An SNP in the 5′-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage

Human Molecular Genetics

Volumn 16, Issue 18, 2007, Pages 2226-2232

  Southam, Lorraine ^a   Rodriguez Lopez, Julio ^b   Wilkins, James M ^a   Pombo Suarez, Manuel ^b   Snelling, Sarah ^a   Gomez Reino, Juan J ^c   Chapman, Kay ^a   Gonzalez, Antonio ^b   Loughlin, John ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 5; RNA; BONE MORPHOGENETIC PROTEIN;

5' UNTRANSLATED REGION; ADULT; AGED; ALLELE; ARTICLE; ARTICULAR CARTILAGE; ASIAN; CONTROLLED STUDY; DISEASE SEVERITY; ETHNIC DIFFERENCE; EUROPE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; JOINT PROSTHESIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; POPULATION GENETICS; PRIORITY JOURNAL; RNA EXTRACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; UNITED KINGDOM; BIOSYNTHESIS; CAUCASIAN; CHINA; CLINICAL TRIAL; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; JAPAN; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY;

5' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CHINA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; HUMANS; JAPAN; MALE; MIDDLE AGED; OSTEOARTHRITIS; POLYMORPHISM, SINGLE NUCLEOTIDE; SPAIN;

EID: 34548409926     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm174     Document Type: Article

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