-
1
-
-
0037283601
-
The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes
-
Kahn SE. The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia. 2003;46:3-19.
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
2
-
-
0031972156
-
UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group
-
Matthews DR, Cull CA, Stratton IM, et al. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabetes Med. 1998;15:297-303.
-
(1998)
Diabetes Med
, vol.15
, pp. 297-303
-
-
Matthews, D.R.1
Cull, C.A.2
Stratton, I.M.3
-
3
-
-
0034853485
-
The importance of β-cell failure in the development and progression of type 2 diabetes
-
Kahn SE. The importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001;86:4047-4058.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4047-4058
-
-
Kahn, S.E.1
-
4
-
-
28044457872
-
Oxidative stress and pancreatic β-cell dysfunction
-
Kaneto H, Kawamori D, Matsuoka T, et al. Oxidative stress and pancreatic β-cell dysfunction. Am J Ther. 2005;12:529-533.
-
(2005)
Am J Ther
, vol.12
, pp. 529-533
-
-
Kaneto, H.1
Kawamori, D.2
Matsuoka, T.3
-
5
-
-
33745863033
-
Islet β cell failure in type 2 diabetes
-
Prentki M, Nolan CJ. Islet β cell failure in type 2 diabetes. J Clin Invest. 2004;116:1802-1812.
-
(2004)
J Clin Invest
, vol.116
, pp. 1802-1812
-
-
Prentki, M.1
Nolan, C.J.2
-
6
-
-
0030048496
-
Oxidative stress and diabetic vascular complications
-
Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care. 1996;19:257-267.
-
(1996)
Diabetes Care
, vol.19
, pp. 257-267
-
-
Giugliano, D.1
Ceriello, A.2
Paolisso, G.3
-
7
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
Nishikawa T, Edelstein D, Du X-L, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787-790.
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.-L.3
-
8
-
-
0346093889
-
A radical explanation for glucose-induced β cell dysfunction
-
Brownlee M. A radical explanation for glucose-induced β cell dysfunction. J Clin Invest. 2003;112:1788-1790.
-
(2003)
J Clin Invest
, vol.112
, pp. 1788-1790
-
-
Brownlee, M.1
-
9
-
-
12344305124
-
Mitochondrial dysfunction and type 2 diabetes
-
Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005;307:384-387.
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Shulman, G.I.2
-
10
-
-
0030456403
-
Reducing sugars trigger oxidative modification and apoptosis in pancreatic β-cells by provoking oxidative stress through the glycation reaction
-
Kaneto H, Fujii J, Myint T, et al. Reducing sugars trigger oxidative modification and apoptosis in pancreatic β-cells by provoking oxidative stress through the glycation reaction. Biochem J. 1996;320:855-863.
-
(1996)
Biochem J
, vol.320
, pp. 855-863
-
-
Kaneto, H.1
Fujii, J.2
Myint, T.3
-
11
-
-
0035903192
-
Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function by provoking oxidative stress
-
Kaneto H, Xu G, Song KH, et al. Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function by provoking oxidative stress. J Biol Chem. 2001;276:31099-31104.
-
(2001)
J Biol Chem
, vol.276
, pp. 31099-31104
-
-
Kaneto, H.1
Xu, G.2
Song, K.H.3
-
12
-
-
0034890040
-
Viràg L, Szabo C. Diabetic endothelial dysfunction: Role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation
-
Garcia Soriano F, Viràg L, Szabo C. Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. J Mol Med. 2001;79:437-448.
-
(2001)
J Mol Med
, vol.79
, pp. 437-448
-
-
Garcia Soriano, F.1
-
14
-
-
0035988181
-
Vascular targets of redox signalling in diabetes mellitus
-
Spitaler MM, Graier WF. Vascular targets of redox signalling in diabetes mellitus. Diabetologia. 2002;45:476-494.
-
(2002)
Diabetologia
, vol.45
, pp. 476-494
-
-
Spitaler, M.M.1
Graier, W.F.2
-
15
-
-
0029805172
-
Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
-
Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol. 1996;271:C1424-C1437.
-
(1996)
Am J Physiol
, vol.271
-
-
Beckman, J.S.1
Koppenol, W.H.2
-
16
-
-
0036163156
-
Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients
-
Sakuraba H, Mizukami H, Yagihashi N, et al. Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia. 2002;45:85-96.
-
(2002)
Diabetologia
, vol.45
, pp. 85-96
-
-
Sakuraba, H.1
Mizukami, H.2
Yagihashi, N.3
-
17
-
-
0037219411
-
β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, et al. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
-
18
-
-
5644248079
-
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet β cells in diabetes
-
Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet β cells in diabetes. J Biol Chem. 2004;279:42351-42354.
