Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-β gene family

Journal of Clinical Investigation

Volumn 100, Issue 2, 1997, Pages 321-330

  Wolfman, Neil M ^a   Hattersley, Gary ^a   Cox, Karen ^a   Celeste, Anthony J ^a   Nelson, Robin ^a,b   Yamaji, Noboru ^a,c   Dube, Jennifer L ^a   DiBlasio Smith, Elizabeth ^a   Nove, John ^a   Song, Jeffrey J ^a   Wozney, John M ^a   Rosen, Vicki ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

Bone morphogenic proteins; Ligament; Orthopedics; Tendon; Tissue repair

Indexed keywords

BONE MORPHOGENETIC PROTEIN; DIFFERENTIATION INDUCING FACTOR; GROWTH FACTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIGAMENT; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RAT; TENDON; TISSUE INDUCTION;

EID: 0030742587     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119537     Document Type: Article

References (40)

1. Daniel, R.K., and W.C. Breidenbach. 1982. Tendon: structure, organization, and healing. In The Musculoskeletal System. Embryology, Biochemistry, and Physiology. R.L. Cruess, editor. Churchill Livingston, New York. 383-399.
2. Byers, P.D. 1994. Histological features of connective tissues. In Diseases of Bones and Joints: Cell Biology, Mechanism and Pathology. J.R. Salisbury, C.G. Woods, and P.D. Byers, editors. Chapman and Hall Medical, London. 476-508.
3. Amiel, D., E. Billings, Jr., and W.H. Akeson. 1990. Ligament structure, chemistry, and physiology. In Knee Ligaments: Structure, Function, Injury and Repair. D. Daniel, W.H. Akeson, and J. O'Connor, editors. Raven Press Ltd., New York. 77-94.
4. Hurle, J.M., M.A. Ros, Y. Ganan, D. Macias, M. Critchlow, and J.R. Hinchliffe. 1990. Experimental analysis of the role of ECM in the patterning of the distal tendons of the developing limb bud. Cell Differ. Dev. 30:97-108.
5. Matyas, J.R., M.G. Anton, N.G. Shrive, and C.B. Frank. 1995. Stress governs tissue phenotype at the femoral insertion of the rabbit MCL. J. Biomech. 28:147-157.
6. Ralphs. J.R., R.N.S. Tyers, and M. Benjamin. 1992. Development of functionally distinct fibrocartilages at two sites in the quadriceps tendon of the rat: the suprapatella and the attachment to the patella. Anat. Embryol. 185:181-187.
7. Oliver, G., R. Wehr, N.A. Jenkins, N.G. Copeland, B.N.R. Cheyette, V. Hartenstein, S.L. Zipursky, and P. Gruss. 1995. Homeobox genes and connective tissue patterning. Development. 121:693-705.
8. Ginsburg, G.T., D. Royster, G. Kassabian, G.F. Shuler, W.R. Dougherty, and A.C. Sank. 1995. Mesenchymal commitment to digital joint formation. Ann Plast. Surg. 35:95-104.
9. Favier, B., F.M. Rijli, C. Fromental-Ramain, V. Fraulob, P. Chambon, and P. Dolle. 1996. Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. Development. 122:449-460.
10. Schmidt, C.C., H.I. Georgescu, C.K. Kwoh, G.L. Blomstrom, C.P. Engle, L.A. Larkin, C.H. Evans, and S.L.-Y. Woo. 1995. Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments. J. Orthop. Res. 13:184-190.
11. Conti, N.A., and L.E. Dahners. 1993. The effect of exogenous growth factors on ligament healing. Trans. Orthop. Res. Soc. 18:60.
12. Letson, A.K., and L.E. Dahners. 1994. The effect of combinations of growth factors on ligament healing. Clin. Orthop. Relat. Res. 308:207-212.
13. Caubaud, J.E., W.G. Rodkey, and J.A. Feagin. 1979. Experimental studies of acute anterior cruciate ligament injury and repair. Am. J. Sports Med. 7: 18-22.
14. Amiel, D., J.B. Kleiner, and W.H. Akeson. 1986. The natural history of the anterior cruciate ligament autograft of patellar tendon origin. Am. J. Sports Med. 14:449-462.
15. Amiel, D., S. Kulper, and W.H. Akeson. 1990. Cruciate ligaments. Response to injury. In Knee Ligaments: Structure, Function, Injury and Repair. D. Daniel, W.H. Akeson, and J. O'Connor, editors. Raven Press Ltd., New York. 365-377.
16. Nakamura, N., S. Horibe, N. Matsumoto, T. Tomita, T. Natsuume, Y. Kaneda, K. Shino, and T. Ochi. 1996. Transient introduction of a foreign gene into healing rat patellar ligament. J. Clin. Invest. 97:226-231.
