-
1
-
-
0036434822
-
The role of structural genes in the pathogenesis of osteoarthritic disorders
-
Reginato AM, Olsen BR: The role of structural genes in the pathogenesis of osteoarthritic disorders. Arthritis. Res. 4, 337-345 (2002).
-
(2002)
Arthritis. Res
, vol.4
, pp. 337-345
-
-
Reginato, A.M.1
Olsen, B.R.2
-
2
-
-
0000774208
-
Heberden's nodes: Heredity in hypertrophic arthritis of finger joints
-
Stecher R: Heberden's nodes: heredity in hypertrophic arthritis of finger joints. Am. J. Med. Sci. 201, 801-809 (1941).
-
(1941)
Am. J. Med. Sci
, vol.201
, pp. 801-809
-
-
Stecher, R.1
-
3
-
-
0031810007
-
Familial aggregation of osteoarthritis: Data from the Baltimore Longitudinal Study on Aging
-
Hirsch R, Lethbridge-Cejku M, Hanson R et al.: Familial aggregation of osteoarthritis: data from the Baltimore Longitudinal Study on Aging. Arthritis Rheum. 41, 1227-1232 (1998).
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1227-1232
-
-
Hirsch, R.1
Lethbridge-Cejku, M.2
Hanson, R.3
-
5
-
-
0030786608
-
Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis
-
Chitnavis J, Sinsheimer JS, Clipsham K et al.: Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis. J. Bone Joint Surg. Br. 79, 660-664 (1997).
-
(1997)
J. Bone Joint Surg. Br
, vol.79
, pp. 660-664
-
-
Chitnavis, J.1
Sinsheimer, J.S.2
Clipsham, K.3
-
6
-
-
0034638651
-
Assessment of a genetic contribution to osteoarthritis of the hip: Sibling study
-
Lanyon P, Muir K, Doherty S, Doherty M: Assessment of a genetic contribution to osteoarthritis of the hip: sibling study. Br. Med. J. 321, 1179-1183 (2000).
-
(2000)
Br. Med. J
, vol.321
, pp. 1179-1183
-
-
Lanyon, P.1
Muir, K.2
Doherty, S.3
Doherty, M.4
-
7
-
-
4344697342
-
Genetic risk of knee osteoarthiritis: A sibling study
-
Neame RL, Muir K, Doherty S, Doherty M. Genetic risk of knee osteoarthiritis: a sibling study. Ann. Rheum. Dis. 63, 1022-1027 (2004).
-
(2004)
Ann. Rheum. Dis
, vol.63
, pp. 1022-1027
-
-
Neame, R.L.1
Muir, K.2
Doherty, S.3
Doherty, M.4
-
8
-
-
1542437233
-
Risk factors for osteoarthritis: Genetics
-
Spector TD, MacGregor AJ: Risk factors for osteoarthritis: genetics. Osteoarthr. Cartil. 12(Suppl. A), S39-S44 (2004).
-
(2004)
Osteoarthr. Cartil
, vol.12
, Issue.SUPPL. A
-
-
Spector, T.D.1
MacGregor, A.J.2
-
9
-
-
0029925223
-
Genetic influences on osteoarthritis in women: A twin study
-
Spector TD, Cicuttini F, Baker J, Loughlin J, Hart D: Genetic influences on osteoarthritis in women: a twin study. Br. Med. J. 312, 940-943 (1996).
-
(1996)
Br. Med. J
, vol.312
, pp. 940-943
-
-
Spector, T.D.1
Cicuttini, F.2
Baker, J.3
Loughlin, J.4
Hart, D.5
-
10
-
-
0033768503
-
The genetic contribution to radiographic hip osteoarthritis in women: Results of a classic twin study
-
MacGregor AJ, Antoniades L, Matson M, Andrew T, Spector TD: The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum. 43, 2410-2416 (2000).
-
(2000)
Arthritis Rheum
, vol.43
, pp. 2410-2416
-
-
MacGregor, A.J.1
Antoniades, L.2
Matson, M.3
Andrew, T.4
Spector, T.D.5
-
12
-
-
0035092827
-
Genetic epidemiology of primary osteoarthritis
-
Loughlin J: Genetic epidemiology of primary osteoarthritis. Curr. Opin. Rheumatol. 13, 111-116 (2001).
-
(2001)
Curr. Opin. Rheumatol
, vol.13
, pp. 111-116
-
-
Loughlin, J.1
-
13
-
-
0036255811
-
Candidate-gene approaches for studying complex genetic traits: Practical considerations
-
Tabor HK, Risch NJ, Myers RM: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat. Rev. Genet. 3, 391-397 (2002).
-
(2002)
Nat. Rev. Genet
, vol.3
, pp. 391-397
-
-
Tabor, H.K.1
Risch, N.J.2
Myers, R.M.3
-
14
-
-
25144480793
-
Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting
-
Loughlin J: Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting. Curr. Opin. Rheumatol. 17, 629-633 (2005).
-
(2005)
Curr. Opin. Rheumatol
, vol.17
, pp. 629-633
-
-
Loughlin, J.1
-
15
-
-
17044392213
-
Recent advances in the genetic investigation of osteoarthritis
-
Peach CA, Carr AJ, Loughlin J: Recent advances in the genetic investigation of osteoarthritis. Trends Mol. Med. 11, 186-191 (2005).