-
(2004)
J Biol Chem
, vol.279
, pp. 42351-42354
-
-
Robertson, R.P.1
-
19
-
-
0030689041
-
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
-
Tiedge M, Lortz S, Drinkgern J, et al. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 1997;46:1733-1742.
-
(1997)
Diabetes
, vol.46
, pp. 1733-1742
-
-
Tiedge, M.1
Lortz, S.2
Drinkgern, J.3
-
20
-
-
0035702761
-
Antioxidant vitamins and prevention of cardiovascular disease: Epidemiological and clinical trial data
-
Marchioli R, Schweiger C, Levantesi G, et al. Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids. 2001;36:S53-S63.
-
(2001)
Lipids
, vol.36
-
-
Marchioli, R.1
Schweiger, C.2
Levantesi, G.3
-
21
-
-
0035101472
-
Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury
-
Cuzzocrea S, Riley DP, Caputi AP, et al. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev. 2001;53:135-159.
-
(2001)
Pharmacol Rev
, vol.53
, pp. 135-159
-
-
Cuzzocrea, S.1
Riley, D.P.2
Caputi, A.P.3
-
22
-
-
0042093769
-
New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy
-
Ceriello A. New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care. 2003;26:1589-1596.
-
(2003)
Diabetes Care
, vol.26
, pp. 1589-1596
-
-
Ceriello, A.1
-
23
-
-
33744918517
-
Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide
-
Nakamura T, Terajima T, Ogata T, et al. Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide. Biol Pharm Bull. 2006;29:1167-1174.
-
(2006)
Biol Pharm Bull
, vol.29
, pp. 1167-1174
-
-
Nakamura, T.1
Terajima, T.2
Ogata, T.3
-
24
-
-
0035884737
-
Measurement of oxidative stress by EPR radical-probe technique
-
Valgimigli L, Pedulli GF, Paolini M. Measurement of oxidative stress by EPR radical-probe technique. Free Radic Biol Med. 2001;31:708-716.
-
(2001)
Free Radic Biol Med
, vol.31
, pp. 708-716
-
-
Valgimigli, L.1
Pedulli, G.F.2
Paolini, M.3
-
25
-
-
0037402398
-
Taking EPR "snapshots" of the oxidative status in human blood
-
Paolini M, Valgimigli L, Marchesi E, et al. Taking EPR "snapshots" of the oxidative status in human blood. Free Radic Res. 2003;37:503-508.
-
(2003)
Free Radic Res
, vol.37
, pp. 503-508
-
-
Paolini, M.1
Valgimigli, L.2
Marchesi, E.3
-
26
-
-
33947305767
-
Gliclazide protects human islet β-cells from apoptosis induced by intermittent high glucose
-
Del Guerra S, Grupillo M, Masini M, et al. Gliclazide protects human islet β-cells from apoptosis induced by intermittent high glucose. Diabetes Metab Res Rev. 2007;23:234-238.
-
(2007)
Diabetes Metab Res Rev
, vol.23
, pp. 234-238
-
-
Del Guerra, S.1
Grupillo, M.2
Masini, M.3
-
27
-
-
0031939587
-
Experimental NIDDM: Development of a new model in adult rats administered streptozotocin and nicotinamide
-
Masiello P, Broca C, Gross R, et al. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes. 1998;47:224-229.
-
(1998)
Diabetes
, vol.47
, pp. 224-229
-
-
Masiello, P.1
Broca, C.2
Gross, R.3
-
28
-
-
0032147208
-
Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species
-
Ischiropoulos H. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys. 1998;356:1-11.
-
(1998)
Arch Biochem Biophys
, vol.356
, pp. 1-11
-
-
Ischiropoulos, H.1
-
29
-
-
0034937703
-
Detection of nitrotyrosine in the diabetic plasma: Evidence of oxidative stress
-
Ceriello A, Mercuri F, Quagliaro L, et al. Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia. 200;144:834-838.
-
Diabetologia.
, vol.200
, Issue.144
, pp. 834-838
-
-
Ceriello, A.1
Mercuri, F.2
Quagliaro, L.3
-
30
-
-
0035946507
-
Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes
-
Novelli M, Fabregat ME, Fernandez-Alvarez J, et al. Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes. Mol Cell Endocrinol. 2001;175:57-66.
