) p16 tumor suppressor gene mutations in Chinese esophageal carcinomas in Hong Kong. Cancer Lett., 115, 201-206.
    • (1995) Cancer Lett. , vol.115 , pp. 201-206
    • Chan, W.C.1    Tang, C.M.C.2    Lau, K.W.3    Lung, M.L.4
  • 20
    • 0031035027 scopus 로고    scopus 로고
    • Multiple types of aberrations in the p16(INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines
    • Tanaka, H., Shimada, Y., Imamura, M., Shibagaki, I. and Ishizaki, K. (1997) Multiple types of aberrations in the p16(INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines. Int. J. Cancer, 70, 437-442.
    • (1997) Int. J. Cancer , vol.70 , pp. 437-442
    • Tanaka, H.1    Shimada, Y.2    Imamura, M.3    Shibagaki, I.4    Ishizaki, K.5
  • 21
    • 9444268107 scopus 로고    scopus 로고
    • Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma
    • Maesawa, C., Tamura, G., Nishizuka, S., Ogasawara, S., Ishida, K., Terashima, M., Sakata, K., Sato, N., Saito, K. and Satodate, R. (1996) Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma. Cancer Res., 56, 3875-3878.
    • (1996) Cancer Res. , vol.56 , pp. 3875-3878
    • Maesawa, C.1    Tamura, G.2    Nishizuka, S.3    Ogasawara, S.4    Ishida, K.5    Terashima, M.6    Sakata, K.7    Sato, N.8    Saito, K.9    Satodate, R.10
  • 22
    • 0030610256 scopus 로고    scopus 로고
    • Immunohistochemical studies of Waf1p21, p16, pRb, and p53 in human esophageal carcinoma and neighboring epithelia from a high-risk area in northern China
    • Yang, G.-Y., Zhang, Z., Jie, L., Seril, D., Wang, L.-D., Goldstein, S. and Yang, C.S. (1997) Immunohistochemical studies of Waf1p21, p16, pRb, and p53 in human esophageal carcinoma and neighboring epithelia from a high-risk area in northern China. Int. J. Cancer, 72, 1-6.
    • (1997) Int. J. Cancer , vol.72 , pp. 1-6
    • Yang, G.-Y.1    Zhang, Z.2    Jie, L.3    Seril, D.4    Wang, L.-D.5    Goldstein, S.6    Yang, C.S.7
  • 24
    • 1842331467 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 9 and p 16 (MTS1, CDKN2) gene mutations in esophageal cancers
    • Muzeau, F., Flejou, J.F., Thomas, G. and Hamelin, R. (1997) Loss of heterozygosity on chromosome 9 and p 16 (MTS1, CDKN2) gene mutations in esophageal cancers. Int. J. Cancer, 72, 27-30.
    • (1997) Int. J. Cancer , vol.72 , pp. 27-30
    • Muzeau, F.1    Flejou, J.F.2    Thomas, G.3    Hamelin, R.4
  • 25
    • 0028168391 scopus 로고
    • p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China
    • Gao, H., Wang, L.-D., Zhou, Q., Hong, J.-Y., Huang, T.-Y. and Yang, C.S. (1994) p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China. Cancer Res., 54, 4342-4346.
    • (1994) Cancer Res. , vol.54 , pp. 4342-4346
    • Gao, H.1    Wang, L.-D.2    Zhou, Q.3    Hong, J.-Y.4    Huang, T.-Y.5    Yang, C.S.6
  • 26
    • 0030909701 scopus 로고    scopus 로고
    • DNA methylation changes in hematologic malignancies - Biologic and clinical implications
    • Issa, J., Baylin, S.B. and Herman, J.G. (1997) DNA methylation changes in hematologic malignancies - biologic and clinical implications. Leukemia, 11, Suppl. S7-S11.
    • (1997) Leukemia , vol.11 , Issue.SUPPL.
    • Issa, J.1    Baylin, S.B.2    Herman, J.G.3
  • 27
    • 0030612290 scopus 로고    scopus 로고
    • p16ink4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas
    • Wong, D.J., Barrett, M.T., Stoger, R., Emond, M.J. and Reid, B.J. (1997) p16ink4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Cancer Res., 57, 2619-2622.
    • (1997) Cancer Res. , vol.57 , pp. 2619-2622
    • Wong, D.J.1    Barrett, M.T.2    Stoger, R.3    Emond, M.J.4    Reid, B.J.5
  • 28
    • 0028970766 scopus 로고
    • Homozygous loss of the p15INK4B gene (and not the p16INK4 gene) during tumor progression in a sporadic melanoma patient
    • Glendening, J.M., Flores, J.F., Walker, G.J., Stone, S., Albino, A.P. and Fountain, J.W. (1995) Homozygous loss of the p15INK4B gene (and not the p16INK4 gene) during tumor progression in a sporadic melanoma patient. Cancer Res., 55, 5531-5535.
    • (1995) Cancer Res. , vol.55 , pp. 5531-5535
    • Glendening, J.M.1    Flores, J.F.2    Walker, G.J.3    Stone, S.4    Albino, A.P.5    Fountain, J.W.6
  • 29
    • 0030837110 scopus 로고    scopus 로고
    • Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma
    • Gonzalez, M.V., Pello, M.F., Lopez-Larrea, C., Suarez, C., Menendez, M.J. and Coto, E. (1997) Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma. J. Clin. Pathol., 50, 509-512.
    • (1997) J. Clin. Pathol. , vol.50 , pp. 509-512
    • Gonzalez, M.V.1    Pello, M.F.2    Lopez-Larrea, C.3    Suarez, C.4    Menendez, M.J.5    Coto, E.6
  • 30
    • 0030963115 scopus 로고    scopus 로고
    • Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia
    • Yamada, Y., Hatta, Y., Murata, K. et al. (1997) Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. J. Clin. Oncol., 15, 1778-1785.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 1778-1785
    • Yamada, Y.1    Hatta, Y.2    Murata, K.3
  • 31
    • 9344247476 scopus 로고    scopus 로고
    • Genetic progression model for head and neck cancer: Implication for field cancerization
    • Califano, J., Riet, P., Westra, W. et al. (1996) Genetic progression model for head and neck cancer: implication for field cancerization. Cancer Res., 56, 2488-2492.
    • (1996) Cancer Res. , vol.56 , pp. 2488-2492
    • Califano, J.1    Riet, P.2    Westra, W.3
  • 32
    • 0030778842 scopus 로고    scopus 로고
    • ARF
    • ARF. Cell, 91, 555-558.
    • (1997) Cell , vol.91 , pp. 555-558
    • Haber, D.A.1
  • 33
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • Hannon, G.J. and Beach, D. (1994) p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature, 371, 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.