Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease

Human Genetics

Volumn 101, Issue 3, 1997, Pages 299-305

  Migliore, Lucia ^a   Testa, Anna ^a   Scarpato, Roberto ^a   Pavese, Nicola ^a   Petrozzi, Lucia ^a   Bonuccelli, Ubaldo ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GRISEOFULVIN; MICROTUBULE ASSOCIATED PROTEIN;

ACROCENTRIC CHROMOSOME; ADULT; AGED; ALZHEIMER DISEASE; ANEUPLOIDY; ARTICLE; CENTROMERE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA PROBE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MALE; METAPHASE; MICRONUCLEUS; MUTATION RATE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

EID: 0031447765     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050632     Document Type: Article

References (46)

1. Becker P, Scherthan H, Zankl H (1990) Use of a centromere-specific DNA probe (p82H) in nonisotopic in situ hybridization for classification of micronuclei. Genes Chromosom Cancer 2: 59-62
2. Blass JP (1993) Pathophysiology of the Alzheimer's syndrome. Neurology 43:25-38
3. Cork LC (1990) Neuropathology of Down syndrome and Alzheimer disease. Am J Med Genet Suppl 7:282-286
4. Cruts M, Hendriks L, Van Broeckhoven C (1996) The presenilin genes: a new gene family involved in Alzheimer disease pathology. Hum Mol Genet 5:1449-1455
5. Eastmond DA, Schuler M, Rupa DS (1995) Advantages and limitations of using fluorescence in situ hybridization for the detection of aneuploidy in interphase human cells. Mutat Res 348: 153-162
6. Fenech M (1993) The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35-44
7. Fitzgerald PH, McEwan CM (1977) Total aneuploidy and age-related sex chromosome aneuploidy in cultured lymphocytes of normal men and women. Hum Genet 39:329-337
8. Fitzgerald PH, Pickering AF, Mercer JM, Miethke PM (1975) Premature centromere division: a mechanism of non-disjunction causing X chromosome aneuploidy in somatic cells of man. Ann Hum Genet 38:417-428
9. Fitzgerald PH, Archer SA, Morris CM (1986) Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division (PCD). Hum Genet 72:58-62
10. Franceschi M, Comola M, Piattoni F, Gualandri W, Canal N (1990) Prevalence of dementia in adult patients with trisomy 21. Am J Med Genet Suppl 7:306-308
11. Gabarron J, Jimenez A, Glover G (1986) Premature centromere division dominantly inherited in a subfertile family. Cytogenet Cell Genet 43:69-71
12. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the micro-tubule-associated protein t (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83:4913-4917
13. Guttenbach M, Schakowski R, Schmid M (1994) Aneuploidy and ageing: sex chromosome exclusion into micronuclei. Hum Genet 94:295-298
14. Heston LL, Mastri AR (1977) The genetics of Alzheimer's disease. Associations with hematologic malignancy and Down syndrome. Arch Gen Psychiatry 34:976-981
15. Jarvik GP, Larson EB, Goddard K, Kukull WA, Schellenberg GD, Wijisman EM (1996) Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. Am J Hum Genet 58:191-200
16. Joachim CL, Mori H, Selkoe DJ (1989) Amyloid b-protein deposition in tissues other than brain in Alzheimer's disease. Nature 341:226-230
17. Kormann-Bortolotto MH, Arruda Cardoso Smith M de, Neto JT (1993) Alzheimer's disease and ageing: a chromosomal approach. Gerontology 39:1-6
18. Matsuyama SS, Jarvik LF (1989) Hypothesis: microtubules, a key to Alzheimer disease. Proc Natl Acad Sci USA 86:8152-8156
19. McDowell KA, Hadjiargyrou M, Patsalis P, Henderson AS (1994) Transcription of rDNA is essential for satellite association. Cytogenet Cell Genet 66:63-67
20. McKhann G, Drachman D, Folstein M, Katzman, Price D, Stadlan EM (1994) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34:939-944
21. Mehes K, Bühler EM (1995) Premature centromere division: a possible manifestation of chromosome instability. Am J Med. Genet 56:76-79
22. Migliore L, Parrini M, Sbrana I, Biagini C, Battaglia A, Loprieno N (1991) Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect. Mutat Res 256:13-20
