Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies

Cancer

Volumn 104, Issue 9, 2005, Pages 1794-1807

  Ludwig, Heinz ^a,e   Khayat, David ^b   Giaccone, Giuseppe ^c   Facon, Thierry ^d  

^a First Department of Medicine and Medical Oncology   (Austria)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d LILLE UNIVERSITY HOSPITAL   (France)

^e 1st Dept of Medicine and Oncology   (Austria)

Author keywords

Apoptosis; Bortezomib; Cancer therapy; Proteasome; Proteasome inhibitor

Indexed keywords

ANTHRACYCLINE; BORTEZOMIB; CELL PROTEIN; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MELPHALAN; PREDNISONE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN BAX; PROTEIN P21; PROTEIN P27; PROTEIN P53; THALIDOMIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BLEEDING; CANCER CELL; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RESISTANCE; CANCER SURVIVAL; CELL CYCLE; CLINICAL TRIAL; DRUG MEGADOSE; DRUG SAFETY; ENZYME INHIBITION; FATIGUE; FEBRILE NEUTROPENIA; FLUID RETENTION; GASTROINTESTINAL SYMPTOM; HEMATOLOGIC MALIGNANCY; HUMAN; LEUKEMIA; LUNG NON SMALL CELL CANCER; MANTLE CELL LYMPHOMA; MONOTHERAPY; MUCOSA INFLAMMATION; MULTIPLE MYELOMA; NAUSEA; NEUROPATHY; NEUROTOXICITY; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; RASH; REVIEW; SIDE EFFECT; SOLID TUMOR; STEM CELL TRANSPLANTATION; THROMBOCYTOPENIA; TOXICITY; TREATMENT OUTCOME; TUMOR LYSIS SYNDROME; VOMITING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BORONIC ACIDS; CLINICAL TRIALS; HEMATOLOGIC NEOPLASMS; HUMANS; MODELS, MOLECULAR; MULTIPLE MYELOMA; NEOPLASMS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; TUMOR CELLS, CULTURED;

EID: 27244460815     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.21414     Document Type: Review

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