-
1
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright K.M., Renatus M., Scott F.L., Sperandio S., Shin H., Pedersen I.M., Ricci J.E., Edris W.A., Sutherlin D.P., Green D.R., and Salvesen G.S. A unified model for apical caspase activation. Mol. Cell 11 (2003) 529-541
-
(2003)
Mol. Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
Renatus, M.2
Scott, F.L.3
Sperandio, S.4
Shin, H.5
Pedersen, I.M.6
Ricci, J.E.7
Edris, W.A.8
Sutherlin, D.P.9
Green, D.R.10
Salvesen, G.S.11
-
2
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou M.A., Ringshausen I., Finch A.J., Swigart L.B., and Evan G.I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443 (2006) 214-217
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
3
-
-
0842281645
-
Cell death: critical control points
-
Danial N.N., and Korsmeyer S.J. Cell death: critical control points. Cell 116 (2004) 205-219
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
4
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., Mukherjee C., Shi Y., Gelinas C., Fan Y., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10 (2006) 51-64
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
Mukherjee, C.7
Shi, Y.8
Gelinas, C.9
Fan, Y.10
-
5
-
-
0034651791
-
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
-
Goyal L., McCall K., Agapite J., Hartwieg E., and Steller H. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19 (2000) 589-597
-
(2000)
EMBO J.
, vol.19
, pp. 589-597
-
-
Goyal, L.1
McCall, K.2
Agapite, J.3
Hartwieg, E.4
Steller, H.5
-
6
-
-
0036463405
-
A matter of life and death
-
Green D.R., and Evan G.I. A matter of life and death. Cancer Cell 1 (2002) 19-30
-
(2002)
Cancer Cell
, vol.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
7
-
-
33847206401
-
The Salvador-Warts-Hippo pathway-an emerging tumour-suppressor network
-
Harvey K., and Tapon N. The Salvador-Warts-Hippo pathway-an emerging tumour-suppressor network. Nat. Rev. Cancer 7 (2007) 182-191
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 182-191
-
-
Harvey, K.1
Tapon, N.2
-
8
-
-
33847400593
-
Metabolic catastrophe as a means to cancer cell death
-
Jin S., DiPaola R.S., Mathew R., and White E. Metabolic catastrophe as a means to cancer cell death. J. Cell Sci. 120 (2007) 379-383
-
(2007)
J. Cell Sci.
, vol.120
, pp. 379-383
-
-
Jin, S.1
DiPaola, R.S.2
Mathew, R.3
White, E.4
-
9
-
-
0015383455
-
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr J.F., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257
-
(1972)
Br. J. Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
10
-
-
33845483887
-
Caspases in cell survival, proliferation and differentiation
-
Lamkanfi M., Festjens N., Declercq W., Vanden Berghe T., and Vandenabeele P. Caspases in cell survival, proliferation and differentiation. Cell Death Differ. 14 (2007) 44-55
-
(2007)
Cell Death Differ.
, vol.14
, pp. 44-55
-
-
Lamkanfi, M.1
Festjens, N.2
Declercq, W.3
Vanden Berghe, T.4
Vandenabeele, P.5
-
11
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A., Bassik M.C., Walensky L.D., Sorcinelli M.D., Weiler S., and Korsmeyer S.J. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2 (2002) 183-192
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
12
-
-
34250025633
-
Engulfment is required for cell competition
-
Li W., and Baker N.E. Engulfment is required for cell competition. Cell 129 (2007) 1215-1225
-
(2007)
Cell
, vol.129
, pp. 1215-1225
-
-
Li, W.1
Baker, N.E.2
-
13
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
14
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
15
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum J.J., Bauer D.E., Kong M., Harris M.H., Li C., Lindsten T., and Thompson C.B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 (2005) 237-248
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
Lindsten, T.6
Thompson, C.B.7
-
16
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X., Budihardjo I., Zou H., Slaughter C., and Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94 (1998) 481-490
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
17
-
-
33947426526
-
The CASBAH: a searchable database of caspase substrates
-
Luthi A.U., and Martin S.J. The CASBAH: a searchable database of caspase substrates. Cell Death Differ. 14 (2007) 641-650
-
(2007)
Cell Death Differ.