23. Migliore L, Bocciardi R, Macrï C, Lo Jacono F (1993) Cytogenetic damage induced in human lymphocytes by four vanadium compounds and micronucleus analysis by fluorescence in situ hybridization with a centromeric probe. Mutat Res 319:205-213
24. Migliore L, Cocchi L, Scarpato R (1996) Detection of the centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocyte micronucleus assay after treatment with four suspected aneugens. Mutagenesis 11: 71-76
25. Moorhead PS, Heyman A (1983) Chromosome studies of patients with Alzheimer disease. Am J Hum Genet 14:545-556
26. Nordenson I, Adolfsson R, Beckman G, Bucht G, Winblad B (1980) Chromosomal abnormality in dementia of Alzheimer type. Lancet I:481-482
27. Nowinski GP, Dyke DL van, Tilley BC, Jacobsen G, Babu VR, Worsham MJ, Wilson GN Weiss L (1990): The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history. Am J Hum Genet 46:1101-1111
28. Ottman R (1995) Gene-environment interaction and public health. Am J Hum Genet 56:821-823
29. Payami H, Zareparsi S, Montee KR, Sexto GJ, Kaye JA, Bird TD, Yu CE, Wijsman EM, Heston LL, Litt M, Schellenberg GD (1996) Gender differences in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet 58:803-811
30. Payão SLM, Smith MAC, Kormann-Bortolotto MH, Toniolo J (1994) Investigation of the nucleolar organizer regions in Alzheimer's disease. Gerontology 40:13-17
31. Pericak-Vance MA, Haines JA (1995) Genetic susceptibility to Alzheimer disease. Trends Genet 11:504-508
32. Potter H (1991) Review and hypothesis: Alzheimer disease and Down syndrome - chromosome 21 nondisjunction may underlie both disorders. Am J Hum Genet 48:1192-1200
33. Reisberg B, Ferris SN, Leon MJ de, Crook KT (1982) The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 139:1136-1139
34. Richards SJ, Holland A, Palmer CR (1994) Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome. Lancet 344:1092-1093
35. Roobol A, Gull K, Pogson CI (1977) Evidence that griseofulvin binds to a microtubule associated protein. FEBS Lett 75:149-153
36. Scarpato R, Landini E, Migliore L (1996) Acrocentric chromosome frequency in spontaneous human lymphocyte micronuclei, evaluated by dual-colour hybridization, is neither sex- nor age-related. Mutat Res 372:195-204
37. Schellenberg GD, Boehnke M, Wijsman EM, Moore DK, Martin GM, Birol TM (1992) Genetic association and linkage analysis of the epolipoprotein CII locus and familial Alzheimer's disease. Ann Neurol 31:223-227
38. Schupf N, Kapell D, Lee JK, Ottman R, Mayeux R (1994) Increased risk of aneuploidy in mothers of adults with Down's syndrome. Lancet 344:353-356
39. Sloboda RD, Van Blaricom G, Creasey WA, Rosembaum JL, Malawista SE (1982) Griseofulvin; association with tubulin and inhibition of in vitro microtubule assembly. Biochem Biophys Res Commun 105:882-888
40. St. George Hyslop P, Tanzi RE, Polinsky R, Haines L, Nee L, Watkins P, Myers R, Feldman R, Pollen D, Drachman D, Growdon J, Bruni A, Foncin J-F, Salmon D, Frommelt P, Amaducci L, Sorbi S, Piacentini S, Stewart GD, Hobbs WE, Conneally MP, Gusella J (1987) The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 235: 885-890
41. Stone JF, Sandberg AA (1995) Sex chromosome aneuploidy and aging. Mutat Res 338:107-113
42. Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR, Han SH, Hulette C, Einstein G, Schmechel DE, PericakVance MA, Roses AD (1994) Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 125:163-171
43. Ward BE, Cook RH, Robinson A, Austin JH (1979) Increased aneuploidy in Alzheimer disease. Am J Med Genet 3:137-144
44. Wehland J, Herzog W, Weber K (1977) Interaction of griseofulvin with microtubules, microtubule protein and tubulin. J Mol Biol 111:329-342
45. White BJ, Crandall C, Goudsmith J, Morrow CH, Alling DW, Gajdusek DC, Tijio JH (1981) Cytogenetic studies of familial and sporadic Alzheimer disease. Am J Hum Genet 10:77-89
46. Wright AF, Whalley LJ (1984) Genetics, ageing and dementia. Br J Psychiatry 145:20-38