High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes

Biochemical and Biophysical Research Communications

Volumn 352, Issue 2, 2007, Pages 543-548

  Neumeier, Markus ^a   Sigruener, Alexander ^b   Eggenhofer, Elke ^a   Weigert, Johanna ^a   Weiss, Thomas S ^b   Schaeffler, Andreas ^a   Schlitt, Hans J ^b   Aslanidis, Charalampos ^b   Piso, Pompiliu ^b   Langmann, Thomas ^b   Schmitz, Gerd ^b   Schölmerich, Jürgen ^a   Buechler, Christa ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adiponectin; Apolipoprotein B; ATP binding cassette transporter A1; Dyslipidaemia; Hepatic nuclear factor 4

Indexed keywords

ABC TRANSPORTER A1; ADIPONECTIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HIGH DENSITY LIPOPROTEIN; HIGH MOLECULAR WEIGHT ADIPONECTIN; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DYSLIPIDEMIA; FUNCTIONAL PROTEOMICS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPOGENESIS; LIPOPROTEIN BLOOD LEVEL; LIVER CELL; LIVER FUNCTION; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADIPONECTIN; APOLIPOPROTEINS B; APOLIPOPROTEINS E; CELLS, CULTURED; HEPATOCYTES; HUMANS; MOLECULAR WEIGHT;

EID: 33751538542     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.11.058     Document Type: Article

References (33)

1. Ginsberg H.N., and Stalenhoef A.F. The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk. J. Cardiovasc. Risk 10 (2003) 121-128
2. Chan D.C., Barrett P.H., and Watts G.F. Lipoprotein transport in the metabolic syndrome: pathophysiological and interventional studies employing stable isotropy and modelling methods. Clin. Sci. (Lond.) 107 (2004) 233-249
3. Ukkola O., and Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities?. J. Mol. Med. 80 (2002) 696-702
4. Zietz B., Herfarth H., Paul G., Ehling A., Muller-Ladner U., Scholmerich J., and Schaffler A. Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes. FEBS Lett. 545 (2003) 103-104
5. Matsubara M., Maruoka S., and Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur. J. Endocrinol. 147 (2002) 173-180
6. Peake P.W., Kriketos A.D., Campbell L.V., Shen Y., and Charlesworth J.A. The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. Eur. J. Endocrinol. 153 (2005) 409-417
7. Lara-Castro C., Luo N., Wallace P., Klein R.L., and Garvey W.T. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 55 (2006) 249-259
8. Bodzioch M., Orso E., Klucken J., Langmann T., Bottcher A., Diederich W., Drobnik W., Barlage S., Buchler C., Porsch-Ozcurumez M., Kaminski W.E., Hahmann H.W., Oette K., Rothe G., Aslanidis C., Lackner K.J., and Schmitz G. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat. Genet. 22 (1999) 347-351
9. Timmins J.M., Lee J.Y., Boudyguina E., Kluckman K.D., Brunham L.R., Mulya A., Gebre A.K., Coutinho J.M., Colvin P.L., Smith T.L., Hayden M.R., Maeda N., and Parks J.S. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J. Clin. Invest. 115 (2005) 1333-1342
10. Von Eckardstein A., Langer C., Engel T., Schaukal I., Cignarella A., Reinhardt J., Lorkowski S., Li Z., Zhou X., Cullen P., and Assmann G. ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages. Faseb. J. 15 (2001) 1555-1561
11. Krimbou L., Denis M., Haidar B., Carrier M., Marcil M., and Genest Jr. J. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J. Lipid Res. 45 (2004) 839-848
12. Greenow K., Pearce N.J., and Ramji D.P. The key role of apolipoprotein E in atherosclerosis. J. Mol. Med. 83 (2005) 329-342
13. Mensenkamp A.R., Jong M.C., van Goor H., van Luyn M.J., Bloks V., Havinga R., Voshol P.J., Hofker M.H., van Dijk K.W., Havekes L.M., and Kuipers F. Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. J. Biol. Chem. 274 (1999) 35711-35718
14. Neumeier M., Weigert J., Schaffler A., Wehrwein G., Muller-Ladner U., Scholmerich J., Wrede C., and Buechler C. Different effects of adiponectin isoforms in human monocytic cells. J. Leukoc. Biol. (2006)
15. Thasler W.E., Weiss T.S., Schillhorn K., Stoll P.T., Irrgang B., and Jauch K.W. Charitable state-controlled foundation human tissue and cell research: ethic and legal aspects in the supply of surgically removed human tissue for research in the academic and commercial sector in Germany. Cell Tissue Bank. 4 (2003) 49-56
16. Weiss T.S., Pahernik S., Scheruebl I., Jauch K.W., and Thasler W.E. Cellular damage to human hepatocytes through repeated application of 5-aminolevulinic acid. J. Hepatol. 38 (2003) 476-482
17. Neumeier M., Weigert J., Schaffler A., Weiss T., Kirchner S., Laberer S., Scholmerich J., and Buechler C. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Biochem. Biophys. Res. Commun. (2005)
18. Drobnik W., Borsukova H., Bottcher A., Pfeiffer A., Liebisch G., Schutz G.J., Schindler H., and Schmitz G. Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains. Traffic 3 (2002) 268-278
19. Buechler C., Bared S.M., Aslanidis C., Ritter M., Drobnik W., and Schmitz G. Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein. J. Biol. Chem. 277 (2002) 41307-41310
20. Fisher F.F., Trujillo M.E., Hanif W., Barnett A.H., McTernan P.G., Scherer P.E., and Kumar S. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 48 (2005) 1084-1087
21. Bobbert T., Rochlitz H., Wegewitz U., Akpulat S., Mai K., Weickert M.O., Mohlig M., Pfeiffer A.F., and Spranger J. Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 54 (2005) 2712-2719
22. Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., and Gonzalez F.J. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell Biol. 21 (2001) 1393-1403
23. Lucas B., Grigo K., Erdmann S., Lausen J., Klein-Hitpass L., and Ryffel G.U. HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. Oncogene 24 (2005) 6418-6431
24. Stoffel M., and Duncan S.A. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. Proc. Natl. Acad. Sci. USA 94 (1997) 13209-13214
25. Heeren J., Beisiegel U., and Grewal T. Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 442-448
26. Tsukamoto K., Maugeais C., Glick J.M., and Rader D.J. Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice. J. Lipid Res. 41 (2000) 253-259
27. Maugeais C., Tietge U.J., Tsukamoto K., Glick J.M., and Rader D.J. Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice. J. Lipid Res. 41 (2000) 1673-1679
28. Xu A., Wang Y., Keshaw H., Xu L.Y., Lam K.S., and Cooper G.J. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112 (2003) 91-100
29. Crooke R.M., Graham M.J., Lemonidis K.M., Whipple C.P., Koo S., and Perera R.J. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. J. Lipid Res. 46 (2005) 872-884
30. Tall A.R., Wang N., and Mucksavage P. Is it time to modify the reverse cholesterol transport model?. J. Clin. Invest. 108 (2001) 1273-1275
31. Shih D.Q., Dansky H.M., Fleisher M., Assmann G., Fajans S.S., and Stoffel M. Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels. Diabetes 49 (2000) 832-837
32. Leclerc I., Lenzner C., Gourdon L., Vaulont S., Kahn A., and Viollet B. Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes 50 (2001) 1515-1521
33. Saborowski M., Kullak-Ublick G.A., and Eloranta J.J. The human organic cation transporter 1 gene is transactivated by hepatocyte nuclear factor-4{alpha}. J. Pharmacol. Exp. Ther. 317 (2006) 778-785