-
(2005)
Trends Mol. Med
, vol.11
, pp. 186-191
-
-
Peach, C.A.1
Carr, A.J.2
Loughlin, J.3
-
16
-
-
34548428772
-
Genetic association of complex traits: Using idiopathic scoliosis as an exarnple
-
Cheng JC, Tang NL, Yeung HY, Miller N: Genetic association of complex traits: using idiopathic scoliosis as an exarnple. Clin. Orthop. Relat. Res. 462, 38-44 (2007).
-
(2007)
Clin. Orthop. Relat. Res
, vol.462
, pp. 38-44
-
-
Cheng, J.C.1
Tang, N.L.2
Yeung, H.Y.3
Miller, N.4
-
17
-
-
34249997024
-
Replicating genotype-phenotype associations
-
NCI-NHGRI Working Group on Replication in Association Studies
-
NCI-NHGRI Working Group on Replication in Association Studies, Chanock SJ, Manolio T et al: Replicating genotype-phenotype associations. Nature 447, 655-660 (2007).
-
(2007)
Nature
, vol.447
, pp. 655-660
-
-
Chanock, S.J.1
Manolio, T.2
-
18
-
-
25844510235
-
Shaking the tree: Mapping complex disease genes with linkage disequilibrium
-
Palmer LJ, Cardon LR: Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 366, 1223-1234 (2005).
-
(2005)
Lancet
, vol.366
, pp. 1223-1234
-
-
Palmer, L.J.1
Cardon, L.R.2
-
19
-
-
3042709473
-
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females
-
Loughlin J, Dowling B, Chapman K et al.: Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc. Natl Acad. Sci. USA 101, 9757-9762 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 9757-9762
-
-
Loughlin, J.1
Dowling, B.2
Chapman, K.3
-
20
-
-
13944259791
-
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis
-
Kizawa H, Kou I, Iida A et al.: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat. Genet. 37, 138-144 (2005).
-
(2005)
Nat. Genet
, vol.37
, pp. 138-144
-
-
Kizawa, H.1
Kou, I.2
Iida, A.3
-
21
-
-
20244378239
-
A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthrids in Japanese
-
Mototani H, Mabuchi A, Saito S et al.: A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthrids in Japanese. Hum. Mol. Genet. 14, 1009-1017 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 1009-1017
-
-
Mototani, H.1
Mabuchi, A.2
Saito, S.3
-
22
-
-
34047103363
-
A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis
-
Miyamoto Y, Mabuchi A, Shi D et al.: A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat. Genet. 39, 529-533 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 529-533
-
-
Miyamoto, Y.1
Mabuchi, A.2
Shi, D.3
-
23
-
-
32444449863
-
Association between a variation in LRCH1 and knee osteoarthritis: A genome-wide single-nucleotide polymorphism association study using DNA pooling
-
Spector TD, Reneland RH, Mah S et al.: Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling. Arthritis Rheum. 54, 524-532 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, pp. 524-532
-
-
Spector, T.D.1
Reneland, R.H.2
Mah, S.3
-
24
-
-
33646045376
-
Cis- and trans-acting gene regulation is associated with osteoarthritis
-
Mahr S, Burmester GR, Hilke D et al.: Cis- and trans-acting gene regulation is associated with osteoarthritis. Am. J. Hum. Genet. 78, 793-803 (2006).
-
(2006)
Am. J. Hum. Genet
, vol.78
, pp. 793-803
-
-
Mahr, S.1
Burmester, G.R.2
Hilke, D.3
-
25
-
-
34250848174
-
In vivo analysis of Wnt signaling in bone
-
Glass DA 2nd, Karsenty G: In vivo analysis of Wnt signaling in bone. Endocrinology 148, 2630-2634 (2007).
-
(2007)
Endocrinology
, vol.148
, pp. 2630-2634
-
-
Glass 2nd, D.A.1
Karsenty, G.2
-
26
-
-
22244439199
-
Wnt influence on chondrocyte differentiation and cartilage function
-
Yates KE, Shortkroff S, Reish RG: Wnt influence on chondrocyte differentiation and cartilage function. DNA Cell Biol. 24, 446-457 (2005).
-
(2005)
DNA Cell Biol
, vol.24
, pp. 446-457
-
-
Yates, K.E.1
Shortkroff, S.2
Reish, R.G.3
-
27
-
-
0029959105
-
Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis
-
Hoang B, Moos M Jr, Vukicevic S, Luyten FP: Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J. Biol. Chem. 271, 26131-26137 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 26131-26137
-
-
Hoang, B.1
Moos Jr, M.2
Vukicevic, S.3
Luyten, F.P.4
-
28
-
-
33846267690
-
Allelic expression analysis suggests that cis- acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility
-
Snelling S, Ferreira A, Loughlin J: Allelic expression analysis suggests that cis- acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. Osteoarthr. Cartil. 15, 90-92 (2007).