-
(2001)
Mol Cell Endocrinol
, vol.175
, pp. 57-66
-
-
Novelli, M.1
Fabregat, M.E.2
Fernandez-Alvarez, J.3
-
31
-
-
0032863183
-
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
-
Tanaka Y, Gleason CE, Tran PO, et al. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A. 1999;96:10857-10862.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10857-10862
-
-
Tanaka, Y.1
Gleason, C.E.2
Tran, P.O.3
-
32
-
-
0033499583
-
Beneficial effects of antioxidants in diabetes. Possible protection of pancreatic β-cells against glucose toxicity
-
Kaneto H, Kajimoto Y, Miyagawa J, et al. Beneficial effects of antioxidants in diabetes. Possible protection of pancreatic β-cells against glucose toxicity. Diabetes. 1999;48:2398-2406.
-
(1999)
Diabetes
, vol.48
, pp. 2398-2406
-
-
Kaneto, H.1
Kajimoto, Y.2
Miyagawa, J.3
-
33
-
-
0036235710
-
Probucol preserves pancreatic β-cell function through reduction of oxidative stress in type 2 diabetes
-
Gorogawa S, Kajimoto Y, Umayahara Y, et al. Probucol preserves pancreatic β-cell function through reduction of oxidative stress in type 2 diabetes. Diabetes Res Clin Pract. 2002;57:1-10.
-
(2002)
Diabetes Res Clin Pract
, vol.57
, pp. 1-10
-
-
Gorogawa, S.1
Kajimoto, Y.2
Umayahara, Y.3
-
34
-
-
10744227975
-
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun N-terminal kinase
-
Kawamori D, Kajimoto Y, Kaneto H, et al. Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun N-terminal kinase. Diabetes. 2003;52:2896-2904.
-
(2003)
Diabetes
, vol.52
, pp. 2896-2904
-
-
Kawamori, D.1
Kajimoto, Y.2
Kaneto, H.3
-
35
-
-
35649013806
-
Insulin secretion defects of human type 2 diabetic islets are corrected by preculture with a new reactive oxygen species scavenger
-
July 6. "Epub ahead of print"
-
Lupi R, Del Guerra S, Mancarella R, et al. Insulin secretion defects of human type 2 diabetic islets are corrected by preculture with a new reactive oxygen species scavenger. Diabetes Metab. 2007 July 6. "Epub ahead of print".
-
(2007)
Diabetes Metab
-
-
Lupi, R.1
Del Guerra, S.2
Mancarella, R.3
-
36
-
-
8744272467
-
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
-
Marchetti P, Del Guerra S, Marselli L, et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab. 2004;89:5535-5541.
-
(2004)
J Clin Endocrinol Metab.
, vol.89
, pp. 5535-5541
-
-
Marchetti, P.1
Del Guerra, S.2
Marselli, L.3
-
37
-
-
0033938076
-
L-Propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector
-
Vanella A, Russo A, Acquaviva R, et al. l-Propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol. 2000;16:99-104.
-
(2000)
Cell Biol Toxicol
, vol.16
, pp. 99-104
-
-
Vanella, A.1
Russo, A.2
Acquaviva, R.3
-
38
-
-
0034773628
-
Molecular aspects of lipoic acid in the prevention of diabetes complications
-
Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17:888-895.
-
(2001)
Nutrition
, vol.17
, pp. 888-895
-
-
Packer, L.1
Kraemer, K.2
Rimbach, G.3
-
39
-
-
0036821898
-
Part I: Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: Studies with FP15, a novel potent peroxynitrite decomposition catalyst
-
Szabo C, Mabley JG, Moeller SM, et al. Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Mol Med. 2002;8:571-580.
-
(2002)
Mol Med
, vol.8
, pp. 571-580
-
-
Szabo, C.1
Mabley, J.G.2
Moeller, S.M.3
-
40
-
-
0036468992
-
Effects of the superoxide dismutase mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats
-
Nassar T, Kadery B, Lotan C, et al. Effects of the superoxide dismutase mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2002;436:111-118.
-
(2002)
Eur J Pharmacol
, vol.436
, pp. 111-118
-
-
Nassar, T.1
Kadery, B.2
Lotan, C.3
-
41
-
-
0034988618
-
Effects of propionyl-l-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart
-
Felix C, Gillis M, Driedzic WR, et al. Effects of propionyl-l-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart. Diabetes Res Clin Pract. 2001;53:17-24.
-
(2001)
Diabetes Res Clin Pract
, vol.53
, pp. 17-24
-
-
Felix, C.1
Gillis, M.2
Driedzic, W.R.3
-
42
-
-
0035430412
-
Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve
-
Coppey LJ, Gellett JS, Davidson EP, et al. Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve. Diabetes. 2001;50:1927-1937.
-
(2001)
Diabetes
, vol.50
, pp. 1927-1937
-
-
Coppey, L.J.1
Gellett, J.S.2
Davidson, E.P.3
|