, vol.14
, pp. 641-650
-
-
Luthi, A.U.1
Martin, S.J.2
-
18
-
-
33845611951
-
Modeling the therapeutic efficacy of p53 restoration in tumors
-
Martins C.P., Brown-Swigart L., and Evan G.I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127 (2006) 1323-1334
-
(2006)
Cell
, vol.127
, pp. 1323-1334
-
-
Martins, C.P.1
Brown-Swigart, L.2
Evan, G.I.3
-
19
-
-
34548096175
-
Why sick cells produce tumors: the protective role of autophagy
-
Mathew R., and White E. Why sick cells produce tumors: the protective role of autophagy. Autophagy 3 (2007) 502-505
-
(2007)
Autophagy
, vol.3
, pp. 502-505
-
-
Mathew, R.1
White, E.2
-
20
-
-
36549089750
-
Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas
-
10.1371/journal.pone.0000441
-
Moreno C.S., Matyunina L., Dickerson E.B., Schubert N., Bowen N.J., Logani S., Benigno B.B., and McDonald J.F. Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas. PLoS ONE 2 (2007) e441 10.1371/journal.pone.0000441
-
(2007)
PLoS ONE
, vol.2
-
-
Moreno, C.S.1
Matyunina, L.2
Dickerson, E.B.3
Schubert, N.4
Bowen, N.J.5
Logani, S.6
Benigno, B.B.7
McDonald, J.F.8
-
21
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T., Elmore S.W., Shoemaker A.R., Armstrong R.C., Augeri D.J., Belli B.A., Bruncko M., Deckwerth T.L., Dinges J., Hajduk P.J., et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435 (2005) 677-681
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
-
22
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S., Tassa A., Qu X., Garuti R., Liang X.H., Mizushima N., Packer M., Schneider M.D., and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122 (2005) 927-939
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
23
-
-
35948994157
-
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
Petersen S.L., Wang L., Yalcin-Chin A., Li L., Peyton M., Minna J., Harran P., and Wang X. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12 (2007) 445-456
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
Wang, L.2
Yalcin-Chin, A.3
Li, L.4
Peyton, M.5
Minna, J.6
Harran, P.7
Wang, X.8
-
24
-
-
27844526600
-
Akt-dependent transformation: there is more to growth than just surviving
-
Plas D.R., and Thompson C.B. Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24 (2005) 7435-7442
-
(2005)
Oncogene
, vol.24
, pp. 7435-7442
-
-
Plas, D.R.1
Thompson, C.B.2
-
25
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H., O'Reilly L.A., Gunn P., Lee L., Kelly P.N., Huntington N.D., Hughes P.D., Michalak E.M., McKimm-Breschkin J., Motoyama N., et al. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129 (2007) 1337-1349
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
Huntington, N.D.6
Hughes, P.D.7
Michalak, E.M.8
McKimm-Breschkin, J.9
Motoyama, N.10
-
26
-
-
33750619348
-
Glucose metabolism and cancer
-
Shaw R.J. Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18 (2006) 598-608
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 598-608
-
-
Shaw, R.J.1
-
27
-
-
2942746419
-
Caspase activation: revisiting the induced proximity model
-
Shi Y. Caspase activation: revisiting the induced proximity model. Cell 117 (2004) 855-858
-
(2004)
Cell
, vol.117
, pp. 855-858
-
-
Shi, Y.1
-
28
-
-
10344262564
-
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
-
Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C.B., and Tsujimoto Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat. Cell Biol. 6 (2004) 1221-1228
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1221-1228
-
-
Shimizu, S.1
Kanaseki, T.2
Mizushima, N.3
Mizuta, T.4
Arakawa-Kobayashi, S.5
Thompson, C.B.6
Tsujimoto, Y.7
-
29
