-
1
-
-
3042536356
-
Mechanism targeted discovery of antitumor marine natural products
-
Nagle D.G., Zhou Y.D., Mora F.D., Mohammed K.A., and Kim Y.P. Mechanism targeted discovery of antitumor marine natural products. Curr Med Chem 11 (2004) 1725-1756
-
(2004)
Curr Med Chem
, vol.11
, pp. 1725-1756
-
-
Nagle, D.G.1
Zhou, Y.D.2
Mora, F.D.3
Mohammed, K.A.4
Kim, Y.P.5
-
2
-
-
4344650390
-
Marine natural products and related compounds in clinical and advanced preclinical trials
-
Newman D.J., and Cragg G.M. Marine natural products and related compounds in clinical and advanced preclinical trials. J Nat Prod 67 (2004) 1216-1238
-
(2004)
J Nat Prod
, vol.67
, pp. 1216-1238
-
-
Newman, D.J.1
Cragg, G.M.2
-
3
-
-
33845941617
-
Anticancer potential of silymarin: from bench to bed side
-
Agarwal R., Agarwal C., Ichikawa H., Singh R.P., and Aggarwal B.B. Anticancer potential of silymarin: from bench to bed side. Anticancer Res 26 (2006) 4457-4498
-
(2006)
Anticancer Res
, vol.26
, pp. 4457-4498
-
-
Agarwal, R.1
Agarwal, C.2
Ichikawa, H.3
Singh, R.P.4
Aggarwal, B.B.5
-
5
-
-
1842423816
-
Nuclear transcription factor NF-kappa B: role in biology and medicine
-
Aggarwal B.B., Takada Y., Shishodia S., Gutierrez A.M., Oommen O.V., Ichikawa H., et al. Nuclear transcription factor NF-kappa B: role in biology and medicine. Indian J Exp Biol 42 (2004) 341-353
-
(2004)
Indian J Exp Biol
, vol.42
, pp. 341-353
-
-
Aggarwal, B.B.1
Takada, Y.2
Shishodia, S.3
Gutierrez, A.M.4
Oommen, O.V.5
Ichikawa, H.6
-
6
-
-
33745298519
-
Nuclear factor-kB in cancer development and progression
-
Karin M. Nuclear factor-kB in cancer development and progression. Nature 441 (2006) 431-436
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
7
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004) 461-466
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
-
8
-
-
33745325007
-
Mechanisms of drug inhibition of signalling molecules
-
Sebolt-Leopold J., and English J. Mechanisms of drug inhibition of signalling molecules. Nature 441 (2006) 457-462
-
(2006)
Nature
, vol.441
, pp. 457-462
-
-
Sebolt-Leopold, J.1
English, J.2
-
9
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell Jr. J.E. Transcription factors as targets for cancer therapy. Nat Rev Cancer 2 (2002) 740-749
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 740-749
-
-
Darnell Jr., J.E.1
-
10
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M., and Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5 (2005) 749-759
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
11
-
-
33749260717
-
NF-κB activity in haemological malignancies
-
Keutgens A., Robert I., Viatour P., Chariot A., and Deregulated. NF-κB activity in haemological malignancies. Biochem Pharmacol 72 (2006) 1069-1080
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1069-1080
-
-
Keutgens, A.1
Robert, I.2
Viatour, P.3
Chariot, A.4
Deregulated5
-
12
-
-
31044443091
-
Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs
-
Evans P. Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs. Exp Rev Mol Med 7 (2005) 1-19
-
(2005)
Exp Rev Mol Med
, vol.7
, pp. 1-19
-
-
Evans, P.1
-
13
-
-
2342477917
-
The novel functions of ubiquitination in signaling
-
Sun L., and Chen Z.J. The novel functions of ubiquitination in signaling. Curr Opin Cell Biol 16 (2004) 119-126
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 119-126
-
-
Sun, L.1
Chen, Z.J.2
-
14
-
-
23144449789
-
Ubiquitin signalling in the NF-kappaB pathway
-
Chen Z.J. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7 (2005) 758-765
-
(2005)
Nat Cell Biol
, vol.7
, pp. 758-765
-
-
Chen, Z.J.1
-
15
-
-
30044449755
-
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappa B activation
-
Blonska M., Shameshakar P., Kobayashi M., Zhang D., Sakurai H., Su B., et al. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappa B activation. J Biol Chem 280 (2005) 43056-43063
