Effects of propionyl-L-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart

Diabetes Research and Clinical Practice

Volumn 53, Issue 1, 2001, Pages 17-24

  Felix, Corey ^a   Gillis, Melissa ^a   Driedzic, William R ^b   Paulson, Dennis J ^c   Broderick, Tom L ^c  

^a DALHOUSIE UNIVERSITY   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^c MIDWESTERN UNIVERSITY   (United States)

Author keywords

Cardiac function; Diabetes; Mitochondria; Propionyl L carnitine; Reperfusion

Indexed keywords

GLUTAMIC ACID; PALMITOYLCARNITINE; PROPIONYLCARNITINE; PYRUVIC ACID;

AEROBIC CAPACITY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CARDIOTONIC AGENTS; CARNITINE; DIABETES MELLITUS, EXPERIMENTAL; DIASTOLE; HEART; HEART RATE; MALE; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; SYSTOLE;

EID: 0034988618     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(01)00240-6     Document Type: Article

References (38)

1. Diabetes and cardiovascular risk factors: The Framingham study
2. Evidence for cardiomyopathy in familial diabetes mellitus
3. Abnormal mechanical function in diabetes: Relationship to altered myocardial carbohydrate/lipid metabolism
4. Defective energy metabolism in the heart of diabetes
5. Carnitine: Metabolism and function
6. Relationship between carbohydrate and lipid metabolism and the energy balance of the heart
7. Effect of L-carnitine treatment on lipid metabolism and cardiac performance in chronically diabetic rats
8. Carnitine and its derivatives in cardiovascular disease
9. L-carnitine increases glucose metabolism and mechanical function following ischemia in diabetic rat heart
10. Improvement of myocardial function in diabetic rats after treatment with L-carnitine
11. Carnitine supplementation improves myocardial function in hearts from ischemic diabetic and euglycemic rats
12. Propionyl-L-carnitine-mediated improvements in contractile function of rat hearts oxidizing acetoacetate
13. Protection of the ischaemic myocardium by L-propionylcarnitine: Effects on recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation
14. Effects of L-propionylcarnitine on mechanical recovery during reflow in intact hearts
15. Protective effects of propionyl-L-carnitine against ischemia and reperfusion damage
16. Protection of the ischemic diabetic heart by L-propionylcarnitine therapy
17. Heart mitochondrial function in chronic experimental diabetes in rats
18. Defective oxidative metabolism of heart mitochondria from genetically diabetic mice
19. Physical training reverses defect in mitochondrial energy production in heart of chronically diabetic rats
20. Decreased rate of ketone body oxidation and decreased availability of D-3-hydroxybutyrate dehydrogenase and succinyl CoA: 3-oxo CoA-transferse in heart mitochondria of diabetic rats
21. L-propionylcarnitine enhancement of substrate oxidation and mitochondrial respiration in the diabetic rat heart
22. Oxidative metabolism of Polytron versus Nagarose mitochondria in hearts of genetically diabetic mice
23. Inhibition of the adenine nucleotide translocator by matrix-localized palmitoyl-CoA in rat heart mitochondria
24. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
25. Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats
26. Effects of diabetes on myocardial glucose transporter systems in rats: Implications for diabetic cardiomyopathy
27. Acute insulin withdrawal from diabetic BB rats decreases myocardial glycolysis during low-flow ischemia
28. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts
29. Anaplerotic effect of propionyl-L-carnitine in rat heart mitochondria
30. Quantification of the effect of L-carnitine on the levels of acid-soluble short-chain acyl CoA in rat heart and liver mitochondria
31. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart
32. The propionyl-L-carnitine hypothesis: An alternative approach to treating heart failure
33. Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart
34. Acute improvement of cardiac function with intravenous L-propionyl-carnitine in humans
35. The diabetic heart is more sensitive to ischemic injury
36. Controversies on the sensitivity of the diabetic heart to ischemic injury: The sensitivity of the diabetic heart to ischemic injury is decreased
37. + exchange in cardiac sarcolemmal vesicles isolated from diabetic rats
38. + exchange during ischemia and reperfusion of normal and diabetic rat hearts