The circadian timekeeping system of Drosophila

Current Biology

Volumn 15, Issue 17, 2005, Pages

  Hardin, Paul E ^a  

^a University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CLK PROTEIN, DROSOPHILA; CYCLE PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; NUCLEAR PROTEIN; PERIOD PROTEIN, INSECT; TIMELESS PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

ANIMAL; ASSOCIATION; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; DROSOPHILA; GENE EXPRESSION REGULATION; LIGHT; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; CUES; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; LIGHT; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 24044444531     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2005.08.019     Document Type: Review

References (96)

1. J.C. Hall Genetics and molecular biology of rhythms in Drosophila and other insects Adv. Genet. 48 2003 1 280
2. J.E. Rutila, V. Suri, M. Le, W.V. So, M. Rosbash, and J.C. Hall CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless Cell 93 1998 805 814
3. R. Allada, N.E. White, W.V. So, J.C. Hall, and M. Rosbash A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless Cell 93 1998 791 804
4. T.K. Darlington, K. Wager-Smith, M.F. Ceriani, D. Staknis, N. Gekakis, T.D. Steeves, C.J. Weitz, J.S. Takahashi, and S.A. Kay Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim Science 280 1998 1599 1603
5. S.A. Cyran, A.M. Buchsbaum, K.L. Reddy, M.C. Lin, N.R. Glossop, P.E. Hardin, M.W. Young, R.V. Storti, and J. Blau vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock Cell 112 2003 329 341
6. J. Blau, and M.W. Young Cycling vrille expression is required for a functional Drosophila clock Cell 99 1999 661 671
7. N.R. Glossop, J.H. Houl, H. Zheng, F.S. Ng, S.M. Dudek, and P.E. Hardin VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator Neuron 37 2003 249 261
8. J.L. Price, J. Blau, A. Rothenfluh, M. Abodeely, B. Kloss, and M.W. Young double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation Cell 94 1998 83 95
9. B. Kloss, J.L. Price, L. Saez, J. Blau, A. Rothenfluh, C.S. Wesley, and M.W. Young The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon Cell 94 1998 97 107
10. J.M. Lin, V.L. Kilman, K. Keegan, B. Paddock, M. Emery-Le, M. Rosbash, and R. Allada A role for casein kinase 2alpha in the Drosophila circadian clock Nature 420 2002 816 820
11. B. Akten, E. Jauch, G.K. Genova, E.Y. Kim, I. Edery, T. Raabe, and F.R. Jackson A role for CK2 in the Drosophila circadian oscillator Nat. Neurosci. 6 2003 251 257
12. S. Martinek, S. Inonog, A.S. Manoukian, and M.W. Young A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock Cell 105 2001 769 779
13. S. Sathyanarayanan, X. Zheng, R. Xiao, and A. Sehgal Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A Cell 116 2004 603 615
14. H.W. Ko, J. Jiang, and I. Edery Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime Nature 420 2002 673 678
15. B. Grima, A. Lamouroux, E. Chelot, C. Papin, B. Limbourg-Bouchon, and F. Rouyer The F-box protein slimb controls the levels of clock proteins period and timeless Nature 420 2002 178 182
16. P.E. Hardin, J.C. Hall, and M. Rosbash Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels Nature 343 1990 536 540
17. N.R. Glossop, L.C. Lyons, and P.E. Hardin Interlocked feedback loops within the Drosophila circadian oscillator Science 286 1999 766 768
18. H. Hao, D.L. Allen, and P.E. Hardin A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster Mol. Cell. Biol. 17 1997 3687 3693
19. M.J. McDonald, M. Rosbash, and P. Emery Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter Mol. Cell. Biol. 21 2001 1207 1217
20. G.K. Wang, A. Ousley, T.K. Darlington, D. Chen, Y. Chen, W. Fu, L.J. Hickman, S.A. Kay, and A. Sehgal Regulation of the cycling of timeless (tim) RNA J. Neurobiol. 47 2001 161 175