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E., Blankenship J.W., Wayson S.M., Fedorova A.V., Kayagaki N., Garg P., Zobel K., Dynek J.N., Elliott L.O., Wallweber H.J., et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 131 (2007) 669-681
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
Zobel, K.7
Dynek, J.N.8
Elliott, L.O.9
Wallweber, H.J.10
-
30
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A., Kirsch D.G., McLaughlin M.E., Tuveson D.A., Grimm J., Lintault L., Newman J., Reczek E.E., Weissleder R., and Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature 445 (2007) 661-665
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
31
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A., Michalak E.M., Coultas L., Mullauer F., Bock G., Ausserlechner M.J., Adams J.M., and Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302 (2003) 1036-1038
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
32
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince J.E., Wong W.W., Khan N., Feltham R., Chau D., Ahmed A.U., Benetatos C.A., Chunduru S.K., Condon S.M., McKinlay M., et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 131 (2007) 682-693
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
Feltham, R.4
Chau, D.5
Ahmed, A.U.6
Benetatos, C.A.7
Chunduru, S.K.8
Condon, S.M.9
McKinlay, M.10
-
33
-
-
0033588273
-
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
-
Wang S.L., Hawkins C.J., Yoo S.J., Muller H.A., and Hay B.A. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 (1999) 453-463
-
(1999)
Cell
, vol.98
, pp. 453-463
-
-
Wang, S.L.1
Hawkins, C.J.2
Yoo, S.J.3
Muller, H.A.4
Hay, B.A.5
-
34
-
-
0028200532
-
Genetic control of programmed cell death in Drosophila
-
White K., Grether M.E., Abrams J.M., Young L., Farrell K., and Steller H. Genetic control of programmed cell death in Drosophila. Science 264 (1994) 677-683
-
(1994)
Science
, vol.264
, pp. 677-683
-
-
White, K.1
Grether, M.E.2
Abrams, J.M.3
Young, L.4
Farrell, K.5
Steller, H.6
-
35
-
-
33846964621
-
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
-
Willis S.N., Fletcher J.I., Kaufmann T., van Delft M.F., Chen L., Czabotar P.E., Ierino H., Lee E.F., Fairlie W.D., Bouillet P., et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 (2007) 856-859
-
(2007)
Science
, vol.315
, pp. 856-859
-
-
Willis, S.N.1
Fletcher, J.I.2
Kaufmann, T.3
van Delft, M.F.4
Chen, L.5
Czabotar, P.E.6
Ierino, H.7
Lee, E.F.8
Fairlie, W.D.9
Bouillet, P.10
-
36
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W., Zender L., Miething C., Dickins R.A., Hernando E., Krizhanovsky V., Cordon-Cardo C., and Lowe S.W. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445 (2007) 656-660
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
Cordon-Cardo, C.7
Lowe, S.W.8
-
37
-
-
33749162486
-
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
-
Yousefi S., Perozzo R., Schmid I., Ziemiecki A., Schaffner T., Scapozza L., Brunner T., and Simon H.U. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell Biol. 8 (2006) 1124-1132
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1124-1132
-
-
Yousefi, S.1
Perozzo, R.2
Schmid, I.3
Ziemiecki, A.4
Schaffner, T.5
Scapozza, L.6
Brunner, T.7
Simon, H.U.8
-
38
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z., Jin S., Yang C., Levine A.J., and Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 100 (2003) 15077-15082
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
39
-
-
29944438881
-
Necrotic death as a cell fate
-
Zong W.X., and Thompson C.B. Necrotic death as a cell fate. Genes Dev. 20 (2006) 1-15
-
(2006)
Genes Dev.
, vol.20
, pp. 1-15
-
-
Zong, W.X.1
Thompson, C.B.2
|