-
1
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
-
Bales KK, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM: Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genet 17:263-264 (1997).
-
(1997)
Nature Genet
, vol.17
, pp. 263-264
-
-
Bales, K.K.1
Verina, T.2
Dodel, R.C.3
Du, Y.4
Altstiel, L.5
Bender, M.6
Hyslop, P.7
Johnstone, E.M.8
Little, S.P.9
Cummins, D.J.10
Piccardo, P.11
Ghetti, B.12
Paul, S.M.13
-
2
-
-
17344362232
-
Alpha-2 macroglobulin is genetically associated with Alzheimer disease
-
Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RCP, Perry R, Watson BJ, Bassett SS, McInnis MG, Albert MS, Hyman BT, Tanzi RE: Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nature Genet 19:357-360 (1998).
-
(1998)
Nature Genet
, vol.19
, pp. 357-360
-
-
Blacker, D.1
Wilcox, M.A.2
Laird, N.M.3
Rodes, L.4
Horvath, S.M.5
Go, R.C.P.6
Perry, R.7
Watson, B.J.8
Bassett, S.S.9
McInnis, M.G.10
Albert, M.S.11
Hyman, B.T.12
Tanzi, R.E.13
-
3
-
-
84937174490
-
Pathophysiology of the Alzheimer's syndrome
-
Blass JP: Pathophysiology of the Alzheimer's syndrome. Neurology 43(Suppl 4):S25-38 (1993).
-
(1993)
Neurology
, vol.43
, Issue.SUPPL. 4
-
-
Blass, J.P.1
-
4
-
-
0026742067
-
Gender differences and the interpretation of genetic instability in Alzheimer's disease
-
Cherry LM, Funk J, Lesser JM, Lesam M: Gender differences and the interpretation of genetic instability in Alzheimer's disease. Mutat Res 275:57-67 (1992).
-
(1992)
Mutat Res
, vol.275
, pp. 57-67
-
-
Cherry, L.M.1
Funk, J.2
Lesser, J.M.3
Lesam, M.4
-
5
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G., Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens. J, Kim S, Schenk D, Fraser P. St. George Hyslop P, Selkoe DJ: Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med 3:67-72 (1997).
-
(1997)
Nature Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George Hyslop, P.22
Selkoe, D.J.23
more..
-
6
-
-
0029813255
-
The presenilin genes: A new gene family involved in Alzheimer disease pathology
-
Cruts M, Hendriks L, Van Broeckhoven C: The presenilin genes: a new gene family involved in Alzheimer disease pathology. Hum molec Genet 5:1449-1455 (1996).
-
(1996)
Hum Molec Genet
, vol.5
, pp. 1449-1455
-
-
Cruts, M.1
Hendriks, L.2
Van Broeckhoven, C.3
-
7
-
-
0027497435
-
The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations
-
Fenech M: The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35-44 (1993).
-
(1993)
Mutat Res
, vol.285
, pp. 35-44
-
-
Fenech, M.1
-
8
-
-
0033033062
-
Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease
-
Geller LN, Potter H: Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease. Neurobiol Dis 6:167-179 (1999).
-
(1999)
Neurobiol Dis
, vol.6
, pp. 167-179
-
-
Geller, L.N.1
Potter, H.2
-
9
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder LI: Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology. Proc natl Acad Sci, USA 83:4913-4917 (1986).
-
(1986)
Proc Natl Acad Sci, USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.-C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
10
-
-
0343573410
-
Alzheimer disease and Down syndrome
-
Holtzman DM: Alzheimer disease and Down syndrome. Cytogenet Cell Genet 77(Suppl 1):17 (1997).
-
(1997)
Cytogenet Cell Genet
, vol.77
, Issue.SUPPL. 1
, pp. 17
-
-
Holtzman, D.M.1
-
12
-
-
0024510518
-
Genetics, Alzheimer's disease and senile dementia
-
Kay DWK: Genetics, Alzheimer's disease and senile dementia. Br J Psychiatr 154:311-320 (1989).
-
(1989)
Br J Psychiatr
, vol.154
, pp. 311-320
-
-
Kay, D.W.K.1
-
13
-
-
0345055313
-
Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production
-
Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP: Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J Neurosci 18:4439-4450 (1998).
-
(1998)
J Neurosci
, vol.18
, pp. 4439-4450
-
-
Keller, J.N.1
Guo, Q.2
Holtsberg, F.W.3
Bruce-Keller, A.J.4
Mattson, M.P.5
-
14
-
-
0030761059
-
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
-
Li J, Xu M, Zhou H, Ma J, Potter H: Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90:917-927 (1997).
-
(1997)
Cell
, vol.90
, pp. 917-927
-
-
Li, J.1
Xu, M.2
Zhou, H.3
Ma, J.4
Potter, H.5
-
15
-
-
0030466741
-
Fluorescence in situ hybridization with chromosome specific centromeric probes: A sensitive method to detect aneuploidy
-
Marshall RR, Murphy M, Kirkland DJ, Bentley BS: Fluorescence in situ hybridization with chromosome specific centromeric probes: a sensitive method to detect aneuploidy. Mutat Res 372:221-233 (1996).