21. D.M. Zerr, J.C. Hall, M. Rosbash, and K.K. Siwicki Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila J. Neurosci. 10 1990 2749 2762
22. I. Edery, L.J. Zwiebel, M.E. Dembinska, and M. Rosbash Temporal phosphorylation of the Drosophila period protein Proc. Natl. Acad. Sci. USA 91 1994 2260 2264
23. A. Sehgal, A. Rothenfluh-Hilfiker, M. Hunter-Ensor, Y. Chen, M.P. Myers, and M.W. Young Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation Science 270 1995 808 810
24. M. Hunter-Ensor, A. Ousley, and A. Sehgal Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light Cell 84 1996 677 685
25. M.P. Myers, K. Wager-Smith, A. Rothenfluh-Hilfiker, and M.W. Young Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock Science 271 1996 1736 1740
26. H. Zeng, Z. Qian, M.P. Myers, and M. Rosbash A light-entrainment mechanism for the Drosophila circadian clock Nature 380 1996 129 135
27. P. Nawathean, and M. Rosbash The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity Mol. Cell 13 2004 213 223
28. B. Kloss, A. Rothenfluh, M.W. Young, and L. Saez Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock Neuron 30 2001 699 706
29. L.J. Ashmore, S. Sathyanarayanan, D.W. Silvestre, M.M. Emerson, P. Schotland, and A. Sehgal Novel insights into the regulation of the timeless protein J. Neurosci. 23 2003 7810 7819
30. O.T. Shafer, M. Rosbash, and J.W. Truman Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster J. Neurosci. 22 2002 5946 5954
31. A. Rothenfluh, M.W. Young, and L. Saez A TIMELESS-independent function for PERIOD proteins in the Drosophila clock Neuron 26 2000 505 514
32. C. Lee, K. Bae, and I. Edery PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription Mol. Cell. Biol. 19 1999 5316 5325
33. Y. Cheng, and P.E. Hardin Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling J. Neurosci. 18 1998 741 750
34. Z. Yang, and A. Sehgal Role of molecular oscillations in generating behavioral rhythms in Drosophila Neuron 29 2001 453 467
35. E.Y. Kim, K. Bae, F.S. Ng, N.R. Glossop, P.E. Hardin, and I. Edery Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity Neuron 34 2002 69 81
36. b mutation identifies cryptochrome as a circadian photoreceptor in Drosophila Cell 95 1998 681 692
37. P. Emery, W.V. So, M. Kaneko, J.C. Hall, and M. Rosbash CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity Cell 95 1998 669 679
38. B. Krishnan, J.D. Levine, M.K. Lynch, H.B. Dowse, P. Funes, J.C. Hall, P.E. Hardin, and S.E. Dryer A new role for cryptochrome in a Drosophila circadian oscillator Nature 411 2001 313 317
39. M. Ivanchenko, R. Stanewsky, and J.M. Giebultowicz Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks J. Biol. Rhythms 16 2001 205 215
40. F.J. Lin, W. Song, E. Meyer-Bernstein, N. Naidoo, and A. Sehgal Photic signaling by cryptochrome in the Drosophila circadian system Mol. Cell. Biol. 21 2001 7287 7294
41. S. Dissel, V. Codd, R. Fedic, K.J. Garner, R. Costa, C.P. Kyriacou, and E. Rosato A constitutively active cryptochrome in Drosophila melanogaster Nat. Neurosci. 7 2004 834 840
42. A. Busza, M. Emery-Le, M. Rosbash, and P. Emery Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception Science 304 2004 1503 1506
43. H. George, and R. Terracol The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors Genetics 146 1997 1345 1363
44. Z. Yang, M. Emerson, H.S. Su, and A. Sehgal Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception Neuron 21 1998 215 223
45. V. Suri, Z. Qian, J.C. Hall, and M. Rosbash Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster Neuron 21 1998 225 234
46. R.J. Konopka Genetic dissection of the Drosophila circadian system Fed. Proc. 38 1979 2602 2605
47. N. Naidoo, W. Song, M. Hunter-Ensor, and A. Sehgal A role for the proteasome in the light response of the timeless clock protein Science 285 1999 1737 1741