-
(2007)
Osteoarthr. Cartil
, vol.15
, pp. 90-92
-
-
Snelling, S.1
Ferreira, A.2
Loughlin, J.3
-
29
-
-
33646372430
-
Frizzled-related protein variants are risk factors for hip osteoarthritis
-
Lane NE, Lian K, Nevitt MC et al.: Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum. 54, 1246-1254 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1246-1254
-
-
Lane, N.E.1
Lian, K.2
Nevitt, M.C.3
-
30
-
-
17244374729
-
Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites
-
Min JL, Meulenbelt I, Riyazi N et al.: Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum. 52, 1077-1080 (2005).
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1077-1080
-
-
Min, J.L.1
Meulenbelt, I.2
Riyazi, N.3
-
31
-
-
34447621655
-
Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis
-
Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A: Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Ann. Rheum. Dis. 66, 1052-1055 (2007).
-
(2007)
Ann. Rheum. Dis
, vol.66
, pp. 1052-1055
-
-
Rodriguez-Lopez, J.1
Pombo-Suarez, M.2
Liz, M.3
Gomez-Reino, J.J.4
Gonzalez, A.5
-
32
-
-
29844457588
-
Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis
-
Lories RJ, Boonen S, Peetess J, de Vlam K, Luyten FP: Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology 45, 113-114 (2006).
-
(2006)
Rheumatology
, vol.45
, pp. 113-114
-
-
Lories, R.J.1
Boonen, S.2
Peetess, J.3
de Vlam, K.4
Luyten, F.P.5
-
33
-
-
34848913487
-
The functional genetic variant Arg324Gly of frizzled-related protein (FRZB) is associated with colorectal cancer risk
-
Shanmugam KS, Brenner H, Hoffmeister M, Chang-Claude J, Burwinkel B: The functional genetic variant Arg324Gly of frizzled-related protein (FRZB) is associated with colorectal cancer risk. Carcinogenesis 28, 1914-1917 (2007).
-
(2007)
Carcinogenesis
, vol.28
, pp. 1914-1917
-
-
Shanmugam, K.S.1
Brenner, H.2
Hoffmeister, M.3
Chang-Claude, J.4
Burwinkel, B.5
-
34
-
-
0035853783
-
Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan
-
Lorenzo P, Aspberg A, Onnerfjord P, Bayliss MT, Neame PJ, Heinegard D: Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan. J. Biol. Chem. 276, 12201-12211 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 12201-12211
-
-
Lorenzo, P.1
Aspberg, A.2
Onnerfjord, P.3
Bayliss, M.T.4
Neame, P.J.5
Heinegard, D.6
-
35
-
-
0035853794
-
Expression pattern and gene characterization of asporin. A newly discovered member of the leucine-rich repeat protein family
-
Henry SP, Takanosu M, Boyd TC et al.: Expression pattern and gene characterization of asporin. A newly discovered member of the leucine-rich repeat protein family. J. Biol. Chem. 276, 12212-12221 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 12212-12221
-
-
Henry, S.P.1
Takanosu, M.2
Boyd, T.C.3
-
36
-
-
0035168796
-
Proteoglycans of the extracellular matrix and growth control
-
Kresse H, Schonherr E: Proteoglycans of the extracellular matrix and growth control. J. Cell. Physiol. 189, 266-274 (2001).
-
(2001)
J. Cell. Physiol
, vol.189
, pp. 266-274
-
-
Kresse, H.1
Schonherr, E.2
-
37
-
-
0036744260
-
Mice deficient in small leucine-rich proteoglycans: Novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases
-
Ameye L, Young MF: Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases. Glycobiology 12, 107R-116R (2002).
-
(2002)
Glycobiology
, vol.12
-
-
Ameye, L.1
Young, M.F.2
-
38
-
-
21444439016
-
Osteoarthritis? Try asporin
-
Cobrun B: Osteoarthritis? Try asporin. Clin. Genet. 67, 394-395 (2005).
-
(2005)
Clin. Genet
, vol.67
, pp. 394-395
-
-
Cobrun, B.1
-
39
-
-
27744578869
-
Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population
-
Mustafa Z, Dowling B, Chapman K, Sinsheimer JS, Carr A, Loughlin J: Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. Arthritis Rheum. 52, 3502-3506 (2005).
-
(2005)
Arthritis Rheum
, vol.52
, pp. 3502-3506
-
-
Mustafa, Z.1
Dowling, B.2
Chapman, K.3
Sinsheimer, J.S.4
Carr, A.5
Loughlin, J.6
-
40
-
-
33646777114
-
Asporin and knee osteoarthritis in patients of Greek origin
-
Kaliakatsos M, Tzetis M, Kanavakis E et al.: Asporin and knee osteoarthritis in patients of Greek origin. Osteoarthr. Cartil. 14, 609-611 (2006).
-
(2006)
Osteoarthr. Cartil
, vol.14
, pp. 609-611
-
-
Kaliakatsos, M.1
Tzetis, M.2
Kanavakis, E.3
-
41
-
-
34247551093
-
Lack, of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: Case-control studies in Spanish Caucasians
-
Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A: Lack, of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Arthritis Res. Ther. 8, R55 (2006).
