Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets?

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 7, Issue 4, 2007, Pages 250-258

  Buechler, Christa ^a   Schaffler A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACUTE PHASE PROTEIN; ADRENOMEDULLIN; ANTINEOPLASTIC AGENT; CATALASE; CYSTEINE RICH PROTEIN 61; FIBROBLAST GROWTH FACTOR 1; FLUOROURACIL; FOLLISTATIN; GELATINASE A; GLUTATHIONE TRANSFERASE A4; INSULIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LACTOFERRIN; METHOTREXATE; ORNITHINE DECARBOXYLASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN B;

ABDOMINAL OBESITY; ADIPOGENESIS; ADIPOSE TISSUE; AEROBIC METABOLISM; ANTIOXIDANT ACTIVITY; CANCER RESEARCH; DISEASE ASSOCIATION; DRUG DESIGN; DRUG EFFICACY; DRUG TARGETING; DYSLIPIDEMIA; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; HEPATITIS; HIGH THROUGHPUT SCREENING; HUMAN; HYPERTENSION; INSULIN RESISTANCE; LIVER PROTECTION; MACROPHAGE; METABOLIC SYNDROME X; MICROARRAY ANALYSIS; MITOCHONDRIAL RESPIRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN FAMILY; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; REVIEW; SERIAL ANALYSIS OF GENE EXPRESSION; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DELIVERY SYSTEMS; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 37549032661     PISSN: 18715303     EISSN: None     Source Type: Journal    
DOI: 10.2174/187153007782794353     Document Type: Review

References (79)

1. Molavi, B.; Rasouli, N. and Kern, P.A. (2006) Curr. Opin. Cardiol., 21(5), 479-485.
2. Poirier, P.; Giles, T.D.; Bray, G.A.; Hong, Y.; Stern, J.S.; Pi-Sunyer, F.X. and Eckel, R.H. (2006) Arterioscler. Thromb. Vasc. Biol., 26(5), 968-976.
3. Bruunsgaard, H. (2005) J. Leukoc. Biol., 78(4), 819-835.
4. Tusie Luna, M.T. (2005) Arch. Med Res., 36(3), 210-222.
5. Gerich, J.E. (1998) Endocr. Rev., 19(4), 491-503.
6. Licinio, J.; Caglayan, S.; Ozata, M.; Yildiz, B.O.; De Miranda, P.B.; O'kirwan, F.; Whitby, R.; Liang, L.; Cohen, P.; Bhasin, S.; Krauss, R.M.; Veldhuis, J.D.; Wagner, A.J.; Depaoli, A.M.; Mccann, S.M. and Wong, M.L. (2004) Proc. Natl. Acad. Sci., US4, 101(13), 4531-4536.
7. Wahitsch, M. (2000) Proc. Nutr. Soc., 59(2), 325-330.
8. Arita, Y.; Kihara, S.; Ouchi, N.; Takahashi, M.; Maeda, K.; Miyagawa, J.; Hotta, K.; Shimomura, I.; Nakamura, T.; Miyaoka, K., Kuriyama, H.; Nishida, M.; Yamashita, S.; Okubo, K.; Matsubara, K.; Muraguchi, M.; Ohmoto, Y.; Funahashi, T. and Matsuzawa, Y. (1999) Biochem. Biophys. Res. Commun., 257(1), 79-83.
