Effects of flavonoid mixtures on the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers: An in vitro and kinetic modeling approach to predict the combined effects on transporter inhibition

Food and Chemical Toxicology

Volumn 46, Issue 2, 2008, Pages 557-566

  Schutte, Maaike E ^a,c   Boersma, Marelle G ^a   Verhallen, Dorien A M ^a   Groten, John P ^b,c   Rietjens, Ivonne M C M ^a,c  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b NV ORGANON   (Netherlands)

^c TNO   (Netherlands)

Author keywords

ABC transporters; Caco 2; Flavonoids; Kinetic modeling; Mixtures; PhIP

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; FLAVONOID;

ARTICLE; BIOAVAILABILITY; CANCER CELL; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; FOOD; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MONOLAYER CULTURE; TOXICOKINETICS; TRANSPORT KINETICS;

BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CARCINOGENS; DRUG SYNERGISM; FLAVONOIDS; HUMANS; IMIDAZOLES; MODELS, BIOLOGICAL;

EID: 37349005480     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.038     Document Type: Article

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