Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue

American Journal of Physiology - Endocrinology and Metabolism

Volumn 291, Issue 6, 2006, Pages

  Warne, James P ^a   John, Christopher D ^a   Christian, Helen C ^b   Morris, John F ^b   Flower, Roderick J ^c   Sugden, David ^d   Solito, Egle ^a   Gillies, Glenda E ^a   Buckingham, Julia C ^a,e  

^a Mental Health Division   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Adipocytes; Catecholamines; Glucocorticoids

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CYCLIC AMP; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLYCEROL; INTERLEUKIN 6; ISOPRENALINE; LIPOCORTIN 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; NORADRENALIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EPIDIDYMIS FAT; GENE DELETION; IN VITRO STUDY; LIPOLYSIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ADIPOCYTES; ADIPOSE TISSUE; ADRENERGIC BETA-AGONISTS; ANIMALS; ANNEXIN A1; BLOTTING, WESTERN; BODY WEIGHT; CATECHOLAMINES; CELL SEPARATION; CELL SIZE; CYCLIC AMP; DEXAMETHASONE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPIDIDYMIS; GENE DELETION; INTERLEUKIN-6; ISOPROTERENOL; LIPOLYSIS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; ORGAN SIZE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS;

EID: 33845443357     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00655.2005     Document Type: Article

References (51)