-
(2006)
Arthritis Res. Ther
, vol.8
-
-
Rodriguez-Lopez, J.1
Pombo-Suarez, M.2
Liz, M.3
Gomez-Reino, J.J.4
Gonzalez, A.5
-
42
-
-
33751300226
-
Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese
-
Jiang Q, Shi D, Yi L et al.: Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese. J. Hum. Genet. 51, 1068-1072 (2006).
-
(2006)
J. Hum. Genet
, vol.51
, pp. 1068-1072
-
-
Jiang, Q.1
Shi, D.2
Yi, L.3
-
43
-
-
0035179971
-
Replication validity of genetic association studies
-
Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG: Replication validity of genetic association studies. Nat. Genet. 29, 306-309 (2001).
-
(2001)
Nat. Genet
, vol.29
, pp. 306-309
-
-
Ioannidis, J.P.1
Ntzani, E.E.2
Trikalinos, T.A.3
Contopoulos-Ioannidis, D.G.4
-
44
-
-
33748552008
-
Replication of association of the D-repeat polymorphism in asporin with osteorarthritis
-
Ikegawa S, Kawamura S, Takahashi A, Nakamura T, Kamatani N: Replication of association of the D-repeat polymorphism in asporin with osteorarthritis. Arthritis Res. Ther. 8, 403 (2006).
-
(2006)
Arthritis Res. Ther
, vol.8
, pp. 403
-
-
Ikegawa, S.1
Kawamura, S.2
Takahashi, A.3
Nakamura, T.4
Kamatani, N.5
-
45
-
-
34547790324
-
Meta-analysis of association between the ASPN D-repeat and osteoarthritis
-
Nakamura T, Shi D, Tzetis M et al.: Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum. Mol. Genet. 16, 1676-1678 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 1676-1678
-
-
Nakamura, T.1
Shi, D.2
Tzetis, M.3
-
46
-
-
0032501730
-
Summing up evidence: One answer is not always enough
-
Lau J, Ioannidis JP, Schmid CH: Summing up evidence: one answer is not always enough. Lancet 351, 123-127 (1998).
-
(1998)
Lancet
, vol.351
, pp. 123-127
-
-
Lau, J.1
Ioannidis, J.P.2
Schmid, C.H.3
-
47
-
-
0036069381
-
Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: The Beijing osteoarthritis study
-
Nevitt MC, Xu L, Zhang Y et al.: Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum. 46, 1773-1779 (2002).
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1773-1779
-
-
Nevitt, M.C.1
Xu, L.2
Zhang, Y.3
-
48
-
-
0028793818
-
Hip osteoarthritis and dysplasia in Chinese men
-
Lau EM, Lin F, Lam D, Silman A, Croft P: Hip osteoarthritis and dysplasia in Chinese men. Ann. Rheum. Dis. 54, 965-969 (1995).
-
(1995)
Ann. Rheum. Dis
, vol.54
, pp. 965-969
-
-
Lau, E.M.1
Lin, F.2
Lam, D.3
Silman, A.4
Croft, P.5
-
49
-
-
0031729375
-
Acetabular dysplasia and hip osteoarthritis in Britain and Japan
-
Yoshimura N, Campbell L, Hashimoto T et al.: Acetabular dysplasia and hip osteoarthritis in Britain and Japan. Br. J. Rheumatol. 37, 1193-1197 (1998).
-
(1998)
Br. J. Rheumatol
, vol.37
, pp. 1193-1197
-
-
Yoshimura, N.1
Campbell, L.2
Hashimoto, T.3
-
50
-
-
4644358680
-
Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis
-
Hatakeyama Y, Tuan RS, Shum L: Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis. J. Cell. Biochem. 91, 1204-1217 (2004).
-
(2004)
J. Cell. Biochem
, vol.91
, pp. 1204-1217
-
-
Hatakeyama, Y.1
Tuan, R.S.2
Shum, L.3
-
51
-
-
0034128748
-
-
Ducy P, Karsenty G: The family of bone morphogenetic proteins. kidney Int. 57, 2207-2214 (2000).
-
Ducy P, Karsenty G: The family of bone morphogenetic proteins. kidney Int. 57, 2207-2214 (2000).
-
-
-
-
52
-
-
0031918786
-
Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis
-
Erlacher L, McCartney J, Piek E et al.: Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. J. Bone Miner. Res. 13, 383-392 (1998).
-
(1998)
J. Bone Miner. Res
, vol.13
, pp. 383-392
-
-
Erlacher, L.1
McCartney, J.2
Piek, E.3
-
53
-
-
8944240374
-
Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for the skeletal development of limbs
-
Hötten GC, Matsumoto T, Kimura M et al.: Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for the skeletal development of limbs. Growth Factors 13, 65-74 (1996).
-
(1996)
Growth Factors
, vol.13
, pp. 65-74
-
-
Hötten, G.C.1
Matsumoto, T.2
Kimura, M.3
-
54
-
-
0031911668
-
Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro
-
Erlacher L, Ng CK, Ullrich R, Krieger S, Luyten FP: Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arthritis Rheum. 41, 263-273 (1998).
-
(1998)
Arthritis Rheum
, vol.41
, pp. 263-273
-
-
Erlacher, L.1
Ng, C.K.2
Ullrich, R.3
Krieger, S.4
Luyten, F.P.5
-
55
-
-
0030742587
-
Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-β gene family
-
Wolfinan NM, Hattersley G, Cox K et al.: Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-β gene family. J. Clin. Invest. 100, 321-330 (1997).
