메뉴 건너뛰기




Volumn 6, Issue 22, 2007, Pages 2760-2767

The mammalian DNA replication elongation checkpoint: Implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses

Author keywords

ATR Chk1; Camptothecin; DNA replication; Fork progression checkpoint; Molecular combing; S phase checkpoint; Topoisomerase

Indexed keywords

CHECKPOINT KINASE 1; DNA;

EID: 37249004667     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.22.4932     Document Type: Review
Times cited : (64)

References (55)
  • 1
    • 33749028012 scopus 로고    scopus 로고
    • Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks
    • Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem 2006; 281:30814-23.
    • (2006) J Biol Chem , vol.281 , pp. 30814-30823
    • Takemura, H.1    Rao, V.A.2    Sordet, O.3    Furuta, T.4    Miao, Z.H.5    Meng, L.6    Zhang, H.7    Pommier, Y.8
  • 2
    • 26244431903 scopus 로고    scopus 로고
    • Right place, right time, and only once: Replication initiation in metazoans
    • Machida YJ, Hamlin JL, Dutta A. Right place, right time, and only once: Replication initiation in metazoans. Cell 2005; 123:13-24.
    • (2005) Cell , vol.123 , pp. 13-24
    • Machida, Y.J.1    Hamlin, J.L.2    Dutta, A.3
  • 3
    • 33749599776 scopus 로고    scopus 로고
    • Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase
    • Petermann E, Caldecott KW. Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle 2006; 5:2203-9.
    • (2006) Cell Cycle , vol.5 , pp. 2203-2209
    • Petermann, E.1    Caldecott, K.W.2
  • 4
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005; 19:1040-52.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 6
    • 29544437558 scopus 로고    scopus 로고
    • Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions
    • Lopes M, Foiani M, Sogo JM. Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell 2006;21:15-27.
    • (2006) Mol Cell , vol.21 , pp. 15-27
    • Lopes, M.1    Foiani, M.2    Sogo, J.M.3
  • 8
    • 34249946978 scopus 로고    scopus 로고
    • Interplay of replication checkpoints and repair proteins at stalled replication forks
    • Branzei D, Foiani M. Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair (Amst) 2007; 6:994-1003.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 994-1003
    • Branzei, D.1    Foiani, M.2
  • 9
  • 10
    • 34547902426 scopus 로고    scopus 로고
    • The intra-S-phase checkpoint affects both DNA replication initiation and elongation: Single-cell and -DNA fiber analyses
    • Seiler JA, Conti C, Syed A, Aladjem MI, Pommier Y. The intra-S-phase checkpoint affects both DNA replication initiation and elongation: Single-cell and -DNA fiber analyses. Mol Cell Biol 2007; 27:5806-18.
    • (2007) Mol Cell Biol , vol.27 , pp. 5806-5818
    • Seiler, J.A.1    Conti, C.2    Syed, A.3    Aladjem, M.I.4    Pommier, Y.5
  • 11
    • 34447565003 scopus 로고    scopus 로고
    • Replication in context: Dynamic regulation of DNA replication patterns in metazoans
    • Aladjem MI. Replication in context: Dynamic regulation of DNA replication patterns in metazoans. Nat Rev Genet 2007; 8:588-600.
    • (2007) Nat Rev Genet , vol.8 , pp. 588-600
    • Aladjem, M.I.1
  • 15
    • 0036668464 scopus 로고    scopus 로고
    • Mapping of early firing origins on a replication profile of budding yeast
    • Yabuki N, Terashima H, Kitada K. Mapping of early firing origins on a replication profile of budding yeast. Genes Cells 2002; 7:781-9.
    • (2002) Genes Cells , vol.7 , pp. 781-789
    • Yabuki, N.1    Terashima, H.2    Kitada, K.3
  • 17
    • 0032752071 scopus 로고    scopus 로고
    • Single molecule analysis of DNA replication
    • Herrick J, Bensimon A. Single molecule analysis of DNA replication. Biochimie 1999;81:859-71.
    • (1999) Biochimie , vol.81 , pp. 859-871
    • Herrick, J.1    Bensimon, A.2
  • 19
    • 34547814092 scopus 로고    scopus 로고
    • Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells
    • Conti C, Sacca B, Herrick J, Lalou C, Pommier Y, Bensimon A. Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell 2007; 18:3059-67.
    • (2007) Mol Biol Cell , vol.18 , pp. 3059-3067
    • Conti, C.1    Sacca, B.2    Herrick, J.3    Lalou, C.4    Pommier, Y.5    Bensimon, A.6
  • 20
    • 34250331269 scopus 로고    scopus 로고
    • Unscheduled DNA replication origin activation at inserted HPV 18 sequences in a HPV-18/MYC amplicon
