Monomeric and dimeric GDF-5 show equal type I receptor binding and oligomerization capability and have the same biological activity

Biological Chemistry

Volumn 387, Issue 4, 2006, Pages 451-460

  Sieber, Christina ^a   Plöger, Frank ^b   Schwappacher, Raphaela ^a   Bechtold, Rolf ^b   Hanke, Michael ^b   Kawai, Shinji ^c   Muraki, Yoshifumi ^d   Katsuura, Mieko ^e   Kimura, Michio ^e   Rechtman, Maya Mouler ^f   Henis, Yoav I ^f   Pohl, Jens ^b   Knaus, Petra ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Biopharm GmbH   (Germany)

^c OSAKA UNIVERSITY   (Japan)

^d SANOFI   (France)

^e JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f TEL AVIV UNIVERSITY   (Israel)

Author keywords

BMP; BMP receptor; GDF 5; Smad signaling; TGF superfamily

Indexed keywords

ALANINE; ALKALINE PHOSPHATASE; CYSTEINE; GROWTH DIFFERENTIATION FACTOR 5; PROCOLLAGEN C PROTEINASE; SMAD PROTEIN;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIMERIZATION; DISULFIDE BOND; ENZYME ASSAY; ESCHERICHIA COLI; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; RECEPTOR BINDING; REPORTER GENE; TRANSACTIVATION;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; ISOELECTRIC FOCUSING; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PROTEIN BINDING; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; SOLUBILITY;

ANIMALIA; ESCHERICHIA COLI;

EID: 33645796954     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2006.060     Document Type: Article

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