-
(1997)
J. Clin. Invest
, vol.100
, pp. 321-330
-
-
Wolfinan, N.M.1
Hattersley, G.2
Cox, K.3
-
56
-
-
0034122107
-
Bone morphogenetic proteins and skeletal development: The kidney-bone connection
-
Reddi AH: Bone morphogenetic proteins and skeletal development: the kidney-bone connection. Pediatr. Nephrol. 14, 598-601 (2000).
-
(2000)
Pediatr. Nephrol
, vol.14
, pp. 598-601
-
-
Reddi, A.H.1
-
57
-
-
2942525503
-
Multiple effects of GDF-5 deficiency on skeletal tissues: Implications for therapeutic bioengineering
-
Mikic B: Multiple effects of GDF-5 deficiency on skeletal tissues: implications for therapeutic bioengineering. Ann. Biomed. Eng. 32, 466-476 (2004).
-
(2004)
Ann. Biomed. Eng
, vol.32
, pp. 466-476
-
-
Mikic, B.1
-
58
-
-
0031230465
-
Mutations in CDMP1 cause autosomal dominant brachydactyly type C
-
Polinkovsky A, Robin NH, Thomas JT et al.: Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nat. Genet. 17, 18-19 (1997).
-
(1997)
Nat. Genet
, vol.17
, pp. 18-19
-
-
Polinkovsky, A.1
Robin, N.H.2
Thomas, J.T.3
-
59
-
-
0029936784
-
A human chondrodysplasia due to a mutation in a TGF-β superfamily member
-
Thomas JT, Lin K, Nandedkar M, Camargo M, Cervenka J, Luyten FP: A human chondrodysplasia due to a mutation in a TGF-β superfamily member. Nat. Genet. 12, 315-317 (1996).
-
(1996)
Nat. Genet
, vol.12
, pp. 315-317
-
-
Thomas, J.T.1
Lin, K.2
Nandedkar, M.3
Camargo, M.4
Cervenka, J.5
Luyten, F.P.6
-
60
-
-
0030763771
-
Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
-
Thomas JT, Kilpatrick MW, Lin K et al.: Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat. Genet. 17, 58-64 (1997).
-
(1997)
Nat. Genet
, vol.17
, pp. 58-64
-
-
Thomas, J.T.1
Kilpatrick, M.W.2
Lin, K.3
-
61
-
-
19444375694
-
Angel-shaped phalangeal dysplasia, hip dysplasia, and positional teeth abnormalities are part of the brachydactyly C spectrum associated with CDMP-1 mutations
-
Holder-Espinasse M, Escande F, Mayrargue E et al.: Angel-shaped phalangeal dysplasia, hip dysplasia, and positional teeth abnormalities are part of the brachydactyly C spectrum associated with CDMP-1 mutations. J. Med. Genet. 41, e78 (2004).
-
(2004)
J. Med. Genet
, vol.41
-
-
Holder-Espinasse, M.1
Escande, F.2
Mayrargue, E.3
-
62
-
-
0036879462
-
Total hip arthroplasty for a patient with angel-shaped phalango-epiphyseal dysplasia (ASPED). A case report
-
Warashina H, Sakano S, Kitamura S, Yamauchi K, Kito H, Hasegawa Y: Total hip arthroplasty for a patient with angel-shaped phalango-epiphyseal dysplasia (ASPED). A case report. Nagoya J. Med. Sci. 65, 103-107 (2002).
-
(2002)
Nagoya J. Med. Sci
, vol.65
, pp. 103-107
-
-
Warashina, H.1
Sakano, S.2
Kitamura, S.3
Yamauchi, K.4
Kito, H.5
Hasegawa, Y.6
-
63
-
-
34548409926
-
A SNP in the 5′ UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
-
Southam L, Rodriguez-Lopez J, Wilkins JM et al.: A SNP in the 5′ UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage. Hum. Mol. Genet. 16, 2226-2232 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 2226-2232
-
-
Southam, L.1
Rodriguez-Lopez, J.2
Wilkins, J.M.3
-
64
-
-
34548181316
-
PLAP-1/asporin: A novel negative regulator of periodontal ligament mineralization
-
Yamada S, Tomoeda M, Ozawa Y et al.: PLAP-1/asporin: A novel negative regulator of periodontal ligament mineralization. J. Biol. Chem. 282, 23070-23080 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 23070-23080
-
-
Yamada, S.1
Tomoeda, M.2
Ozawa, Y.3
-
65
-
-
0033178337
-
p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells
-
Nakamura K, Shirai T, Morishita S, Uchida S, Saeki-Miura K, Makishima F: p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells. Exp. Cell Res. 250, 351-363 (1999).
-
(1999)
Exp. Cell Res
, vol.250
, pp. 351-363
-
-
Nakamura, K.1
Shirai, T.2
Morishita, S.3
Uchida, S.4
Saeki-Miura, K.5
Makishima, F.6
-
66
-
-
33645796954
-
Monomeric and dimeric GDF5 show equal type I receptor binding and oligomerization capability and have the same biological activity
-
Sieber C, Ploger F, Schwappacher R et al.: Monomeric and dimeric GDF5 show equal type I receptor binding and oligomerization capability and have the same biological activity. Biol. Chem. 387, 451-460 (2006).