9. Kadowaki, T.; Yamauchi, T.; Kubota, N.; Hara, K.; Ueki, K. and Tobe, K. (2006) J. Clin. Invest., 116(7), 1784-1792.
10. Kadowaki, T. and Yamauchi, T. (2005) Endocr. Rev., 26(3), 439-451.
11. Schaffler, A.; Scholmerich, J. and Buchler, C. (2005) Nat. Clin. Pract. Gastroenterol. Hepatol., 2(6), 273-280.
12. Boel, E.; Albrektsen, T.; Fleckner, J. and Selmer, J. (2000) Curr. Pharm. Biotechnol., 1(1), 63-71.
13. Browning, J.D. and Horton, J.D. (2004) J. Clin. Invest., 114(2), 147-152.
14. Youssef, W.I. and Mccullough, A.J. (2002) Best Pract. Res. Clin. Gastroenterol., 16(5), 733-747.
15. Zelber-Sagi, S.; Nitzan-Kaluski, D.; Halpern, Z. and Oren, R. (2006) Liver Int., 26(7), 856-863.
16. Younossi, Z.M.; Gorreta, F.; Ong, J.P.; Schlauch, K.; Giacco, L.D., Elariny, H.; Van Meter, A.; Younoszai, A.; Goodman, Z.; Baranova, A.; Christensen, A.; Grant, G. and Chandhoke, V. (2005) Liver Int., 25(4), 760-771.
17. Attia, N.; Tamborlane, W.V.; Heptulla, R.; Maggs, D.; Grozman, A.; Sherwin, R.S. and Caprio, S. (1998) J. Clin. Endocrinol. Metab., 83(5), 1467-1471.
18. Allen-Jennings, A.E.; Hartman, M.G.; Kociba, G.J. and Hai, T. (2002) J. Biol. Chem., 277(22), 20020-20025.
19. Steiling, H.; Muhlbauer, M.; Bataille, F.; Scholmerich, J.; Werner, S. and Hellerbrand, C. (2004) Am. J. Pathol., 165(4), 1233-1241.
20. Younossi, Z.M.; Baranova, A.; Ziegler, K.; Del Giacco, L.; Schlauch, K.; Born, T.L.; Elariny, H.; Gorreta, F.; Vanmeter, A.; Younoszai, A.; Ong, J.P.; Goodman, Z. and Chandhoke, V. (2005) Hepatology, 42(3), 665-674.
21. Frystyk, J.; Skjaerbaek, C.; Vestbo, E.; Fisker, S. and Orskov, H. (1999) Diabetes Metab. Res. Rev., 15(5), 314-322.
22. Wang, Y.; Zhang, J.S.; Huang, G.C.; Cheng, Q. and Zhao, Z.H. (2005) World J. Gastroenterol., 11(23), 3549-3553.
23. Isoda, K.; Sawada, S.; Ayaori, M.; Matsuki, T.; Horai, R.; Kagata, Y.; Miyazaki, K.; Kusuhara, M.; Okazaki, M.; Matsubara, O.; Iwakura, Y. and Ohsuzu, F. (2005) J. Biol. Chem., 280(8), 7002-7009.
24. Chiappini, F.; Barrier, A.; Saffroy, R.; Domart, M.C.; Dagues, N.; Azoulay, D.; Sebagh, M.; Franc, B.; Chevalier, S.; Debuire, B., Dudoit, S. and Lemoine, A. (2006) Lab. Invest., 86(2), 154-165.
25. Serini, G. and Gabbiani, G. (1999) Exp. Cell. Res., 250(2), 273-283.
26. Boers, W.; Aarrass, S.; Linthorst, C.; Pinzani, M.; Elferink, R.O. and Bosma, P. (2006) J. Biol. Chem., 281(24), 16289-16295.
27. Sanz, S.; Pucilowska, J.B.; Liu, S.; Rodriguez-Ortigosa, C.M.; Lund, P.K.; Brenner, D.A.; Fuller, C.R.; Simmons, J.G.; Pardo, A.; Martinez-Chantar, M.L.; Fagin, J.A. and Prieto, J. (2005) Gut, 54(1), 134-141.
28. Sreekumar, R.; Rosado, B.; Rasmussen, D. and Charlton, M. (2003) Hepatology, 38(1), 244-251.
29. Johns, D.G. (1967) J. Clin. Invest., 46(9,), 1492-1505.
30. Neumeier, M.; Weigert, J.; Schaffler, A.; Weiss, T.S.; Schmidt, C.; Buttner, R.; Bollheimer, C.; Aslanidis, C.; Scholmerich, J. and Buechler, C. (2006) Biochem. Biophys. Res. Commun., 350(3), 731-735.