-
(1996)
Mutat Res
, vol.372
, pp. 221-233
-
-
Marshall, R.R.1
Murphy, M.2
Kirkland, D.J.3
Bentley, B.S.4
-
16
-
-
0024342580
-
Hypothesis: Microtubules, a key to Alzheimer disease
-
Matsuyama SS, Jarvik LF: Hypothesis: microtubules, a key to Alzheimer disease, Proc natl Acad Sci, USA 86:8152-8156 (1989).
-
(1989)
Proc Natl Acad Sci, USA
, vol.86
, pp. 8152-8156
-
-
Matsuyama, S.S.1
Jarvik, L.F.2
-
17
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the department of health and human services task force on Alzheimer's disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34:939-944 (1984).
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
18
-
-
0031447765
-
Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease
-
Migliore L, Testa A, Scarpato R, Pavese N, Petrozzi L, Bonuccelli U: Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. Hum Genet 101:299-305 (1997).
-
(1997)
Hum Genet
, vol.101
, pp. 299-305
-
-
Migliore, L.1
Testa, A.2
Scarpato, R.3
Pavese, N.4
Petrozzi, L.5
Bonuccelli, U.6
-
19
-
-
0020580305
-
Chromosome studies of patients with Alzheimer disease
-
Moorhead PS, Heyman A: Chromosome studies of patients with Alzheimer disease. Am J med Genet 14:545-556 (1983).
-
(1983)
Am J Med Genet
, vol.14
, pp. 545-556
-
-
Moorhead, P.S.1
Heyman, A.2
-
20
-
-
0031661968
-
The cell pathophysiology of Alzheimer's disease
-
Nagy ZS, Esiri MM, Smith AD: The cell pathophysiology of Alzheimer's disease. Neuroscience 87:731-739 (1998).
-
(1998)
Neuroscience
, vol.87
, pp. 731-739
-
-
Nagy, Z.S.1
Esiri, M.M.2
Smith, A.D.3
-
21
-
-
0027474055
-
Age-associated chromosome 21 loss in Down syndrome: Possible relevance to mosaicism and Alzheimer disease
-
Percy ME, Markovic VD, Dalton AJ, McLachlan DRC, Berg JM, Rusk ACM, Somerville MJ, Chodakowski B, Andrews DF: Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease. Am J med Genet 45:584-588 (1993).
-
(1993)
Am J Med Genet
, vol.45
, pp. 584-588
-
-
Percy, M.E.1
Markovic, V.D.2
Dalton, A.J.3
McLachlan, D.R.C.4
Berg, J.M.5
Rusk, A.C.M.6
Somerville, M.J.7
Chodakowski, B.8
Andrews, D.F.9
-
22
-
-
0025801967
-
Review and hypothesis: Alzheimer disease and Down syndrome-chromosome 21 nondisjunction may underlie both disorders
-
Potter H: Review and hypothesis: Alzheimer disease and Down syndrome-chromosome 21 nondisjunction may underlie both disorders. Am J hum Genet 48:1192-1200 (1991).
-
(1991)
Am J Hum Genet
, vol.48
, pp. 1192-1200
-
-
Potter, H.1
-
23
-
-
0029974802
-
Alzheimer's disease, Down's syndrome, and chromosome segregation
-
Potter H, Geller LN: Alzheimer's disease, Down's syndrome, and chromosome segregation. Lancet 348:66 (1996).
-
(1996)
Lancet
, vol.348
, pp. 66
-
-
Potter, H.1
Geller, L.N.2
-
24
-
-
0031939059
-
Molecular mapping of Alzheimer-type dementia in Down's syndrome
-
Prasher VP, Farrer MJ, Kessling AM, Fisher EMC, West RJ, Barber PC, Butler AC: Molecular mapping of Alzheimer-type dementia in Down's syndrome. Annls Neurol 43:380-383 (1998).
-
(1998)
Annls Neurol
, vol.43
, pp. 380-383
-
-
Prasher, V.P.1
Farrer, M.J.2
Kessling, A.M.3
Fisher, E.M.C.4
West, R.J.5
Barber, P.C.6
Butler, A.C.7
-
25
-
-
0031928259
-
Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease
-
Preuss U, Mandelkow EM: Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease. Eur J Cell Biol 76:176-184 (1998).
-
(1998)
Eur J Cell Biol
, vol.76
, pp. 176-184
-
-
Preuss, U.1
Mandelkow, E.M.2
-
26
-
-
0019967975
-
The global deterioration scale for assessment of primary degenerative dementia
-
Reisberg B, Ferris SN, de Leon MJ, Crook KT: The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatr 139:1136-1139 (1982).