-
(2006)
Biol. Chem
, vol.387
, pp. 451-460
-
-
Sieber, C.1
Ploger, F.2
Schwappacher, R.3
-
67
-
-
34247851097
-
Wnt3a binds to several sFRPs in the nanomolar range
-
Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L: Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357, 1119-1123 (2007).
-
(2007)
Biochem. Biophys. Res. Commun
, vol.357
, pp. 1119-1123
-
-
Wawrzak, D.1
Metioui, M.2
Willems, E.3
Hendrickx, M.4
de Genst, E.5
Leyns, L.6
-
68
-
-
34249664330
-
Wnt5a fuctions in planar cell polarity regulation in mice
-
Qian D, Jones C, Rzadzinska A et al.: Wnt5a fuctions in planar cell polarity regulation in mice. Dev. Biol. 306, 121-133 (2007).
-
(2007)
Dev. Biol
, vol.306
, pp. 121-133
-
-
Qian, D.1
Jones, C.2
Rzadzinska, A.3
-
69
-
-
11844273942
-
Frzb modulates Wnt-9a-mediated β-catenin signaling during avian atrioventricular cardiac cushion development
-
Person AD, Garriock RJ, Krieg PA, Runyan RB, Klewer SE: Frzb modulates Wnt-9a-mediated β-catenin signaling during avian atrioventricular cardiac cushion development. Dev. Biol. 278, 35-48 (2005).
-
(2005)
Dev. Biol
, vol.278
, pp. 35-48
-
-
Person, A.D.1
Garriock, R.J.2
Krieg, P.A.3
Runyan, R.B.4
Klewer, S.E.5
-
70
-
-
2542577369
-
Cooperation between TGF-β and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells
-
Zhou S, Eid K, Glowacki J: Cooperation between TGF-β and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J. Bone Miner. Res. 19, 463-470 (2004).
-
(2004)
J. Bone Miner. Res
, vol.19
, pp. 463-470
-
-
Zhou, S.1
Eid, K.2
Glowacki, J.3
-
71
-
-
33846987195
-
β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation
-
Chen Y, Whetstone HC, Youn A et al.: β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. J Mol. Chem. 282, 526-533 (2007).
-
(2007)
J Mol. Chem
, vol.282
, pp. 526-533
-
-
Chen, Y.1
Whetstone, H.C.2
Youn, A.3
-
72
-
-
4644276225
-
Wnt/ β-catenin signaling is sufficient and necessary for synovial joint formation
-
Guo X, Day TF, Jiang X, Garrett-Beal L, Topol L, Yang Y: Wnt/ β-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 18, 2404-2417 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 2404-2417
-
-
Guo, X.1
Day, T.F.2
Jiang, X.3
Garrett-Beal, L.4
Topol, L.5
Yang, Y.6
-
73
-
-
33644982685
-
The Wnt-inducible transcription factor Twistl inhibits chondrogenesis
-
Reinhold MI, Kapadia RM, Liao Z, Naski MC: The Wnt-inducible transcription factor Twistl inhibits chondrogenesis. J. Biol. Chem. 281, 1381-1388 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1381-1388
-
-
Reinhold, M.I.1
Kapadia, R.M.2
Liao, Z.3
Naski, M.C.4
-
74
-
-
0033027322
-
Involvement of Wnt-5a in chondrogenic pattern formation in the chick limb bud
-
Kawakami Y, Wada N, Nishimatsu SI, Ishikawa T, Noji S, Nohno T: Involvement of Wnt-5a in chondrogenic pattern formation in the chick limb bud. Dev. Growth Differ. 41, 29-40 (1999).
-
(1999)
Dev. Growth Differ
, vol.41
, pp. 29-40
-
-
Kawakami, Y.1
Wada, N.2
Nishimatsu, S.I.3
Ishikawa, T.4
Noji, S.5
Nohno, T.6
-
75
-
-
33748148734
-
Wnt9a signaling is required for joint integrity aad regulation of Ihh during chondrogenesis
-
Spater D, Hill TP, O'Sullivan RJ, Gruber M, Conner DA, Hartmann C: Wnt9a signaling is required for joint integrity aad regulation of Ihh during chondrogenesis. Development 133, 3039-3049 (2006).
-
(2006)
Development
, vol.133
, pp. 3039-3049
-
-
Spater, D.1
Hill, T.P.2
O'Sullivan, R.J.3
Gruber, M.4
Conner, D.A.5
Hartmann, C.6
-
76
-
-
34447526524
-
Chondrogenic differentiation of bovine synovium: Bone morphogenetic proteins 2 and 7 and transfarming growth factor β1 induce the formation of different types of cartilaginous tissue
-
Shintani N, Hunziker EB: Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transfarming growth factor β1 induce the formation of different types of cartilaginous tissue. Arthritis Rheum. 56, 1869-1879 (2007).