-
(2005)
J Biol Chem
, vol.280
, pp. 43056-43063
-
-
Blonska, M.1
Shameshakar, P.2
Kobayashi, M.3
Zhang, D.4
Sakurai, H.5
Su, B.6
-
16
-
-
0031126395
-
I kappa B proteins: structure, function and regulation
-
Whiteside S.T., and Israel A. I kappa B proteins: structure, function and regulation. Semin Cancer Biol 8 (1997) 75-82
-
(1997)
Semin Cancer Biol
, vol.8
, pp. 75-82
-
-
Whiteside, S.T.1
Israel, A.2
-
17
-
-
0029949257
-
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
-
Hsu H., Huang J., Shu H., Baichwal V., and Goeddel D.V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4 (1996) 387-396
-
(1996)
Immunity
, vol.4
, pp. 387-396
-
-
Hsu, H.1
Huang, J.2
Shu, H.3
Baichwal, V.4
Goeddel, D.V.5
-
18
-
-
4544228457
-
Functions of NF-κB1 and NF-κB2 in immune cell biology
-
Beinke S., and Ley S.C. Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem J 382 (2004) 393-409
-
(2004)
Biochem J
, vol.382
, pp. 393-409
-
-
Beinke, S.1
Ley, S.C.2
-
19
-
-
0242664121
-
IκB kinase-independent IκBα degradation pathway: functional NF-κB activity and implications for cancer therapy
-
Tergaonkar V., Bottero V., Ikawa M., Li Q., and Verma I.M. IκB kinase-independent IκBα degradation pathway: functional NF-κB activity and implications for cancer therapy. Mol Cell Biol 23 (2003) 8070-8083
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8070-8083
-
-
Tergaonkar, V.1
Bottero, V.2
Ikawa, M.3
Li, Q.4
Verma, I.M.5
-
20
-
-
0032573165
-
Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
-
Li N., and Karin M. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms. Proc Natl Acad Sci USA 95 (1998) 13012-13017
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13012-13017
-
-
Li, N.1
Karin, M.2
-
21
-
-
0029665597
-
Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IκBα
-
Schwarz E., Van Antwerp D., and Verma I.M. Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IκBα. Mol Cell Biol 16 (1996) 3554-3559
-
(1996)
Mol Cell Biol
, vol.16
, pp. 3554-3559
-
-
Schwarz, E.1
Van Antwerp, D.2
Verma, I.M.3
-
22
-
-
0036217821
-
Natural products as targeted modulators of the nuclear factor-kappa B pathway
-
Bremner P., and Heinrich M. Natural products as targeted modulators of the nuclear factor-kappa B pathway. J Pharm Pharmacol 54 (2002) 453-472
-
(2002)
J Pharm Pharmacol
, vol.54
, pp. 453-472
-
-
Bremner, P.1
Heinrich, M.2
-
23
-
-
0038809627
-
Inhibition of transcription factor NF-kappa B by sesquiterpene lactones: a proposed molecular mechanism of action
-
Rungeler P., Castro V., Mora G., Goren N., Vichnewski W., Pahl H.L., et al. Inhibition of transcription factor NF-kappa B by sesquiterpene lactones: a proposed molecular mechanism of action. Bioorg Med Chem 7 (1999) 2343-2352
-
(1999)
Bioorg Med Chem
, vol.7
, pp. 2343-2352
-
-
Rungeler, P.1
Castro, V.2
Mora, G.3
Goren, N.4
Vichnewski, W.5
Pahl, H.L.6
-
24
-
-
0035955729
-
Cysteine 38 in p65/NF-kappa B plays a crucial role in DNA binding inhibition by sesquiterpene lactones
-
Garcia-Pineres A.J., Castro V., Mora G., Schmidt T.J., Strunck E., Pahl H.L., et al. Cysteine 38 in p65/NF-kappa B plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J Biol Chem 276 (2001) 39713-39720
-
(2001)
J Biol Chem
, vol.276
, pp. 39713-39720
-
-
Garcia-Pineres, A.J.1
Castro, V.2
Mora, G.3
Schmidt, T.J.4
Strunck, E.5
Pahl, H.L.6
-
25
-
-
0003922509
-
-
Oxford University Press, Oxford
-
Clayden J., Greeves N., Warren S., and Wothers P. Organic chemistry (2001), Oxford University Press, Oxford
-
(2001)
Organic chemistry
-
-
Clayden, J.1
Greeves, N.2
Warren, S.3
Wothers, P.4
-
26
-
-
1942443229
-
A molecular modeling study of inhibitors of nuclear factor kappa-B (p50) - DNA binding
-
Pande V., Sharma R.K., Inoue J.I., Otsuka M., and Ramos M.J. A molecular modeling study of inhibitors of nuclear factor kappa-B (p50) - DNA binding. J Comput-Aided Mol Design 17 (2003) 825-836
