An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

Nature Genetics

Volumn 37, Issue 2, 2005, Pages 138-144

  Kizawa, Hideki ^a,b   Kou, Ikuyo ^a   Iida, Aritoshi ^a   Sudo, Akihiro ^c   Miyamoto, Yoshinari ^a   Fukuda, Akira ^d   Mabuchi, Akihiko ^a   Kotani, Akihiro ^e   Kawakami, Akira ^f   Yamamoto, Seizo ^g   Uchida, Atsumasa ^c   Nakamura, Kozo ^d   Notoya, Kohei ^b   Nakamura, Yusuke ^a   Ikegawa, Shiro ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^c MIE UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e KYORIN UNIVERSITY   (Japan)

^f TOKYO TEISHIN HOSPITAL   (Japan)

^g Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; ASPARTIC ACID; ASPORIN; COLLAGEN TYPE 2; PROTEOGLYCAN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; AGC1 PROTEIN, HUMAN; ASPN PROTEIN, HUMAN; CARRIER PROTEIN; GLYCOPROTEIN; LECTIN;

ADULT; AGED; ALLELE; ARTICLE; ARTICULAR CARTILAGE; BINDING ASSAY; CHONDROGENESIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; HIP OSTEOARTHRITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; CHROMOSOME MAP; DRUG ANTAGONISM; GENETIC POLYMORPHISM; GENETICS; IN VITRO STUDY; MOLECULAR GENETICS; VARIABLE NUMBER OF TANDEM REPEAT;

AGGRECANS; ASPARTIC ACID; CARRIER PROTEINS; CHONDROGENESIS; CHROMOSOME MAPPING; DISEASE SUSCEPTIBILITY; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; HUMANS; LECTINS, C-TYPE; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; OSTEOARTHRITIS; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; POLYMORPHISM, GENETIC; PROTEOGLYCANS; TRANSFORMING GROWTH FACTOR BETA;

EID: 13944259791     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1496     Document Type: Article

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