31. Esterbauer, H.; Schaur, R.J. and Zollner, H. (1991) Free Radic. Biol. Med., 11(1), 81-128.
32. Moriwaki, Y.; Yamamoto, T. and Higashino, K. (1997) Histol. Histopathol., 12(2), 513-524.
33. Kitamura, S.; Sugihara, K. and Ohta, S. (2096) Drug Metab. Pharmacokinet., 21(2), 83-98.
34. Yesilova, Z.; Yaman, H.; Oktenli, C.; Ozcan, A.; Uygun, A.; Cakir, E.; Sanisoglu, S.Y.; Erdil, A.; Ates, Y.; Aslan, M.; Musabak, U.; Erbil, M.K.; Karaeren, N. and Dagalp, K. (2005) Am. J. Gastroenterol., 100(4), 850-855.
35. Lafontan, M. and Berlan, M. (2003) Trends Pharmacol. Sci., 24(6), 276-283.
36. Vohl, M.C.; Sladek, R.; Robitaille, J.; Gurd, S.; Marceau, P.; Richard, D.; Hudson, T.J. and Tchernof, A. (2004) Obes. Res., 12(8), 1217-1222.
37. Bruum, J.M.; Lihn, A.S.; Pedersen, S.B. and Richelsen, B. (2005) J. Clin. Endocrinol. Metab., 90(4), 2282-2289.
38. Bonta, P.I.; Van Tiel, C.M.; Vos, M.; Van Thienen, J.V.; Ferreira, V.; Arkenbout E.K.; Seppen, J.; Spek, C.A.; Van Der Poll, T.; Pannekoek, H. and De Vries, C.J. (2006) Arterioscler. Thromb. Vasc. Biol., 26(10), 2288-2294
39. Davies, M.R.; Harding, C.J.; Raines, S.; Tolley, K.; Parker, A.E.; Downey-Jones, M. and Needham, M.R. (2005) J. Inflamm. (Lond)., 2, 15.
40. Ross, S.E.; Erickson, R.L.; Gerin, I.; Derose, P.M.; Bajnok, L.; Longo, K.A.; Misek, D.E.; Kuick, R.; Hanash, S.M.; Atkins, K.B.; Andresen, S.M.; Nebb, H.I.; Madsen, L.; Kristiansen, K. and Macdougald, O.A. (2002) Mol. Cell. Biol., 22(16), 5989-5999.
41. Cadoudal, T.; Leroyer, S.; Reis, A.F.; Tordjman, J.; Durant, S.; Fouque, F.; Collinet, M.; Quette, J.; Chauvet, G.; Beale, E.; Velho, G.; Antoiné, B.; Benelli, C. and Forest, C. (2005) Biochimie, 87(1), 27-32.
42. Kim, H.B.; Kong, M.; Kim, T.M.; Sub, Y.H.; Kim, W.H.; Lim, J.H.; Song, J.H. and Jung, M.H. (2006) Diabetes, 55(5), 1342-1352.
43. Schutze, N.; Kunzi-Rapp, K.; Wagemanns, R.; Noth, U.; Jatzke, S. and Jakob, F. (2005) Protein Expr. Purif., 42(1), 219-225.
44. Raynal, P.; Pollard, H.B.; Cuthman, S.W. and Guerre-Millo, M. (1996) Biochem. Biophys. Res. Commun, 225(1), 116-121.
45. Zhao, W.Q.; Chen, G.H.; Chen, H.; Pascale, A.; Ravindranath, L.; Quon, M.I. and Alkon, D.L. (2003) J. Biol. Chem., 278(6), 4205-4215.
46. Biener Y.; Feinstein, R.; Mayak, M.; Kaburagi, Y.; Kadowaki, T. and Zick, Y. (1996) J. Biol. Chem., 271(46), 29489-21496.