-
(2003)
J Comput-Aided Mol Design
, vol.17
, pp. 825-836
-
-
Pande, V.1
Sharma, R.K.2
Inoue, J.I.3
Otsuka, M.4
Ramos, M.J.5
-
28
-
-
0036379624
-
Early clinical experience with the novel proteasome inhibitor PS-519
-
Shah I.M., Lees K.R., Pien C.P., and Elliott P.J. Early clinical experience with the novel proteasome inhibitor PS-519. Br J Clin Pharmacol 54 (2002) 269-276
-
(2002)
Br J Clin Pharmacol
, vol.54
, pp. 269-276
-
-
Shah, I.M.1
Lees, K.R.2
Pien, C.P.3
Elliott, P.J.4
-
29
-
-
0346505340
-
The IKK NF-kappa B system: a treasure trove for drug development
-
Karin M., Yamamoto Y., and Wang Q.M. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Disc 3 (2004) 17-26
-
(2004)
Nat Rev Drug Disc
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, Q.M.3
-
30
-
-
0035572083
-
Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination
-
Banerjee D., and Liefshitz A. Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res 21 (2001) 3941-3947
-
(2001)
Anticancer Res
, vol.21
, pp. 3941-3947
-
-
Banerjee, D.1
Liefshitz, A.2
-
31
-
-
0036087686
-
Ubiquitin proteasome inhibition and cancer therapy
-
Shah S.A., Potter M.W., and Callery M.P. Ubiquitin proteasome inhibition and cancer therapy. Surgery 131 (2002) 595-600
-
(2002)
Surgery
, vol.131
, pp. 595-600
-
-
Shah, S.A.1
Potter, M.W.2
Callery, M.P.3
-
32
-
-
2642559887
-
Targeting E3 ubiquitin ligases for cancer therapy
-
Sun Y. Targeting E3 ubiquitin ligases for cancer therapy. Cancer Biol Ther 2 (2003) 623-629
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 623-629
-
-
Sun, Y.1
-
33
-
-
33744951304
-
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappa B activation
-
Li H., Kobayashi M., Blonska M., Yon Y., and Lin X. Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem (2006) 281
-
(2006)
J Biol Chem
, pp. 281
-
-
Li, H.1
Kobayashi, M.2
Blonska, M.3
Yon, Y.4
Lin, X.5
-
34
-
-
33846471122
-
Proteasome-independent functions of ubiquitin in endocytosis and signaling
-
Mukhopadhyay D., and Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315 (2007) 201-205
-
(2007)
Science
, vol.315
, pp. 201-205
-
-
Mukhopadhyay, D.1
Riezman, H.2
-
35
-
-
30344482590
-
Lingering mysteries of ubiquitin-chain assembly
-
Hochstrasser M. Lingering mysteries of ubiquitin-chain assembly. Cell 124 (2006) 27-34
-
(2006)
Cell
, vol.124
, pp. 27-34
-
-
Hochstrasser, M.1
-
36
-
-
0036773256
-
Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme
-
Sekizawa R., Ikeno S., Nakamura H., Naganawa H., Matsui S., Iinuma H., et al. Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme. J Nat Prod 65 (2002) 1491-1493
-
(2002)
J Nat Prod
, vol.65
, pp. 1491-1493
-
-
Sekizawa, R.1
Ikeno, S.2
Nakamura, H.3
Naganawa, H.4
Matsui, S.5
Iinuma, H.6
-
37
-
-
9644281548
-
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp
-
Tsukamoto S., Hirota H., Imachi M., Fujimuro M., Onuki H., Ohta T., et al. Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp. Bioorg Med Chem Lett 15 (2005) 191-194
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 191-194
-
-
Tsukamoto, S.1
Hirota, H.2
Imachi, M.3
Fujimuro, M.4
Onuki, H.5
Ohta, T.6
-
38
-
-
0026728171
-
Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile
-
Berleth E.S., Kasperek E.M., Grill S.P., Braunscheidel J.A., Graziani L.A., and Pickart C.M. Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile. J Biol Chem 267 (1992) 16403-16411
-
(1992)
J Biol Chem
, vol.267
, pp. 16403-16411
-
-
Berleth, E.S.1
Kasperek, E.M.2
Grill, S.P.3
Braunscheidel, J.A.4
Graziani, L.A.5
Pickart, C.M.6
-
39
-
-
2442712663
-
A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit
-
Ogino S., Tsuruma K., Uehara T., Nomura Y., and Herbimycin. A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit. Mol Pharmacol 65 (2004) 1344-1351
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1344-1351
-
-
Ogino, S.1
Tsuruma, K.2