-
(2007)
Arthritis Rheum
, vol.56
, pp. 1869-1879
-
-
Shintani, N.1
Hunziker, E.B.2
-
77
-
-
24744456615
-
Tramforming growth factor-β1 (TGF-β1) regulates ATDC5 chondrogenic differenriation and fibronectin isoform expression
-
Han F, Adams CS, Tao Z et al.: Tramforming growth factor-β1 (TGF-β1) regulates ATDC5 chondrogenic differenriation and fibronectin isoform expression. J. Cell. Biochem. 95, 750-762 (2005).
-
(2005)
J. Cell. Biochem
, vol.95
, pp. 750-762
-
-
Han, F.1
Adams, C.S.2
Tao, Z.3
-
78
-
-
0031032181
-
Differential effects of transforming growth factors β 1, β 2, β 3 and β 5 on chondrogenesis in mouse limb bud mesenchymal cells
-
Chimal-Monroy J, Diaz de Leon L: Differential effects of transforming growth factors β 1, β 2, β 3 and β 5 on chondrogenesis in mouse limb bud mesenchymal cells. Int. J. Dev. Biol. 41, 91-102 (1997).
-
(1997)
Int. J. Dev. Biol
, vol.41
, pp. 91-102
-
-
Chimal-Monroy, J.1
Diaz de Leon, L.2
-
79
-
-
34248181957
-
Adeno-associated viral gene transfer of transforming growth factor-βl to human mesenchymal stem cells improves cartilage repair
-
Pagnotto MR, Wang Z, Karpie JC, Ferretti M, Xiao Y, Chu CR: Adeno-associated viral gene transfer of transforming growth factor-βl to human mesenchymal stem cells improves cartilage repair. Gene Ther. 14, 804-813 (2007).
-
(2007)
Gene Ther
, vol.14
, pp. 804-813
-
-
Pagnotto, M.R.1
Wang, Z.2
Karpie, J.C.3
Ferretti, M.4
Xiao, Y.5
Chu, C.R.6
-
80
-
-
0031570755
-
Mechanical loading and TGF-β regulate proteoglycan synthesis in tendon
-
Robbins JR, Evanko SP, Vogel KG: Mechanical loading and TGF-β regulate proteoglycan synthesis in tendon. Arch. Biochem. Bioplys. 342, 203-211 (1997).
-
(1997)
Arch. Biochem. Bioplys
, vol.342
, pp. 203-211
-
-
Robbins, J.R.1
Evanko, S.P.2
Vogel, K.G.3
-
81
-
-
0030198962
-
Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor β
-
Spindler KP, Imro AK, Mayes CE, Davidson JM: Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor β. J. Orthop. Res. 14, 542-546 (1996).
-
(1996)
J. Orthop. Res
, vol.14
, pp. 542-546
-
-
Spindler, K.P.1
Imro, A.K.2
Mayes, C.E.3
Davidson, J.M.4
-
82
-
-
2442489944
-
Transforming growth Factor-β 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx
-
Selvamurugan N, Kwok S, Alliston T, Reiss M, Partridge NC: Transforming growth Factor-β 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx:2. J. Mol. Chem. 279, 19327-19334 (2004).
-
(2004)
J. Mol. Chem
, vol.2
-
-
Selvamurugan, N.1
Kwok, S.2
Alliston, T.3
Reiss, M.4
Partridge, N.C.5
-
83
-
-
0141593471
-
Growth/differentiation factor 5 enhances chondrocyte maturation
-
Coleman CM, Tuan RS: Growth/differentiation factor 5 enhances chondrocyte maturation. Dev. Dyn. 228, 208-216 (2003).
-
(2003)
Dev. Dyn
, vol.228
, pp. 208-216
-
-
Coleman, C.M.1
Tuan, R.S.2
-
84
-
-
0032905901
-
Mechanisms of GDF5 action during skeletal development
-
Francis-West PH, Abdelfattah A, Chen P et al.: Mechanisms of GDF5 action during skeletal development. Development 126, 1305-1315 (1999).
-
(1999)
Development
, vol.126
, pp. 1305-1315
-
-
Francis-West, P.H.1
Abdelfattah, A.2
Chen, P.3
-
85
-
-
33645118695
-
Adenovirus-mediated gene transfer of growth and differentiation factor-5 into tenocytes; and the healing rat Achilles tendon
-
Rickert M, Wang H, Wieloch P et al.: Adenovirus-mediated gene transfer of growth and differentiation factor-5 into tenocytes; and the healing rat Achilles tendon. Connect. Tissue Res. 46, 175-183 (2005).
-
(2005)
Connect. Tissue Res
, vol.46
, pp. 175-183
-
-
Rickert, M.1
Wang, H.2
Wieloch, P.3
-
86
-
-
0344304448
-
Effects of growth/ differentiation factor-5 on human periodontal ligament cells
-
Nakamura T, Yamamoto M, Tamura M, Izumi Y. Effects of growth/ differentiation factor-5 on human periodontal ligament cells. J. Periodontal Res. 38, 597-605 (2003).