47. Warne, J.P.; John, C.D.; Christian, H.C.; Morris, J.F.; Flower, R.J.; Sugden, D.; Solito, E.; Gillies, G.G. and Buckingham, J.C. (2006) Am. J. Physiol. Endocrinol. Metab., 291(6), E1264-1273.
48. Gomez-Ambrosi, J.; Catalan, V.; Diez-Caballero, A.; Martinez-Cruz, L.A.; Gil, J.; Garcia-Foncillas, J.; Cienfuegos, J.A.; Salvador, J.; Mato, J.M. and Fruhbeck, G. (2004) FASEB J., 18(1), 215-217.
49. Hutley, L.; Shurety, W.; Newell, F.; Mcgeary, R.; Pelton, N.; Grant, J.; Herington, A.; Cameron, D.; Whitehead, J. and Prins, J. (2004) Diabetes, 53(12), 3097-3106.
50. Hu, E.; Kim, J.B.; Sarraf, P. and Spiegelman, B.M. (1996) Science, 274(5295), 2100-2103.
51. Kamai, Y.; Mikawa, S.; Endo, K.; Sakai, H. and Komano, T. (1996) J. Biol. Chem., 271(17), 9883-9886.
52. Lee, Y.H.; Nair, S.; Rousseau, E.; Allison, D.B.; Page, G.P.; Tataranni, P.A.; Bogardus, C. and Permana, P.A. (2005) Diabetologia, 48(9), 1776-1783.
53. Leonhardt, W.; Haller, H. and Hanefeld, M. (1978) In.t J. Obes., 2(4), 429-439.
54. Farnier, C.; Krief, S.; Blache, M.; Diot-Dupuy, F.; Mory, G.; Ferre, P. and Bazin, R. (2003) Int. J. Obes. Relat. Metab. Disord., 27(10), 1178-1186.
55. Jernas, M.; Palming, J.; Sjoholm, K.; Jennische, E.; Svensson, P.A.; Gabrielsson, B.G.; Levin, M.; Sjogren, A.; Rudemo, M.; Lystig, T.C.; Carlsson, B.; Carlsson, L.M. and Lonn, M. (2006) FASEB J., 20(9), 1540-1542.
56. Troseid, M.; Lappegard, K.T.; Mollnes, T.E.; Arnesen, H. and Seljeflot I. (2005) Scand. J. Clin. Lab. Invest., 65(4), 283-290.
57. Gabrielsson, B.G.; Johansson, J.M.; Lonn, M.; Jernas, M.; Olbers, T.; Peltonen, M.; Larsson, I.; Lonn, L.; Sjostrom, L.; Carlsson, B. and Carlsson, L.M. (2003) Obes. Res., 11(6), 699-708.
58. Poitou, C.; Coussieu, C.; Rouault C.; Coupaye, M.; Cancello, R.; Bedel, J.F.; Gouillon, M.; Bouillot, J.L.; Oppert, J.M.; Basdevant, A. and Clement, K. (2006) Obesity (Silver Spring), 14(2), 309-318.
59. Clement, K.; Viguerie, N.; Poitou, C.; Carette, C.; Pelloux, V.; Curat, C.A.; Sicard, A.; Rome, S.; Benis, A.; Zucker, J.D.; Vidal, H.; Laville, M.; Barsh, G.S.; Basdevant, A.; Stich, V.; Cancello, R. and Langin, D. (2004) FASEB J., 18(14), 1657-1669.
60. Nair, S.; Lee, Y.H.; Rousseau, E.; Cam, M.; Tataranni, P.A.; Baier, L.J.; Bogardus, C. and Permana, P.A. (2005) Diabetologia., 48(9), 1784-1788.