Uehara, T.3
Nomura, Y.4
Herbimycin5
-
40
-
-
0033140337
-
Antioxidants differentially regulate activation of Nuclear Factor-κB, activator protein-1, c-Jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-κB activation are not linked to apoptosis
-
Shrivastava A., and Aggarwal B.B. Antioxidants differentially regulate activation of Nuclear Factor-κB, activator protein-1, c-Jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-κB activation are not linked to apoptosis. Antiox Redox Signal 1 (1999) 181-191
-
(1999)
Antiox Redox Signal
, vol.1
, pp. 181-191
-
-
Shrivastava, A.1
Aggarwal, B.B.2
-
42
-
-
0038527353
-
Marine natural products as novel antioxidant prototypes
-
Takamatsu S., Hodges T.W., Rajbhandari I., Gerwick W.H., Hamann M.T., and Nagle D.G. Marine natural products as novel antioxidant prototypes. J Nat Prod 66 (2003) 605-608
-
(2003)
J Nat Prod
, vol.66
, pp. 605-608
-
-
Takamatsu, S.1
Hodges, T.W.2
Rajbhandari, I.3
Gerwick, W.H.4
Hamann, M.T.5
Nagle, D.G.6
-
43
-
-
0028167846
-
Inhibition of NF-κB by sodium-salicylate and aspirin
-
Kopp E.B., and Ghosh S. Inhibition of NF-κB by sodium-salicylate and aspirin. Science 265 (1994) 956-959
-
(1994)
Science
, vol.265
, pp. 956-959
-
-
Kopp, E.B.1
Ghosh, S.2
-
44
-
-
2942618506
-
Role of cysteine residues of p65/NF-kappa B on the inhibition by the sesquiterpene lactone parthenolide and-N-ethyl maleimide, and on its transactivating potential
-
Garcia-Pineres A.J., Lindenmeyer M.T., and Merfort I. Role of cysteine residues of p65/NF-kappa B on the inhibition by the sesquiterpene lactone parthenolide and-N-ethyl maleimide, and on its transactivating potential. Life Sci 75 (2004) 841-856
-
(2004)
Life Sci
, vol.75
, pp. 841-856
-
-
Garcia-Pineres, A.J.1
Lindenmeyer, M.T.2
Merfort, I.3
-
45
-
-
8644276334
-
Quantitative structure - activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappa B
-
Siedle B., Garcia-Pineres A.J., Murillo R., Schulte-Monting J., Castro V., Rungeler P., et al. Quantitative structure - activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappa B. J Med Chem 47 (2004) 6042-6054
-
(2004)
J Med Chem
, vol.47
, pp. 6042-6054
-
-
Siedle, B.1
Garcia-Pineres, A.J.2
Murillo, R.3
Schulte-Monting, J.4
Castro, V.5
Rungeler, P.6
-
46
-
-
33644821070
-
Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives
-
Folmer F., Blasius R., Morceau F., Tabudravu J., Dicato M., Jaspars M., et al. Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives. Biochem Pharmacol 71 (2006) 1206-1218
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1206-1218
-
-
Folmer, F.1
Blasius, R.2
Morceau, F.3
Tabudravu, J.4
Dicato, M.5
Jaspars, M.6
-
47
-
-
33748744148
-
Curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells
-
Zambre A.P., Kulkarni V., Padhye S., Sandur S.K., and Aggarwal B.B. Curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells. Bioorg Med Chem 14 (2006) 7196-7204
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 7196-7204
-
-
Zambre, A.P.1
Kulkarni, V.2
Padhye, S.3
Sandur, S.K.4
Aggarwal, B.B.5
-
48
-
-
27244460815
-
Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies
-
Ludwig H., Khayat D., Giaccone G., and Facon T. Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies. Cancer 104 (2005) 1794-1807
-
(2005)
Cancer
, vol.104
, pp. 1794-1807
-
-
Ludwig, H.1
Khayat, D.2
Giaccone, G.3
Facon, T.4
-
49
-
-
20944450476
-
A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer
-
Dy G.K., Thomas J.P., Wilding G., Bruzek L., Mandrekar S., Erlichman C., et al. A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer. Clin Cancer Res 11 (2005) 3410-3416
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3410-3416
-
-
Dy, G.K.1
Thomas, J.P.2
Wilding, G.3
Bruzek, L.4
Mandrekar, S.5
Erlichman, C.6
-
50
-
-
33646752928
-
Transcription factors in asthma: are transcription factors a new target for asthma therapy?
