Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity

Molecular Cancer Therapeutics

Volumn 1, Issue 11, 2002, Pages 937-941

  Blagosklonny, Mikhail V ^a   Robey, Robert ^b   Sackett, Dan L ^b   Du, Litong ^a   Traganos, Frank ^a   Darzynkiewicz, Zbigniew ^a   Fojo, Tito ^b   Bates, Susan E ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC ANTIBIOTIC; BUTYRIC ACID DERIVATIVE; CDKN1A PROTEIN, HUMAN; COLORING AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; CYCLOPEPTIDE; DEPSIPEPTIDE; DNA; ENZYME INHIBITOR; FR 901228; HISTONE DEACETYLASE; HYDROXAMIC ACID; INTRAVENOUS ANESTHETIC AGENT; OXYBATE SODIUM; PEPTIDE; PROTEIN SYNTHESIS INHIBITOR; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; TRICHOSTATIN A; TUBULIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL LINE; CELL STRAIN HL 60; DOSE RESPONSE; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; HUMAN; IMMUNOBLOTTING; LEUKEMIA CELL LINE; METABOLISM; MITOSIS; TIME;

ANESTHETICS, INTRAVENOUS; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BUTYRATES; CELL CYCLE; CELL LINE; COLORING AGENTS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DEPSIPEPTIDES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; G2 PHASE; HISTONE DEACETYLASES; HL-60 CELLS; HUMANS; HYDROXAMIC ACIDS; IMMUNOBLOTTING; JURKAT CELLS; MITOSIS; PEPTIDES; PEPTIDES, CYCLIC; PROTEIN SYNTHESIS INHIBITORS; SODIUM OXYBATE; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TRANSCRIPTION, GENETIC; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0036731055     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Weidle, U. H., and Grossmann, A. Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment. Anticancer Res., 20: 1471-1485, 2000. (Pubitemid 30628153)
2. Marks, P. A., Rifkind, R. A., Richon, V. M., and Breslow, R. Inhibitors of histone deacetylase are potentially effective anticancer agents. Clin. Cancer Res., 7: 759-760, 2001. (Pubitemid 32708707)
3. Marks, P. A., Richon, V. M., and Rifkind, R. A. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J. Natl. Cancer Inst. (Bethesda), 92: 1210-1216, 2000. (Pubitemid 30627729)
4. Sambucetti, L. C., Fischer, D. D., Zabludoff, S., Kwon, P. O., Chamberlin, H., Trogani, N., Xu, H., and Cohen, D. Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects. J. Biol. Chem., 274: 34940-34947, 1999. (Pubitemid 129509542)
5. Sowa, Y., Orita, T., Minamikawa, S., Nakano, K., Mizuno, T., Nomura, H., and Sakai, T. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the SP1 sites. Biochem. Biophys. Res. Comm., 241: 142-150, 1997. (Pubitemid 28033553)
6. Xiao, H., Hasegawa, T., Miyaishi, O., Ohkusu, K., and Isobe, K. Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. Biochem. Biophys. Res. Commun., 237: 457-460, 1997. (Pubitemid 27406052)
7. Rajgolikar, G., Chan, K. K., and Wang, H. C. Effects of a novel antitumor depsipeptide. FR901228, on human breast cancer cells. Breast Cancer Res. Treat., 51: 29-38, 1998. (Pubitemid 28550158)
8. 1 arrest results from p21 independent disruption of retinoblastoma protein-mediated signals. Cell Growth Differ., 1998.
9. Huang, L., Sowa, Y., Sakai, T., and Pardee, A. B. Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites. Oncogene, 19: 5712-5719, 2000.
10. Huang, L., and Pardee, A. B. Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer. Mol. Med., 6: 849-866, 2000.
11. Sandor, V., Senderowicz, A., Mertins, S., Sackett, D., Sausville, E., Blagosklonny, M. V., and Bates, S. E. P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br. J. Cancer, 83: 817-825, 2000.
12. Burgess, A. J., Pavey, S., Warrener, R., Hunter, L. J., Piva, T. J., Musgrove, E. A., Saunders, N., Parsons, P. G., and Gabrielli, B. G. Upregulation of p21(WAF1/CIP1) by histone deacetylase inhibitors reduces their cytotoxicity. Mol. Pharmacol., 60: 828-837, 2001. (Pubitemid 32900266)
13. Medina, V., Edmonds, B., Young, G. P., James, R., Appleton, S., and Zalewski, P. D. Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res., 57: 3697-3707, 1997. (Pubitemid 27381212)
14. Bernhard, D., Ausserlechner, M. J., Tonko, M., Loffler, M., Hartmann, B. L., Csordas, A., and Kofler, R. Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts. FASEB J., 13: 1991-2001, 1999. (Pubitemid 29517629)
15. An, W. G., Hwang, S. G., Trepel, J. B., and Blagosklonny, M. V. Protease inhibitor induced apoptosis: accumulation wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia (Baltimore), 14: 1276-1283, 2000. (Pubitemid 30445036)
16. 2 cell cycle arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity. Oncogene, 20: 3806-3813, 2001.
17. Blagosklonny, M. V., Robey, R., Sheikh, M. S., and Fojo, T. Paclitaxel-induced FasL independent apoptosis and slow (non-apoptotic) cell death. Cancer Biol. Ther., 1: 113-117, 2002.
18. Sandor, V., Robbins, A. R., Robey, R., Myers, T., Sausville, E., Bates, S. E., and Sackett, D. L. FR901228 causes mitotic arrest but does not alter microtubule polymerization. Anticancer Drugs, 11: 445-454, 2000.
19. Taddei, A., Maison, C., Roche, D., and Almouzni, G. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. Nat. Cell Biol., 3: 114-120, 2001. (Pubitemid 32118363)
20. Chai, F., Evdokiou, A., Young, G. P., and Zalewski, P. D. Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. Carcinogenesis (Lond.), 21: 7-14, 2000. (Pubitemid 30064137)
21. Halicka, H. D., Smolewski, P., Darzynkiewicz, Z., Dai, W., Traganos, F. Arsenic trioxide arrests cells early in mitosis leading to apoptosis. Cell Cycle, 1: 201-209, 2002.
22. 3): still a mystery. Cell Cycle, 1: 183-186, 2002.
23. Perkins, C., Kim, C. N., Fang, G., Bhalla, K. N. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood, 95: 1014-1022, 2000. (Pubitemid 30062726)
24. Maruta, H., Greer, K., and Rosenbaum, J. L. The acetylation of α-tubulin and its relationship to the assembly and disassembly of microtubules. J. Cell. Biol., 103: 571-579, 1986. (Pubitemid 16055052)
25. Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X. F., and Yao, T. P. HDAC6 is a microtubule-associated deacetylase. Nature (Lond.), 417: 455-458, 2002. (Pubitemid 34563539)