    • Conti C, Herrick J, Bensimon A. Unscheduled DNA replication origin activation at inserted HPV 18 sequences in a HPV-18/MYC amplicon. Genes Chromosomes Cancer 2007; 46:724-34.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 724-734
    • Conti, C.1    Herrick, J.2    Bensimon, A.3
  • 22
    • 0042743766 scopus 로고    scopus 로고
    • Dynamics of replication in mammalian somatic cells:nucleotide pool modulates origin choice and interorigin spacing
    • Anglana MAF, Bensimon A, Debatisse M. Dynamics of replication in mammalian somatic cells:nucleotide pool modulates origin choice and interorigin spacing. Cell 2003; 114:385-394.
    • (2003) Cell , vol.114 , pp. 385-394
    • Anglana, M.A.F.1    Bensimon, A.2    Debatisse, M.3
  • 23
    • 26444467122 scopus 로고    scopus 로고
    • Phosphorylation of BLM, dissociation for topoisomerase IIIα and colocalization with γ-H2AX after topoisomerase I-induced replication damage
    • Rao A, Fan AM, Meng L, Doe CL, North PS, Hickson I, Pommier Y. Phosphorylation of BLM, dissociation for topoisomerase IIIα and colocalization with γ-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol 2005; 25:8925-37.
    • (2005) Mol Cell Biol , vol.25 , pp. 8925-8937
    • Rao, A.1    Fan, A.M.2    Meng, L.3    Doe, C.L.4    North, P.S.5    Hickson, I.6    Pommier, Y.7
  • 24
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: Structure, function, and mechanism
    • Champoux JJ. DNA topoisomerases: Structure, function, and mechanism. Annu Rev Biochem 2001; 70:369-413.
    • (2001) Annu Rev Biochem , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 25
    • 0032539981 scopus 로고    scopus 로고
    • Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen
    • Pommier Y, Kohlhagen G, Wu C, Simmons DT. Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen. Biochemistry 1998; 37:3818-23.
    • (1998) Biochemistry , vol.37 , pp. 3818-3823
    • Pommier, Y.1    Kohlhagen, G.2    Wu, C.3    Simmons, D.T.4
  • 26
    • 0036085460 scopus 로고    scopus 로고
    • Cellular roles of DNA topoisomerases: A molecular perspective
    • Wang JC. Cellular roles of DNA topoisomerases: A molecular perspective. Nat Rev Mol Cell Biol 2002; 3:430-40.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 430-440
    • Wang, J.C.1
  • 28
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors, camptothecins and beyond
    • In press
    • Pommier Y. Topoisomerase I inhibitors, camptothecins and beyond. Nature Review Cancer 2006, (In press).
    • (2006) Nature Review Cancer
    • Pommier, Y.1
  • 32
    • 4644318231 scopus 로고    scopus 로고
    • Potentiation of cytotoxicity of topoisomerase I poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe
    • Tse AN, Schwartz GK. Potentiation of cytotoxicity of topoisomerase I poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe. Cancer Res 2004; 64:6635-44.
    • (2004) Cancer Res , vol.64 , pp. 6635-6644
    • Tse, A.N.1    Schwartz, G.K.2
  • 34
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang YH, Hertzberg R, Hecht S, Liu LF. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985; 260:14873-8.
    • (1985) J Biol Chem , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 35
    • 0033104517 scopus 로고    scopus 로고
    • Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
    • Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J 1999; 18:1397-406.
    • (1999) EMBO J , vol.18 , pp. 1397-1406
    • Shao, R.G.1    Cao, C.X.2    Zhang, H.3    Kohn, K.W.4    Wold, M.S.5    Pommier, Y.6
  • 36
    • 0034124053 scopus 로고    scopus 로고
    • Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff
    • Strumberg D, Pilon AA, Smith M, Hickey R, Malkas L, Pommier Y. Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol 2000; 20:3977-87.
    • (2000) Mol Cell Biol , vol.20 , pp. 3977-3987
    • Strumberg, D.1    Pilon, A.A.2    Smith, M.3    Hickey, R.4    Malkas, L.5    Pommier, Y.6
  • 38
    • 0024460479 scopus 로고
    • Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I
    • Covey JM, Jaxel C, Kohn KW, Pommier Y. Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I. Cancer Res 1989; 49:5016-22.
    • (1989) Cancer Res , vol.49 , pp. 5016-5022
    • Covey, J.M.1    Jaxel, C.2    Kohn, K.W.3    Pommier, Y.4
  • 39
    • 24044444531 scopus 로고    scopus 로고
    • The circadian timekeeping system of Drosophila
    • Hardin PE. The circadian timekeeping system of Drosophila. Curr Biol 2005; 15:R714-22.
    • (2005) Curr Biol , vol.15