48. C. Lee, V. Parikh, T. Itsukaichi, K. Bae, and I. Edery Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex Science 271 1996 1740 1744
49. C. Helfrich-Forster, C. Winter, A. Hofbauer, J.C. Hall, and R. Stanewsky The circadian clock of fruit flies is blind after elimination of all known photoreceptors Neuron 30 2001 249 261
50. A. Klarsfeld, S. Malpel, C. Michard-Vanhee, M. Picot, E. Chelot, and F. Rouyer Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila J. Neurosci. 24 2004 1468 1477
51. A.R. Cashmore, J.A. Jarillo, Y.J. Wu, and D. Liu Cryptochromes: blue light receptors for plants and animals Science 284 1999 760 765
52. E. Rosato, V. Codd, G. Mazzotta, A. Piccin, M. Zordan, R. Costa, and C.P. Kyriacou Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY Curr. Biol. 11 2001 909 917
53. M.F. Ceriani, T.K. Darlington, D. Staknis, P. Mas, A.A. Petti, C.J. Weitz, and S.A. Kay Light-dependent sequestration of TIMELESS by CRYPTOCHROME Science 285 1999 553 556
54. K.K. Siwicki, C. Eastman, G. Petersen, M. Rosbash, and J.C. Hall Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system Neuron 1 1988 141 150
55. J.D. Plautz, M. Kaneko, J.C. Hall, and S.A. Kay Independent photoreceptive circadian clocks throughout Drosophila Science 278 1997 1632 1635
56. X. Liu, L. Lorenz, Q.N. Yu, J.C. Hall, and M. Rosbash Spatial and temporal expression of the period gene in Drosophila melanogaster Genes Dev. 2 1988 228 238
57. C. Helfrich-Forster The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster Microsc. Res. Tech. 62 2003 94 102
58. P.E. Hardin Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators Mol. Cell. Biol. 14 1994 7211 7218
59. D.M. Hege, R. Stanewsky, J.C. Hall, and J.M. Giebultowicz Rhythmic expression of a PER-reporter in the Malpighian tubules of decapitated Drosophila: evidence for a brain-independent circadian clock J. Biol. Rhythms 12 1997 300 308
60. J.H. Houl, W. Yu, S.M. Dudek, and P.E. Hardin Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells 2005 Submitted.
61. J.M. Giebultowicz, R. Stanewsky, J.C. Hall, and D.M. Hege Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host Curr. Biol. 10 2000 107 110
62. M. Kaneko, and J.C. Hall Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections J. Comp. Neurol. 422 2000 66 94
63. L.M. Beaver, B.L. Rush, B.O. Gvakharia, and J.M. Giebultowicz Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster J. Biol. Rhythms 18 2003 463 472
64. R. Stanewsky, C.F. Jamison, J.D. Plautz, S.A. Kay, and J.C. Hall Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila EMBO J. 16 1997 5006 5018
65. C. Brandes, J.D. Plautz, R. Stanewsky, C.F. Jamison, M. Straume, K.V. Wood, S.A. Kay, and J.C. Hall Novel features of Drosophila period Transcription revealed by real-time luciferase reporting Neuron 16 1996 687 692
66. B. Krishnan, S.E. Dryer, and P.E. Hardin Circadian rhythms in olfactory responses of Drosophila melanogaster Nature 400 1999 375 378
67. J.D. Levine, P. Funes, H.B. Dowse, and J.C. Hall Advanced analysis of a cryptochrome mutation's effects on the robustness and phase of molecular cycles in isolated peripheral tissues of Drosophila BMC Neurosci. 3 2002 5
68. Y. Peng, D. Stoleru, J.D. Levine, J.C. Hall, and M. Rosbash Drosophila free-running rhythms require intercellular communication PLoS Biol. 1 2003 E13
69. D. Stoleru, Y. Peng, J. Agosto, and M. Rosbash Coupled oscillators control morning and evening locomotor behaviour of Drosophila Nature 431 2004 862 868
70. B. Grima, E. Chelot, R. Xia, and F. Rouyer Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain Nature 431 2004 869 873
71. E.M. Myers, J. Yu, and A. Sehgal Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster Curr. Biol. 13 2003 526 533
72. A. Claridge-Chang, H. Wijnen, F. Naef, C. Boothroyd, N. Rajewsky, and M.W. Young Circadian regulation of gene expression systems in the Drosophila head Neuron 32 2001 657 671
