Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP

Organic Letters

Volumn 7, Issue 6, 2005, Pages 1073-1076

  Yang, Lu ^a   Williams, David E ^a   Mui, Alice ^b   Ong, Christopher ^b   Krystal, Gerald ^c   Van Soest, Rob ^d   Andersen, Raymond J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b JACK BELL RESEARCH CENTRE   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; FUNCTIONAL GROUP; INOSITOL 5 PHOSPHATASE SHIP; PELOROL; PHOSPHATASE; SCLAREOLIDE; TERPENOID; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; SPONGE (PORIFERA);

ANIMALS; ANTI-INFLAMMATORY AGENTS; DITERPENES; MICE; MODELS, ANIMAL; MOLECULAR STRUCTURE; PHOSPHORIC MONOESTER HYDROLASES; PORIFERA; SESQUITERPENES; STEREOISOMERISM;

EID: 18244399323     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol047316m     Document Type: Article

References (21)

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21. Pure compounds were tested at 5 μg/mL. In the SHIP assay, 22 showed >6-fold activation, whereas 1 and 21 showed ca. 2-fold activation. See Supporting Information for experimental details of the in vivo assays. A complete description of the biological activity of pelorol and the synthetic analogues will be published elsewhere.