    • Hardin, P.E.1
  • 40
    • 16244408025 scopus 로고    scopus 로고
    • Coupling of human circadian and cell cycles by the timeless protein
    • Unsal-Kacmaz K, Mullen TE, Kaufmann WK, Sancar A. Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol 2005; 25:3109-16.
    • (2005) Mol Cell Biol , vol.25 , pp. 3109-3116
    • Unsal-Kacmaz, K.1    Mullen, T.E.2    Kaufmann, W.K.3    Sancar, A.4
  • 41
    • 0033555771 scopus 로고    scopus 로고
    • Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae
    • Park H, Sternglanz R. Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae. Yeast 1999; 15:35-41.
    • (1999) Yeast , vol.15 , pp. 35-41
    • Park, H.1    Sternglanz, R.2
  • 42
    • 0038499675 scopus 로고    scopus 로고
    • Gotter AL. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J Mol Biol 2003; 331:167-76.
    • Gotter AL. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J Mol Biol 2003; 331:167-76.
  • 43
    • 33845320139 scopus 로고    scopus 로고
    • Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function
    • Chou DM, Elledge SJ. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc Natl Acad Sci USA 2006; 103:18143-7.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18143-18147
    • Chou, D.M.1    Elledge, S.J.2
  • 44
    • 4544250127 scopus 로고    scopus 로고
    • Swi1 and Swi3 are components of a replication fork protection complex in fission yeast
    • Noguchi E, Noguchi C, McDonald WH, Yates IIIrd JR, Russell P. Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol 2004; 24:8342-55.
    • (2004) Mol Cell Biol , vol.24 , pp. 8342-8355
    • Noguchi, E.1    Noguchi, C.2    McDonald, W.H.3    Yates IIIrd, J.R.4    Russell, P.5
  • 45
    • 34047261441 scopus 로고    scopus 로고
    • Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint
    • Yoshizawa-Sugata N, Masai H. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J Biol Chem 2007; 282:2729-40.
    • (2007) J Biol Chem , vol.282 , pp. 2729-2740
    • Yoshizawa-Sugata, N.1    Masai, H.2
  • 46
    • 33751520767 scopus 로고    scopus 로고
    • DNA replication timing: Random thoughts about origin firing
    • Rhind N. DNA replication timing: Random thoughts about origin firing. Nat Cell Biol 2006; 8:1313-6.
    • (2006) Nat Cell Biol , vol.8 , pp. 1313-1316
    • Rhind, N.1
  • 47
    • 0036860727 scopus 로고    scopus 로고
    • The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells
    • Dimitrova DS, Berezney R. The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells. J Cell Sci 2002; 115:4037-51.
    • (2002) J Cell Sci , vol.115 , pp. 4037-4051
    • Dimitrova, D.S.1    Berezney, R.2
  • 49
    • 0022504648 scopus 로고
    • Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus
    • Nakamura H, Morita T, Sato C. Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res 1986; 165:291-7.
    • (1986) Exp Cell Res , vol.165 , pp. 291-297
    • Nakamura, H.1    Morita, T.2    Sato, C.3
  • 50
    • 0033546210 scopus 로고    scopus 로고
    • The organization of replication and transcription
    • Cook PR. The organization of replication and transcription. Science 1999; 284:1790-5.
    • (1999) Science , vol.284 , pp. 1790-1795
    • Cook, P.R.1
  • 51
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-16.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 52
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 53
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody
    • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002; 158:486-92.
    • (2002) Radiat Res , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 54
    • 0034655281 scopus 로고    scopus 로고
    • The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
    • Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res 2000; 60:2108-12.
    • (2000) Cancer Res , vol.60 , pp. 2108-2112
    • Busby, E.C.1    Leistritz, D.F.2    Abraham, R.T.3    Karnitz, L.M.4    Sarkaria, J.N.5
  • 55
    • 27944452746 scopus 로고    scopus 로고
    • Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development
    • Norio P, Kosiyatrakul S, Yang Q, Guan Z, Brown NM, Thomas S, Riblet R, Schildkraut CL. Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development. Mol Cell 2005; 20:575-87.
    • (2005) Mol Cell , vol.20 , pp. 575-587
    • Norio, P.1    Kosiyatrakul, S.2    Yang, Q.3    Guan, Z.4    Brown, N.M.5    Thomas, S.6    Riblet, R.7    Schildkraut, C.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.