-
(2003)
J. Periodontal Res
, vol.38
, pp. 597-605
-
-
Nakamura, T.1
Yamamoto, M.2
Tamura, M.3
Izumi, Y.4
-
87
-
-
0042889115
-
GDF5 deficiency in mice delays Achilles tendon healing
-
Chhabra A, Tsou D, Clark RT, Gaschen V, Hunziker EB, Mikic B: GDF5 deficiency in mice delays Achilles tendon healing. J. Orthop Res. 21, 826-835 (2003).
-
(2003)
J. Orthop Res
, vol.21
, pp. 826-835
-
-
Chhabra, A.1
Tsou, D.2
Clark, R.T.3
Gaschen, V.4
Hunziker, E.B.5
Mikic, B.6
-
88
-
-
0033178337
-
p38 mitogen-activated protein kinase funtionally contributes to chondrogenesis induced by growth/differendation factor-5 in ATDC5 cells
-
Nakamura K, Shirai T, Morishita S, Uchida S, Saeki-Miura K, Makishima F: p38 mitogen-activated protein kinase funtionally contributes to chondrogenesis induced by growth/differendation factor-5 in ATDC5 cells. Exp. Cell Res. 250, 351-363 (1999).
-
(1999)
Exp. Cell Res
, vol.250
, pp. 351-363
-
-
Nakamura, K.1
Shirai, T.2
Morishita, S.3
Uchida, S.4
Saeki-Miura, K.5
Makishima, F.6
-
89
-
-
10244267459
-
Modulation of GDF5/BR1-P signalling through interaction with the tyrosine kinase receptor Ror2
-
Sammar M, Stricker S, Schwabe GC et al.: Modulation of GDF5/BR1-P signalling through interaction with the tyrosine kinase receptor Ror2. Genes Cells 9, 1227-1238 (2004).
-
(2004)
Genes Cells
, vol.9
, pp. 1227-1238
-
-
Sammar, M.1
Stricker, S.2
Schwabe, G.C.3
-
90
-
-
33846069310
-
BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway
-
Jin EJ, Lee SY. Choi YA, Jung JC, Bang OS, Kang SS: BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol. Cells 22, 353-359 (2006).
-
(2006)
Mol. Cells
, vol.22
, pp. 353-359
-
-
Jin, E.J.1
Lee, S.Y.2
Choi, Y.A.3
Jung, J.C.4
Bang, O.S.5
Kang, S.S.6
-
91
-
-
33846987195
-
β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation
-
Chen Y, Whetstone HC, Youn A et al.: β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. J. Biol. Chem. 282, 526-533 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 526-533
-
-
Chen, Y.1
Whetstone, H.C.2
Youn, A.3
-
92
-
-
7244245762
-
Finishing the euchromatic sequence of the human genome
-
International Human Genome Sequencing Consortium
-
International Human Genome Sequencing Consortium: Finishing the euchromatic sequence of the human genome. Nature 431, 931-945 (2004).
-
(2004)
Nature
, vol.431
, pp. 931-945
-
-
-
93
-
-
0035865322
-
A map of human genome sequence variation containing 1.42 million single nucleodde polymorphisms
-
Sachidanandam R, Weissman D, Schmidt SC et al.: A map of human genome sequence variation containing 1.42 million single nucleodde polymorphisms. Nature 409, 928-933 (2001).
-
(2001)
Nature
, vol.409
, pp. 928-933
-
-
Sachidanandam, R.1
Weissman, D.2
Schmidt, S.C.3
-
94
-
-
0034612015
-
Waiting for the working draft from the human genome project. A huge achievement, but not of immediate medical use
-
Cardon LR, Watkins H: Waiting for the working draft from the human genome project. A huge achievement, but not of immediate medical use. Br. Med. J. 320, 1223-1224 (2000).
-
(2000)
Br. Med. J
, vol.320
, pp. 1223-1224
-
-
Cardon, L.R.1
Watkins, H.2
-
95
-
-
79959503826
-
The International HapMap Project
-
The International HapMap Consortium
-
The International HapMap Consortium: The International HapMap Project. Nature 426, 789-796 (2003).
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
96
-
-
33745279056
-
Evaluating coverage of genome-wide association studies
-
Barrett JC, Cardon LR: Evaluating coverage of genome-wide association studies. Nat. Genet. 38, 659-662 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 659-662
-
-
Barrett, J.C.1
Cardon, L.R.2
-
97
-
-
33745279392
-
Evaluating and improving power in whole-genome association studies using fixed marker sets
-
Peer I, de Bakker PI, Maller J, Yelensky R, Altshuler D, Daly MJ: Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat. Genet. 38, 663-667 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 663-667
-
-
Peer, I.1
de Bakker, P.I.2
Maller, J.3
Yelensky, R.4
Altshuler, D.5
Daly, M.J.6
-
98
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
99
-
-
34250305146
-
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
-
ENCODE Project Consortium
-
ENCODE Project Consortium: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816 (2007).
-
(2007)
Nature
, vol.447
, pp. 799-816
-
-
-
100
-
-
15044364239
-
Regulatory polymorphisms underlying complex disease traits
-
Knight JC: Regulatory polymorphisms underlying complex disease traits. J. Mol. Med. 83, 97-109 (2005).
-
(2005)
J. Mol. Med
, vol.83
, pp. 97-109
-
-
Knight, J.C.1
|