Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians

Diabetologia

Volumn 48, Issue 9, 2005, Pages 1784-1788

  Nair, S ^a   Lee, Y H ^a   Rousseau, E ^a   Cam, M ^a   Tataranni, P A ^a   Baier, L J ^a   Bogardus, C ^a   Permana, P A ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b CARL T HAYDEN VA MEDICAL CENTER   (United States)

Author keywords

Adipocyte; Adipose tissue; Gene expression; Inflammation; Microarray; Obesity; Obesity related inflammation; Preadipocyte; Stromal vascular cells; Tissue remodelling

Indexed keywords

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CELL CULTURE; CELL FUNCTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOCOMPETENT CELL; INDIAN; INFLAMMATION; MALE; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STROMA CELL; UPREGULATION;

ADIPOCYTES; ADULT; BODY MASS INDEX; BODY WEIGHT; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INDIANS, NORTH AMERICAN; INFLAMMATION; MALE; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; REFERENCE VALUES; STROMAL CELLS; UNITED STATES;

EID: 24944588778     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1868-2     Document Type: Article

References (13)

1. Bruun JM, Pedersen SB, Richelsen B (2001) Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro. J Clin Endocrinol Metab 86:1267-1273
2. Fried SK, Bunkin DA, Greenberg AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
3. Lee Y-H, Nair S, Rousseau E et al (2005) Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia 48:DOI 10.1007/s00125-005-1867-3
4. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
5. Xu H, Barnes GT, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
6. Charriere G, Cousin B, Arnaud E et al (2003) Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem 278:9850-9855
7. Cousin B, Andre M, Casteilla L, Penicaud L (2001) Altered macrophage-like functions of preadipocytes in inflammation and genetic obesity. J Cell Physiol 186:380-386
8. Permana PA, Nair S, Lee YH, Luczy-Bachman G, Vozarova De Courten B, Tataranni PA (2004) Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity. Am J Physiol Endocrinol Metabol 286:E958-E962
9. Bruun JM, Lihn AS, Madan AK et al (2004) Higher production of IL-8 in visceral vs subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metabol 286:E8-E13
10. Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145:2273-2282
11. Mulayim N, Savlu A, Guzeloglu-Kayisli O, Kayisli UA, Arici A (2004) Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8. Fertil Steril 81(Suppl 1):904-911
12. Bouloumie A, Sengenes C, Portolan G, Galitzky J, Lafontan M (2001) Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes 50:2080-2086
13. Starckx S, Van den Steen PE, Wuyts A, Van Damme J, Opdenakker G (2002) Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization. Leuk Lymphoma 43:233-241