-
Roth M., and Black J.L. Transcription factors in asthma: are transcription factors a new target for asthma therapy?. Curr Drug Targets 7 (2006) 589-595
-
(2006)
Curr Drug Targets
, vol.7
, pp. 589-595
-
-
Roth, M.1
Black, J.L.2
-
51
-
-
33646028804
-
Molecular targets of dietary agents for prevention and therapy of cancer
-
Aggarwal B.B., and Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71 (2006) 1397-1421
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1397-1421
-
-
Aggarwal, B.B.1
Shishodia, S.2
-
52
-
-
0025248103
-
Some marine ecological phenomena - chemical basis and biomedical potential
-
Scheuer P.J. Some marine ecological phenomena - chemical basis and biomedical potential. Science 248 (1990) 173-177
-
(1990)
Science
, vol.248
, pp. 173-177
-
-
Scheuer, P.J.1
-
53
-
-
0032788030
-
Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes
-
Pancer Z., Rast J.P., and Davidson E.H. Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes. Immunogenetics 49 (1999) 773-786
-
(1999)
Immunogenetics
, vol.49
, pp. 773-786
-
-
Pancer, Z.1
Rast, J.P.2
Davidson, E.H.3
-
54
-
-
0034178267
-
Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists
-
Schlezinger J.J., Blickarz C.E., Mann K.K., Doerre S., and Stegeman J.J. Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact 126 (2000) 137-157
-
(2000)
Chem Biol Interact
, vol.126
, pp. 137-157
-
-
Schlezinger, J.J.1
Blickarz, C.E.2
Mann, K.K.3
Doerre, S.4
Stegeman, J.J.5
-
55
-
-
0028095711
-
Ubiquitin and ubiquitination in cells from the marine sponge Geodia cydonium
-
Muller W.E., Gamulin V., Rinkevich B., Spreitzer I., Weinblum D., and Schroder H.C. Ubiquitin and ubiquitination in cells from the marine sponge Geodia cydonium. Bio Chem Hoppe-Seyler 375 (1994) 53-60
-
(1994)
Bio Chem Hoppe-Seyler
, vol.375
, pp. 53-60
-
-
Muller, W.E.1
Gamulin, V.2
Rinkevich, B.3
Spreitzer, I.4
Weinblum, D.5
Schroder, H.C.6
-
56
-
-
33645234317
-
Evidence for the ancient origin of the NF-{kappa}B/I{kappa}B cascade: its archaic role in pathogen infection and immunity
-
Wang X.W., Tan N.S., Ho B., and Ding J.L. Evidence for the ancient origin of the NF-{kappa}B/I{kappa}B cascade: its archaic role in pathogen infection and immunity. Proc Natl Acad Sci USA 103 (2006) 4204-4209
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4204-4209
-
-
Wang, X.W.1
Tan, N.S.2
Ho, B.3
Ding, J.L.4
-
57
-
-
0030610403
-
An NF-kappaB-like transcription factor in axoplasm is rapidly inactivated after nerve injury in Aplysia
-
Povelones M., Tran K., Thanos D., and Ambron R.T. An NF-kappaB-like transcription factor in axoplasm is rapidly inactivated after nerve injury in Aplysia. J Neurosci 17 (1997) 4915-4920
-
(1997)
J Neurosci
, vol.17
, pp. 4915-4920
-
-
Povelones, M.1
Tran, K.2
Thanos, D.3
Ambron, R.T.4
-
58
-
-
0037066922
-
The I kappa B kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus
-
Merlo E., Freudenthal R., and Romano A. The I kappa B kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus. Neuroscience 112 (2002) 161-172
-
(2002)
Neuroscience
, vol.112
, pp. 161-172
-
-
Merlo, E.1
Freudenthal, R.2
Romano, A.3
-
59
-
-
0036199303
-
Molecular evolution of the NF-kappaB signaling system
-
Friedman R., and Hughes A.L. Molecular evolution of the NF-kappaB signaling system. Immunogenetics 53 (2002) 964-974
-
(2002)
Immunogenetics
, vol.53
, pp. 964-974
-
-
Friedman, R.1
Hughes, A.L.2
-
60
-
-
0032802759
-
Oyster IKK-like protein shares structural and functional properties with its mammalian homologues
-
Escoubas J.M., Briant L., Montagnani C., Hez S., Devaux C., and Roch P. Oyster IKK-like protein shares structural and functional properties with its mammalian homologues. FEBS Lett 453 (1999) 293-298
-
(1999)
FEBS Lett
, vol.453
, pp. 293-298
-
-
Escoubas, J.M.1
Briant, L.2
Montagnani, C.3
Hez, S.4
Devaux, C.5
Roch, P.6
-
61
-
-
0035029810
-
Involvement of Rel/NF-kappaB in regulation of ascidian notochord formation
-
Shimada M., Satoh N., and Yokosawa H. Involvement of Rel/NF-kappaB in regulation of ascidian notochord formation. Dev Growth Differ 43 (2001) 145-154
-
(2001)
Dev Growth Differ
, vol.43
, pp. 145-154
-
-
Shimada, M.1
Satoh, N.2
Yokosawa, H.3
-
62
-
-
0035139943
-
Hostile takeovers: viral appropriation of the NF-kappa B pathway
-