73. M.F. Ceriani, J.B. Hogenesch, M. Yanovsky, S. Panda, M. Straume, and S.A. Kay Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior J. Neurosci. 22 2002 9305 9319
74. Y. Lin, M. Han, B. Shimada, L. Wang, T.M. Gibler, A. Amarakone, T.A. Awad, G.D. Stormo, R.N. Van Gelder, and P.H. Taghert Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster Proc. Natl. Acad. Sci. USA 99 2002 9562 9567
75. M.J. McDonald, and M. Rosbash Microarray analysis and organization of circadian gene expression in Drosophila Cell 107 2001 567 578
76. H.R. Ueda, A. Matsumoto, M. Kawamura, M. Iino, T. Tanimura, and S. Hashimoto Genome-wide transcriptional orchestration of circadian rhythms in Drosophila J. Biol. Chem. 277 2002 14048 14052
77. C. McCabe, and A. Birley Oviposition in the period genotypes of Drosophila melanogaster Chronobiol. Int. 15 1998 119 133
78. R.J. Konopka, and S. Benzer Clock mutants of Drosophila melanogaster Proc. Natl. Acad. Sci. USA 68 1971 2112 2116
79. T. Sakai, T. Tamura, T. Kitamoto, and Y. Kidokoro A clock gene, period, plays a key role in long-term memory formation in Drosophila Proc. Natl. Acad. Sci. USA 101 2004 16058 16063
80. M.N. Nitabach, J. Blau, and T.C. Holmes Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock Cell 109 2002 485 495
81. S.C. Renn, J.H. Park, M. Rosbash, J.C. Hall, and P.H. Taghert A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila Cell 99 1999 791 802
82. J.H. Park, C. Helfrich-Forster, G. Lee, L. Liu, M. Rosbash, and J.C. Hall Differential regulation of circadian pacemaker output by separate clock genes in Drosophila Proc. Natl. Acad. Sci. USA 97 2000 3608 3613
83. J.S. de Belle, and M. Heisenberg Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies Science 263 1994 692 695
84. C. Helfrich-Forster The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster Proc. Natl. Acad. Sci. USA 92 1995 612 616
85. C. Helfrich-Forster, M. Tauber, J.H. Park, M. Muhlig-Versen, S. Schneuwly, and A. Hofbauer Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster J. Neurosci. 20 2000 3339 3353
86. E.C. Johnson, L.M. Bohn, L.S. Barak, R.T. Birse, D.R. Nassel, M.G. Caron, and P.H. Taghert Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions J. Biol. Chem. 278 2003 52172 52178
87. C. Helfrich-Forster Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster-sex-specific differences suggest a different quality of activity J. Biol. Rhythms 15 2000 135 154
88. C.S. Pittendrigh, and S. Daan A functional analysis of pacemakers in nocturnal rodents. V. Pacemaker structure: A clock for all seasons J. Comp. Physiol. 106 1976 333 355
89. J. Majercak, D. Sidote, P.E. Hardin, and I. Edery How a circadian clock adapts to seasonal decreases in temperature and day length Neuron 24 1999 219 230
90. S. Tanoue, P. Krishnan, B. Krishnan, S.E. Dryer, and P.E. Hardin Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila Curr. Biol. 14 2004 638 649
91. D.S. Saunders Insect circadian rhythms and photoperiodism Invert. Neurosci. 3 1997 155 164
92. B.M. Sweeney, and J.W. Hastings Effects of temperature upon diurnal rhythms Cold Spring Harb. Symp. Quant. Biol. 25 1960 87 104
93. B.H. Collins, E. Rosato, and C.P. Kyriacou Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C Proc. Natl. Acad. Sci. USA 101 2004 1945 1950
94. J. Majercak, W.F. Chen, and I. Edery Splicing of the period gene 3′-terminal intron is regulated by light, circadian clock factors, and phospholipase C Mol. Cell. Biol. 24 2004 3359 3372
95. J. Zhao, V.L. Kilman, K.P. Keegan, Y. Peng, P. Emery, M. Rosbash, and R. Allada Drosophila clock can generate ectopic circadian clocks Cell 113 2003 755 766
96. P.E. Hardin Transcription regulation within the circadian clock: the E-box and beyond J. Biol. Rhythms 19 2004 348 360