-
(1982)
Am J Psychiatr
, vol.139
, pp. 1136-1139
-
-
Reisberg, B.1
Ferris, S.N.2
De Leon, M.J.3
Crook, K.T.4
-
28
-
-
0028095222
-
Increased risk of Alzhcimer's disease in mothers of adults with Down's syndrome
-
Schupf N, Kapell D, Lee JH, Ottman R, Mayeux R: Increased risk of Alzhcimer's disease in mothers of adults with Down's syndrome. Lancet 344:353-356 (1994).
-
(1994)
Lancet
, vol.344
, pp. 353-356
-
-
Schupf, N.1
Kapell, D.2
Lee, J.H.3
Ottman, R.4
Mayeux, R.5
-
29
-
-
0028942632
-
Tau protein directly interacts with the amyloid β-protein precursor: Implications for Alzheimer's disease
-
Smith MA, Siedlak SL, Richey PL, Mulvihill P, Ghiso J, Frangione B, Tagliavini F, Giaccone G, Bugiani O, Praprotnik D, Kalaria RN, Perry G: Tau protein directly interacts with the amyloid β-protein precursor: implications for Alzheimer's disease. Nature Med 1:365-369 (1995).
-
(1995)
Nature Med
, vol.1
, pp. 365-369
-
-
Smith, M.A.1
Siedlak, S.L.2
Richey, P.L.3
Mulvihill, P.4
Ghiso, J.5
Frangione, B.6
Tagliavini, F.7
Giaccone, G.8
Bugiani, O.9
Praprotnik, D.10
Kalaria, R.N.11
Perry, G.12
-
31
-
-
0028269666
-
Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype
-
Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong L-M, Jakes R, Alberts MJ, Gilbert JR, Han SH, Hulette C, Einstein G, Schemeehel DE, Pericak-Vance MA, Roses AD: Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Expl Neurol 125:163-171 (1994).
-
(1994)
Expl Neurol
, vol.125
, pp. 163-171
-
-
Strittmatter, W.J.1
Weisgraber, K.H.2
Goedert, M.3
Saunders, A.M.4
Huang, D.5
Corder, E.H.6
Dong, L.-M.7
Jakes, R.8
Alberts, M.J.9
Gilbert, J.R.10
Han, S.H.11
Hulette, C.12
Einstein, G.13
Schemeehel, D.E.14
Pericak-Vance, M.A.15
Roses, A.D.16
-
32
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold K-H, Mistl C, Rothacher S, Ledermann B, Bürki K, Frey P, Paganetti PA. Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B: Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc natl Acad Sci, USA 94:13287-13292 (1997).
-
(1997)
Proc Natl Acad Sci, USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.-H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Bürki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
33
-
-
13344293701
-
Presence of soluble amyloid plaque formation in Down's syndrome
-
Teller JK, Russo C, DeBusk LM, Angelini G, Zaccheo D, Dagna-Bricarelli F., Scartezzini P, Bertolini S, Mann DMA, Tabaton M, Gambetti P: Presence of soluble amyloid plaque formation in Down's syndrome. Nature Med 2:93-95 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 93-95
-
-
Teller, J.K.1
Russo, C.2
DeBusk, L.M.3
Angelini, G.4
Zaccheo, D.5
Dagna-Bricarelli, F.6
Scartezzini, P.7
Bertolini, S.8
Mann, D.M.A.9
Tabaton, M.10
Gambetti, P.11
-
34
-
-
0032521531
-
A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome
-
Tyrrel J, Cosgrave M, Hawi Z, McPherson J, O'Brien C, McCalvert J, McLaughlin M, Lawlor B, Gill M: A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome. Biol Psychiatr 43:397-400 (1998).
-
(1998)
Biol Psychiatr
, vol.43
, pp. 397-400
-
-
Tyrrel, J.1
Cosgrave, M.2
Hawi, Z.3
McPherson, J.4
O'Brien, C.5
McCalvert, J.6
McLaughlin, M.7
Lawlor, B.8
Gill, M.9
-
35
-
-
0029411573
-
Presenilins and Alzheimer disease
-
Van Broeckhoven C: Presenilins and Alzheimer disease. Nature Genet 11:230-232 (1995).
-
(1995)
Nature Genet
, vol.11
, pp. 230-232
-
-
Van Broeckhoven, C.1
-
36
-
-
0019385328
-
Cytogenetic studies of familial and sporadic Alzheimer disease
-
White BJ, Crandall C, Goldsmit J, Morrow CH, Ailing DW, Carleton Gajdusek DC, Tjio J-H: Cytogenetic studies of familial and sporadic Alzheimer disease. Am J med Genet 10:77-89 (1981).
-
(1981)
Am J Med Genet
, vol.10
, pp. 77-89
-
-
White, B.J.1
Crandall, C.2
Goldsmit, J.3
Morrow, C.H.4
Ailing, D.W.5
Carleton Gajdusek, D.C.6
Tjio, J.-H.7
|