Hiscott J., Kwon H., and Genin P. Hostile takeovers: viral appropriation of the NF-kappa B pathway. J Clin Invest 107 (2001) 143-151
-
(2001)
J Clin Invest
, vol.107
, pp. 143-151
-
-
Hiscott, J.1
Kwon, H.2
Genin, P.3
-
63
-
-
0346730010
-
Viral strategies in modulation of NF-kappaB activity
-
Lisowska K., and Witkowski J.M. Viral strategies in modulation of NF-kappaB activity. Arch Immunol Ther Exp 51 (2003) 367-375
-
(2003)
Arch Immunol Ther Exp
, vol.51
, pp. 367-375
-
-
Lisowska, K.1
Witkowski, J.M.2
-
64
-
-
0142135122
-
A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos
-
Romano G., Russo G.L., Buttino I., Ianora A., and Miralto A. A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos. J Exp Biol 206 (2003) 3487-3494
-
(2003)
J Exp Biol
, vol.206
, pp. 3487-3494
-
-
Romano, G.1
Russo, G.L.2
Buttino, I.3
Ianora, A.4
Miralto, A.5
-
65
-
-
0036827627
-
The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore
-
Stevenson C.S., Capper E.A., Roshak A.K., Marquez B., Eichman C., Jackson J.R., et al. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther 303 (2002) 858-866
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 858-866
-
-
Stevenson, C.S.1
Capper, E.A.2
Roshak, A.K.3
Marquez, B.4
Eichman, C.5
Jackson, J.R.6
-
67
-
-
14844312905
-
Marine natural products as anticancer drugs
-
Simmons T.L., Andrianasolo E., McPhail K., Flatt P., and Gerwick W.H. Marine natural products as anticancer drugs. Mol Cancer Ther 4 (2005) 333-342
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 333-342
-
-
Simmons, T.L.1
Andrianasolo, E.2
McPhail, K.3
Flatt, P.4
Gerwick, W.H.5
-
68
-
-
11844262569
-
New marine derived anticancer therapeutics - a journey from the sea to clinical trials
-
Jimeno J., Faircloth G., Fernandez Sousa-Faro J.M., Scheuer P.J., and Rinehart K.L. New marine derived anticancer therapeutics - a journey from the sea to clinical trials. Mar Drugs 2 (2004) 14-29
-
(2004)
Mar Drugs
, vol.2
, pp. 14-29
-
-
Jimeno, J.1
Faircloth, G.2
Fernandez Sousa-Faro, J.M.3
Scheuer, P.J.4
Rinehart, K.L.5
-
69
-
-
3042617137
-
Advanced preclinical and clinical trials of natural products and related compounds from marine sources
-
Newman D.J., and Cragg G.M. Advanced preclinical and clinical trials of natural products and related compounds from marine sources. Curr Med Chem 11 (2004) 1693-1713
-
(2004)
Curr Med Chem
, vol.11
, pp. 1693-1713
-
-
Newman, D.J.1
Cragg, G.M.2
-
70
-
-
0038461995
-
Drugs from the deep: marine natural products as drug candidates
-
Haefner B. Drugs from the deep: marine natural products as drug candidates. Drug Discovery Today 8 (2003) 536-544
-
(2003)
Drug Discovery Today
, vol.8
, pp. 536-544
-
-
Haefner, B.1
-
71
-
-
0037953171
-
Cacospongionolide B suppresses the expression of inflammatory enzymes and tumour necrosis factor-alpha by inhibiting nuclear factor-kappa B activation
-
Posadas I., De Rosa S., Terencio M.C., Paya M., and Alcaraz M.J. Cacospongionolide B suppresses the expression of inflammatory enzymes and tumour necrosis factor-alpha by inhibiting nuclear factor-kappa B activation. Br J Pharmacol 138 (2003) 1571-1579
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1571-1579
-
-
Posadas, I.1
De Rosa, S.2
Terencio, M.C.3
Paya, M.4
Alcaraz, M.J.5
-
72
-
-
20044397059
-
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
-
Macherla V.R., Mitchell S.S., Manam R.R., Reed K.A., Chao T.H., Nicholson B., et al. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J Med Chem 48 (2005) 3684-3687
-
(2005)
J Med Chem
, vol.48
, pp. 3684-3687
-
-
Macherla, V.R.1
Mitchell, S.S.2
Manam, R.R.3
Reed, K.A.4
Chao, T.H.5
Nicholson, B.6
-
73
-
-
22344444743
-
Secomycalolide A: a new proteasome inhibitor isolated from a marine sponge of the genus Mycale
-
Tsukamoto S., Koimaru K., and Ohta T. Secomycalolide A: a new proteasome inhibitor isolated from a marine sponge of the genus Mycale. Mar Drugs 3 (2005) 29-35
-
(2005)
Mar Drugs
, vol.3
, pp. 29-35
-
-
Tsukamoto, S.1
Koimaru, K.2
Ohta, T.3
-
74
-
-
0141566434
-
New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp
-
Tsukamoto S., Tatsuno M., van Soest R.W., Yokosawa H., and Ohta T. New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp. J Nat Prod 66 (2003) 1181-1185
-
(2003)
J Nat Prod
, vol.66
, pp. 1181-1185
-
-
Tsukamoto, S.1
Tatsuno, M.2
van Soest, R.W.3
Yokosawa, H.4
Ohta, T.5
-
75
-
-