17. Hotten, G., H. Neidhardt, B. Jacobwsky, and J. Pohl. 1994. Cloning and expression of recombinant human growth/differentiation factor 5. Biochem. Biophys. Res. Commum. 204:646-652.
18. Wolfman, N.M., A.J. Celeste, K. Cox, G. Hattersley, R. Nelson, N. Yamaji, E. DiBlasio-Smith, J. Nove, J.J. Song, J.M. Wozney, and V. Rosen. 1995. Preliminary characterization of the biological activities of rhBMP-12. J. Bone Miner. Res. 10:s148.
19. Storm, E.E., T.V. Huynh, N.G. Copeland, N.A. Jenkins, D.M. Kingsley, and S.-J. Lee. 1994. Limb alterations in brachypodism mice due to mutations in a new member of the TGF-β superfamily. Nature (Lond.). 368:639-642.
20. Chang, S.C., B. Hoang, J.T. Thomas, S. Vukicevic, F.P. Luyten, N.J.P. Ryba, C.A. Kozak, A.H. Reddi, and M. Moos, Jr. 1994. Cartilage-derived morphogenetic proteins. J. Biol. Chem. 269:28227-28234.
21. Rosen, V., and R.S. Thies. 1992. The BMP proteins in bone formation and repair. Trends Genet. 8:97-102.
22. Wang, E.A., V. Rosen, P. Cordes, R.M. Hewick, M.J. Kriz, D.P. Luxenberg, B.S. Sibley, and J.M. Wozney. 1988. Purification and characterization of other distinct bone-inducing factors. Proc. Natl. Acad. Sci. USA. 85:9484-9488.
23. Schlunegger, M.P., Cerletti, N., Cox, D.A., McMaster, G.K., Schmitz, A., and Grutter, M.G. 1992. Crystallization and preliminary X-ray analysis of recombinant human transforming growth factor B2. FEBS (Fed. Eur. Biochem. Soc.) Lett. 303:91-93.
24. Karnovsky, M.J. 1965. A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J. Cell Biol. 27:137a.
25. Spurr, A.R. 1969. A low-viscosity epoxy resin embedding medium for electron microscopy. J. Ultrastruct. Res. 26:31-43.
26. Sato, J. 1968. A modified method for lead staining of thin sections. J. Electron. Microsc. (Tokyo). 17:158-159.
27. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
28. Lyons, K.M., R.W. Pelton, and B.M.L. Hogan. 1990. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development. 190:833-844.
29. Christel, P.S., and D.F. Gibbons. 1993. Collagen fiber changes in the exercised, immobilized, or injured anterior cruciate ligament. In The Anterior Cruciate Ligament: Current and Future Concepts. D.W. Jackson, editor. Raven Press Ltd., New York. 195-209.
30. Grotendorst, G.R., and G.R. Martin. 1986. Cell movements in wound-healing and fibrosis. Rheumatology. 10:385-403.
31. Arnoczky, S.P., J.R. Matyas, J.A. Buckwalter, and D. Amiel. 1993. Anatomy of the anterior cruciate ligament. In The Anterior Cruciate Ligament: Current and Future Concepts. D.W. Jackson, editor. Raven Press Ltd., New York. 5-22.
32. Lian, J.B., and C.M. Gundberg. 1988. Osteocalcin. Clin. Orthop. Rel. Res. 226:267-291.
33. Hurle, J.M., G. Corson, K. Daniels, R.S. Rieter, L.Y. Sakai, and M.S. Solursh. 1994. Elastin exhibits a distinctive temporal and spatial pattern of distribution in the developing chick limb in association with the establishment of the cartilaginous skeleton. J. Cell Sci. 107:2623-2634.
34. Robbins, J.R., and K.G. Vogel. 1994. Regional expression of mRNA for proteoglycans and collagen in tendon. Eur. J. Cell. Biol. 64:264-270.
35. Vogel, K.G., J.D. Sandy, G. Pogany, and J.R. Robbins. 1994. Aggrecan in bovine tendon. Matrix Biol. 14:171-179.
36. Vogel, K.G., A. Ordog, G. Pogany, and J. Olah. 1993. Proteoglycans in the compressed region of human tibialis posterior tendon and in ligaments. J. Orthop. Res. 11:68-77.
37. Parr, B.A., and A.P. McMahon. 1995. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (Lond.). 374:350-353.
38. Kieny, M., and A. Chevallier. 1979. Autonomy of tendon development in the embryonic chick wing. J. Embryol. Exp. Morphol. 49:153-165.
39. Hurle, J.M., and Y. Ganan. 1986. Interdigital tissue chondrogenesis induced by surgical removal of the ectoderm in the embryonic chick leg bud. J. Embryol. Exp. Morphol. 94:231-244.
40. Grunenberg, H., and A.J. Lee. 1973. The anatomy and development of brachypodism in the mouse. J. Embryol. Exp. Morphol. 30:119-141.