1. Ajpru S, McArthur AJ, Piggins HD, and Sugden D. Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus. Brain Res Mol Brain Res 105: 29-37, 2002.
2. Ajuwon KM, Jacobi SK, Kuske JL, and Spurlock ME. Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-γ in primary pig adipocytes. Am J Physiol Regul Integr Comp Physiol 286: R547-R553, 2004.
3. Albano JD, Ekins RP, Maritz G, and Turner RC. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh) 70: 487-509, 1972.
4. Alldridge LC, Harris HJ, Plevin R, Hannon R, and Bryant CE. The annexin protein lipocortin 1 regulates the MAPK/ERK pathway. J Biol Chem 274: 37620-37628, 1999.
5. Blackwell GJ, Carnuccio R, Di Rosa M, Flower RJ, Parente L, and Persico P. Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature 287: 147-149, 1980.
6. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
7. Buckingham JC, Solito E, John C, Tierney T, Taylor A, Flower R, Christian H, and Morris J. Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system. Cell Biochem Funct 21: 217-221, 2003.
8. Cigolini M and Smith U. Human adipose tissue in culture. VIII. Studies on the insulin-antagonistic effect of glucocorticoids. Metabolism 28: 502-510, 1979.
9. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, and Obin MS. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46: 2347-2355, 2005.
10. Croxtall JD, Choudhury Q, Newman S, and Flower RJ. Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation. Biochem Pharmacol 52: 351-356, 1996.
11. Damazo AS, Yona S, D'Acquisto F, Flower RJ, Oliani SM, and Perretti M. Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. Am J Pathol 166: 1607-1617, 2005.
12. de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M, and Solito E. Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. Am J Pathol 159: 1435-1443, 2001.
13. Fava RA, McKanna J, and Cohen S. Lipocortin I (p35) is abundant in a restricted number of differentiated cell types in adult organs. J Cell Physiol 141: 284-293, 1989.
14. Flower L, Gray R, Pinkney J, and Mohamed-Ali V. Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes. Cytokine 21: 32-37, 2003.
15. Fried SK, Bunkin DA, and Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83: 847-850, 1998.
16. Frost GS, Keogh BE, Smith D, Leeds AR, and Dornhorst A. Reduced adipocyte insulin sensitivity in Caucasian and Asian subjects with coronary heart disease. Diabet Med 15: 1003-1009, 1998.
17. Fujiwara K, Mori K, Kaneko YS, Nakashima A, Nagasaka A, Itoh M, and Ota A. Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide. Biochim Biophys Acta 1670: 181-198, 2004.
18. Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FN, Perretti M, Morris JF, Buckingham JC, and Flower RJ. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J 17: 253-255, 2003.
19. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, and Martin RJ. The biology of white adipocyte proliferation. Obes Rev 2: 239-254, 2001.
20. Hellstrom L, Blaak E, and Hagstrom-Toft E. Gender differences in adrenergic regulation of lipid mobilization during exercise. Int J Sports Med 17: 439-447, 1996.
21. Iizuka H, Kajita S, Mizumoto T, and Kawaguchi H. Glucocorticoid-induced modulation of the beta-adrenergic adenylate cyclase response of epidermis: its relation to epidermal phospholipase A2 activity. J Invest Dermatol 87: 577-581, 1986.
22. John C, Cover P, Solito E, Morris J, Christian H, Flower R, and Buckingham J. Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C. Endocrinology 143: 3060-3070, 2002.
23. John CD, Christian HC, Morris JF, Flower RJ, Solito E, and Buckingham JC. Annexin 1 and the regulation of endocrine function. Trends Endocrinol Metab 15: 103-109, 2004.
24. Kawasaki M, Yagasaki K, Miura Y, and Funabiki R. Comparison of the changes in lipid metabolism between hepatoma-bearing and lipopolysaccharide- treated rats. Biosci Biotechnol Biochem 68: 72-78, 2004.
25. Klover PJ, Zimmers TA, Koniaris LG, and Mooney RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52: 2784-2789, 2003.
26. Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, and Bloom SR. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100: 2729-2736, 1997.
27. Lafontan M and Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 34: 1057-1091, 1993.
28. Laurell S and Tibbling G. An enzymatic fluorometric micromethod for the determination of glycerol. Clin Chim Acta 13: 317-322, 1966.
29. Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, and Scherer PE. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 275: 24255-24263, 2000.
30. Loxley HD, Cowell AM, Flower RJ, and Buckingham JC. Effects of lipocortin 1 and dexamethasone on the secretion of corticotrophin-releasing factors in the rat: in vitro and in vivo studies. J Neuroendocrinol 5: 51-61, 1993.
31. MacDougald OA and Mandrup S. Adipogenesis: forces that tip the scales. Trends Endocrinol Metab 13: 5-11, 2002.
32. Mattacks CA, Sadler D, and Pond CM. The cellular structure and lipid/protein composition of adipose tissue surrounding chronically stimulated lymph nodes in rats. J Anat 202: 551-561, 2003.
33. Melki V, Hullin F, Mazarguil H, Fauvel J, Ragab-Thomas JM, and Chap H. Annexin I as a potential inhibitor of insulin receptor protein tyrosine kinase. Biochem Biophys Res Commun 203: 813-819, 1994.
34. Ohnishi M, Tokuda M, Masaki T, Fujimura T, Tai Y, Itano T, Matsui H, Ishida T, Konishi R, Takahara J, and Hatase O. Involvement of annexin-I in glucose-induced insulin secretion in rat pancreatic islets. Endocrinology 136: 2421-2426, 1995.
35. Ottosson M, Lonnroth P, Bjorntorp P, and Eden S. Effects of cortisol and growth hormone on lipolysis in human adipose tissue. J Clin Endocrinol Metab 85: 799-803, 2000.
36. Path G, Bornstein SR, Gurniak M, Chrousos GP, Scherbaum WA, and Hauner H. Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function. J Clin Endocrinol Metab 86: 2281-2288, 2001.
37. Perretti M and Gavins FN. Annexin 1: an endogenous anti-inflammatory protein. News Physiol Sci 18: 60-64, 2003.
38. Philip JG, Flower RJ, and Buckingham JC. Glucocorticoids modulate the cellular disposition of lipocortin 1 in the rat brain in vivo and in vitro. Neuroreport 8: 1871-1876, 1997.
39. Raynal P, Pollard HB, Cushman SW, and Guerre-Millo M. Unique subcellular distribution of five annexins in resting and insulin-stimulated rat adipose cells. Biochem Biophys Res Commun 225: 116-121, 1996.
40. Ritchie RH, Sun X, and Dusting GJ. Lipocortin-1 preserves myocardial responsiveness to beta-adrenergic stimulation in rat papillary muscle. Clin Exp Pharmacol Physiol 26: 522-524, 1999.
41. Schlaepfer DD and Haigler HT. Expression of annexins as a function of cellular growth state. J Cell Biol 111: 229-238, 1990.
42. Solito E, Raguenes-Nicol C, de Coupade C, Bisagni-Faure A, and Russo-Marie F. U937 cells deprived of endogenous annexin 1 demonstrate an increased PLA2 activity. Br J Pharmacol 124: 1675-1683, 1998.
43. Solito E, Raugei G, Melli M, and Parente L. Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells. FEBS Lett 291: 238-244, 1991.
44. Taylor AD, Cowell AM, Flower J, and Buckingham JC. Lipocortin 1 mediates an early inhibitory action of glucocorticoids on the secretion of ACTH by the rat anterior pituitary gland in vitro. Neuroendocrinology 58: 430-439, 1993.
45. Vicennati V, Vottero A, Friedman C, and Papanicolaou DA. Hormonal regulation of interleukin-6 production in human adipocytes. Int J Obes Relat Metab Disord 26: 905-911, 2002.
46. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF, and Flier JS. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 99: 2416-2422, 1997.
47. Wahrenberg H, Lonnqvist F, and Arner P. Mechanisms underlying regional differences in lipolysis in human adipose tissue. J Clin Invest 84: 458-467, 1989.
48. Wells D, Wells K, Liu K, Hannon R, Croxtall JD, Damazo AS, Oliani SM, Getting SJ, Parente L, Paul-Clark MJ, Yona S, Gavins FN, Martin J, Christian HC, Cover PO, John CD, Solito E, Morris JF, Perretti M, Buckingham JC, and Flower RJ. The Annexin 1-/-mouse: phenotypic studies. Annexins 1: 109-120, 2004.
49. Wong WT, Nick HS, and Frost SC. Regulation of annexin I in adipogenesis: cAMP-independent action of methylisobutylxanthine. Am J Physiol Cell Physiol 262: C91-C97, 1992.
50. Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, Hannon R, Buckingham JC, Perretti M, and Flower RJ. Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis Rheum 50: 976-984, 2004.
51. Yudkin JS, Stehouwer CD, Emeis JJ, and Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19: 972-978, 1999.