0034653528
-
Cyclolinteinone, a sesterterpene from sponge Cacospongia linteiformis, prevents inducible nitric oxide synthase and inducible cyclo-oxygenase protein expression by blocking nuclear factor-kappa B activation in J774 macrophages
-
D'Acquisto F., Lanzotti V., and Carnuccio R. Cyclolinteinone, a sesterterpene from sponge Cacospongia linteiformis, prevents inducible nitric oxide synthase and inducible cyclo-oxygenase protein expression by blocking nuclear factor-kappa B activation in J774 macrophages. Biochem J 346 (2000) 793-798
-
(2000)
Biochem J
, vol.346
, pp. 793-798
-
-
D'Acquisto, F.1
Lanzotti, V.2
Carnuccio, R.3
-
76
-
-
0030770363
-
The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB
-
Breton J.J., and Chabot-Fletcher M.C. The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB. J Pharmacol Exp Ther 282 (1997) 459-466
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 459-466
-
-
Breton, J.J.1
Chabot-Fletcher, M.C.2
-
77
-
-
0035913952
-
Cycloprodigiosin hydrochloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappa B
-
Kamata K., Okamoto S., Oka S., Kamata H., Yagisawa H., and Hirata H. Cycloprodigiosin hydrochloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappa B. FEBS Lett 507 (2000) 74-80
-
(2000)
FEBS Lett
, vol.507
, pp. 74-80
-
-
Kamata, K.1
Okamoto, S.2
Oka, S.3
Kamata, H.4
Yagisawa, H.5
Hirata, H.6
-
78
-
-
22544452429
-
A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line
-
Oda T., Namikoshi K., Akamo K., Honma Y., Kasahara T., and Verrucarin. A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line. Mar Drugs 3 (2005) 64-73
-
(2005)
Mar Drugs
, vol.3
, pp. 64-73
-
-
Oda, T.1
Namikoshi, K.2
Akamo, K.3
Honma, Y.4
Kasahara, T.5
Verrucarin6
-
79
-
-
33846110872
-
Ilimaquinone, a marine metabolite, displays anticancer activity via GADD153-mediated pathway
-
Lu P.H., Chuch S.C., Kung F.L., Pan S.L., Shen Y.C., and Guh J.H. Ilimaquinone, a marine metabolite, displays anticancer activity via GADD153-mediated pathway. Eur J Pharmacol 556 (2007) 45-54
-
(2007)
Eur J Pharmacol
, vol.556
, pp. 45-54
-
-
Lu, P.H.1
Chuch, S.C.2
Kung, F.L.3
Pan, S.L.4
Shen, Y.C.5
Guh, J.H.6
-
80
-
-
33750481912
-
Characterization of apoptosis induced by marine natural products in non small cell lung cancer A549 cells
-
Catassi A., Cesario A., Arzani D., Menichini P., Alama A., Bruzzo C., et al. Characterization of apoptosis induced by marine natural products in non small cell lung cancer A549 cells. Cell Mol Life Sci 63 (2006) 2377-2386
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2377-2386
-
-
Catassi, A.1
Cesario, A.2
Arzani, D.3
Menichini, P.4
Alama, A.5
Bruzzo, C.6
-
81
-
-
0346340070
-
In vitro anti-inflammatory and pro-aggregative effects of a lipid compound, petrocortyne A, from marine sponges
-
Hong S., Kim S.H., Rhee M.H., Kim A.R., Jung J.H., Chun T., et al. In vitro anti-inflammatory and pro-aggregative effects of a lipid compound, petrocortyne A, from marine sponges. Naunyn Schmiedebergs Arch Pharmacol 368 (2003) 448-456
-
(2003)
Naunyn Schmiedebergs Arch Pharmacol
, vol.368
, pp. 448-456
-
-
Hong, S.1
Kim, S.H.2
Rhee, M.H.3
Kim, A.R.4
Jung, J.H.5
Chun, T.6
-
82
-
-
2942709705
-
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-κB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-κB-regulated gene expression and up-regulation of apoptosis
-
Takada Y., Khuri F., and Aggarwal B.B. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-κB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-κB-regulated gene expression and up-regulation of apoptosis. J Biol Chem 279 (2004) 26287-26299
-
(2004)
J Biol Chem
, vol.279
, pp. 26287-26299
-
-
Takada, Y.1
Khuri, F.2
Aggarwal, B.B.3
-
83
-
-
27144477415
-
Activated AKT regulates NF-κB activation, p53 inhibition, and cell survival in HTLV-1-transformed cells
-
Jeong S.J., Pise-Masison C.A., Radonvich M.F., Park H.U., and Brady J.N. Activated AKT regulates NF-κB activation, p53 inhibition, and cell survival in HTLV-1-transformed cells. Oncogene 24 (2005) 6719-6728
-
(2005)
Oncogene
, vol.24
, pp. 6719-6728
-
-
Jeong, S.J.1
Pise-Masison, C.A.2
Radonvich, M.F.3
Park, H.U.4
Brady, J.N.5
-
84
-
-
0033517190
-
NF-kappaB is a target of Akt in anti-apoptotic PDGF signalling
-
Romashkova J.A., and Makarov S.S. NF-kappaB is a target of Akt in anti-apoptotic PDGF signalling. Nature 401 (1999) 86-90