61. Taleb, S.; Cancello, R.; Clement K. and Lacasa, D. (2006) Endocrinology, 147(10), 4950-4959.
62. Taleb, S.; Cancello, R.; Poitou, C.; Rouault C.; Sellam, P.; Levy, P.; Bouillot J.L.; Coussieu, C.; Basdevant, A.; Guerre-Millo, M.; Lacasa, D. and Clement, K. (2006) J. Clin. Endocrinol. Metab., 91(3), 1042-1047.
63. Kim, T.R.; Yoon, J.H.; Kim, Y.C.; Yook, Y.H.; Kim, I.G.; Kim, Y.S.; Lee, H. and Paik, S.G. (2004) Mol. Cells., 17(1), 125-131.
64. Busch-Petersen, J. (2006) Curr. Top Med. Chem., 6(13), 1345-1352.
65. Eriksson, J.; Franssila-Kallunki, A.; Ekstrand, A.; Saloranta, C.; Widen, E.; Schalin, C. and Groop, L. (1989) N. Engl. J. Med., 321(6), 337-343.
66. Nguyen, L.L.; Kriketos, A.D.;. Hancock, D.P.; Caterson, I.D. and Denyer, G.S. (2006) J. Biochem. Mol. Biol., 39(4), 457-463.
67. Yang, X.; Pratley, R.E.; Tokraks, S.; Bogardus, C. and Permana, P.A. (2002) Diabetologia, 45(11), 1584-1593.
68. Jehle, P.M.; Jehle, D.R.; Mohan, S. and Bohm, B.O. (1998) J. Endocrinol., 159(2), 297-306.
69. Sreekumar, R.; Halvatsiotis, P.; Schimke, J.C. and Nair, K.S. (2002) Diabetes, 51(6), 1913-1920.
70. Patti, M.E.; Butte, A.J.; Crunkhorn, S.; Cusi, K.; Berria, R.; Kashyap, S.; Miyazaki, Y.; Kohane, I.; Costello, M.; Saccone, R.; Landaker, E.J., Goldfine, A.B.; Mun, E.; Defronzo, R.; Finlayson, J.; Kahn, C.R. and Mandarino, L.J. (2003) Proc. Natl. Acad. Sc., USA, 100(14), 8466-8471.
71. Mootha, V.K.; Lindgren, C.M.; Eriksson, K.F.; Subramanian, A.; Sihag, S.; Lehar, J.; Puigserver, P.; Carlsson, E.; Ridderstrale, M.; Laurila, E.; Houstis, N.; Daly, M.J.; Patterson, N.; Mesirov, J.P.; Golub, T.R.; Tamayo, P.; Spiegelman, B.; Lander, E.S.; Hirschhorn, J.N.; Altshuler, D. and Groop, L.C. (2003) Nat. Genet., 34(3), 267-273.
72. Sparks, L.M.; Xie, H.; Koza, R.A.; Mynatt R.; Hulver, M.W.; Bray, G.A. and Smith, S.R. (2005) Diabetes, 54(7), 1926-1933.
73. Finck, B.N. and Kelly, D.P. (2006) J. Clin. Invest., 116(3), 615-622.
74. Tilstone, C. (2003) Nature, 424(6949), 610-612.
75. Neumeier, M.; Sigruener, A.; Eggenhofer, E.; Weigert J.; Weiss, T.S.; Schaeffler, A.; Schlitt, H.J.; Aslanidis, C.; Piso, P.; Langmann, T.; Schmitz, G.; Scholmerich, J. and Buechler, C. (2007) Biochem. Biophys. Res. Commun., 352(2), 543-548.
76. Rensink, W.A. and Hazen, S.P. (2006) Methods Mol. Biol., 323, 359-366.
77. Steinhoff, C. and Vingron, M. (2006) Brief Bioinform., 7(2), 166-177.
78. Stern, S.; Dror, T.; Stolovicki, E.; Brenner, N. and Braun, E. (2007) Mol. Syst. Biol., 3, 106.
79. Fong, S.S.; Joyce, A.R. and Palsson, B.O. (2005) Genome Res., 15(10), 1365-1372.