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
85
-
-
33747047324
-
A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder
-
Tamarkin F.J., Kang W.S., Cohen J.J., Wheeler M.A., and Weiss R.M. A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder. Naunyn Schmiedebergs Arch Pharmacol 373 (2006) 349-359
-
(2006)
Naunyn Schmiedebergs Arch Pharmacol
, vol.373
, pp. 349-359
-
-
Tamarkin, F.J.1
Kang, W.S.2
Cohen, J.J.3
Wheeler, M.A.4
Weiss, R.M.5
-
86
-
-
23944480042
-
Scalaradial inhibition of epidermal growth factor receptor-mediated Akt phosphorylation is independent of secretory phospholipase A2
-
Xie Y., Liu L., Huang X., Guo Y.W., and Lou L. Scalaradial inhibition of epidermal growth factor receptor-mediated Akt phosphorylation is independent of secretory phospholipase A2. J Pharmacol Exp Ther 314 (2005) 1210-1217
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 1210-1217
-
-
Xie, Y.1
Liu, L.2
Huang, X.3
Guo, Y.W.4
Lou, L.5
-
87
-
-
0027034136
-
Phospholipase A2 inhibitors from marine organisms
-
Potts B.C., Faulkner D.J., and Jacobs R.S. Phospholipase A2 inhibitors from marine organisms. J Nat Prod 55 (1992) 1701-1717
-
(1992)
J Nat Prod
, vol.55
, pp. 1701-1717
-
-
Potts, B.C.1
Faulkner, D.J.2
Jacobs, R.S.3
-
89
-
-
33745761029
-
Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclo-oxygenase, NF-κB and other unidentified targets
-
Terracciano S., Rodriquez M., Aquino M., Monti M.C., Casapullo A., Riccio R., et al. Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclo-oxygenase, NF-κB and other unidentified targets. Curr Med Chem 13 (2006) 1947-1969
-
(2006)
Curr Med Chem
, vol.13
, pp. 1947-1969
-
-
Terracciano, S.1
Rodriquez, M.2
Aquino, M.3
Monti, M.C.4
Casapullo, A.5
Riccio, R.6
-
90
-
-
0032193215
-
Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappaB and expression of ICAM-1
-
Thommesen L., Sjursen W., Gasvik K., Hanssen W., Brekke O., Skattebol L., et al. Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappaB and expression of ICAM-1. J Immunol 161 (1998) 3421-3430
-
(1998)
J Immunol
, vol.161
, pp. 3421-3430
-
-
Thommesen, L.1
Sjursen, W.2
Gasvik, K.3
Hanssen, W.4
Brekke, O.5
Skattebol, L.6
-
91
-
-
18244399323
-
Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP
-
Yang L., Williams D.E., Mui A., Ong C.N., Krystal G., Van Soest R., et al. Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP. Org Lett 7 (2005) 1073-1076
-
(2005)
Org Lett
, vol.7
, pp. 1073-1076
-
-
Yang, L.1
Williams, D.E.2
Mui, A.3
Ong, C.N.4
Krystal, G.5
Van Soest, R.6
-
92
-
-
33748433789
-
Restoration of SHIP-1 activity in human leukemic cells modifies NF-κB activation pathway and cellular survival upon oxidative stress
-
Gloire G., Charlier E., Rahmouni S., Volanti C., Chariot A., Erneux C., et al. Restoration of SHIP-1 activity in human leukemic cells modifies NF-κB activation pathway and cellular survival upon oxidative stress. Oncogene 25 (2006) 5485-5494
-
(2006)
Oncogene
, vol.25
, pp. 5485-5494
-
-
Gloire, G.1
Charlier, E.2
Rahmouni, S.3
Volanti, C.4
Chariot, A.5
Erneux, C.6
-
94
-
-
1342311388
-
Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery
-
Salomon C.E., Magarvey N.A., and Sherman D.H. Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Nat Prod Rep 21 (2004) 105-121
-
(2004)
Nat Prod Rep
, vol.21
, pp. 105-121
-
-
Salomon, C.E.1
Magarvey, N.A.2
Sherman, D.H.3
-
95
-
-
33646012006
-
New methods for medicinal chemistry - universal gene cloning and expression systems for production of marine bioactive metabolites
-
Dunlap W.C., Jaspars M., Hranueli D., Battershill C.N., Peric-Concha N., Zucko J., et al. New methods for medicinal chemistry - universal gene cloning and expression systems for production of marine bioactive metabolites. Curr Med Chem 13 (2006) 697-710
-
(2006)
Curr Med Chem
, vol.13
, pp. 697-710
-
-
Dunlap, W.C.1
Jaspars, M.2
Hranueli, D.3
Battershill, C.N.4
Peric-Concha, N.5
Zucko, J.6
-
96
-
-
29344444077
-
Phenotypic taxonomy and metabolite profiling in microbial drug discovery
-
Larsen T., Smedsgaard J., Nielsen K., Hansen M., and Frisvad J. Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat Prod Rep 22 (2005) 672-695
-
(2005)
Nat Prod Rep
, vol.22
, pp. 672-695
-
-
Larsen, T.1
Smedsgaard, J.2
Nielsen, K.3
Hansen, M.4
Frisvad, J.5
|